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Specificity of Migraine Treatment in Women 女性偏头痛治疗的特异性
Q3 Medicine Pub Date : 2023-02-20 DOI: 10.20471/may.2023.59.01.05
Koraljka Bačić Baronica, S. Tomasović, Jelena Košćak Lukač, Josip Sremec, R. Baronica
The prevalence of migraine is higher in women than in men, with female to male ratio 3:1 in reproductive age. It is believed that sex hormones play significant role in migraine pathogenesis. Therefore, treatment of migraine in women has some specificities due to hormonal differences between sexes and due to hormonal fluctuations during menstrual cycle, pregnancy, lactation and perimenopause. Treatment of migraine during pregnancy depends on safety profile of the therapy. NSAID-s like naproxen and ibuprofen are being considered safe during the second trimester, but during the first and third trimester they may have adverse effects on pregnancy and foetus. CGRP antagonists should be avoided during pregnancy. Acetaminophen, ibuprofen, and diclofenac are considered to be safe acute therapy during breastfeeding and for preventive treatment propranolol should be used as first line therapy. Women with severe menstrual and menstrual related migraine without aura may be treated with hormonal therapy, whereas it should be avoided among patients with aura due to increased risk of stroke.
女性偏头痛的患病率高于男性,育龄期女性与男性的比例为3:1。人们认为性激素在偏头痛的发病机制中起着重要作用。因此,由于性别之间的激素差异以及月经周期、妊娠、哺乳和围绝经期的激素波动,女性偏头痛的治疗具有一些特异性。妊娠期偏头痛的治疗取决于治疗的安全性。非甾体抗炎药如萘普生和布洛芬在妊娠中期被认为是安全的,但在妊娠早期和晚期,它们可能对妊娠和胎儿产生不良影响。妊娠期间应避免使用CGRP拮抗剂。对乙酰氨基酚、布洛芬和双氯芬酸被认为是母乳喂养期间安全的急性治疗,预防性治疗应使用普萘洛尔作为一线治疗。患有严重月经和月经相关偏头痛且无先兆的女性可以接受激素治疗,而先兆患者应避免激素治疗,因为中风风险增加。
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引用次数: 0
Sex Differences of Oral Anticoagulant Therapy in Atrial Fibrillation 房颤口服抗凝治疗的性别差异
Q3 Medicine Pub Date : 2023-02-20 DOI: 10.20471/may.2023.59.01.22
Janja Pretnar Oblak
Letter to the Editor
给编辑的信
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引用次数: 0
Cluster Headache: Literature Review with Reference to Sex Differences 丛集性头痛:涉及性别差异的文献综述
Q3 Medicine Pub Date : 2023-02-20 DOI: 10.20471/may.2023.59.01.10
D. Mahović, Matea Bračić
Cluster headache is a pain syndrome characterised by severe, unilateral and predominantly orbital pain which lasts 15 - 180 minutes. It is accompanied by a range of ipsilateral autonomic symptoms, such as lacrimation, rhinorrhoea and myosis. Cluster headaches can be episodic with periods of remission or chronic. Even though it is a relatively rare condition, the excruciating pain causes significant disruption of patients’ daily life. The pathophysiology behind cluster headaches is complex and despite making significant progress, the pathogenetic cascade of events hasn’t been entirely elucidated yet. However, research into this subject has discovered brain structures, peripheral pathways and neuropeptides which have key roles in pathogenesis. The basis of diagnosing cluster headaches is a detailed patient history and the exclusion of other primary headaches and potential secondary causes. Sex differences in clinical presentation need to be taken into consideration in order to avoid misdiagnosis. Treatment options are divided into three categories: acute, transitional and prophylactic treatment. Although there are a lot of treatment modalities available, further research is necessary in order to find new therapeutic targets and more effective prophylaxis, especially for chronic cluster headache.
丛集性头痛是一种疼痛综合征,其特征是严重的,单侧的,主要是眼眶疼痛,持续15 - 180分钟。它伴有一系列同侧自主神经症状,如流泪、鼻漏和肌萎缩。丛集性头痛可以是发作性的,有缓解期或慢性期。尽管这是一种相对罕见的疾病,但剧烈的疼痛会严重干扰患者的日常生活。丛集性头痛背后的病理生理学是复杂的,尽管取得了重大进展,但发病级联事件尚未完全阐明。然而,对这一主题的研究已经发现了在发病机制中起关键作用的脑结构、外周通路和神经肽。诊断丛集性头痛的基础是详细的患者病史,并排除其他原发性头痛和潜在的继发原因。临床表现的性别差异需要考虑,以避免误诊。治疗方案分为三类:急性治疗、过渡性治疗和预防性治疗。虽然有许多治疗方法,但为了找到新的治疗靶点和更有效的预防措施,特别是慢性丛集性头痛,还需要进一步的研究。
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引用次数: 0
Young Female with Recurrent Spontaneous Cervical Artery Dissection 年轻女性复发性自发性颈动脉夹层
Q3 Medicine Pub Date : 2023-02-20 DOI: 10.20471/may.2023.59.01.17
Melanija Pintarić, Rafaela Vukasović, A. Lovrenčić‐Huzjan
Previous neurosonological study demonstrated the value of neurosonology in daily monitoring of the cervical artery dissection. This study showed rate of recurrence of 27 % in unaffected arteries. There are two group of recurrences, early and late. Early spontaneous cervical artery dissection (sCAD) recurrences are not uncommon and usually involve arteries previously unaffected by dissection. They are oligosymptomatic (headache or neck pain) or asymptomatic and might be correlated with a transient arterial disorder. Late sCAD recurrences are rare and can occur at site of previous sCAD and might be indicative of an underlying persistent connective tissue weakness. In this case report we present a 31- year old female patient who presented to emergency room because of headache and pain in the neck which started 3 days before. Initial brain CT scan and CT-angiography were normal. Next day she became disoriented and complained of headache, vertigo, nausea. Magnetic resonance of the brain showed little hematoma in quadrigeminal cistern and left vertebral artery dissection in V2 segment. Initial neurovascular ultrasound (nUS) showed dissection in V2 segment left vertebral artery. Next nUS after five days showed new dissection in V1 and V2 segment in right vertebral artery. Following nUS showed initial regression hematoma in both vertebral arteries. To conclude, early sCAD recurrences are not uncommon and usually involve arteries previously unaffected by dissection. Because of that it is important to daily neurosonology monitoring of the dissection.
先前的神经超声研究证实了神经超声在颈动脉夹层日常监测中的价值。该研究显示未受影响动脉的复发率为27%。有两组复发,早期和晚期。早期自发性颈动脉夹层(sCAD)复发并不罕见,通常涉及先前未受夹层影响的动脉。它们是少症状(头痛或颈部疼痛)或无症状,可能与一过性动脉疾病有关。晚期sCAD复发是罕见的,可发生在以前的sCAD部位,可能表明潜在的持续性结缔组织无力。在这个病例报告中,我们提出了一个31岁的女性患者,她因为头痛和颈部疼痛而出现在3天前的急诊室。初始脑CT扫描及CT血管造影正常。第二天,她开始迷失方向,抱怨头痛、眩晕、恶心。脑磁共振示四股池小血肿,左侧椎动脉V2段剥离。初始神经血管超声显示左椎动脉V2段夹层。5 d后复查,右侧椎动脉V1、V2段出现新的夹层。超声造影显示双椎动脉初始消退性血肿。总之,早期sCAD复发并不罕见,通常涉及先前未受剥离影响的动脉。因此,对夹层的日常神经超声监测是非常重要的。
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引用次数: 0
Sex Differences in the Therapy of Advanced Movement Disorders 晚期运动障碍治疗中的性别差异
Q3 Medicine Pub Date : 2023-02-20 DOI: 10.20471/may.2023.59.01.14
V. Vuletić
The influence of sex differences in movement disorders is still under-recognized. There are significant sex differences in the pathophysiology, epidemiology, clinical manifestations, and treatments outcome of many of movement disorders especially Parkinson’s disease. Importance of sex specific differences in invasive treatment outcomes emphasize the importance of their considering when devising patient’s individual management strategies. Increased recognition and future prospective studies specifically addressing sex differences in invasive treatments’ outcomes may help and provide a tailored therapeutic and precision medicine approach to movement disorders. We highlight the most relevant invasive treatment’s effects in advanced movement disorders that differ between men and women. But also, the differences in selection of invasive methods. Increased recognition of sex differences and their impact on treatment of advanced phase of movement disorders, that are very disabling, is very important for future studies and precise and personalized medicine. In this article, we provide a review of sex- related differences in treatment of advanced movement disorders, mostly Parkinson’s diseases.
性别差异对运动障碍的影响仍未得到充分认识。许多运动障碍,尤其是帕金森病,在病理生理、流行病学、临床表现和治疗结果等方面存在显著的性别差异。侵袭性治疗结果的性别特异性差异的重要性强调了在设计患者个体管理策略时考虑其重要性。提高认识和未来的前瞻性研究,特别是针对侵入性治疗结果的性别差异,可能有助于为运动障碍提供量身定制的治疗和精准医学方法。我们强调了最相关的侵入性治疗对晚期运动障碍的影响,这在男性和女性之间是不同的。而且,在选择侵入性方法上的差异。提高对性别差异的认识及其对晚期运动障碍治疗的影响,这对未来的研究和精确和个性化的医疗非常重要。在这篇文章中,我们将对晚期运动障碍(主要是帕金森病)治疗中的性别差异进行综述。
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引用次数: 0
Epidemiology of Parkinson’s Disease 帕金森病的流行病学
Q3 Medicine Pub Date : 2023-02-20 DOI: 10.20471/may.2023.59.01.24
Srđana Telarović
Letter to the Editor
给编辑的信
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引用次数: 1
Why She? A Retrospective Study on Sex Inequality Related to Subarachnoid Haemorrhage 为什么是她?蛛网膜下腔出血相关性别不平等的回顾性研究
Q3 Medicine Pub Date : 2023-02-20 DOI: 10.20471/may.2023.59.01.02
F. Silconi, Marijana Radić, M. Bralic, Žana Besser Silconi
Subarachnoid haemorrhage (SAH) is the only type of stroke with female predominance. We conducted a retrospective analysis of SAH patients throughout a decade and tried to establish any reason for such remarkable sex difference. We conducted a retrospective analysis of subarachnoid haemorrhages treated in Istria County between 2010 and 2021. Some of those patients were referred to a comprehensive stroke centre and we collected those data too. We also collected data regarding the outcome recorded at follow up exams of patients treated for SAH in that period. A total of 193 patients with subarachnoid haemorrhage were found in observed period. We found a lower incidence regarding general population but with a tendency to increase, compared with data from other studies. Among all SAH, 113 were female, which makes a Risk Ratio (RR) of 1.44. The highest RR in females was in aneurysmal subarachnoid haemorrhages, 2.06. We obtained a similar high RR of 2.03 in the case of female ruptured multiple intracranial aneurysms (IA), clearly with a worse outcome. Conversely, the RR in non-aneurysmal subarachnoid haemorrhages and perimesencephalic subarachnoid haemorrhages was lower in the case of female sex and amounted 0.67. We noticed similar sex inequality as shown in other studies, so we can also state that women are at higher risk of IA rupture than men. The reason has to be multifactorial. As found in this study, women have different predilection sites of IA rupture compared with men so we strongly believe that certain hemodynamic forces may lead to aneurysm growth and rupture. As we also confirmed IA rupture is age dependent more in women than in men. As shown in other studies, oestrogen level might be the reason for that. Future studies should further establish and prove these risk factors for IA aneurysm rupture and improve preventive measures.
蛛网膜下腔出血(SAH)是唯一以女性为主的中风类型。我们对SAH患者进行了十年的回顾性分析,并试图确定这种显著性别差异的任何原因。我们对伊斯特里亚县2010年至2021年间治疗的蛛网膜下腔出血进行了回顾性分析。其中一些患者被转诊到综合中风中心,我们也收集了这些数据。我们还收集了该时期接受SAH治疗的患者随访检查时记录的结果数据。观察期共发现193例蛛网膜下腔出血患者。我们发现,与其他研究的数据相比,普通人群的发病率较低,但有增加的趋势。在所有SAH中,113人为女性,这使得风险比(RR)为1.44。女性的RR最高的是动脉瘤性蛛网膜下腔出血,为2.06。在女性多发性颅内动脉瘤(IA)破裂的病例中,我们获得了类似的2.03的高RR,显然结果更糟。相反,女性非动脉瘤性蛛网膜下腔出血和中脑周围蛛网膜下腔大出血的RR较低,为0.67。我们注意到了其他研究中显示的类似的性别不平等,因此我们也可以说,女性患IA破裂的风险高于男性。原因必须是多因素的。正如本研究中发现的那样,与男性相比,女性有不同的IA破裂的偏好部位,因此我们坚信某些血液动力学力量可能导致动脉瘤生长和破裂。正如我们所证实的,IA破裂在女性中比在男性中更依赖于年龄。正如其他研究所表明的,雌激素水平可能是造成这种情况的原因。未来的研究应进一步确定和证明IA动脉瘤破裂的这些危险因素,并改进预防措施。
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引用次数: 0
A Cross Sectional Study of Psychiatric Morbidity and Quality of Life in Vitiligo Patients 白癜风患者精神病发病率和生活质量的横断面研究
Q3 Medicine Pub Date : 2022-10-20 DOI: 10.20471/dec.2022.58.02.07
Pallavi Abhilasha, V. Panneer Selvam, Thenmozhi Lakshmanamoorthy, Arul Saravanan Ramachandran
Introduction: Vitiligo is a chronic disorder of skin pigmentation caused by the selective destruction of melanocytes. It causes psychological distress and affects quality of life. Materials and method: An institution based case control study with 55 cases and 55 controls with vitiligo and without vitiligo was undertaken. They were assessed using the Vitiligo area severity index (VASI), Vitiligo Disease Activity Scoring (VDAS), Hamilton Depression Scale (HAMD) and Dermatology life quality index (DLQI). Results: In our study sample 29.1 % had vulgaris, 27.3 % had focal type of vitiligo, and 32.7 % had acro-facial vitiligo, 5.5 % mixed and 5.5 % segmental type of vitiligo was respectively seen. 76.4 % of the cases scored for mild depression and 16.4 % of the cases scored for moderate degree of depression. 23 (41.8 %) of the cases had mild degree of anxiety and 2 (3.6 %) had moderate degree of anxiety. Acro- facial and vulgaris group scored more for anxiety. Significant difference between two groups on WHO Quality of Life scale BREF and DLQI scores. Discussion: Psychiatric morbidity and Quality of Life was found to be significant in patient group with vitiligo than normal controls. There was a higher positive correlation between QOL and VASI scores, denoting the poor quality of life in patients attributable to the severity of the lesions. Conclusion: Psycho-dermatological services will help to mitigate the sufferings and improve the quality of life of patients with vitiligo.
简介:白癜风是一种由黑色素细胞选择性破坏引起的皮肤色素沉着的慢性疾病。它会造成心理困扰,影响生活质量。材料和方法:一项基于机构的病例对照研究,包括55例白癜风患者和55例对照者。他们使用白癜风区域严重程度指数(VASI)、白癜风活动评分(VDAS)、汉密尔顿抑郁量表(HAMD)和皮肤科生活质量指数(DLQI)进行评估。结果:在我们的研究样本中,29.1%的人患有寻常型,27.3%的人患有局灶型白癜风,32.7%的人患有肩面型白癜风,5.5%的人患有混合型和5.5%的节段型白癜风。76.4%的病例为轻度抑郁症,16.4%的病例为中度抑郁症。23例(41.8%)轻度焦虑,2例(3.6%)中度焦虑。Acro-face和vulgaris组在焦虑方面得分更高。两组在世界卫生组织生活质量量表BREF和DLQI评分上存在显著差异。讨论:白癜风患者组的精神病发病率和生活质量明显高于正常对照组。QOL和VASI评分之间存在较高的正相关性,这表明患者的生活质量较差可归因于病变的严重程度。结论:心理皮肤科服务有助于减轻白癜风患者的痛苦,提高患者的生活质量。
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引用次数: 0
Life Challenges with Psychological Consequences Connected to Growing up in War and Post-War Conditions 在战争和战后条件下长大带来的生活挑战和心理后果
Q3 Medicine Pub Date : 2022-10-20 DOI: 10.20471/may.2022.58.02.09
Josip Bošnjaković
The article examines the relationship between the “Don’t Exist” injunction and the developmental conditions of two groups of adolescents: those who grew up alongside parents who experienced war and post-war conditions, and those who grew up in conditions of peace. Growing up in war and post-war conditions means, for adolescents, that they incorporate the injunctive messages “Do not exist” more than those who grow up in conditions of peace. Injunctive messages from parents were expressed non-verbally during the early years of today’s adolescents’ upbringing. The consequence of having high levels of the injunction “Don’t Exist” is observed through the psychological indisposition that we detected with the ESPERO questionnaire. The research results reported in this article refer to research conducted among Croatian adolescents in the spring of 2011. These adolescents were born during the war against Croatia (1991-1995) and were between 1-3 years old. The results show us that there is a statistically significant difference between adolescents raised in war and post-war conditions with adolescents raised in peaceful conditions. Based on the data, seven psychoeducational steps are suggested for the healthy development of a person and for a possible way of life for those who have suffered the consequences of war. In addition to this, the significant contribution of transactional analysis to the understanding of psychological processes in social relationships is highlighted.
这篇文章考察了“不存在”禁令与两组青少年的发展条件之间的关系:一组是与经历过战争和战后条件的父母一起长大的青少年,另一组是在和平条件下长大的青少年。对青少年来说,在战争和战后条件下长大意味着,他们比那些在和平条件下长大的人更多地融入了“不存在”的禁令信息。在当今青少年成长的最初几年,来自父母的虚拟信息是非言语表达的。通过我们用ESPERO问卷检测到的心理不适,观察到了“不存在”禁令水平高的后果。本文报告的研究结果是指2011年春季在克罗地亚青少年中进行的研究。这些青少年出生于对克罗地亚的战争期间(1991-1995年),年龄在1-3岁之间。研究结果表明,在战争和战后条件下长大的青少年与在和平条件下成长的青少年之间存在统计学上的显著差异。根据这些数据,提出了七个心理教育步骤,以促进一个人的健康发展,并为那些遭受战争后果的人提供一种可能的生活方式。除此之外,交易分析对理解社会关系中的心理过程的重要贡献也得到了强调。
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引用次数: 0
Rey-Osterrieth Complex Figure Test in Differentiating Between Left and Right Lesions Caused by Brain Tumors and Stroke Rey-Osterrieth复形检验在区分脑肿瘤和脑卒中引起的左右病变中的应用
Q3 Medicine Pub Date : 2022-10-20 DOI: 10.20471/may.2022.58.02.01
S. Galić, K. Matešić, B. Vuković
The aim of this study was to examine whether the ROCF qualitative scoring system developed by Loring, Lee and Meador for differentiating complex partial seizures originating from either the right or left temporal lobe is effective in differentiating left-sided and right-sided brain lesions that are the result of cerebrovascular insult or brain tumours. We were also interested in determining whether this scoring system, which was developed for scoring trials with delayed recall, could be applied to trials with immediate recall and copying. The study consisted of 24 participants with lesions of the left hemisphere and 33 participants with right-sided lesions. Participants with right-sided lesions had a significantly greater number of qualitative errors in copying, immediate and delayed recall, and these three variables are the major contributors in distinguishing between groups. Based on these variables and quantitative results on copying, immediate and delayed recall, we were able to correctly classify 78.3 % of participants with left-sided lesions and 66.7 % of participants with right-sided lesions. Given that more than 90 % of participants with left-sided lesions had two or more errors in delayed recall, it is clear that the criterion of two or more errors which was set by Loring, Lee and Meador for patients with a right-sided focus in epilepsy is not applicable to patients with tumours and strokes. These results do not confirm the usefulness of qualitative errors for distinguishing left-sided and right-sided lesions caused by a tumour or stroke, except, perhaps, in cases of very high results (six or more errors) and when one of these errors is error X in immediate and/or delayed recall.
本研究的目的是检验由Loring、Lee和Meador开发的用于鉴别源自左右颞叶的复杂部分性癫痫发作的ROCF定性评分系统是否能有效地鉴别由脑血管损伤或脑肿瘤引起的左右脑病变。我们也有兴趣确定这个评分系统,它是为延迟回忆的评分试验开发的,是否可以应用于即时回忆和复制的试验。这项研究包括24名左半球有病变的参与者和33名右半球有病变的参与者。右侧病变的参与者在复制、即时和延迟回忆方面有更多的定性错误,这三个变量是区分组间的主要因素。基于这些变量和复制、即时和延迟回忆的定量结果,我们能够正确分类78.3%的左侧病变参与者和66.7%的右侧病变参与者。考虑到超过90%的左侧病变参与者在延迟回忆中有两次或两次以上的错误,很明显,Loring、Lee和Meador为癫痫患者的右侧病灶设定的两次或两次以上错误的标准不适用于肿瘤和中风患者。这些结果并不能证实定性误差对于区分肿瘤或中风引起的左、右脑病变的有用性,除非,可能,在结果非常高的情况下(6个或更多的错误),当这些错误中的一个在立即和/或延迟回忆中是错误X。
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引用次数: 0
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Archives of Psychiatry Research
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