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Combined Use of Phosphatidylethanol and the Audit Test for Detecting of Alcohol Abuse 联合使用磷脂酰乙醇和审计测试检测酒精滥用情况
Q3 Medicine Pub Date : 2024-07-02 DOI: 10.20471/mjune.2024.60.02.06
Yury Evgeny Razvodovsky, Schuriberco Aleksey Vladimirovitz
Aim: To estimate the prevalence of alcohol abuse among men by using combined the direct biochemical marker phosphatidylethanol (PEth) and the AUDIT questionnaire (Alcohol Use Disorders Identification Test). Subjects and Methods: The concentration of PEth was determined in 136 blood samples of men aged 15 - 65 years. The blood was obtained from the laboratory of the medical advisory centre, where it was submitted for routine biochemical analysis. Immediately before blood sampling, clients were asked to complete the AUDIT questionnaire. Determination of the concentration of PEth was carried out using the method of high performance liquid chromatography - tandem mass spectrometry (HPLC - MS). Statistical data processing was carried out using the Statistica 10.0 program. Results: Discrimination by the level of alcohol consumption using the concentration of PEth showed that the proportion of abstinents (practically not drinking alcohol) among men was 20.6 %; the proportion of moderate drinkers was 63.1 %; the proportion of alcohol abusers was 16.3 %. The highest average concentration of PEth, as well as the proportion of those who abuse alcohol, was observed in the age groups of 50 - 59 and 60+ years. The distribution by level of alcohol consumption according to the total score of the AUDIT test was as follows: abstinents - 17.9 %; moderate drinkers - 69.6 %; alcohol abusers - 12.5 %. The highest average test score, as well as the highest share of alcohol abusers, was observed in the age group 50 - 59 years. Correlation analysis did not reveal any relationship between the concentration of PEth in the blood and the total score of the AUDIT test in any of the age groups of men. Conclusion: The results indicate a fairly high prevalence of alcohol abuse among men. Alcohol-related problems are especially high among middle-aged men. The outcomes suggest a low concordance between the concentration of PEth in the blood and the AUDIT score.
目的:结合使用直接生化标记磷脂酰乙醇(PEth)和 AUDIT 问卷(酒精使用障碍识别测试),估计男性酗酒的流行率。研究对象和方法:测定了 136 份 15 - 65 岁男性血液样本中的磷脂酰乙醇浓度。血液取自医疗咨询中心实验室,并在那里进行常规生化分析。在采血前,客户被要求填写 AUDIT 问卷。采用高效液相色谱-串联质谱法(HPLC-MS)测定 PEth 的浓度。统计数据处理采用 Statistica 10.0 程序进行。研究结果根据 PEth 的浓度对饮酒水平进行的区分显示,男性中戒酒者(基本不饮酒)的比例为 20.6%;中度饮酒者的比例为 63.1%;酗酒者的比例为 16.3%。50 - 59 岁和 60 岁以上年龄组的平均饮酒浓度和酗酒比例最高。根据 AUDIT 测试的总分,饮酒水平的分布情况如下:戒酒者 - 17.9%;中度饮酒者 - 69.6%;酗酒者 - 12.5%。测试平均得分最高以及酗酒者比例最高的年龄组是 50 - 59 岁。相关分析表明,在任何年龄组的男性中,血液中 PEth 的浓度与 AUDIT 测试总分之间都没有任何关系。结论结果表明,男性酗酒的发生率相当高。与酒精相关的问题在中年男性中尤其多见。结果表明,血液中 PEth 的浓度与 AUDIT 分数之间的一致性较低。
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引用次数: 0
Eccentric Positionality in Addictions - Moral Aspect of Addictions 吸毒成瘾的偏心立场 - 吸毒成瘾的道德问题
Q3 Medicine Pub Date : 2024-07-02 DOI: 10.20471/june.2024.60.02.10
Luka Maršić, Daniela Vojnović
Aim: The aim of this paper is to review the moral aspect of addictions. With the advancement of technology that brings more and more possibilities to a human being, understanding the principles of one’s own mind and the principles of the epoch in which the same mind lives, becomes necessary for a free life. Materials and Methods: The materials we included into our work include a noteworthy literature dealing with this challenges. Results: In addiction, in which a person has the impression of controlling the substance, enjoying the blissful role of the victor carried on a misbalanced concept of eccentric positionality, until he/she himself/herself becomes the very object he longed for, being a mere object in his own life, so the postmodernist concept of humanity sinks and withers in a bubble of the safety of the supra-cultural mind hooked on the illusion and the power of technique. The concepts of science bring a different view of things, and thus the metaphysical abstract concept of conscience as a divine voice that leads towards the principles that in some epoch arose from the knowledge reached at that time, that is, beliefs, disintegrates. Conclusion: The significance of these theses is that they could be applicable in expanding the view on addictions, which is necessary, taking into account the changes in the mental environment (epoch).
目的:本文旨在回顾成瘾的道德层面。随着科技的进步,人类有了越来越多的可能性,了解自己的思想原则和同一思想所处时代的原则,对自由生活来说是必要的。材料与方法:我们在工作中使用的材料包括有关这一挑战的重要文献。结果:在吸毒成瘾的过程中,人们会产生一种控制毒品的印象,在一种失衡的偏执概念中享受胜利者的幸福角色,直到他/她自己成为他所渴望的对象,成为他自己生活中的一个纯粹的对象,因此,后现代主义的人性概念在迷恋于幻觉和技术力量的超文化思想的安全泡沫中沉沦和枯萎。科学的概念带来了对事物的不同看法,因此,形而上学的抽象概念--良知是一种神圣的声音,它引导人们走向在某个时代从当时的知识(即信仰)中产生的原则--也就瓦解了。结论:这些论点的意义在于,它们可以适用于扩展关于成瘾的观点,考虑到精神环境(时代)的变化,这是必要的。
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引用次数: 0
Professionals’ Satisfaction with the Available Early Support Services, the Professional Role and the Support Provided to Children with Developmental Disabilities and Their Families 专业人员对现有早期支持服务、专业角色以及为发育障碍儿童及其家庭提供的支持的满意度
Q3 Medicine Pub Date : 2024-07-02 DOI: 10.20471/june.2024.60.02.03
Katarina Šarčević Ivić-Hofman, Ana Wagner Jakab, Lelia Kiš-Glavaš
Aim: The objective of this research was to determine the satisfaction of professionals with early support services, professional role and support provided to families of children with developmental disabilities in Brod-Posavina and Istria counties. Subjects and Methods: The sample included 82 professionals from the fields of healthcare, social welfare, and early and preschool education, and a measuring instrument was designed for the purposes of this research. In the first part of the questionnaire, data on sociodemographic characteristics were collected, and in the second part, data on professionals’ satisfaction with early support services, satisfaction with their professional role and satisfaction with the support provided to families of children with disabilities. Results: The results show that most professionals are satisfied with the advisory support services of pediatricians from the health center, the inclusion of children with developmental disabilities in kindergarten and the advisory support of kindergarten teachers. A very small number of professionals express their satisfaction with telephone counseling, the service of a social pedagogue in Centre for Social Welfare, and an assistant in a kindergarten. It was identified that only self-assessment of knowledge about children with developmental disabilities is a significant positive predictor of satisfaction with the professional role (ß = 0.37, p < 0.01). Conclusion: It was also shown that professionals who have more knowledge are more satisfied with their professional role and the support they provide. Findings of this research suggested that quality education and knowledge can be key to achieving a high level of satisfaction with the professional role and the support provided.
目的:本研究旨在确定布罗德-波萨维纳县和伊斯特拉县的专业人员对早期支持服务、专业角色和为发育障碍儿童家庭提供的支持的满意度。研究对象和方法:样本包括来自医疗保健、社会福利、早期和学前教育领域的 82 名专业人员,并为此次研究设计了一份测量工具。问卷的第一部分收集了有关社会人口特征的数据,第二部分收集了有关专业人员对早期支持服务的满意度、对其专业角色的满意度以及对为残疾儿童家庭提供的支持的满意度的数据。结果显示结果显示,大多数专业人员对保健中心儿科医生的咨询支持服务、将发育障碍儿童纳入幼儿园以及幼儿园教师的咨询支持表示满意。极少数专业人员对电话咨询、社会福利中心社会教育学家的服务和幼儿园助理表示满意。结果表明,只有对发育障碍儿童知识的自我评估对专业角色的满意度有显著的正向预测作用(ß = 0.37,p < 0.01)。结论研究还表明,拥有更多知识的专业人员对其专业角色和所提供的支持更为满意。研究结果表明,优质教育和知识是专业角色和所提供支持获得高满意度的关键。
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引用次数: 0
Association between Brain-derived Neurotrophic Factor (BDNF) Val66Met polymorphism and Clinical Outcomes as Measured with PANSS Scale in Patients With Schizophrenia in Two Psychiatric Centres in East Java – Indonesia 印度尼西亚东爪哇两家精神病治疗中心精神分裂症患者脑源性神经营养因子 (BDNF) Val66Met 多态性与 PANSS 量表测量的临床结果之间的关系
Q3 Medicine Pub Date : 2024-07-02 DOI: 10.20471/june.2024.60.02.01
Dearisa Surya Yudhantara, Kresna Septiandy Runtuk, Felix Wijovi, Darien Alfa Cipta
Aim: The etiology of schizophrenia has been linked to complex interactions of genetic and environmental factors, and among them are genes that regulate BDNF (Brain-derived Neurotrophic Factor) expression. The BDNF has been linked to the pathophysiology of schizophrenia, particularly the Val66Met polymorphism. This study aims to assess BDNF Val66Met polymorphism and its role in positive and negative symptoms in patients with schizophrenia in East Java. Subjects and Methods: A total of 52 subjects with schizophrenia living in East Java were assessed for BDNF Val66Met polymorphism. The analysis was performed using Statistical the Social Sciences (SPSS) software version 22. Clinical assessment was conducted using the positive and negative syndrome scale (PANSS). Data were analyzed using linear regression multivariate analysis. Results: Our study found that Val/Met polymorphism is associated negatively with the total PANSS scores (beta coefficient = -12.299, p = 0.017). The Val/Val polymorphism is associated with negative symptoms (beta coefficient = 22.607, p = 0.043). The present study’s findings considered age, gender, education level, number of antipsychotics consumed, medication adherence, and duration of untreated psychosis. Conclusion: Val/Val polymorphism is associated with a higher PANSS total score. Val/Met genotype is associated with more severe positive symptoms, while the Val/Val genotype is associated with more negative symptoms. Further study with a larger and multicenter sample is needed to clarify further the relationship of BDNF polymorphism to clinical outcomes of schizophrenia.
目的:精神分裂症的病因与遗传和环境因素的复杂相互作用有关,其中包括调控脑源性神经营养因子(BDNF)表达的基因。BDNF 与精神分裂症的病理生理学有关,尤其是 Val66Met 多态性。本研究旨在评估 BDNF Val66Met 多态性及其在东爪哇精神分裂症患者阳性和阴性症状中的作用。研究对象和方法:对居住在东爪哇的 52 名精神分裂症患者进行 BDNF Val66Met 多态性评估。分析使用社会科学统计(SPSS)软件 22 版进行。临床评估采用阳性和阴性综合征量表(PANSS)进行。数据采用线性回归多变量分析法进行分析。结果我们的研究发现,Val/Met 多态性与 PANSS 总分呈负相关(β系数 = -12.299,p = 0.017)。Val/Val多态性与阴性症状相关(β系数=22.607,p=0.043)。本研究的结果考虑了年龄、性别、教育程度、服用抗精神病药物的次数、服药依从性和未治疗精神病的持续时间。结论Val/Val多态性与较高的PANSS总分有关。Val/Met基因型与更严重的阳性症状相关,而Val/Val基因型与更多的阴性症状相关。要进一步阐明BDNF多态性与精神分裂症临床结果的关系,还需要进行更大规模的多中心样本研究。
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引用次数: 0
ChatGPT and other Chatbots in Psychiatry 精神病学中的 ChatGPT 和其他聊天机器人
Q3 Medicine Pub Date : 2024-07-02 DOI: 10.20471/june.2024.60.02.07
Goran Arbanas
Aim: Artificial intelligence (AI) is making significant inroads into the field of psychiatry, offering new tools and applications. ChatGPT, a specific chatbot, is at the forefront of this digital revolution. AI’s use in psychiatry ranges from identifying psychiatric symptoms, predicting treatment responses, and improving medication adherence to assisting in patient education, monitoring, and bridging gaps in mental health care. Materials and Methods: This review used a literature study method. Results: ChatGPT functions as a clinical decision support tool. It can analyse patient data and provide diagnostic insights, recommend evidence-based treatments, and offer drug information. It has demonstrated proficiency in generating summaries from medical records, saving clinicians time and enabling them to focus on patient care. Additionally, chatbots like ChatGPT serve as therapist assistants, offering emotional support between therapy sessions and potentially conducting psychotherapy. Studies have shown positive outcomes, with chatbots reducing depression, anxiety symptoms, and providing 24/7 availability for crisis situations. Users find them non-judgmental and comfortable for discussing sensitive issues. Despite their potential, chatbots have limitations, such as the risk of incorrect or biased information due to their training data. They lack genuine understanding, creativity, and the ability to clarify user input. Ethical considerations regarding responsibility and data usage are paramount. Conclusion: AI, particularly ChatGPT, holds substantial promise in modern psychiatry, enhancing diagnostics, patient education, monitoring, and therapeutic support. Its integration into everyday psychiatric practice requires careful use, continuous oversight, and ethical considerations. Psychiatrists must become more familiar with AI tools to leverage their benefits in patient care.
目的:人工智能(AI)正大举进入精神病学领域,为其提供新的工具和应用。特定聊天机器人 ChatGPT 正处于这场数字革命的前沿。人工智能在精神病学中的应用范围很广,从识别精神症状、预测治疗反应、改善服药依从性,到协助患者教育、监测和弥补精神卫生保健方面的差距。材料与方法本综述采用文献研究法。结果ChatGPT 具有临床决策支持工具的功能。它可以分析患者数据,提供诊断见解,推荐循证治疗,并提供药物信息。它已证明能熟练地从医疗记录中生成摘要,从而节省临床医生的时间,使他们能专注于病人护理。此外,像 ChatGPT 这样的聊天机器人还能充当治疗师助手,在治疗间隙提供情感支持,并有可能进行心理治疗。研究显示,聊天机器人能减少抑郁和焦虑症状,并能全天候应对危机情况,取得了积极的效果。用户认为它们不带偏见,在讨论敏感问题时也很舒适。尽管聊天机器人很有潜力,但也有其局限性,比如由于其训练数据,它们有可能提供不正确或有偏见的信息。它们缺乏真正的理解力、创造力和澄清用户输入的能力。有关责任和数据使用的道德考虑至关重要。结论人工智能,尤其是 ChatGPT,在现代精神病学中大有可为,它能增强诊断、患者教育、监测和治疗支持。将其融入日常精神病学实践需要谨慎使用、持续监督和道德考量。精神科医生必须更加熟悉人工智能工具,才能在患者护理中充分发挥其优势。
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引用次数: 0
Emergency Hospital Admissions of Elderly Patients with Dementia: General Characteristics, Outcome, and Areas of Improvement at an Accident and Emergency Department 老年痴呆症患者的急诊入院情况:急诊室的一般特征、结果和改进领域
Q3 Medicine Pub Date : 2024-07-02 DOI: 10.20471/june.2024.60.02.04
Foteini Christopoulou, Ioannis Andrianopoulos, A. Tatsioni, Matilda Florentin, Athanasios Kitsakos, V. Peritogiannis
Aim: Age-related disorders, such as dementia, are relevant for healthcare services and health systems worldwide. The prevalence of dementia across European countries is estimated to exceed 7 %, and may rise over time. Those patients are at increased risk for hospital admission and prolonged hospitalization, and such care increases the cost for the healthcare system. Less is known regarding patients with dementia in Greece that visit the Accident and Emergency departments (A&E) in general hospitals. The present retrospective study aimed to address this issue. Subjects and methods: The sample of patients and the control group were traced in the A&E department of the University Hospital of Ioannina, Northwest Greece. The study sample consisted of 100 patients with dementia, aged > 65 years and 100 matched controls. The median age of patients with dementia was 85 years, for the control group 83 years, and 63 % were females. In most cases the diagnosis had been made by primary care physicians, and in of patients 21 % by neurologists/psychiatrists. Results: In both groups a median of 2 comorbidities was recorded, with hypertension, heart failure and dyslipidaemia being the most common. Fever and falls were the most common reasons for dementia patients visiting the A&E department. Infection was the most common diagnosis in dementia patients, whereas in 17 % of cases no diagnosis was made and no interventions were needed. The probability of admission after an A&E visit was significantly higher for the dementia group, whereas there were no differences regarding length of hospital stay between patients and controls. Conclusions: The results of the study are in line with international research and highlight the need for the establishment of a national register for patients with dementia, that would enable information exchange between primary and tertiary care and would enable proper diagnosis, management and discharge arrangements.
目的:老年痴呆症等与年龄有关的疾病与全世界的医疗服务和医疗系统息息相关。据估计,欧洲各国的痴呆症发病率超过 7%,并可能随着时间的推移而上升。这些患者入院治疗和长期住院的风险增加,而此类护理增加了医疗系统的成本。人们对希腊综合医院急诊科(A&E)的痴呆症患者知之甚少。本回顾性研究旨在解决这一问题。研究对象和方法:在希腊西北部的约阿尼纳大学医院急诊科对患者样本和对照组进行了追踪调查。研究样本包括 100 名年龄大于 65 岁的痴呆症患者和 100 名匹配的对照组。痴呆症患者的中位年龄为 85 岁,对照组为 83 岁,63% 为女性。在大多数情况下,诊断是由初级保健医生做出的,21%的患者是由神经科医生/精神病医生做出的。结果显示在两组患者中,合并症的中位数均为 2,其中高血压、心力衰竭和血脂异常最为常见。发烧和跌倒是痴呆症患者到急诊科就诊的最常见原因。感染是痴呆症患者最常见的诊断,但有17%的病例没有做出诊断,也不需要采取干预措施。痴呆症患者在急诊室就诊后入院的概率明显较高,而住院时间在患者和对照组之间没有差异。结论:研究结果与国际研究结果一致,并强调了建立全国痴呆症患者登记册的必要性,该登记册将促进初级和三级医疗机构之间的信息交流,并有助于做出正确的诊断、管理和出院安排。
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引用次数: 0
Psychological Techniques in Crisis Negotiation 危机谈判中的心理技巧
Q3 Medicine Pub Date : 2024-07-02 DOI: 10.20471/june.2024.60.02.08
Ivana Glavina Jelaš, Franjo Filipović, Ivan Pranjić
Aim: Crisis negotiation is a very effective police tool for the successful and peaceful resolution of various types of crisis interventions, with different types of interventions being the focus of this review. Materials and Methods: One of the most effective communication skills negotiators use is active listening. Active listening involves focusing attention on what the person is saying without judging, while non-verbally and verbally letting the person know that he is being listened to. In the negotiation context, it calms the perpetrator, encourages him to talk, enables rapport building between the negotiator and the perpetrator, and encourages a change in the perpetrator’s behaviour. Results: Techniques that are most effective in crisis negotiation are paraphrasing, mirroring, “I” messages, minimal encouragements, pause, open-ended questions and emotion labelling. The paper also describes important factors for the effective use of active listening in crisis negotiation. Conclusion: Important factors for the effective use of active listening in crisis negotiation are non-judgmental acceptance, rapport building, maintaining dignity, authenticity, and empathy.
目的:危机谈判是成功、和平解决各类危机干预的一种非常有效的警务工具,不同类型的干预是本综述的重点。材料和方法:谈判人员使用的最有效的沟通技巧之一是积极倾听。积极倾听包括集中精力倾听对方在说什么,而不做任何评判,同时以非语言和语言的方式让对方知道他在被倾听。在谈判中,积极倾听可以安抚施暴者的情绪,鼓励他开口说话,使谈判者和施暴者之间建立融洽的关系,并促使施暴者改变行为。结果:在危机谈判中最有效的技巧是转述、镜像、"我 "的信息、最少的鼓励、停顿、开放式问题和情绪标签。本文还介绍了在危机谈判中有效使用积极倾听的重要因素。结论在危机谈判中有效使用积极倾听的重要因素是非评判性接受、建立融洽关系、维护尊严、真实性和同理心。
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引用次数: 0
Reliability of the Croatian Version of Motivation Scale for Free Time 克罗地亚语版自由时间动机量表的可靠性
Q3 Medicine Pub Date : 2024-07-02 DOI: 10.20471/june.2024.60.02.05
Vanja Blažun, Vesna Mijoč, Tamara Fehervari
Aim: The Motivation scale for free time was developed to measure motivation for activity of population in their free time. The aim of this study was to determine test-retest reliability of Croatian version of Motivation scale for free time on students. Subjects and Methods: The sample was consisted of 97 students of Karlovac University of Applied Sciences 64 men and 33 women). Study was conducted on two occasions and there were 137 students in first measurement and 97 students in second. The response rate to the second measurement was 70,8 %. Statistical data analysis was performed with the software package SPSS 23.0. The normality of the distribution was checked by the Kolmogorov - Smirnov test to justify the use of parametric procedures. The asymmetry coefficient ranged from +/- 3, and the flattening coefficient from +/- 10, and the distribution is considered normal, so the use of parametric procedures is allowed. The validity was checked in the form of correlations of individual particles with the total result in both measurements. Results: The validity in both measurements proved to be statistically significant. In the first measurement, the correlation range of each particle with the total score on the scale ranged between 0.4 to 0.74, which was statistically significant at a risk level of less than 1 %. In the second measurement, the correlation range of each particle with the total score on the scale ranged between 0.31 to 0.73, which was statistically significant at a risk level of less than 1 %. Conclusion: The results showed satisfactory reliability of Croatian version of motivation scale for free time on students.
目的:制定自由时间动机量表是为了测量人们在自由时间的活动动机。本研究旨在确定克罗地亚语版自由时间动机量表在学生中的测试-再测可靠性。研究对象和方法:样本由卡尔洛瓦茨应用科学大学的 97 名学生(64 名男生和 33 名女生)组成。研究分两次进行,第一次测量有 137 名学生,第二次测量有 97 名学生。第二次测量的回复率为 70.8%。统计数据分析使用 SPSS 23.0 软件包进行。通过 Kolmogorov - Smirnov 检验检查了分布的正态性,以证明使用参数化程序的合理性。不对称系数范围为 +/- 3,扁平系数范围为 +/- 10,分布被认为是正态的,因此允许使用参数化程序。通过两次测量中单个颗粒与总结果的相关性检验了有效性。结果:两次测量的有效性都具有显著的统计学意义。在第一次测量中,每个微粒与量表总分的相关范围在 0.4 至 0.74 之间,在小于 1 % 的风险水平上具有统计学意义。在第二次测量中,每个微粒与量表总分的相关范围在 0.31 至 0.73 之间,在风险水平低于 1 % 时具有统计学意义。结论结果表明,克罗地亚版学生自由时间动机量表的可靠性令人满意。
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引用次数: 0
Evenamide 偶氮酰胺
Q3 Medicine Pub Date : 2024-07-02 DOI: 10.20471/june.2024.60.02.11
Vjekoslav Peitl, Darko Vlahović
In light of the persistent struggles encountered with treatment-resistant schizophrenia (TRS), the pressing urgency remains for the development and implementa- tion of novel therapeutic interventions, an essential re- quirement in the realm of health care as a notable por- tion of individuals diagnosed with schizophrenia exhibit minimal positive reactions to antipsychotic medications, even with proper treatment. Evenamide, a newly developed oral compound, selectively inhibits voltage-gated sodium channels (VGSCs) with minimal impact on over 130 other CNS targets. VGSCs are crucial for neuronal excitability and the maintenance of resting potential, playing a vital role in the creation and transmission of action potentials within neurons. Evenamide's primary action involves normalizing glutamate release induced by irregular sodium channel activity without altering baseline glutamate levels, achieved through VGSC inhibition. In animal models of psychosis, evenamide combined with other antipsychotics, including clozapine, showed beneficial outcomes, suggesting potential synergistic mechanisms. Newron’s study 014/015 revealed positive results with evenamide, showing excellent tolerability and minimal adverse effects, with 85 out of 100 patients continuing treatment for 30 weeks. The improvement in TRS symptoms was substantial and increased over time. If corroborated by forthcoming randomized and placebo-controlled trials, evenamide could potentially supplement existing antipsychotics to ameliorate symptoms in TRS cases.
鉴于耐药性精神分裂症(TRS)的治疗一直举步维艰,开发和实施新型治疗干预措施仍是当务之急,这也是医疗保健领域的一项基本要求,因为即使接受了适当的治疗,仍有相当一部分被诊断为精神分裂症的患者对抗精神病药物的积极反应微乎其微。Evenamide 是一种新开发的口服化合物,可选择性地抑制电压门控钠通道(VGSCs),而对其他 130 多个中枢神经系统靶点的影响却微乎其微。电压门控钠通道对神经元的兴奋性和静息电位的维持至关重要,在神经元内动作电位的产生和传递过程中发挥着重要作用。Evenamide 的主要作用是通过抑制 VGSC,在不改变谷氨酸基线水平的情况下,使不规则钠通道活动引起的谷氨酸释放正常化。在精神病动物模型中,埃文酰胺与包括氯氮平在内的其他抗精神病药物联用,显示出有益的结果,这表明存在潜在的协同机制。纽伦的 014/015 号研究显示,偶氮酰胺的治疗效果良好,耐受性极佳,不良反应极小,100 名患者中有 85 人持续治疗了 30 周。TRS 症状得到了显著改善,并随时间推移而加重。如果即将进行的随机和安慰剂对照试验能够证实这一点,偶氮酰胺就有可能补充现有的抗精神病药物,改善TRS病例的症状。
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引用次数: 0
Meaning of Life in Secondary Abstainers from Alcohol (Abstain From Alcohol and Meaning of Life) 二次戒酒者的人生意义(戒酒与人生意义)
Q3 Medicine Pub Date : 2024-07-02 DOI: 10.20471/june.2024.60.02.02
Marin Mamić, Tomislav Gretzer, Ivanka Zirdum, Hrvoje Vidić, Anamarija Tomić, Š. Mikšić, Ivana Mamić, Tihomir Jovanović, Ivana Jelinčić, D. Degmečić, S. Galić, Ivan Vukoja
Aim: Alcoholism is a major public health problem, and it has not yet been clarified which are the factors that influence the relapse of the disease. Aim of this research is to examine whether there is a connection between meaning of life in secondary abstainers from alcohol and variables (demographic, alcohol consumption and severity of addiction before abstinence) and to determine which variables are predictors of the meaning of life in secundary abstainers. Subjects and methods: The research was conducted in 2019 and 2020 at the County Hospital of Požega, at the Department of Neurology, Psychiatry and Clinical Psychology. 113 adults participated in this research who were diagnosed with alcohol addiction and are currently abstaining from alcohol. Results: Meaning of life in the examined addicts in abstinence is low positively related to the length of abstinence (p = 0.030), low negative with the number of hospitalizations due to alcohol addiction (p = 0.013), moderately negative with the severity of alcohol addiction before abstinence (p < 0.001) and moderately positive with financial status (p < 0.001). Hierarchical regression analysis showed that beeing unmerried (p = 0.021), financial status (p < 0.001) and severity of addiction (p < 0.001) are significant predictors of the meaning of life among abstainers from alcohol. Conclusion: It has been shown that alcoholism affects the meaning of life for alcohol addicts, and that it should be considered at the beginning and during the treatment of alcohol addicts.
目的:酗酒是一个重大的公共卫生问题,目前尚未明确哪些因素会影响酗酒者复发。本研究旨在探讨二次戒酒者的生命意义与变量(人口统计学、饮酒量和戒酒前成瘾严重程度)之间是否存在联系,并确定哪些变量可预测二次戒酒者的生命意义。研究对象和方法:研究于2019年和2020年在波泽加县医院神经病学、精神病学和临床心理学部进行。113名被诊断为酒精成瘾且目前正在戒酒的成年人参与了此次研究。研究结果受访戒酒者的生活意义与戒酒时间长短呈低度正相关(p = 0.030),与因酒瘾住院次数呈低度负相关(p = 0.013),与戒酒前酒瘾严重程度呈中度负相关(p < 0.001),与财务状况呈中度正相关(p < 0.001)。层次回归分析表明,未婚(p = 0.021)、经济状况(p < 0.001)和酒瘾严重程度(p < 0.001)对戒酒者的人生意义有显著的预测作用。结论研究表明,酗酒会影响酗酒者的生活意义,在酗酒者戒酒之初和治疗过程中都应考虑到这一点。
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Archives of Psychiatry Research
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