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Archives of pediatrics最新文献

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Equitable Opportunities for Students with Neurodevelopmental Disorders? A Preliminary Framework for Fostering Academic and Social Participation 给神经发育障碍学生公平的机会?促进学术和社会参与的初步框架
Pub Date : 2023-05-15 DOI: 10.29011/2575-825x.100261
Liane Kaufmann, M. Aster, Erwin Concepcion, Martin, Schöfl
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引用次数: 0
A Case of Infant Botulism Caused by Clostridium baratii type F: Evaluation and Experience with Administration of Equine-derived Heptavalent Botulism Antitoxin F型巴氏梭菌致婴儿肉毒杆菌中毒1例:马源七价肉毒杆菌抗毒素的评价与应用体会
Pub Date : 2023-05-14 DOI: 10.29011/2575-825x.100262
D. Primdahl, Megan A. Derrer, Shawn Allen, L. Edwards, F. Tobolowsky, Jessica M. Khouri, A. Waclawik, Lydia Wraight, C. Ikonomidou
nfant botulism is the most common form of human botulism in the United States. Most cases are caused by toxin types A and B, which are treated with Human Botulism Immune Globulin Intravenous (BIG-IV; BabyBIG ® ). We present the case of a 10-day-old male with rapidly progressive paralysis and respiratory failure who was diagnosed with botulism caused by Clostridium baratii toxin type F, a rare form of botulism with poorly defined sources. BIG-IV has no demonstrated efficacy against this serotype of botulism. While the young age, rapid onset of symptoms, and severe presentation are consistent with other reported cases of toxin type F infant botulism, this case is interesting due to improvement with the administration of pyridostigmine and treatment with equine-derived heptavalent botulism antitoxin (HBAT), which has been rarely used in the treatment of infant botulism. This report adds to the literature on the efficacy and safety profile of HBAT administration in infants. Furthermore, this case report suggests that healthcare providers should be aware of the possibility of botulism caused by Clostridium baratii toxin type F in an infant presenting with sudden onset of paralysis and consider early treatment with equine-derived HBAT.
婴儿肉毒杆菌中毒是美国最常见的人类肉毒杆菌中毒。大多数病例是由A型和B型毒素引起的,用人肉毒中毒免疫球蛋白静脉注射(BIG-IV;BabyBIG®)。我们提出的情况下,10天大的男性迅速进行性麻痹和呼吸衰竭谁被诊断为肉毒杆菌引起的巴氏梭菌毒素F型肉毒中毒,一种罕见的肉毒杆菌中毒与不明来源。BIG-IV尚未证实对这种血清型肉毒杆菌中毒有效。虽然年轻,症状发作迅速,症状严重与其他报告的毒素F型婴儿肉毒杆菌中毒病例一致,但由于给予吡多斯的明和马源性七价肉毒杆菌抗毒素(HBAT)治疗后得到改善,该病例很有趣,HBAT很少用于治疗婴儿肉毒杆菌中毒。本报告补充了关于婴儿使用HBAT的有效性和安全性的文献。此外,本病例报告建议,医疗保健提供者应意识到由F型巴拉氏梭菌毒素引起的婴儿肉毒中毒的可能性,并考虑使用马源性HBAT进行早期治疗。
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引用次数: 0
Cost Analysis of Telehealth for Management of Infantile Hemangioma in the United States 美国婴幼儿血管瘤远程医疗管理的成本分析
Pub Date : 2023-05-10 DOI: 10.29011/2575-825x.100259
Ernesto Mejia, M. Midha, Sonal D Shah, Amit Kumar, Mark, Votruba, C. Snyder
Background: Hemangiomas are the most common soft-tissue tumors affecting neonates and rarely lead to complications. Objectives: Assess cost-effectiveness of managing infantile hemangiomas via Telehealth (TH) versus in-person (IP) visits. Methods: Patients with vascular anomalies were assumed to be in 1 of 3 states: infantile hemangioma, nonserious condition, or serious condition. Decision models were constructed for initial and long-term cost of care for patients with infantile hemangiomas. Management was defined as initial visit at 3 months of age with follow-up visits every 3 months until 15 months of age. Reimbursement values were extracted from Medicare data and economic estimates of indirect costs. The expected value of patient visits were calculated in the model, and the lower expected cost was considered optimal. Expected values were calculated under two perspectives: a patient/ payer perspective and a “societal” (patient/payer/provider) perspective, the former assuming TH and IP visits would be equally reimbursed, and the latter incorporating the estimated cost saving arising from lower overhead costs. Deterministic sensitivity analysis was conducted to assess the most salient model inputs. Results: After accounting for increased risk of misdiagnosis and serious conditions, from a patient (payer) perspective, TH was associated with $10.26 cost savings for initial visit, and $51.30 through complete treatment course. From societal perspective TH saved $55.26 initially and $276.30 through complete course. Thus, in comparison to IP, TH is associated with 3.89% and 18.01% cost savings from the payer and societal perspectives, respectively. Conclusion: The use of TH for management infantile hemangioma proved to be cost effective.
背景:血管瘤是影响新生儿最常见的软组织肿瘤,很少引起并发症。目的:评估通过远程医疗(TH)与亲自(IP)就诊管理婴儿血管瘤的成本效益。方法:血管异常患者被假设为3种状态之一:婴儿血管瘤、非严重状态、严重状态。建立了婴幼儿血管瘤患者的初始和长期护理成本决策模型。管理被定义为在3个月大时进行首次访问,每3个月随访一次,直到15个月大。报销值是从医疗保险数据和间接成本的经济估计中提取的。在模型中计算患者就诊的期望值,期望费用越低越优。期望值是在两个角度下计算的:患者/付款人角度和“社会”(患者/付款人/提供者)角度,前者假设tth和IP访问将得到同等的报销,后者纳入了管理费用降低所带来的估计成本节约。进行确定性敏感性分析以评估最显著的模型输入。结果:考虑到误诊和严重情况的风险增加,从患者(付款人)的角度来看,TH与首次就诊节省10.26美元的费用相关,与完成整个疗程节省51.30美元的费用相关。从社会角度来看,他最初节省了55.26美元,完成课程后节省了276.30美元。因此,与知识产权相比,从支付方和社会的角度来看,TH分别节省了3.89%和18.01%的成本。结论:应用甲状腺激素治疗婴幼儿血管瘤具有较好的成本效益。
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引用次数: 0
A Variation in Newborn Head Shape 新生儿头部形状的变异
Pub Date : 2023-05-06 DOI: 10.29011/2575-825x.100257
Tara Venable
There are many variations in newborn head shape after delivery, some of which are suggestive of underlying abnormalities warranting further evaluation while others are normal variations that will resolve with time. It is imperative that clinicians can distinguish among physical exam findings of the newborn head to guide management and decision making. The focus of this paper is to discuss a rare, but benign, variant of the newborn head shape known as bathrocephaly.
分娩后新生儿头部形状有许多变化,其中一些提示潜在的异常,需要进一步评估,而另一些是正常的变化,将随着时间的推移而解决。临床医生必须能够区分新生儿头部的体检结果,以指导管理和决策。本文的重点是讨论一种罕见的,但良性的,新生儿头部形状的变体,称为bathcephaly。
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引用次数: 0
Clinical Outcomes of Orchiopexy for Undescended Testes in Syndromic Patients with Developmental Delay, Genetic Syndromes, and Congenital Anomalies 伴有发育迟缓、遗传综合征和先天性异常的隐睾综合征患者的睾丸切除术的临床结果
Pub Date : 2023-03-08 DOI: 10.29011/2575-825x.100250
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引用次数: 0
Impact of COVID-19 Pandemic on Health Care System, Education, and Mental Well-being of Children with Cystic Fibrosis and their Parents COVID-19大流行对囊性纤维化儿童及其父母的医疗保健系统、教育和心理健康的影响
Pub Date : 2023-02-24 DOI: 10.29011/2575-825x.100240
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引用次数: 0
Changes in Depressive Symptoms and Perceived Stress in Women Coping with Infertility, Following Mind-Body Interventions 心身干预后不孕妇女抑郁症状和感知压力的变化
Pub Date : 2023-02-24 DOI: 10.29011/2575-825x.100247
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引用次数: 0
Bariatric Surgery to Conception Intervals and Breastfeeding Initiation 减肥手术对受孕间隔和母乳喂养开始的影响
Pub Date : 2023-02-20 DOI: 10.29011/2575-825x.100244
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引用次数: 1
Urinary Creatinine from Multiple, Random Samples for Estimating Diuresis in Children 多随机样本尿肌酐用于估计儿童利尿
Pub Date : 2023-02-09 DOI: 10.29011/2575-825x.100241
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引用次数: 0
Determining the Breastfeeding Condition of Children Diagnosed with Leukemia 白血病患儿母乳喂养状况的测定
Pub Date : 2023-02-06 DOI: 10.29011/2575-825x.100239
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引用次数: 0
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Archives of pediatrics
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