Y. Allanore, O. Distler, A. Jagerschmidt, S. Illiano, Laetitia Ledein, E. Boitier, I. Agueusop, C. Denton, D. Khanna
BACKGROUND Preclinical studies suggest a role for lysophosphatidic acid (LPA) in the pathogenesis of systemic sclerosis (SSc). OBJECTIVES SAR100842, a potent selective oral antagonist of LPA1 receptor, was assessed for safety, biomarkers and clinical efficacy in patients with diffuse cutaneous SSc (dcSSc). METHODS An 8-week double-blind, randomized, placebo-controlled study followed by a 16-week open label extension with SAR100842 was performed in patients with early dcSSc and a baseline Rodnan skin score (mRSS) of at least 15. The primary endpoint was safety during the double-blind phase of the trial. Exploratory endpoints included the identification of a LPA-induced gene signature in patients 'skin. RESULTS 17 of 32 subjects were randomized to placebo and 15 to SAR100842; 30 patients participated in the extension study. The most frequent adverse events reported for SAR100842 during the blinded phase were headache, diarrhea, nausea and fall and the safety profile was acceptable during the extension part. At Week 8, mean reduction in mRSS was numerically greater in the SAR100842 compared to placebo (mean change [SD]: -3.57 [4.18] versus -2.76 [4.85]; difference [95% CI]: -1.2 [-4.37 to 2.02], p=0.46). A greater reduction of LPA related genes was observed in skin of SAR100842 group at Week 8, indicating LPA target engagement. CONCLUSION SAR100842, a selective orally available LPA receptor antagonist, was well tolerated in patients with dcSSc. MRSS improved during the study although not reaching significance, and additional gene signature analysis suggested target engagement. These results need to be confirmed in a larger controlled trial. This article is protected by copyright. All rights reserved.
{"title":"Double-blind, Randomized, 8-week Placebo-controlled followed by a 16-week open label extension study, with the LPA1 receptor antagonist SAR100842 for Patients With Diffuse Cutaneous Systemic Sclerosis","authors":"Y. Allanore, O. Distler, A. Jagerschmidt, S. Illiano, Laetitia Ledein, E. Boitier, I. Agueusop, C. Denton, D. Khanna","doi":"10.5167/UZH-151637","DOIUrl":"https://doi.org/10.5167/UZH-151637","url":null,"abstract":"BACKGROUND Preclinical studies suggest a role for lysophosphatidic acid (LPA) in the pathogenesis of systemic sclerosis (SSc). OBJECTIVES SAR100842, a potent selective oral antagonist of LPA1 receptor, was assessed for safety, biomarkers and clinical efficacy in patients with diffuse cutaneous SSc (dcSSc). METHODS An 8-week double-blind, randomized, placebo-controlled study followed by a 16-week open label extension with SAR100842 was performed in patients with early dcSSc and a baseline Rodnan skin score (mRSS) of at least 15. The primary endpoint was safety during the double-blind phase of the trial. Exploratory endpoints included the identification of a LPA-induced gene signature in patients 'skin. RESULTS 17 of 32 subjects were randomized to placebo and 15 to SAR100842; 30 patients participated in the extension study. The most frequent adverse events reported for SAR100842 during the blinded phase were headache, diarrhea, nausea and fall and the safety profile was acceptable during the extension part. At Week 8, mean reduction in mRSS was numerically greater in the SAR100842 compared to placebo (mean change [SD]: -3.57 [4.18] versus -2.76 [4.85]; difference [95% CI]: -1.2 [-4.37 to 2.02], p=0.46). A greater reduction of LPA related genes was observed in skin of SAR100842 group at Week 8, indicating LPA target engagement. CONCLUSION SAR100842, a selective orally available LPA receptor antagonist, was well tolerated in patients with dcSSc. MRSS improved during the study although not reaching significance, and additional gene signature analysis suggested target engagement. These results need to be confirmed in a larger controlled trial. This article is protected by copyright. All rights reserved.","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41424214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Coates, D. Gladman, P. Nash, O. FitzGerald, A. Kavanaugh, L. Rasouliyan, L. Pricop, K. Ding, C. Gaillez
Abstract not available. Disclosures: Study sponsored by Novartis. Copyright 2018 SKIN
摘要不可用。披露:研究由诺华赞助。版权所有2018 SKIN
{"title":"Secukinumab Achievement of Psoriatic Arthritis Disease Activity Score (PASDAS) Related Remission: 2-Year Results from a Phase 3 Study","authors":"L. Coates, D. Gladman, P. Nash, O. FitzGerald, A. Kavanaugh, L. Rasouliyan, L. Pricop, K. Ding, C. Gaillez","doi":"10.25251/SKIN.2.SUPP.17","DOIUrl":"https://doi.org/10.25251/SKIN.2.SUPP.17","url":null,"abstract":"Abstract not available. Disclosures: Study sponsored by Novartis. Copyright 2018 SKIN","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43786896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
William Y. Raynor, V. Jonnakuti, Kaiyuan Zheng, P. Høilund-Carlsen, A. Alavi, J. Baker
{"title":"Assessment of methods to quantitatively evaluate global synovitis activity with FDG-PET/CT","authors":"William Y. Raynor, V. Jonnakuti, Kaiyuan Zheng, P. Høilund-Carlsen, A. Alavi, J. Baker","doi":"10.1002/ART.4032","DOIUrl":"https://doi.org/10.1002/ART.4032","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51519159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Chighizola, L. Andreoli, M. Tonello, M. Raimondo, F. Pregnolato, C. Nalli, E. Mattia, L. Cesana, R. Kumar, C. Comerio, C. Grossi, F. Mombelli, M. Gerosa, M. Borghi, A. Ruffatti, A. Tincani, Marcus John Beasley
Ayten Yazici , OZAN UNLU , Cecilia B. Chighizola , Doruk Erkan , Michelle Petri and On Behalf of APS ACTION . , Hospital for Special Surgery, Cornell Weill Cornell Medicine, NEW YORK CITY, NY, Turkey, Rheumatology, Kocaeli University School of Medicine, Kocaeli, Turkey, Rheumatology Department, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, Department of Clinical Sciences and Community Health, University of Milan, IRCCS Istituto Auxologico Italiano, Milano, Italy, Rheumatology, Hospital for Special SurgeryWeill Cornell Medicine, New York, NY, Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD, ., New York, NY
{"title":"Antibodies Against Domain 1 and Domain 4/5 of β2 Glycoprotein I : Clinical Relevance in Obstetric Anti-Phospholipid Syndrome","authors":"C. Chighizola, L. Andreoli, M. Tonello, M. Raimondo, F. Pregnolato, C. Nalli, E. Mattia, L. Cesana, R. Kumar, C. Comerio, C. Grossi, F. Mombelli, M. Gerosa, M. Borghi, A. Ruffatti, A. Tincani, Marcus John Beasley","doi":"10.1002/art.39977/full","DOIUrl":"https://doi.org/10.1002/art.39977/full","url":null,"abstract":"Ayten Yazici , OZAN UNLU , Cecilia B. Chighizola , Doruk Erkan , Michelle Petri and On Behalf of APS ACTION . , Hospital for Special Surgery, Cornell Weill Cornell Medicine, NEW YORK CITY, NY, Turkey, Rheumatology, Kocaeli University School of Medicine, Kocaeli, Turkey, Rheumatology Department, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, Department of Clinical Sciences and Community Health, University of Milan, IRCCS Istituto Auxologico Italiano, Milano, Italy, Rheumatology, Hospital for Special SurgeryWeill Cornell Medicine, New York, NY, Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD, ., New York, NY","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51519079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Duda, S. Fenton, J. V. Zanten, G. Metsios, P. Rouse, N. Ntoumanis, Chen-an Yu, Y. Koutedakis, G. Kitas
{"title":"A Self-Determination Theory Based Intervention to Increase Levels of Cardiorespiratory Fitness, Self-Determined Motivation, Physical Activity and Improve Health Outcomes Among Patients Living with Rheumatoid Arthritis","authors":"J. Duda, S. Fenton, J. V. Zanten, G. Metsios, P. Rouse, N. Ntoumanis, Chen-an Yu, Y. Koutedakis, G. Kitas","doi":"10.1002/ART.V68.S10","DOIUrl":"https://doi.org/10.1002/ART.V68.S10","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51519191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-01DOI: 10.1016/J.JOCA.2016.01.634
F. Comblain, C. Lambert, Isabelle Lesponne, Christelle Sanchez, J. Dubuc, Y. Henrotin
{"title":"Identification of a Spectrum of Therapeutic Targets of a New Treatment for Osteoarthritis Composed By Curcuminoids Extract, Hydrolyzed Collagen and Green Tea Extract","authors":"F. Comblain, C. Lambert, Isabelle Lesponne, Christelle Sanchez, J. Dubuc, Y. Henrotin","doi":"10.1016/J.JOCA.2016.01.634","DOIUrl":"https://doi.org/10.1016/J.JOCA.2016.01.634","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/J.JOCA.2016.01.634","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54658975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Identification of Long-Term Physical Activity Trajectories in Individuals with Chronic Widespread Pain Who Received Exercise Treatment As Part of a Randomized Controlled Trial","authors":"K. Martin, K. Druce, L. D’Ambruoso, G. Macfarlane","doi":"10.1002/art.39448_2","DOIUrl":"https://doi.org/10.1002/art.39448_2","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51519058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-04-01DOI: 10.1016/J.JOCA.2015.02.782
Runhaar, Christelle Sanchez, S. Taralla, Y. Henrotin, S. Bierma-Zeinstra
{"title":"Baseline Fibulin3 Concentrations Are Associated with Incidence of Clinical Knee OA after 30 Months in Overweight and Obese Women","authors":"Runhaar, Christelle Sanchez, S. Taralla, Y. Henrotin, S. Bierma-Zeinstra","doi":"10.1016/J.JOCA.2015.02.782","DOIUrl":"https://doi.org/10.1016/J.JOCA.2015.02.782","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/J.JOCA.2015.02.782","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54650399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. J. G. Carnota, Antonio González Martínez-Pedrayo, Aida Ferreiro Iglesias
{"title":"Replication of PTPRC As Genetic Biomarker of Response to TNF Inhibitors in Patients with Rheumatoid Arthritis.","authors":"J. J. G. Carnota, Antonio González Martínez-Pedrayo, Aida Ferreiro Iglesias","doi":"10.1002/ART.38..","DOIUrl":"https://doi.org/10.1002/ART.38..","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51519012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Sernissi, C. Baldini, D. Martini, L. Lorenzini, L. Bazzichi, A. Sabbatini, G. D. Marchi, C. Giacomelli, M. Mosca, S. Bombardieri
{"title":"Salivary Expression of S100A7/Psoriasin and Oral Damage in Primary Sjögren's Syndrome and Overlapping Disorders.","authors":"F. Sernissi, C. Baldini, D. Martini, L. Lorenzini, L. Bazzichi, A. Sabbatini, G. D. Marchi, C. Giacomelli, M. Mosca, S. Bombardieri","doi":"10.1002/ART.38914/PDF","DOIUrl":"https://doi.org/10.1002/ART.38914/PDF","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51519034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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