Pub Date : 2013-11-23DOI: 10.1016/J.JOCA.2014.02.879
Christelle Sanchez, M. Horcajada, Fanny Membrez, P. Drion, F. Comblain, E. Offord, Y. Henrotin
{"title":"Oleuropein or rutin consumption decreases the spontaneous development of OA in Hartley guinea pig","authors":"Christelle Sanchez, M. Horcajada, Fanny Membrez, P. Drion, F. Comblain, E. Offord, Y. Henrotin","doi":"10.1016/J.JOCA.2014.02.879","DOIUrl":"https://doi.org/10.1016/J.JOCA.2014.02.879","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/J.JOCA.2014.02.879","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54638075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Osteoarthritis clinical trials have not identified efficacious therapies because traditional imaging outcome measures are inadequate","authors":"K. Brandt","doi":"10.1002/ART.38084","DOIUrl":"https://doi.org/10.1002/ART.38084","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ART.38084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51519024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiovascular disease management in RA.","authors":"M J L Peters, Michael Nurmohamed","doi":"10.1002/art.37974","DOIUrl":"10.1002/art.37974","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31374261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Serge D Steinfeld, Paul Demols, Isabelle Salmon, Robert Kiss, Thierry Appelboom
{"title":"Notice of retraction of two articles (“Infliximab in patients with primary Sjögren’s syndrome: a pilot study” and “Infliximab in patients with primary Sjögren’s syndrome: one-year followup”).","authors":"Serge D Steinfeld, Paul Demols, Isabelle Salmon, Robert Kiss, Thierry Appelboom","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31341193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-06-01DOI: 10.6968/TJCCM.201206.0018
林高士
Erythema nodosum is a type of panniculitis, often manifests as acute onset, swelling, painful, non-ulcerated red lumps. It is quite common in the extension side of the lower extremities in 20 to 30 years old female.Most patients' onsets of Erythema nodosum are not clear yet. Some of them might be related to certain infectious diseases such as streptococcal infection, TB, certain pancreatic diseases, and some immune deficiencies such as SLE etc. Because erythema nodosum often takes place in the lower extremities, we found similar descriptions in Chinese Medicine archives such as ”san li fa” and ”stagnation of dampness and toxin”. This article discusses the etiology, mechanism and Chinese medicine treatment of erythema nodosum.
{"title":"Erythema nodosum.","authors":"林高士","doi":"10.6968/TJCCM.201206.0018","DOIUrl":"https://doi.org/10.6968/TJCCM.201206.0018","url":null,"abstract":"Erythema nodosum is a type of panniculitis, often manifests as acute onset, swelling, painful, non-ulcerated red lumps. It is quite common in the extension side of the lower extremities in 20 to 30 years old female.Most patients' onsets of Erythema nodosum are not clear yet. Some of them might be related to certain infectious diseases such as streptococcal infection, TB, certain pancreatic diseases, and some immune deficiencies such as SLE etc. Because erythema nodosum often takes place in the lower extremities, we found similar descriptions in Chinese Medicine archives such as ”san li fa” and ”stagnation of dampness and toxin”. This article discusses the etiology, mechanism and Chinese medicine treatment of erythema nodosum.","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72909331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Independent development of inflammation and new bone formation in ankylosing spondylitis.","authors":"Georg Schett","doi":"10.1002/art.34441","DOIUrl":"10.1002/art.34441","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30476770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Abstracts of the American College of Rheumatology & Association of Rheumatology Health Professionals Annual Scientific Meeting. November 4-9, 2011. Chicago, Illinois, USA.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30343708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W. Martin, O. Shaw, Xiao Liu, S. Steiger, J. Harper
{"title":"MSU crystal-recruited non-inflammatory monocytes differentiate into M1-like pro-inflammatory macrophages in a peritoneal murine model of gout","authors":"W. Martin, O. Shaw, Xiao Liu, S. Steiger, J. Harper","doi":"10.1002/ART.30245","DOIUrl":"https://doi.org/10.1002/ART.30245","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51518979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Valentini, M. Iudici, G. Abignano, S. Vettori, G. Cuomo
{"title":"European Scleroderma Study Group (ESCSG) Activity Index is correlated to quality of life measures both at admission and overtime","authors":"G. Valentini, M. Iudici, G. Abignano, S. Vettori, G. Cuomo","doi":"10.1002/ART.28341","DOIUrl":"https://doi.org/10.1002/ART.28341","url":null,"abstract":"","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51518896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jose-Ezequiel Martin, B. Alizadeh, M. González-Gay, A. Balsa, D. Pascual‐Salcedo, B. Fernández-Gutiérrez, E. Raya
Objective: Genome-wide association studies (GWASs) carried out in rheumatoid arthritis (RA) have led to the discovery of several genetic associations with this disease. Still, the current associated genetic variations can explain only part of the genetic risk involved in RA, and it is well recognised that these GWASs are likely underpowered to detect all common disease variants. Therefore, we explored the genomic regions showing low-significance associations in previous GWASs of RA. Methods: To reduce the false-positive signal fraction, we exploited pathway analysis to prioritise regions containing genes most likely to be implicated in RA. We hypothesised that true disease genes would be in a similar pathway. Therefore, genes from similar pathways but located in different regions were prioritised for replication using Prioritizer software. 384 genetic variants selected from previous RA GWASs were tested in a Spanish case/control discovery cohort comprising 376 RA patients and 478 healthy controls for replication. Statistically significant associations were further validated in replication cohorts from Spain and Netherlands, up to a total of 1,818 RA patients and 2,498 controls. Results: We detected a novel genetic association between RA and the MSRA gene (rs10903323, P = 2.91×10-5, OR = 1.51) in the Spanish combined population. This association was further tested in our independent Dutch replication cohort. Combined analysis showed an overall association of MSRA with RA (P = 2.19×10-4, OR = 1.28). Conclusion: Novel association in the MSRA gene related to oxidative stress is described herein and support a major role for this process in RA.
目的:在类风湿关节炎(RA)中开展的全基因组关联研究(GWASs)发现了与该疾病的几种遗传关联。尽管如此，目前相关的遗传变异只能解释与类风湿性关节炎相关的部分遗传风险，而且人们普遍认为，这些GWASs在检测所有常见疾病变异方面可能能力不足。因此，我们探索了在先前的RA GWASs中显示低显著相关性的基因组区域。方法:为了减少假阳性信号的比例，我们利用通路分析来优先考虑包含最有可能与RA相关的基因的区域。我们假设真正的疾病基因会在类似的途径中。因此，来自相似途径但位于不同区域的基因被优先使用优先权软件进行复制。从以前的RA GWASs中选择的384个遗传变异在西班牙病例/对照发现队列中进行了测试，该队列包括376名RA患者和478名健康对照进行复制。在西班牙和荷兰的重复队列中，共有1818名RA患者和2498名对照组，进一步验证了统计学上显著的相关性。结果:我们在西班牙联合人群中检测到RA与MSRA基因(rs10903323, P = 2.91×10-5, OR = 1.51)之间的一种新的遗传关联。在我们独立的荷兰重复队列中进一步验证了这种关联。综合分析显示MSRA与RA的总体相关性(P = 2.19×10-4, OR = 1.28)。结论:本文描述了与氧化应激相关的MSRA基因的新关联，并支持该过程在RA中起主要作用。
{"title":"Genome-wide pathway analysis identifies oxidative stress related gene MSRA as rheumatoid arthritis susceptibility locus","authors":"Jose-Ezequiel Martin, B. Alizadeh, M. González-Gay, A. Balsa, D. Pascual‐Salcedo, B. Fernández-Gutiérrez, E. Raya","doi":"10.1002/ART.29365","DOIUrl":"https://doi.org/10.1002/ART.29365","url":null,"abstract":"Objective: Genome-wide association studies (GWASs) carried out in rheumatoid arthritis (RA) have led to the discovery of several genetic associations with this disease. Still, the current associated genetic variations can explain only part of the genetic risk involved in RA, and it is well recognised that these GWASs are likely underpowered to detect all common disease variants. Therefore, we explored the genomic regions showing low-significance associations in previous GWASs of RA. Methods: To reduce the false-positive signal fraction, we exploited pathway analysis to prioritise regions containing genes most likely to be implicated in RA. We hypothesised that true disease genes would be in a similar pathway. Therefore, genes from similar pathways but located in different regions were prioritised for replication using Prioritizer software. 384 genetic variants selected from previous RA GWASs were tested in a Spanish case/control discovery cohort comprising 376 RA patients and 478 healthy controls for replication. Statistically significant associations were further validated in replication cohorts from Spain and Netherlands, up to a total of 1,818 RA patients and 2,498 controls. Results: We detected a novel genetic association between RA and the MSRA gene (rs10903323, P = 2.91×10-5, OR = 1.51) in the Spanish combined population. This association was further tested in our independent Dutch replication cohort. Combined analysis showed an overall association of MSRA with RA (P = 2.19×10-4, OR = 1.28). Conclusion: Novel association in the MSRA gene related to oxidative stress is described herein and support a major role for this process in RA.","PeriodicalId":8405,"journal":{"name":"Arthritis and rheumatism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51518943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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