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Large language models in medical and healthcare fields: applications, advances, and challenges 医疗保健领域的大型语言模型:应用、进步与挑战
IF 10.7 2区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2024-09-20 DOI: 10.1007/s10462-024-10921-0
Dandan Wang, Shiqing Zhang

Large language models (LLMs) are increasingly recognized for their advanced language capabilities, offering significant assistance in diverse areas like medical communication, patient data optimization, and surgical planning. Our survey meticulously searched for papers with keywords such as “medical,” “clinical,” “healthcare,” and “LLMs” across various databases, including ACM and Google Scholar. It sought to delve into the latest trends and applications of LLMs in healthcare, analyzing 175 relevant publications to support both practitioners and researchers in the field. We have compiled 56 experimental datasets, various evaluation methods and reviewed cutting-edge LLMs across tasks. Our comprehensive analysis of LLMs in healthcare applications, including medical question-answering, dialogue summarization, electronic health record generation, scientific research, medical education, medical product safety monitoring, clinical health reasoning, and clinical decision support. Furthermore, we have identified the challenges, including data security, inaccurate information, fairness and bias, plagiarism, copyrights, and accountability, and the potential solutions, namely de-identification framework, references,counterfactually fair prompting,opening and ending control codes, and establishing normative standards,to address these open issues,respectively. The findings of this survey exert a profound impact on spurring innovation in practical applications and addressing inherent challenges within the academic and medical communities.

大型语言模型(LLMs)因其先进的语言能力而日益得到认可,在医疗交流、患者数据优化和手术规划等多个领域提供了重要帮助。我们的调查在各种数据库(包括 ACM 和 Google Scholar)中精心搜索了关键词为 "医学"、"临床"、"医疗保健 "和 "LLMs "的论文。它试图深入研究 LLM 在医疗保健领域的最新趋势和应用,分析了 175 篇相关出版物,为该领域的从业人员和研究人员提供支持。我们汇编了 56 个实验数据集和各种评估方法,并审查了各种任务中的前沿 LLM。我们全面分析了 LLM 在医疗保健领域的应用,包括医疗问题解答、对话总结、电子健康记录生成、科学研究、医学教育、医疗产品安全性监测、临床健康推理和临床决策支持。此外,我们还发现了一些挑战,包括数据安全、信息不准确、公平与偏见、剽窃、版权和责任,以及可能的解决方案,即去身份化框架、参考文献、反事实公平提示、开头和结尾控制代码以及建立规范标准,以分别解决这些开放性问题。这项调查的结果将对促进实际应用创新和解决学术界和医学界固有的挑战产生深远影响。
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引用次数: 0
Review of medical image processing using quantum-enabled algorithms 使用量子算法的医学图像处理回顾
IF 10.7 2区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2024-09-20 DOI: 10.1007/s10462-024-10932-x
Fei Yan, Hesheng Huang, Witold Pedrycz, Kaoru Hirota

Efficient and reliable storage, analysis, and transmission of medical images are imperative for accurate diagnosis, treatment, and management of various diseases. Since quantum computing can revolutionize big data analytics by providing faster solutions and security tactics, numerous studies in this field have focused on the use of quantum and quantum-inspired algorithms to enhance the performance of traditional medical image processing approaches. This review aims to provide readers with a succinct yet adequate compendium of the advances in medical image processing combined with quantum behaviors for disease diagnosis and medical image security. Some open challenges are outlined, identifying the performance limitations of current quantum technology in their applications, while addressing the short-, medium-, and long-term development plans of this field in designing future quantum healthcare systems. We hope that this review will provide full guidance for upcoming researchers interested in this area and will stimulate further appetite of experts already active in this area aimed at the pursuit of more advanced quantum paradigms in medical image processing applications.

要准确诊断、治疗和管理各种疾病,就必须高效可靠地存储、分析和传输医学图像。由于量子计算可以通过提供更快的解决方案和安全策略彻底改变大数据分析,该领域的许多研究都集中在使用量子和量子启发算法来提高传统医学图像处理方法的性能。本综述旨在为读者提供一份简洁而充分的简编,介绍医学图像处理与量子行为相结合在疾病诊断和医学图像安全方面的进展。本综述概述了当前量子技术在其应用中的性能限制,同时探讨了该领域在设计未来量子医疗系统方面的短期、中期和长期发展计划。我们希望这篇综述能为即将对这一领域感兴趣的研究人员提供全面指导,并进一步激发活跃在这一领域的专家的兴趣,从而在医学图像处理应用中追求更先进的量子范式。
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引用次数: 0
A survey of deep causal models and their industrial applications 深度因果模型及其工业应用概览
IF 10.7 2区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2024-09-19 DOI: 10.1007/s10462-024-10886-0
Zongyu Li, Xiaobo Guo, Siwei Qiang

The notion of causality assumes a paramount position within the realm of human cognition. Over the past few decades, there has been significant advancement in the domain of causal effect estimation across various disciplines, including but not limited to computer science, medicine, economics, and industrial applications. Given the continous advancements in deep learning methodologies, there has been a notable surge in its utilization for the estimation of causal effects using counterfactual data. Typically, deep causal models map the characteristics of covariates to a representation space and then design various objective functions to estimate counterfactual data unbiasedly. Different from the existing surveys on causal models in machine learning, this review mainly focuses on the overview of the deep causal models based on neural networks, and its core contributions are as follows: (1) we cast insight on a comprehensive overview of deep causal models from both timeline of development and method classification perspectives; (2) we outline some typical applications of causal effect estimation to industry; (3) we also endeavor to present a detailed categorization and analysis on relevant datasets, source codes and experiments.

因果关系的概念在人类认知领域中占据着至高无上的地位。在过去几十年里,各学科在因果效应估计领域取得了显著进步,包括但不限于计算机科学、医学、经济学和工业应用。鉴于深度学习方法的不断进步,利用反事实数据估算因果效应的应用明显激增。通常,深度因果模型会将协变量的特征映射到一个表示空间,然后设计各种目标函数来无偏估计反事实数据。与现有的机器学习因果模型研究不同,本综述主要关注基于神经网络的深度因果模型概述,其核心贡献如下:(1)从发展时间轴和方法分类两个角度对深度因果模型进行了全面梳理;(2)概述了因果效应估计在行业中的一些典型应用;(3)对相关数据集、源代码和实验进行了详细分类和分析。
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引用次数: 0
Explainable deep learning approach for advanced persistent threats (APTs) detection in cybersecurity: a review 用于检测网络安全中的高级持续性威胁(APTs)的可解释深度学习方法:综述
IF 10.7 2区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2024-09-18 DOI: 10.1007/s10462-024-10890-4
Noor Hazlina Abdul Mutalib, Aznul Qalid Md Sabri, Ainuddin Wahid Abdul Wahab, Erma Rahayu Mohd Faizal Abdullah, Nouar AlDahoul

In recent years, Advanced Persistent Threat (APT) attacks on network systems have increased through sophisticated fraud tactics. Traditional Intrusion Detection Systems (IDSs) suffer from low detection accuracy, high false-positive rates, and difficulty identifying unknown attacks such as remote-to-local (R2L) and user-to-root (U2R) attacks. This paper addresses these challenges by providing a foundational discussion of APTs and the limitations of existing detection methods. It then pivots to explore the novel integration of deep learning techniques and Explainable Artificial Intelligence (XAI) to improve APT detection. This paper aims to fill the gaps in the current research by providing a thorough analysis of how XAI methods, such as Shapley Additive Explanations (SHAP) and Local Interpretable Model-agnostic Explanations (LIME), can make black-box models more transparent and interpretable. The objective is to demonstrate the necessity of explainability in APT detection and propose solutions that enhance the trustworthiness and effectiveness of these models. It offers a critical analysis of existing approaches, highlights their strengths and limitations, and identifies open issues that require further research. This paper also suggests future research directions to combat evolving threats, paving the way for more effective and reliable cybersecurity solutions. Overall, this paper emphasizes the importance of explainability in enhancing the performance and trustworthiness of cybersecurity systems.

近年来,通过复杂的欺诈手段对网络系统发动的高级持续性威胁(APT)攻击日益增多。传统的入侵检测系统(IDS)存在检测准确率低、误报率高、难以识别未知攻击(如远程到本地(R2L)和用户到根(U2R)攻击)等问题。本文通过对 APT 和现有检测方法局限性的基础性讨论来应对这些挑战。然后,本文转而探索深度学习技术与可解释人工智能(XAI)的新型集成,以改进 APT 检测。本文旨在通过深入分析 XAI 方法(如 Shapley Additive Explanations (SHAP) 和 Local Interpretable Model-agnostic Explanations (LIME))如何使黑盒模型更加透明和可解释,填补当前研究的空白。其目的是证明可解释性在 APT 检测中的必要性,并提出提高这些模型可信度和有效性的解决方案。本文对现有方法进行了批判性分析,强调了这些方法的优势和局限性,并指出了需要进一步研究的开放性问题。本文还提出了未来的研究方向,以应对不断演变的威胁,为制定更有效、更可靠的网络安全解决方案铺平道路。总之,本文强调了可解释性在提高网络安全系统性能和可信度方面的重要性。
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引用次数: 0
A systematic review of aspect-based sentiment analysis: domains, methods, and trends 基于方面的情感分析系统综述:领域、方法和趋势
IF 10.7 2区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2024-09-17 DOI: 10.1007/s10462-024-10906-z
Yan Cathy Hua, Paul Denny, Jörg Wicker, Katerina Taskova

Aspect-based sentiment analysis (ABSA) is a fine-grained type of sentiment analysis that identifies aspects and their associated opinions from a given text. With the surge of digital opinionated text data, ABSA gained increasing popularity for its ability to mine more detailed and targeted insights. Many review papers on ABSA subtasks and solution methodologies exist, however, few focus on trends over time or systemic issues relating to research application domains, datasets, and solution approaches. To fill the gap, this paper presents a systematic literature review (SLR) of ABSA studies with a focus on trends and high-level relationships among these fundamental components. This review is one of the largest SLRs on ABSA. To our knowledge, it is also the first to systematically examine the interrelations among ABSA research and data distribution across domains, as well as trends in solution paradigms and approaches. Our sample includes 727 primary studies screened from 8550 search results without time constraints via an innovative automatic filtering process. Our quantitative analysis not only identifies trends in nearly two decades of ABSA research development but also unveils a systemic lack of dataset and domain diversity as well as domain mismatch that may hinder the development of future ABSA research. We discuss these findings and their implications and propose suggestions for future research.

基于方面的情感分析(ABSA)是一种细粒度情感分析,它能从给定文本中识别出方面及其相关观点。随着数字舆情文本数据的激增,ABSA 因其能够挖掘更详细、更有针对性的见解而越来越受欢迎。目前已有许多关于 ABSA 子任务和解决方法的综述论文,但很少有论文关注 ABSA 的发展趋势或与研究应用领域、数据集和解决方法相关的系统性问题。为了填补这一空白,本文对 ABSA 研究进行了系统的文献综述 (SLR),重点关注这些基本组成部分之间的趋势和高层次关系。本综述是关于 ABSA 的最大规模 SLR 之一。据我们所知,这也是第一次系统性地考察 ABSA 研究和跨领域数据分布之间的相互关系,以及解决方案范式和方法的趋势。我们的样本包括从 8550 个搜索结果中通过创新的自动过滤程序筛选出的 727 项主要研究,没有时间限制。我们的定量分析不仅确定了近二十年 ABSA 研究发展的趋势,还揭示了数据集和领域多样性的系统性缺乏以及领域不匹配可能会阻碍未来 ABSA 研究的发展。我们将讨论这些发现及其影响,并对未来研究提出建议。
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引用次数: 0
Big data applications: overview, challenges and future 大数据应用:概述、挑战和未来
IF 10.7 2区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2024-09-16 DOI: 10.1007/s10462-024-10938-5
Afzal Badshah, Ali Daud, Riad Alharbey, Ameen Banjar, Amal Bukhari, Bader Alshemaimri

Big Data (i.e., social big data, vehicular big data, healthcare big data etc) points to massive and complex data, that require special technologies and approaches for storage, processing, and analysis. Similarly, big data applications are software and systems utilizing large and complex datasets to extract insights, support decision-making, and address diverse business and societal challenges. Recently, the significance of big data applications has grown immensely for organizations across diverse sectors as they increasingly rely on insights derived from data. The increasing reliance on data insights has rendered traditional technologies and platforms inefficient due to scalability limitations and performance issues. This study contributes by identifying key domains impacted by big data, examining its effect on decision-making, addressing inherent complexities and opportunities, exploring core technologies, and offering solutions for potential concerns. Additionally, it conducts a comparative analysis to demonstrate the superiority of this research. These contributions provide valuable insights into the evolving landscape shaped by big data applications.

大数据(即社会大数据、车辆大数据、医疗保健大数据等)指的是海量和复杂的数据,需要特殊的技术和方法来存储、处理和分析。同样,大数据应用是指利用大型复杂数据集提取洞察力、支持决策以及应对各种商业和社会挑战的软件和系统。近来,大数据应用对各行各业的组织机构来说意义重大,因为它们越来越依赖从数据中获得的洞察力。由于对数据洞察力的依赖与日俱增,传统技术和平台已因可扩展性限制和性能问题而变得效率低下。本研究通过确定受大数据影响的关键领域、研究大数据对决策的影响、解决固有的复杂性和机遇、探索核心技术以及针对潜在问题提供解决方案,为本研究做出贡献。此外,它还进行了比较分析,以证明这项研究的优越性。这些贡献为了解大数据应用所塑造的不断演变的格局提供了宝贵的见解。
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引用次数: 0
Graph pooling in graph neural networks: methods and their applications in omics studies 图神经网络中的图集合:方法及其在 omics 研究中的应用
IF 10.7 2区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2024-09-16 DOI: 10.1007/s10462-024-10918-9
Yan Wang, Wenju Hou, Nan Sheng, Ziqi Zhao, Jialin Liu, Lan Huang, Juexin Wang

Graph neural networks (GNNs) process the graph-structured data using neural networks and have proven successful in various graph processing tasks. Currently, graph pooling operators have emerged as crucial components that bridge the gap between node representation learning and diverse graph-level tasks by transforming node representations into graph representations. Given the rapid growth and widespread adoption of graph pooling, this review aims to summarize the existing graph pooling operators for GNNs and their representative applications in omics. Specifically, we first present a comprehensive taxonomy of existing graph pooling algorithms, expanding the categorization for both global and hierarchical pooling operators, and for the first time reviewing the inverse operation of graph pooling, named unpooling. Next, we describe the general evaluation framework for graph pooling operators, encompassing three fundamental aspects: experimental setup, ablation analysis, and model interpretation. We also discuss open issues that significantly influence the design of graph pooling operators, including complexity, connectivity, adaptability, additional loss, and attention mechanisms. Finally, we summarize bioinformatics applications of graph pooling operators in omics, including graphs of gene interaction, medical images, and protein structures for drug discovery and disease diagnosis. Furthermore, we showcase the impact of graph pooling operators on research in specific real-world domains, with a focus on prediction performance and model interpretability. This review provides methodological insights in machine learning based graph modeling and related omics research, as well as an ongoing resource by gathering related papers and code in a dedicated GitHub repository (https://github.com/Hou-WJ/Graph-Pooling-Operators-and-Bioinformatics-Applications).

图神经网络(GNN)利用神经网络处理图结构数据,并在各种图处理任务中取得了成功。目前,图池算子已成为关键组件,通过将节点表征转换为图表征,在节点表征学习和各种图级任务之间架起了桥梁。鉴于图池化的快速发展和广泛应用,本综述旨在总结现有的 GNN 图池化算子及其在全息图学中的代表性应用。具体来说,我们首先介绍了现有图池算法的综合分类法,扩展了全局池算子和分层池算子的分类,并首次回顾了图池的逆操作,即unpooling。接下来,我们介绍了图集合算子的一般评估框架,包括三个基本方面:实验设置、消融分析和模型解释。我们还讨论了对图集合算子设计有重大影响的开放性问题,包括复杂性、连通性、适应性、额外损失和注意机制。最后,我们总结了图集合算子在生物信息学中的应用,包括用于药物发现和疾病诊断的基因相互作用图、医学图像和蛋白质结构。此外,我们还展示了图集合算子对特定现实世界领域研究的影响,重点是预测性能和模型可解释性。这篇综述提供了基于机器学习的图建模和相关 omics 研究的方法论见解,并通过在专门的 GitHub 存储库 (https://github.com/Hou-WJ/Graph-Pooling-Operators-and-Bioinformatics-Applications) 中收集相关论文和代码提供了一种持续性资源。
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引用次数: 0
An enhanced Moth-Flame optimizer with quality enhancement and directional crossover: optimizing classic engineering problems 具有质量增强和定向交叉功能的增强型飞蛾-火焰优化器:优化经典工程问题
IF 10.7 2区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2024-09-16 DOI: 10.1007/s10462-024-10923-y
Helong Yu, Jiale Quan, Yongqi Han, Ali Asghar Heidari, Huiling Chen

As a popular meta-heuristic algorithm, the Moth-Flame Optimization (MFO) algorithm has garnered significant interest owing to its high flexibility and straightforward implementation. However, when addressing engineering constraint problems with specific parameters, MFO also exhibits limitations such as fast convergence and a tendency to converge to local optima. In order to address these challenges, this paper introduces an enhanced version of the MFO, EQDXMFO. EQDXMFO integrates a Quality Enhancement (EQ) strategy and a Directional Crossover (DX) mechanism, fortifying the algorithm’s search dynamics. Specifically, the DX mechanism is designed to augment the population’s diversity, enhancing the algorithm’s exploratory potential. Concurrently, the EQ strategy is employed to elevate the solution quality, which in turn refines the convergence precision of the algorithm. To verify the effectiveness of EQDXMFO, experiments are carried out on the test set of the IEEE CEC2017. A total of 5 classical algorithms, five excellent MFO variants, and seven state-of-the-art algorithms are selected for comparison, which confirm the significant advantages of EQDXMFO. Next, EQDXMFO is applied to five complex engineering constraint problems, demonstrating that EQDXMFO can optimize realistic problems. The comprehensive analysis shows that EQDXMFO has strong optimization capabilities and provides methods for research on other complex real-world problems.

作为一种流行的元启发式算法,飞蛾-火焰优化(MFO)算法因其高度灵活性和简单易行而备受关注。然而,在解决具有特定参数的工程约束问题时,MFO 也表现出了一些局限性,如收敛速度快,容易收敛到局部最优。为了应对这些挑战,本文介绍了 MFO 的增强版 EQDXMFO。EQDXMFO 集成了质量增强(EQ)策略和定向交叉(DX)机制,强化了算法的搜索动态。具体来说,DX 机制旨在增强群体的多样性,从而提高算法的探索潜力。与此同时,EQ 策略还能提高解决方案的质量,进而提高算法的收敛精度。为了验证 EQDXMFO 的有效性,我们在 IEEE CEC2017 的测试集上进行了实验。共选取了 5 种经典算法、5 种优秀的 MFO 变体和 7 种最先进的算法进行比较,结果证实了 EQDXMFO 的显著优势。接下来,将 EQDXMFO 应用于五个复杂工程约束问题,证明 EQDXMFO 可以优化现实问题。综合分析表明,EQDXMFO 具有很强的优化能力,为其他复杂实际问题的研究提供了方法。
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引用次数: 0
Deep learning for surgical workflow analysis: a survey of progresses, limitations, and trends 用于手术工作流程分析的深度学习:进展、局限和趋势调查
IF 10.7 2区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2024-09-16 DOI: 10.1007/s10462-024-10929-6
Yunlong Li, Zijian Zhao, Renbo Li, Feng Li

Automatic surgical workflow analysis, which aims to recognize the ongoing surgical events in videos, is fundamental for developing context-aware computer-assisted systems. This paper reviews representative surgical workflow recognition algorithms based on deep learning, outlining their merits, limitations, and future research directions. The literature survey was performed on three large bibliographic databases, covering 67 lary sources, which were comparatively analyzed in terms of spatial feature modeling, spatio-temporal feature modeling, input pre-processing, regularization and post-processing algorithms, as well as learning strategies. Then, common public datasets and evaluation metrics for surgical workflow recognition are also described in detail. Finally, we discuss all literature from different perspectives, and point out the challenges, possible solutions and future trends. The need for more diverse and larger datasets, the potential of unsupervised and semi-supervised learning approaches, comprehensive and equitable metrics, establishing complete regulatory and data standards, and interoperability will be key challenges in translating models to clinical operating rooms. And we propose that surgical activity anticipation and employing large language model as training assistant are interesting research directions in surgical workflow analysis.

自动手术工作流程分析旨在识别视频中正在进行的手术事件,是开发情境感知计算机辅助系统的基础。本文综述了基于深度学习的代表性手术工作流程识别算法,概述了其优点、局限性和未来研究方向。文献调查基于三个大型文献数据库,涵盖 67 个文献来源,从空间特征建模、时空特征建模、输入预处理、正则化和后处理算法以及学习策略等方面进行了比较分析。然后,还详细介绍了手术工作流程识别的常用公共数据集和评价指标。最后,我们从不同角度讨论了所有文献,并指出了面临的挑战、可能的解决方案和未来趋势。将模型转化为临床手术室所面临的主要挑战包括:需要更多样化和更大的数据集、无监督和半监督学习方法的潜力、全面和公平的衡量标准、建立完整的监管和数据标准以及互操作性。我们建议,手术活动预测和采用大型语言模型作为训练助手是手术工作流程分析的有趣研究方向。
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引用次数: 0
A survey of video-based human action recognition in team sports 团队运动中基于视频的人类动作识别研究
IF 10.7 2区 计算机科学 Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2024-09-16 DOI: 10.1007/s10462-024-10934-9
Hongwei Yin, Richard O. Sinnott, Glenn T. Jayaputera

Over the past few decades, numerous studies have focused on identifying and recognizing human actions using machine learning and computer vision techniques. Video-based human action recognition (HAR) aims to detect actions from video sequences automatically. This can cover simple gestures to complex actions involving multiple people interacting with objects. Actions in team sports exhibit a different nature compared to other sports, since they tend to occur at a faster pace and involve more human-human interactions. As a result, research has typically not focused on the challenges of HAR in team sports. This paper comprehensively summarises HAR-related research and applications with specific focus on team sports such as football (soccer), basketball and Australian rules football. Key datasets used for HAR-related team sports research are explored. Finally, common challenges and future work are discussed, and possible research directions identified.

过去几十年来,大量研究都集中在利用机器学习和计算机视觉技术识别和辨认人类动作上。基于视频的人类动作识别(HAR)旨在自动检测视频序列中的动作。其中既包括简单的手势,也包括多人与物体互动的复杂动作。与其他运动相比,团队运动中的动作表现出不同的性质,因为它们往往以更快的速度发生,并涉及更多的人与人之间的互动。因此,研究通常并不关注团队运动中 HAR 所面临的挑战。本文全面总结了与 HAR 相关的研究和应用,重点关注足球、篮球和澳式足球等团队运动。本文还探讨了与 HAR 相关的团队运动研究中使用的关键数据集。最后,讨论了共同面临的挑战和未来的工作,并确定了可能的研究方向。
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引用次数: 0
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