Pub Date : 2023-08-26DOI: 10.52711/2231-5659.2023.00043
Sushma. NC, J Adlin Jino Nesalin, E. Gopinath, Vineeth Chandy
The nanotechnology sector is regarded as a developing technology due to its capacity to improve the already existing items and create new ones for a range of uses. The primary drivers of this expansion are cyclodextrin-based porous nanoparticles or distinctive nanosponges, which have lately been applied in the pharmaceutical, biomedical, and cosmetic industries. This superior technology can circumvent the defects of current techniques through its ability to attack and visualize tumor sites. The organization of this review article is such that we first looked at the distinctive characteristics of these nanosponges and the various synthesizing techniques, then about the drug loading and release principle and applications based on drug delivery, targeting, increasing the solubility of BCS Class II and IV drugs, other applications in biomedicine, and more. The most recent developments on the employment of biomimetic nanosponge as a pandemic tool because of the SARS-CoV-2 virus briefly align. Due to several significant limitations, effective targeted drug delivery systems have long been an aspiration. These issues might be resolved by the creation of new colloidal carriers termed Nanosponges.
{"title":"An Outlook towards Nanosponges: A Propitious Nanocarrier for Novel Drug Delivery","authors":"Sushma. NC, J Adlin Jino Nesalin, E. Gopinath, Vineeth Chandy","doi":"10.52711/2231-5659.2023.00043","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00043","url":null,"abstract":"The nanotechnology sector is regarded as a developing technology due to its capacity to improve the already existing items and create new ones for a range of uses. The primary drivers of this expansion are cyclodextrin-based porous nanoparticles or distinctive nanosponges, which have lately been applied in the pharmaceutical, biomedical, and cosmetic industries. This superior technology can circumvent the defects of current techniques through its ability to attack and visualize tumor sites. The organization of this review article is such that we first looked at the distinctive characteristics of these nanosponges and the various synthesizing techniques, then about the drug loading and release principle and applications based on drug delivery, targeting, increasing the solubility of BCS Class II and IV drugs, other applications in biomedicine, and more. The most recent developments on the employment of biomimetic nanosponge as a pandemic tool because of the SARS-CoV-2 virus briefly align. Due to several significant limitations, effective targeted drug delivery systems have long been an aspiration. These issues might be resolved by the creation of new colloidal carriers termed Nanosponges.","PeriodicalId":8545,"journal":{"name":"Asian Journal of Research in Pharmaceutical Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-26DOI: 10.52711/2231-5659.2023.00036
Reshma Omanakuttan, Indira G, Soorya L S
Cassia fistula L., also known as ‘Golden shower tree’ or ‘Indian laburnum’ of the Fabaceae family, is a common ornamental tree with various medicinal uses. It is a medium or large-sized deciduous tree found in Asian countries, especially in India, Myanmar, Sri Lanka, Thailand, etc. This species has cultural importance as it is the national tree of Thailand and the flower is considered as the state flower of Kerala. Various medicinal activities are identified on basis of traditional knowledge. This research article enlightens the physicochemical characters, comparative successive solvent extraction, and qualitative phytochemical screening of various extracts of Cassia fistula L. roots. The present study aims to compare successive solvent extraction (maceration and soxhlation) for the estimation of yield and qualitative phytochemical screening of extracts obtained through both extractions. Two methods of successive solvent extraction were done, i.e., maceration and soxhlation using solvents of increasing polarity such as petroleum ether, chloroform, ethyl acetate, methanol, and distilled water. The phytochemical tests were carried out for each extract using standard methods of analysis and these investigations. The yields of extract were calculated as %w/w in all five solvents. Comparison of extraction methods helps to determine which method gives the maximum yield of extraction and preliminary phytochemical studies help to find out the secondary metabolites present in the extracts from both methods and compare the results.
{"title":"Comparative Analysis of Maceration and Soxhlation for the Extraction and Preliminary Phytochemical Screening of the Roots of Cassia fistula L.","authors":"Reshma Omanakuttan, Indira G, Soorya L S","doi":"10.52711/2231-5659.2023.00036","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00036","url":null,"abstract":"Cassia fistula L., also known as ‘Golden shower tree’ or ‘Indian laburnum’ of the Fabaceae family, is a common ornamental tree with various medicinal uses. It is a medium or large-sized deciduous tree found in Asian countries, especially in India, Myanmar, Sri Lanka, Thailand, etc. This species has cultural importance as it is the national tree of Thailand and the flower is considered as the state flower of Kerala. Various medicinal activities are identified on basis of traditional knowledge. This research article enlightens the physicochemical characters, comparative successive solvent extraction, and qualitative phytochemical screening of various extracts of Cassia fistula L. roots. The present study aims to compare successive solvent extraction (maceration and soxhlation) for the estimation of yield and qualitative phytochemical screening of extracts obtained through both extractions. Two methods of successive solvent extraction were done, i.e., maceration and soxhlation using solvents of increasing polarity such as petroleum ether, chloroform, ethyl acetate, methanol, and distilled water. The phytochemical tests were carried out for each extract using standard methods of analysis and these investigations. The yields of extract were calculated as %w/w in all five solvents. Comparison of extraction methods helps to determine which method gives the maximum yield of extraction and preliminary phytochemical studies help to find out the secondary metabolites present in the extracts from both methods and compare the results.","PeriodicalId":8545,"journal":{"name":"Asian Journal of Research in Pharmaceutical Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-26DOI: 10.52711/2231-5659.2023.00033
Biswajit Sarma
Jaundice is one of the very common diseases affecting general people of Assam. Traditionally used medicinal plants are found to be very much effective for the treatment of various types of diseases including Jaundice. The common people of Assam are mostly dependent on herbal medicines for the management of jaundice. The main objective of the present study was to investigate the medicinal plants used for the management of jaundice. A field study focused on the uses of herbal plants by the jaundice patients was carried out among the peoples of few lower Assam districts of North Eastern region of India. This article describes various ethnomedicinal plant species used to cure jaundice by the people of Assam. Information on 30 plant species, plant parts used, local name and mode of utilization of the plant parts which are traditionally used against jaundice was recorded. Further investigations are required to explore the biological activity of different active ingredients of traditionally used medicinal plants.
{"title":"Medicinal Plants used for the Treatment of Jaundice in Lower Assam Districts of North East India","authors":"Biswajit Sarma","doi":"10.52711/2231-5659.2023.00033","DOIUrl":"https://doi.org/10.52711/2231-5659.2023.00033","url":null,"abstract":"Jaundice is one of the very common diseases affecting general people of Assam. Traditionally used medicinal plants are found to be very much effective for the treatment of various types of diseases including Jaundice. The common people of Assam are mostly dependent on herbal medicines for the management of jaundice. The main objective of the present study was to investigate the medicinal plants used for the management of jaundice. A field study focused on the uses of herbal plants by the jaundice patients was carried out among the peoples of few lower Assam districts of North Eastern region of India. This article describes various ethnomedicinal plant species used to cure jaundice by the people of Assam. Information on 30 plant species, plant parts used, local name and mode of utilization of the plant parts which are traditionally used against jaundice was recorded. Further investigations are required to explore the biological activity of different active ingredients of traditionally used medicinal plants.","PeriodicalId":8545,"journal":{"name":"Asian Journal of Research in Pharmaceutical Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-10DOI: 10.52711/2231-5659.2021-11-2-13
Radhika G. Sojitra, Urvi Chotaliya
According to the Centers for Disease Control and Prevention (CDC), the transmission of SARS-COV-II occurs mostly person-to-person via respiratory droplets within a range of 180 cm. The virus can also be transmitted if a person touches a mucosal surface after touching an object with the virus on it.14 Human-to-human transmission of the Severe acute respiratory syndrome coronavirus 2 (SARS-COV-II) occurs most often when people are in the incubation stage of the disease or are carriers and have no symptoms. [...]the role of environmental factors and conditions such as temperature, humidity, wind speed as well as food, water and sewage, air, insects, inanimate surfaces, and hands in COVID-19 transmission. [...]SARS-COV-II transmission through food, food packages, and food handlers has not been identified as a risk factor for the disease.15 Transmission may also occur through fomites in the immediate environment around the infected person. [...]the transmission of the COVID-19 virus can occur by direct contact with infected people and indirect contact with surfaces in the immediate environment or with objects used on the infected person like a stethoscope or thermometer.16 Consumption of alcohol will not kill the virus in the inhaled air;it will not disinfect your mouth and throat, and it will not give you any kind of protection against COVID-19.17 1.2 Introduction of Disinfectant and Sanitizer: Germ-killing products are used in foodservice and health care. Disinfectants kill 100% of certain microorganisms, but they are not used on people, only inanimate surfaces. Because disinfectants do not kill all microorganisms, especially bacterial spores, they are different from sterilants.18 1.2.2 Sanitizer: An agent that reduces the number of disease-causing (pathogenic) bacteria on an inanimate food contact surface to safe levels as judged by public health requirements.
{"title":"Saltwater as a Disinfectant and Cleaning agent for Environmental Surfaces in the context of SARS-COV-II.","authors":"Radhika G. Sojitra, Urvi Chotaliya","doi":"10.52711/2231-5659.2021-11-2-13","DOIUrl":"https://doi.org/10.52711/2231-5659.2021-11-2-13","url":null,"abstract":"According to the Centers for Disease Control and Prevention (CDC), the transmission of SARS-COV-II occurs mostly person-to-person via respiratory droplets within a range of 180 cm. The virus can also be transmitted if a person touches a mucosal surface after touching an object with the virus on it.14 Human-to-human transmission of the Severe acute respiratory syndrome coronavirus 2 (SARS-COV-II) occurs most often when people are in the incubation stage of the disease or are carriers and have no symptoms. [...]the role of environmental factors and conditions such as temperature, humidity, wind speed as well as food, water and sewage, air, insects, inanimate surfaces, and hands in COVID-19 transmission. [...]SARS-COV-II transmission through food, food packages, and food handlers has not been identified as a risk factor for the disease.15 Transmission may also occur through fomites in the immediate environment around the infected person. [...]the transmission of the COVID-19 virus can occur by direct contact with infected people and indirect contact with surfaces in the immediate environment or with objects used on the infected person like a stethoscope or thermometer.16 Consumption of alcohol will not kill the virus in the inhaled air;it will not disinfect your mouth and throat, and it will not give you any kind of protection against COVID-19.17 1.2 Introduction of Disinfectant and Sanitizer: Germ-killing products are used in foodservice and health care. Disinfectants kill 100% of certain microorganisms, but they are not used on people, only inanimate surfaces. Because disinfectants do not kill all microorganisms, especially bacterial spores, they are different from sterilants.18 1.2.2 Sanitizer: An agent that reduces the number of disease-causing (pathogenic) bacteria on an inanimate food contact surface to safe levels as judged by public health requirements.","PeriodicalId":8545,"journal":{"name":"Asian Journal of Research in Pharmaceutical Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89966904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-10DOI: 10.52711/2231-5659.2021-11-2-6
Sagar Singh Jough, R. Saini, A. Parveen
Hypertension is a turning into a significant danger to the world. In the hunt of lead atoms from plant beginning as a substitute for poisonous engineered drugs, 26 Indian restorative plants and nourishments were screened for their ACE (Angiotensin Converting Enzyme) inhibitory movement. IC50 (half restraint of ACE) estimations of hydroalcoholic unrefined concentrates and division were dictated by a colorimetric technique. Dynamic parts were additionally screened to decide the compound energy, mode, explicitness and instrument of restraint. Normalization was finished by deciding aggregate phenolics and flavonoids as gallic corrosive and quercetin counterparts/mg of concentrate individually. Among 26 unrefined concentrates, Cynara scolymus extricate indicated the best action, IC50 esteem 356.62µg/mL. Pro restraint coming about because of protein precipitation was most noteworthy in Coscinium fenestratum. Lineweaver-Burk plots uncovered a serious method of restraint for Punica granatum ethyl acetic acid derivation part. Divisions of Cynara scolymus were seen as vague inhibitors of ACE. Coscinium fenestratum parts restrained the ACE by Zn2+ particle chelation. Further, in the quest for sheltered and powerful lead atoms from normal sources, (MP) Mucuna pruriens L. (Fabaceae) seeds were used for investigating the antihypertensive potential. Generally it is utilized as diuretic and Hypotensive. Bioassay-guided divisions were used for the separation of dynamic mixes by segment chromatography. IC50 esteem, protein energy and restraint system were resolved. In vivo time and portion subordinate hypotensive examination followed by changes in the MAP (Mean blood vessel pressure) actuated by angiotensin I (3 nmol/kg), angiotensin II (3nmol/kg), and to bradykinin (10nmol/kg) in anesthetized rodents was finished. Plasma and tissue ACE exercises were additionally decided. Phytochemical examination by spectroscopic methods uncovered the nearness of realized mixes like genistein, ursolic corrosive and L-DOPA from the ethyl acetic acid derivation and water part separately. In vitro examination uncovered MP ethyl acetic acid derivation portion (MPEA) and genistein as the most dynamic part (IC50 156.45µg/mL) and compound (IC50 253.81µM) individually. Lineweaver-Burk plots uncovered a non-serious method of hindrance. Expert protein precipitation was the recommended instrument for restraint. The concentrate indicated a time and portion subordinate decline in the MAP.
高血压正在转变为对世界的重大危险。在寻找铅原子作为有毒工程药物的替代品的过程中，对26种印度恢复性植物和营养物进行了ACE(血管紧张素转换酶)抑制运动的筛选。用比色法测定了未精制氢醇浓缩物的IC50 (ACE的半抑制)和分裂。对动态部件进行了筛选，确定了复合能、约束方式、约束显式和约束手段。通过测定总酚和总黄酮分别为没食子腐蚀物和槲皮素对应物/mg的浓缩物来完成归一化。在26种未精制的浓缩物中，蛇尾草提取物的IC50值为356.62µg/mL，效果最好。蛋白沉淀引起的亲抑制在黄芩中最为显著。Lineweaver-Burk图揭示了石榴乙酯乙酸衍生部分的严重抑制方法。弓形虫的分裂被认为是ACE的模糊抑制剂。孔雀石部分通过Zn2+颗粒螯合抑制ACE。此外，为了从正常来源寻求庇护和强大的铅原子，(MP) Mucuna pruriens L. (Fabaceae)种子被用于研究降压潜力。一般用作利尿剂和降压药。生物测定引导分离采用段色谱法对动态混合物进行分离。IC50自尊、蛋白质能量和约束系统进行了求解。实验完成了在体时间和局部降压检查，并观察了血管紧张素I (3nmol/kg)、血管紧张素II (3nmol/kg)和缓激素(10nmol/kg)对麻醉啮齿动物MAP(平均血管压)的影响。血浆和组织ACE运动也决定。通过光谱学方法进行植物化学检测，发现分别从乙酸乙酯衍生物和水组分中分离出染料木素、熊果酸和左旋多巴等化合物。体外检测发现MP乙酸乙酯衍生物部分(MPEA)和染料木素分别为活性最强的部分(IC50为156.45µg/mL)和化合物(IC50为253.81µM)。织线者-伯克图揭示了一种非严重的阻碍方法。专家蛋白沉淀是推荐的抑制仪器。浓缩物的MAP呈时间和比例递减。
{"title":"A Comprehensive Study on Anti-hypertensive properties of Punica granatum (Pomegranate), Cynara scolymus (Artichoke), Coscinium fenestratum (Yellow vine) in Phytopharmacological, Molecular Biology Researches","authors":"Sagar Singh Jough, R. Saini, A. Parveen","doi":"10.52711/2231-5659.2021-11-2-6","DOIUrl":"https://doi.org/10.52711/2231-5659.2021-11-2-6","url":null,"abstract":"Hypertension is a turning into a significant danger to the world. In the hunt of lead atoms from plant beginning as a substitute for poisonous engineered drugs, 26 Indian restorative plants and nourishments were screened for their ACE (Angiotensin Converting Enzyme) inhibitory movement. IC50 (half restraint of ACE) estimations of hydroalcoholic unrefined concentrates and division were dictated by a colorimetric technique. Dynamic parts were additionally screened to decide the compound energy, mode, explicitness and instrument of restraint. Normalization was finished by deciding aggregate phenolics and flavonoids as gallic corrosive and quercetin counterparts/mg of concentrate individually. Among 26 unrefined concentrates, Cynara scolymus extricate indicated the best action, IC50 esteem 356.62µg/mL. Pro restraint coming about because of protein precipitation was most noteworthy in Coscinium fenestratum. Lineweaver-Burk plots uncovered a serious method of restraint for Punica granatum ethyl acetic acid derivation part. Divisions of Cynara scolymus were seen as vague inhibitors of ACE. Coscinium fenestratum parts restrained the ACE by Zn2+ particle chelation. Further, in the quest for sheltered and powerful lead atoms from normal sources, (MP) Mucuna pruriens L. (Fabaceae) seeds were used for investigating the antihypertensive potential. Generally it is utilized as diuretic and Hypotensive. Bioassay-guided divisions were used for the separation of dynamic mixes by segment chromatography. IC50 esteem, protein energy and restraint system were resolved. In vivo time and portion subordinate hypotensive examination followed by changes in the MAP (Mean blood vessel pressure) actuated by angiotensin I (3 nmol/kg), angiotensin II (3nmol/kg), and to bradykinin (10nmol/kg) in anesthetized rodents was finished. Plasma and tissue ACE exercises were additionally decided. Phytochemical examination by spectroscopic methods uncovered the nearness of realized mixes like genistein, ursolic corrosive and L-DOPA from the ethyl acetic acid derivation and water part separately. In vitro examination uncovered MP ethyl acetic acid derivation portion (MPEA) and genistein as the most dynamic part (IC50 156.45µg/mL) and compound (IC50 253.81µM) individually. Lineweaver-Burk plots uncovered a non-serious method of hindrance. Expert protein precipitation was the recommended instrument for restraint. The concentrate indicated a time and portion subordinate decline in the MAP.","PeriodicalId":8545,"journal":{"name":"Asian Journal of Research in Pharmaceutical Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82193608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-10DOI: 10.52711/2231-5659.2021-11-2-10
D. Prashar, P. Johri, Sanjay Kumar
The Pharmaceutical aspects of the medications are very much essential for proper drug scheduling. But the economical prospect is also essential for the proper patient compliance. These two parameters act in symbiotic relationship. Therefore, there is always the prerequisite for combining these parameters as Pharmaco-economical. This present work tries to present the Pharmaceutical medications of HIV/AIDS from economical view point/scenario.
{"title":"Pharmaco-Economical Projection of HIV/AIDS Therapy","authors":"D. Prashar, P. Johri, Sanjay Kumar","doi":"10.52711/2231-5659.2021-11-2-10","DOIUrl":"https://doi.org/10.52711/2231-5659.2021-11-2-10","url":null,"abstract":"The Pharmaceutical aspects of the medications are very much essential for proper drug scheduling. But the economical prospect is also essential for the proper patient compliance. These two parameters act in symbiotic relationship. Therefore, there is always the prerequisite for combining these parameters as Pharmaco-economical. This present work tries to present the Pharmaceutical medications of HIV/AIDS from economical view point/scenario.","PeriodicalId":8545,"journal":{"name":"Asian Journal of Research in Pharmaceutical Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76888971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-10DOI: 10.52711/2231-5659.2021-11-2-12
Ravi Kumar, G. Gautam, Sweta Pundir, Shafqat Zaidi, C. Gupta
The human infertility is a major problem at this time in entire world. Some important factors that responsible for this cause like as Daily routine, Food contents, less physical activity etc. About 40% infertility cases count due to male factors. The spermatogenetic failure is one of the major causes of male infertility while the in female infertility is due to Pelvic inflammatory disease (PID), uterine problems, previous tubal ligation, Endometriosis etc. A number of medicinal plants used in the treatment of this disorder. So in this review, we have summarized most of the data dealing with the positive effects of plant extracts on spermatogenesis.
{"title":"Treatment of Human Infertility","authors":"Ravi Kumar, G. Gautam, Sweta Pundir, Shafqat Zaidi, C. Gupta","doi":"10.52711/2231-5659.2021-11-2-12","DOIUrl":"https://doi.org/10.52711/2231-5659.2021-11-2-12","url":null,"abstract":"The human infertility is a major problem at this time in entire world. Some important factors that responsible for this cause like as Daily routine, Food contents, less physical activity etc. About 40% infertility cases count due to male factors. The spermatogenetic failure is one of the major causes of male infertility while the in female infertility is due to Pelvic inflammatory disease (PID), uterine problems, previous tubal ligation, Endometriosis etc. A number of medicinal plants used in the treatment of this disorder. So in this review, we have summarized most of the data dealing with the positive effects of plant extracts on spermatogenesis.","PeriodicalId":8545,"journal":{"name":"Asian Journal of Research in Pharmaceutical Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77059059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-10DOI: 10.52711/2231-5659.2021-11-2-5
D. Prashar, Khushboo Jasra
The dental herbs are very much essential for the treatment of many dental problems. They can be used as such or in the form of dental formulations. These dental formulations of the herbs have enormous economical importance too. Apart from the pharmaco-therapeutic role the pharmacognostic and it’s chemical composition is also essential. These parameters help to modify the formulations and to overcome the adverse drug effects associated with these. The present review work tries to highlight the Pharmacognostic and Phytochemical aspects of three dental herbs.
{"title":"Pharmacognostic, Phytochemical and Therapeutic Overview of three Allied Herbs used in Dentistry","authors":"D. Prashar, Khushboo Jasra","doi":"10.52711/2231-5659.2021-11-2-5","DOIUrl":"https://doi.org/10.52711/2231-5659.2021-11-2-5","url":null,"abstract":"The dental herbs are very much essential for the treatment of many dental problems. They can be used as such or in the form of dental formulations. These dental formulations of the herbs have enormous economical importance too. Apart from the pharmaco-therapeutic role the pharmacognostic and it’s chemical composition is also essential. These parameters help to modify the formulations and to overcome the adverse drug effects associated with these. The present review work tries to highlight the Pharmacognostic and Phytochemical aspects of three dental herbs.","PeriodicalId":8545,"journal":{"name":"Asian Journal of Research in Pharmaceutical Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72838000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Many evidences suggested that stressful experience might affect diabetes. The estimate of the actual number of diabetes in India is around 40 million. This means India actually has the highest number of diabetic’s patient of any one country in entire world. No doubt, one of the natural element of life i.e. Stress is a major contributor to the diabetes. Stress can bring many unexpected changes in the blood sugar level; this could trigger symptoms associated with diabetes. Some retrospective human studies have suggested that the stress can participate in Type-1 diabetes, animal studies have shown that stress can cause Type-1 diabetes. impaired glucose tolerance and metabolic disease, however human studies have shown that stress can stimulate hyperglycaemia, insulin resistance. In contrast more consistentevidence support the role of stress in Type-2 diabetes. In recent year the complexities of the relationship between stress and diabetes have become well known but have been less well researched. Some studies have suggested that stressful experience may affect the onset and the metabolic control of diabetes, but finding have often been inconclusive. In this article we reviewed some of this research going on to consider how stress might affect the diabetes and physiological mechanism through which this may occurs and their preventions and management.
{"title":"Stress Induced Diabetes","authors":"Vaishnav Priti Baludas, Kadam Kavita Shivaji, Kalunkhe Amruta Dadasaheb, Pagar Swati Aappasaheb, M. Sitaram","doi":"10.52711/2231-5659.2021-11-2-9","DOIUrl":"https://doi.org/10.52711/2231-5659.2021-11-2-9","url":null,"abstract":"Many evidences suggested that stressful experience might affect diabetes. The estimate of the actual number of diabetes in India is around 40 million. This means India actually has the highest number of diabetic’s patient of any one country in entire world. No doubt, one of the natural element of life i.e. Stress is a major contributor to the diabetes. Stress can bring many unexpected changes in the blood sugar level; this could trigger symptoms associated with diabetes. Some retrospective human studies have suggested that the stress can participate in Type-1 diabetes, animal studies have shown that stress can cause Type-1 diabetes. impaired glucose tolerance and metabolic disease, however human studies have shown that stress can stimulate hyperglycaemia, insulin resistance. In contrast more consistentevidence support the role of stress in Type-2 diabetes. In recent year the complexities of the relationship between stress and diabetes have become well known but have been less well researched. Some studies have suggested that stressful experience may affect the onset and the metabolic control of diabetes, but finding have often been inconclusive. In this article we reviewed some of this research going on to consider how stress might affect the diabetes and physiological mechanism through which this may occurs and their preventions and management.","PeriodicalId":8545,"journal":{"name":"Asian Journal of Research in Pharmaceutical Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90926106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-10DOI: 10.52711/2231-5659.2021-11-2-7
A. Usha, M. Kumari, E. R. Rani, M. Ramadevi
The barrier properties of the topmost layer of the skin, stratum corneum have significant limitations for successful systemic delivery of a wide range of therapeutic molecules, especially macromolecules and genetic material. One solution is to utilize microneedles (MNs), which are capable of painlessly traversing through the stratum corneum and directly translocating protein drugs into the systematic circulation. This strategy involves the use of micron sized needles fabricated from different materials and using different geometries to create transient aqueous conduits across the skin. Microneedles in isolation, or in combination with other enhancing strategies, have been shown to dramatically enhance the skin permeability of numerous therapeutic molecules including biopharmaceuticals either in vitro, ex vivo or in vivo. MNs can be designed to incorporate appropriate structural materials as well as therapeutics or formulations with tailored physicochemical properties. This platform technique has been applied to deliver drugs both locally and systemically in applications ranging from vaccination to diabetes and cancer therap. As an alternative to hypodermic needles, coated polymer microneedles (MNs) are able to deliver drugs to subcutaneous tissues after being inserted into the skin. The dip-coating process is a versatile, rapid fabricating method that can form coated MNs in a short time. However, it is still a challenge to fabricate coated MNs with homogeneous and precise drug doses in the dip-coating process. This review article focuses on recent and potential future developments in microneedle technologies. This will include the detailing of progress made in microneedle design, an exploration of the challenges faced in this field and potential forward strategies to embrace the exploitation of microneedle methodologies, while considering the inherent safety aspects of such therapeutic tools. The clinical potential and future translation of MNs are also discussed.
{"title":"A Novel Technique for Intradermal Delivery of Drugs – Coated Polymeric Needles","authors":"A. Usha, M. Kumari, E. R. Rani, M. Ramadevi","doi":"10.52711/2231-5659.2021-11-2-7","DOIUrl":"https://doi.org/10.52711/2231-5659.2021-11-2-7","url":null,"abstract":"The barrier properties of the topmost layer of the skin, stratum corneum have significant limitations for successful systemic delivery of a wide range of therapeutic molecules, especially macromolecules and genetic material. One solution is to utilize microneedles (MNs), which are capable of painlessly traversing through the stratum corneum and directly translocating protein drugs into the systematic circulation. This strategy involves the use of micron sized needles fabricated from different materials and using different geometries to create transient aqueous conduits across the skin. Microneedles in isolation, or in combination with other enhancing strategies, have been shown to dramatically enhance the skin permeability of numerous therapeutic molecules including biopharmaceuticals either in vitro, ex vivo or in vivo. MNs can be designed to incorporate appropriate structural materials as well as therapeutics or formulations with tailored physicochemical properties. This platform technique has been applied to deliver drugs both locally and systemically in applications ranging from vaccination to diabetes and cancer therap. As an alternative to hypodermic needles, coated polymer microneedles (MNs) are able to deliver drugs to subcutaneous tissues after being inserted into the skin. The dip-coating process is a versatile, rapid fabricating method that can form coated MNs in a short time. However, it is still a challenge to fabricate coated MNs with homogeneous and precise drug doses in the dip-coating process. This review article focuses on recent and potential future developments in microneedle technologies. This will include the detailing of progress made in microneedle design, an exploration of the challenges faced in this field and potential forward strategies to embrace the exploitation of microneedle methodologies, while considering the inherent safety aspects of such therapeutic tools. The clinical potential and future translation of MNs are also discussed.","PeriodicalId":8545,"journal":{"name":"Asian Journal of Research in Pharmaceutical Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76364383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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