Pub Date : 2021-05-10DOI: 10.52711/2231-5659.2021-11-2-3
N ShaikhSiraj, Jayesh C Chaudhary, G. Khan, I MakraniShaharukhIsmail, S. Kshirsagar, Magan G Vasave
At present-day, computers are so communal in pharmaceutical research and development that it may be rough to visualize a time when there were no computers to help the medicinal chemist or biologist. Nowadays, computers are completely essential for generating, managing, and transmitting information. The primary computers were designed for military and accounting applications, but gradually it became apparent that computers would have a massive number of uses. At modern, computers are so common in pharmaceutical research and development. The purpose of this review is to give a brief description of the historical development in respect applications of computers in Research and Development.
{"title":"Olden times of Computers in Pharmaceutical Research and Development: A Brief Review","authors":"N ShaikhSiraj, Jayesh C Chaudhary, G. Khan, I MakraniShaharukhIsmail, S. Kshirsagar, Magan G Vasave","doi":"10.52711/2231-5659.2021-11-2-3","DOIUrl":"https://doi.org/10.52711/2231-5659.2021-11-2-3","url":null,"abstract":"At present-day, computers are so communal in pharmaceutical research and development that it may be rough to visualize a time when there were no computers to help the medicinal chemist or biologist. Nowadays, computers are completely essential for generating, managing, and transmitting information. The primary computers were designed for military and accounting applications, but gradually it became apparent that computers would have a massive number of uses. At modern, computers are so common in pharmaceutical research and development. The purpose of this review is to give a brief description of the historical development in respect applications of computers in Research and Development.","PeriodicalId":8545,"journal":{"name":"Asian Journal of Research in Pharmaceutical Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79394985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-10DOI: 10.52711/2231-5659.2021-11-2-2
A. Varsha, K. Yadav, Shailendra Bindaiya
Our studies on the performance of formulation development and evaluation of fast dissolving films of Oloptadine HCL its anti-allergic drug. Prepare mouth dissolving film of Oloptadine HCl by solvent casting method. To characterize the prepared mouth dissolving film of Oloptadine HCL in terms of— Thickness, percent elongation, tack test, swelling index, in-vitro disintegration time and dissolution test. Oloptadine OLO), 11-[{z}-3-(Dimethlamino) propylidene]-6-11-dihydrobenz [b, e] oxepin-2-acetic acid hydrochloride, is widely used as an antihistaminic. Oloptadine HCL is a relatively selective histamine H1-receptor antagonist that inhibits the release of histamine from mast cells. Oloptadine does not affect alpha-adrenergic dopamine, muscarinic type 1 and 2 or serotonin receptor. They are hydrophobic in nature and non-polar, sparingly soluble in water and freely soluble methanol, ethanol. Olopatadine HCl is a mouth dissolving film. We is trying to sort out the problem of allergic. They are rapidly onset of action, when placed upon the tongue that it is disperse rapidly swallowing within 3-5 seconds without need of water or chewing.
{"title":"Formulation Development and Evaluation of Fast Dissolving Films of Oloptadine HCl","authors":"A. Varsha, K. Yadav, Shailendra Bindaiya","doi":"10.52711/2231-5659.2021-11-2-2","DOIUrl":"https://doi.org/10.52711/2231-5659.2021-11-2-2","url":null,"abstract":"Our studies on the performance of formulation development and evaluation of fast dissolving films of Oloptadine HCL its anti-allergic drug. Prepare mouth dissolving film of Oloptadine HCl by solvent casting method. To characterize the prepared mouth dissolving film of Oloptadine HCL in terms of— Thickness, percent elongation, tack test, swelling index, in-vitro disintegration time and dissolution test. Oloptadine OLO), 11-[{z}-3-(Dimethlamino) propylidene]-6-11-dihydrobenz [b, e] oxepin-2-acetic acid hydrochloride, is widely used as an antihistaminic. Oloptadine HCL is a relatively selective histamine H1-receptor antagonist that inhibits the release of histamine from mast cells. Oloptadine does not affect alpha-adrenergic dopamine, muscarinic type 1 and 2 or serotonin receptor. They are hydrophobic in nature and non-polar, sparingly soluble in water and freely soluble methanol, ethanol. Olopatadine HCl is a mouth dissolving film. We is trying to sort out the problem of allergic. They are rapidly onset of action, when placed upon the tongue that it is disperse rapidly swallowing within 3-5 seconds without need of water or chewing.","PeriodicalId":8545,"journal":{"name":"Asian Journal of Research in Pharmaceutical Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80246221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-10DOI: 10.52711/2231-5659.2021-11-2-8
S. Parkar, Prajakta Kegade, Akshay Gade, Rutuja Sawant
Varicella zoster virus is one of the eight herpes viruses that are pathogenic only for humans. It is alpha-herpes zoster of the genus varicellovirus, which causes varicella (chickenpox) and zoster (shingles). Herpes zoster is described as a multivesicular eruptive rash that follows a single or multiple adjacent dermatomal distribution. VZV infection begins with replication in epithelial cells of upper respiratory mucosa, which is followed by widely distributed vesicular rash. Cell-mediated immunity plays a role in this reactivation. Patients with conditions that decrease cell-mediated immunity are 20 to 100 times more prone to develop herpes zoster. It is often accompanied by acute pain and itchiness. Complications may be dermatological (e.g. secondary bacterial infection), neurological (e.g. long-term pain, segmental paresis, stroke), ophthalmological (e.g. keratitis, iridocyclitis, secondary glaucoma) or visceral (e.g. pneumonia, hepatitis). Most common Complications of the infection are post herpetic neuralgia and ophthalmic zoster. Treatment includes antiviral medications such as acyclovir, famciclovir, and valacyclovir given within 72 hours of symptom has been shown to reduce severity and complications associated with herpes zoster and post-herpetic neuralgia, both these diseases are vaccine preventable. Before the invention of the recombinant VZV vaccine, live VZV vaccine was the recommended immunization, approved for adults 50 years and older.
{"title":"An Overview of Herpes zoster: Aetiology, Pathogenesis and Treatment","authors":"S. Parkar, Prajakta Kegade, Akshay Gade, Rutuja Sawant","doi":"10.52711/2231-5659.2021-11-2-8","DOIUrl":"https://doi.org/10.52711/2231-5659.2021-11-2-8","url":null,"abstract":"Varicella zoster virus is one of the eight herpes viruses that are pathogenic only for humans. It is alpha-herpes zoster of the genus varicellovirus, which causes varicella (chickenpox) and zoster (shingles). Herpes zoster is described as a multivesicular eruptive rash that follows a single or multiple adjacent dermatomal distribution. VZV infection begins with replication in epithelial cells of upper respiratory mucosa, which is followed by widely distributed vesicular rash. Cell-mediated immunity plays a role in this reactivation. Patients with conditions that decrease cell-mediated immunity are 20 to 100 times more prone to develop herpes zoster. It is often accompanied by acute pain and itchiness. Complications may be dermatological (e.g. secondary bacterial infection), neurological (e.g. long-term pain, segmental paresis, stroke), ophthalmological (e.g. keratitis, iridocyclitis, secondary glaucoma) or visceral (e.g. pneumonia, hepatitis). Most common Complications of the infection are post herpetic neuralgia and ophthalmic zoster. Treatment includes antiviral medications such as acyclovir, famciclovir, and valacyclovir given within 72 hours of symptom has been shown to reduce severity and complications associated with herpes zoster and post-herpetic neuralgia, both these diseases are vaccine preventable. Before the invention of the recombinant VZV vaccine, live VZV vaccine was the recommended immunization, approved for adults 50 years and older.","PeriodicalId":8545,"journal":{"name":"Asian Journal of Research in Pharmaceutical Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73341662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-10DOI: 10.52711/2231-5659.2021-11-2-14
Farha Fatma, Anil Kumar
{"title":"The Cell Cycle, Cyclins, Checkpoints and Cancer","authors":"Farha Fatma, Anil Kumar","doi":"10.52711/2231-5659.2021-11-2-14","DOIUrl":"https://doi.org/10.52711/2231-5659.2021-11-2-14","url":null,"abstract":"","PeriodicalId":8545,"journal":{"name":"Asian Journal of Research in Pharmaceutical Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84364927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-10DOI: 10.52711/2231-5659.2021-11-2-1
A. MohammedWaseem, Ajin P Kurian, Y. Dhanapal
{"title":"Chronomodulated Drug Delivery System of Salmeterol Fluticasone Nlcs Loaded Tablets: Preparation, Characterization, Stability and Drug Release Studies for Management of Asthma","authors":"A. MohammedWaseem, Ajin P Kurian, Y. Dhanapal","doi":"10.52711/2231-5659.2021-11-2-1","DOIUrl":"https://doi.org/10.52711/2231-5659.2021-11-2-1","url":null,"abstract":"","PeriodicalId":8545,"journal":{"name":"Asian Journal of Research in Pharmaceutical Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91426494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-10DOI: 10.52711/2231-5659.2021-11-2-4
N. Sharma, T. Sharma, V. Pandit, M. Ashawat
Transdermal drug delivery system used to transport the drug across the skin deep into systemic circulation. The main advantages of Transdermal drug delivery system improved patient compliance, sustained release, avoidance of gastric irritation, as well as elimination of pre-systemic first-pass effect. But most of therapeutic agents is limited due to thickness of stratum corneum, which act as a barrier for the delivery of various drug molecules and only few molecules are able to reach the action site. Microneedles are the new form of delivery system, which are used to increase the delivery of drug through this route and overcoming the number of problems related to conventional drug delivery system the main aim of this review to focus on new innovation in transdermal drug delivery systems. In the microneedle drug delivery system, the skin is temporarily broken, that creating micron size pathways that deliver the sufficient amount of drug directly into the stratum corneum from which the drug can directly go into the systemic circulation. In this review, we describe different type of microneedles can be solid, coated, dissolving and biodegradable microneedles and their method of fabrication. Microneedles can be manufactured in different forms like hollow, solid, and dissolving. Also describe materials used for fabrication, fabrication techniques, methodology of drug delivery such as Poke and patch, Coat and poke, Poke and release, Poke and flow and evaluation parameters.
{"title":"A Smart and Potential approach for Transdermal Drug Delivery using Microneedles: A Review","authors":"N. Sharma, T. Sharma, V. Pandit, M. Ashawat","doi":"10.52711/2231-5659.2021-11-2-4","DOIUrl":"https://doi.org/10.52711/2231-5659.2021-11-2-4","url":null,"abstract":"Transdermal drug delivery system used to transport the drug across the skin deep into systemic circulation. The main advantages of Transdermal drug delivery system improved patient compliance, sustained release, avoidance of gastric irritation, as well as elimination of pre-systemic first-pass effect. But most of therapeutic agents is limited due to thickness of stratum corneum, which act as a barrier for the delivery of various drug molecules and only few molecules are able to reach the action site. Microneedles are the new form of delivery system, which are used to increase the delivery of drug through this route and overcoming the number of problems related to conventional drug delivery system the main aim of this review to focus on new innovation in transdermal drug delivery systems. In the microneedle drug delivery system, the skin is temporarily broken, that creating micron size pathways that deliver the sufficient amount of drug directly into the stratum corneum from which the drug can directly go into the systemic circulation. In this review, we describe different type of microneedles can be solid, coated, dissolving and biodegradable microneedles and their method of fabrication. Microneedles can be manufactured in different forms like hollow, solid, and dissolving. Also describe materials used for fabrication, fabrication techniques, methodology of drug delivery such as Poke and patch, Coat and poke, Poke and release, Poke and flow and evaluation parameters.","PeriodicalId":8545,"journal":{"name":"Asian Journal of Research in Pharmaceutical Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87497089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-10DOI: 10.52711/2231-5659.2021-11-2-11
Goshiya A. Shaikh
For hassle-free management and reduce this errors tour booking 75% as compared to manual methods visual analytics is most sought-after technique in clinical trials for data presentation it evaluates large number of data and makes it easier to review dimensional database model and traditional relational database model explode in self-service mode and can deliver results with Precision and efficiency the graphs charts are few of the examples the promising future looking at vigorously changing market and technologies health care system adopting the good digital Moto for reducing cost and accelerate authorization process. The terabytes of the machineries get involved and management is looking after the easier on confidence systems to work on with Data Analytics the safety and delivery system of Healthcare is improving gradually with clinical professionals leveraging the information technology. The EHR is employed to nullify management in patient care for hassle-free management and reduce this errors to whooping 75% as compared to manual methods.
{"title":"Major Roles of Technology and Analytics together towards Advancement in Clinical Trials","authors":"Goshiya A. Shaikh","doi":"10.52711/2231-5659.2021-11-2-11","DOIUrl":"https://doi.org/10.52711/2231-5659.2021-11-2-11","url":null,"abstract":"For hassle-free management and reduce this errors tour booking 75% as compared to manual methods visual analytics is most sought-after technique in clinical trials for data presentation it evaluates large number of data and makes it easier to review dimensional database model and traditional relational database model explode in self-service mode and can deliver results with Precision and efficiency the graphs charts are few of the examples the promising future looking at vigorously changing market and technologies health care system adopting the good digital Moto for reducing cost and accelerate authorization process. The terabytes of the machineries get involved and management is looking after the easier on confidence systems to work on with Data Analytics the safety and delivery system of Healthcare is improving gradually with clinical professionals leveraging the information technology. The EHR is employed to nullify management in patient care for hassle-free management and reduce this errors to whooping 75% as compared to manual methods.","PeriodicalId":8545,"journal":{"name":"Asian Journal of Research in Pharmaceutical Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87671008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.5958/2231-5659.2021.00001.1
P. Ashok, N. Meyyanathan.S., R. Vadivelan, N. Jawahar
{"title":"Nanosuspensions by Solid Lipid Nanoparticles method for the Formulation and In vitro/in vivo, characterization of Nifedipine","authors":"P. Ashok, N. Meyyanathan.S., R. Vadivelan, N. Jawahar","doi":"10.5958/2231-5659.2021.00001.1","DOIUrl":"https://doi.org/10.5958/2231-5659.2021.00001.1","url":null,"abstract":"","PeriodicalId":8545,"journal":{"name":"Asian Journal of Research in Pharmaceutical Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75480781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.5958/2231-5659.2021.00003.5
L. Remi.S., Joyamma Varkey, A. J. Nair, Vishnu. S. Sanjeev
{"title":"Application of an Eco-friendly, Cost-effective Hydrotropic solution as mobile phase for the estimation and validation of Ornidazole in bulk and Pharmaceutical Formulation by RP-HPLC","authors":"L. Remi.S., Joyamma Varkey, A. J. Nair, Vishnu. S. Sanjeev","doi":"10.5958/2231-5659.2021.00003.5","DOIUrl":"https://doi.org/10.5958/2231-5659.2021.00003.5","url":null,"abstract":"","PeriodicalId":8545,"journal":{"name":"Asian Journal of Research in Pharmaceutical Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75291543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.5958/2231-5659.2021.00013.8
J. Panigrahi, Simran Nathwani, Shubham Rathod
{"title":"Food safety: Another Soldiery to Save life","authors":"J. Panigrahi, Simran Nathwani, Shubham Rathod","doi":"10.5958/2231-5659.2021.00013.8","DOIUrl":"https://doi.org/10.5958/2231-5659.2021.00013.8","url":null,"abstract":"","PeriodicalId":8545,"journal":{"name":"Asian Journal of Research in Pharmaceutical Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84924693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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