Asia-Pacific Journal of Oncology Nursing最新文献_第3页

Symptom clusters and network analysis in patients with gynecologic cancer undergoing chemotherapy: A cross-sectional study 接受化疗的妇科癌症患者的症状群和网络分析：横断面研究

IF 2.4 3区医学 Q1 NURSING

Asia-Pacific Journal of Oncology Nursing

Pub Date : 2024-10-26 DOI: 10.1016/j.apjon.2024.100612

Jiajia Zhang , Shan Wang , Yuan Wang , Jiaru Zhuang , Ling Hang , Yibo Wu , Dewu Xu , Chunyan Huang

Objective

This study aimed to explore the complex relationships among symptoms and symptom clusters in patients with gynecologic cancer receiving chemotherapy using symptom network analysis, and to identify core symptoms and core symptom clusters.

Methods

A cross-sectional study was conducted at the Affiliated Hospital of Jiangnan University from December 2023 to June 2024, including 221 patients with gynecologic tumors. Participants completed demographic and clinical information questionnaires and the Chinese version of the MD Anderson Symptom Inventory (MDASI-C). Univariate analysis and multiple linear regression were used to screen covariates, exploratory factor analysis to determine symptom clusters, and network analysis to identify core symptoms and core symptom clusters.

Results

A total of 221 patients were included, with an average age of 58.73 years (SD = 11.50). Fatigue (n = 197, 89.1%) and lack of appetite (n = 192, 86.9%) were the most common symptoms, while fatigue (mean = 4.17, SD = 2.07) and distress (mean = 3.43, SD = 2.20) were the most severe symptoms. Several distinct symptom clusters were identified: sickness behavior, gastrointestinal, psychological, and side-effect clusters. In the constructed network, fatigue emerged as the most central symptom (rs = 1.28), while the sickness behavior cluster was identified as the most central symptom cluster (rs = 1.11).

Conclusions

Patients with gynecologic cancer undergoing chemotherapy commonly experience a range of symptoms. Our findings suggest that targeted interventions focusing on the sickness behavior symptom cluster may help reduce the overall symptom burden and assist caregivers in developing more effective symptom management strategies.

方法 2023年12月至2024年6月在江南大学附属医院进行了一项横断面研究，共纳入221例妇科肿瘤患者。参与者填写了人口统计学和临床信息问卷以及中文版 MD 安德森症状量表（MDASI-C）。采用单变量分析和多元线性回归筛选协变量，探索性因子分析确定症状群，网络分析确定核心症状和核心症状群。疲劳（n = 197，89.1%）和食欲不振（n = 192，86.9%）是最常见的症状，而疲劳（平均 = 4.17，SD = 2.07）和痛苦（平均 = 3.43，SD = 2.20）是最严重的症状。研究发现了几个不同的症状集群：疾病行为集群、胃肠道集群、心理集群和副作用集群。结论接受化疗的妇科癌症患者通常会出现一系列症状。我们的研究结果表明，针对疾病行为症状群进行有针对性的干预可能有助于减轻整体症状负担，并帮助护理人员制定更有效的症状管理策略。

{"title":"Symptom clusters and network analysis in patients with gynecologic cancer undergoing chemotherapy: A cross-sectional study","authors":"Jiajia Zhang , Shan Wang , Yuan Wang , Jiaru Zhuang , Ling Hang , Yibo Wu , Dewu Xu , Chunyan Huang","doi":"10.1016/j.apjon.2024.100612","DOIUrl":"10.1016/j.apjon.2024.100612","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to explore the complex relationships among symptoms and symptom clusters in patients with gynecologic cancer receiving chemotherapy using symptom network analysis, and to identify core symptoms and core symptom clusters.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted at the Affiliated Hospital of Jiangnan University from December 2023 to June 2024, including 221 patients with gynecologic tumors. Participants completed demographic and clinical information questionnaires and the Chinese version of the MD Anderson Symptom Inventory (MDASI-C). Univariate analysis and multiple linear regression were used to screen covariates, exploratory factor analysis to determine symptom clusters, and network analysis to identify core symptoms and core symptom clusters.</div></div><div><h3>Results</h3><div>A total of 221 patients were included, with an average age of 58.73 years (SD = 11.50). Fatigue (<em>n</em> = 197, 89.1%) and lack of appetite (<em>n</em> = 192, 86.9%) were the most common symptoms, while fatigue (mean = 4.17, SD = 2.07) and distress (mean = 3.43, SD = 2.20) were the most severe symptoms. Several distinct symptom clusters were identified: sickness behavior, gastrointestinal, psychological, and side-effect clusters. In the constructed network, fatigue emerged as the most central symptom (rs = 1.28), while the sickness behavior cluster was identified as the most central symptom cluster (rs = 1.11).</div></div><div><h3>Conclusions</h3><div>Patients with gynecologic cancer undergoing chemotherapy commonly experience a range of symptoms. Our findings suggest that targeted interventions focusing on the sickness behavior symptom cluster may help reduce the overall symptom burden and assist caregivers in developing more effective symptom management strategies.</div></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"11 12","pages":"Article 100612"},"PeriodicalIF":2.4,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142698892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time toxicity in cancer care: A concept analysis using Walker and Avant's method 癌症护理中的时间毒性：使用沃克和阿凡特方法进行概念分析

IF 2.4 3区医学 Q1 NURSING

Asia-Pacific Journal of Oncology Nursing

Pub Date : 2024-10-23 DOI: 10.1016/j.apjon.2024.100610

Chinomso Nwozichi , Salako Omolabake , Margaret O. Ojewale , Funmilola Faremi , Deliverance Brotobor , Elizabeth Olaogun , Mosidat Oshodi-Bakare , Oluwaseun Martins-Akinlose

Objective

The purpose of this concept analysis was to explore and clarify the concept of time toxicity in the context of cancer care using Walker and Avant's method, identify its defining attributes, antecedents, and consequences, and explore its implications for cancer care.

Methods

Walker and Avant's eight-step method was employed to analyze time toxicity. The literature was reviewed, focusing on peer-reviewed articles, grey literature, and cancer care policy documents to identify the defining attributes, antecedents, consequences, and empirical referents of time toxicity. Contextual factors, such as health care infrastructure and socioeconomic status, shape the manifestation of time toxicity in different patient populations. Model, borderline, and contrary cases were developed to clarify the concept further.

Results

Time toxicity is characterized by its defining attributes of temporal burden, disruption of daily life, cumulative effect, opportunity cost, and emotional strain. Antecedents include cancer diagnosis, complex treatment regimens, and health care inefficiencies, while consequences involve reduced quality of life, non-adherence to treatment, and economic strain. Empirical referents include time logs, patient-reported outcomes, and health care utilization data.

Conclusions

Our findings underscore the multidimensional nature of time toxicity and its significant implications for cancer patients’ well-being. Importantly, we highlight the vital role of oncology nurses in mitigating its effects through care coordination and patient support, thereby making our research directly applicable to clinical practice.

本概念分析旨在使用 Walker 和 Avant 的方法探讨和澄清癌症护理中的时间毒性概念，确定其定义属性、前因和后果，并探讨其对癌症护理的影响。我们查阅了相关文献，重点是同行评议文章、灰色文献和癌症护理政策文件，以确定时间毒性的定义属性、前因、后果和经验参考。医疗基础设施和社会经济地位等环境因素决定了时间毒性在不同患者群体中的表现形式。结果时间毒性的特征是时间负担、对日常生活的干扰、累积效应、机会成本和情绪压力。前因包括癌症诊断、复杂的治疗方案和医疗效率低下，后果包括生活质量下降、不坚持治疗和经济压力。我们的研究结果强调了时间毒性的多面性及其对癌症患者福祉的重要影响。重要的是，我们强调了肿瘤科护士在通过护理协调和患者支持减轻时间毒性影响方面的重要作用，从而使我们的研究直接应用于临床实践。

{"title":"Time toxicity in cancer care: A concept analysis using Walker and Avant's method","authors":"Chinomso Nwozichi , Salako Omolabake , Margaret O. Ojewale , Funmilola Faremi , Deliverance Brotobor , Elizabeth Olaogun , Mosidat Oshodi-Bakare , Oluwaseun Martins-Akinlose","doi":"10.1016/j.apjon.2024.100610","DOIUrl":"10.1016/j.apjon.2024.100610","url":null,"abstract":"<div><h3>Objective</h3><div>The purpose of this concept analysis was to explore and clarify the concept of time toxicity in the context of cancer care using Walker and Avant's method, identify its defining attributes, antecedents, and consequences, and explore its implications for cancer care.</div></div><div><h3>Methods</h3><div>Walker and Avant's eight-step method was employed to analyze time toxicity. The literature was reviewed, focusing on peer-reviewed articles, grey literature, and cancer care policy documents to identify the defining attributes, antecedents, consequences, and empirical referents of time toxicity. Contextual factors, such as health care infrastructure and socioeconomic status, shape the manifestation of time toxicity in different patient populations. Model, borderline, and contrary cases were developed to clarify the concept further.</div></div><div><h3>Results</h3><div>Time toxicity is characterized by its defining attributes of temporal burden, disruption of daily life, cumulative effect, opportunity cost, and emotional strain. Antecedents include cancer diagnosis, complex treatment regimens, and health care inefficiencies, while consequences involve reduced quality of life, non-adherence to treatment, and economic strain. Empirical referents include time logs, patient-reported outcomes, and health care utilization data.</div></div><div><h3>Conclusions</h3><div>Our findings underscore the multidimensional nature of time toxicity and its significant implications for cancer patients’ well-being. Importantly, we highlight the vital role of oncology nurses in mitigating its effects through care coordination and patient support, thereby making our research directly applicable to clinical practice.</div></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"11 12","pages":"Article 100610"},"PeriodicalIF":2.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142698891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Character strength patterns, social support and psychological distress in adolescents and young adults with cancer: A multicenter cross-sectional study 青少年癌症患者的性格强度模式、社会支持和心理困扰：一项多中心横断面研究

IF 2.4 3区医学 Q1 NURSING

Asia-Pacific Journal of Oncology Nursing

Pub Date : 2024-10-20 DOI: 10.1016/j.apjon.2024.100609

Ning Qin , Yinglong Duan , Yi Zhou , Yuxuan Li , Juan Luo , Yue Kang , Jian Zhou , Jianfei Xie , Andy S.K. Cheng

Objective

Adolescents and young adults with cancer (AYAC) experience severe psychological distress worldwide. Social support was associated with reduced distress among cancer patients, but the role of character strength patterns in this association is unexplored. This study explored whether character strength patterns influence the association between social support and psychological distress in AYAC.

Methods

A multicenter cross-sectional study was conducted at four hospitals in Changsha, China. Participants completed questionnaires assessing sociodemographic, distress, social support, and character strengths. Latent profile analysis determined character strength patterns, and multiple linear regression models examined the association. Interaction terms tested moderation effects, and adjusted models examined confounding, all stratified by gender.

Results

Among 728 participants, three character strength patterns emerged: low (LCS), moderate (MCS), and high (HCS). Across all patterns, higher social support was significantly associated with lower distress in AYAC (female: β = −0.124, 95% CI = −0.051 to −0.015; male: β = −0.180, 95% CI = −0.080 to −0.030; P < 0.001). AYAC with MCS and HCS experienced significantly less distress than those with LCS, across both genders. However, the association between character strength patterns and lower distress was stronger in males (MCS: β = −0.384, 95% CI = −1.898 to −1.033; HCS: β = −0.777, 95% CI = −3.420 to −2.495; P < 0.001) compared to females (MCS: β = −0.284, 95% CI = −1.215 to −0.700; HCS: β = −0.593, 95% CI = −2.776 to −2.102; P < 0.001).

Conclusions

Character strength patterns didn't moderate or confound the association between social support and psychological distress, but had stronger protective effects against psychological distress than social support. Higher character strength patterns showed a stronger association with lower psychological distress, especially for males.

目的全世界的青少年癌症患者（AYAC）都经历过严重的心理困扰。社会支持与减轻癌症患者的心理压力有关，但性格力量模式在这种关联中的作用尚未得到探讨。本研究探讨了性格强度模式是否会影响社会支持与青少年癌症患者心理困扰之间的关联。参与者填写了评估社会人口学、心理困扰、社会支持和性格力量的问卷。潜在特征分析确定了性格强度模式，多元线性回归模型检验了两者之间的关联。在 728 名参与者中，出现了三种性格强度模式：低（LCS）、中（MCS）和高（HCS）。在所有模式中，较高的社会支持与较低的 AYAC 痛苦显著相关（女性：β = -0.124，95% CI = -0.051 至 -0.015；男性：β = -0.180，95% CI = -0.080 至 -0.030；P <0.001）。无论男女，具有 MCS 和 HCS 的青少亚博app客服生经历的痛苦明显少于具有 LCS 的青少亚博app客服生。然而，与女性（MCS：β = -0.284，95% CI = -1.898 至 -1.033; HCS：β = -0.777，95% CI = -3.420 至 -2.495；P < 0.001）相比，男性（MCS：β = -0.284，95% CI = -1.215 至 -0.结论性格强度模式并没有缓和或混淆社会支持与心理困扰之间的关系，但与社会支持相比，性格强度模式对心理困扰具有更强的保护作用。较高的性格强度模式与较低的心理压力有更强的关联，尤其是对男性而言。

{"title":"Character strength patterns, social support and psychological distress in adolescents and young adults with cancer: A multicenter cross-sectional study","authors":"Ning Qin , Yinglong Duan , Yi Zhou , Yuxuan Li , Juan Luo , Yue Kang , Jian Zhou , Jianfei Xie , Andy S.K. Cheng","doi":"10.1016/j.apjon.2024.100609","DOIUrl":"10.1016/j.apjon.2024.100609","url":null,"abstract":"<div><h3>Objective</h3><div>Adolescents and young adults with cancer (AYAC) experience severe psychological distress worldwide. Social support was associated with reduced distress among cancer patients, but the role of character strength patterns in this association is unexplored. This study explored whether character strength patterns influence the association between social support and psychological distress in AYAC.</div></div><div><h3>Methods</h3><div>A multicenter cross-sectional study was conducted at four hospitals in Changsha, China. Participants completed questionnaires assessing sociodemographic, distress, social support, and character strengths. Latent profile analysis determined character strength patterns, and multiple linear regression models examined the association. Interaction terms tested moderation effects, and adjusted models examined confounding, all stratified by gender.</div></div><div><h3>Results</h3><div>Among 728 participants, three character strength patterns emerged: low (LCS), moderate (MCS), and high (HCS). Across all patterns, higher social support was significantly associated with lower distress in AYAC (female: <em>β</em> = −0.124, 95% CI = −0.051 to −0.015; male: <em>β</em> = −0.180, 95% CI = −0.080 to −0.030; <em>P</em> < 0.001). AYAC with MCS and HCS experienced significantly less distress than those with LCS, across both genders. However, the association between character strength patterns and lower distress was stronger in males (MCS: <em>β</em> = −0.384, 95% CI = −1.898 to −1.033; HCS: <em>β</em> = −0.777, 95% CI = −3.420 to −2.495; <em>P</em> < 0.001) compared to females (MCS: <em>β</em> = −0.284, 95% CI = −1.215 to −0.700; HCS: <em>β</em> = −0.593, 95% CI = −2.776 to −2.102; <em>P</em> < 0.001).</div></div><div><h3>Conclusions</h3><div>Character strength patterns didn't moderate or confound the association between social support and psychological distress, but had stronger protective effects against psychological distress than social support. Higher character strength patterns showed a stronger association with lower psychological distress, especially for males.</div></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"11 12","pages":"Article 100609"},"PeriodicalIF":2.4,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142698890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral self-management of palbociclib using mobile technology: Findings from a nurse-led randomized controlled trial.

IF 2.4 3区医学 Q1 NURSING

Asia-Pacific Journal of Oncology Nursing

Pub Date : 2024-10-15 eCollection Date: 2024-12-01 DOI: 10.1016/j.apjon.2024.100604

AnnMarie Mazzella-Ebstein, Margaret Barton-Burke, Venice Anthony, Charlie White, Zhigang Zhang, Andrea Smith, Mark Robson

Objective: Test the feasibility and effectiveness of a text message reminder intervention for the self-management of oral anticancer medication in patients with metastatic breast cancer.

Methods: Forty-three females initiating treatment with palbociclib participated in a two-armed prospective randomized clinical trial. Participants were randomized into the control (n = 21) and intervention groups (n = 22) from January 2020 to January 2023. Survey responses were collected at three-time points; (1) at consent, (2) end of treatment cycles, and (3) at a follow-up clinic visit. Surveys included a demographic questionnaire, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, post-study assessment, and the R-15 Participant Satisfaction Questionnaire. Nurse providers completed the Adaptation of Stamps Nurse Workload questionnaire.

Results: The COVID-19 pandemic and regulatory decisions supporting other CDK4/6 medications negatively influence recruitment; thus, a small sample for each arm only detected large differences between the two arms regarding effectiveness. Feasibility analysis was not conducted due to insufficient data, but the participants frequently used their smartphones for text messaging. Although the survey data were limited, participants provided anecdotal information supporting the use of text messaging as a positive method to remind them to take their medication, have their labs drawn, and attend MD visits. Participants would have liked text messages at the exact time they took their medications as a simple reminder.

Conclusions: Given the importance of cancer treatments and the difficulties patients experience during these treatments, text messages using smartphones can actively improve patients' engagement and their ability to manage their treatment regimens.

Trial registration: ClinicalTrials.gov; ID: NCT04216576.

{"title":"Oral self-management of palbociclib using mobile technology: Findings from a nurse-led randomized controlled trial.","authors":"AnnMarie Mazzella-Ebstein, Margaret Barton-Burke, Venice Anthony, Charlie White, Zhigang Zhang, Andrea Smith, Mark Robson","doi":"10.1016/j.apjon.2024.100604","DOIUrl":"10.1016/j.apjon.2024.100604","url":null,"abstract":"<p><strong>Objective: </strong>Test the feasibility and effectiveness of a text message reminder intervention for the self-management of oral anticancer medication in patients with metastatic breast cancer.</p><p><strong>Methods: </strong>Forty-three females initiating treatment with palbociclib participated in a two-armed prospective randomized clinical trial. Participants were randomized into the control (<i>n</i> = 21) and intervention groups (<i>n</i> = 22) from January 2020 to January 2023. Survey responses were collected at three-time points; (1) at consent, (2) end of treatment cycles, and (3) at a follow-up clinic visit. Surveys included a demographic questionnaire, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, post-study assessment, and the R-15 Participant Satisfaction Questionnaire. Nurse providers completed the Adaptation of Stamps Nurse Workload questionnaire.</p><p><strong>Results: </strong>The COVID-19 pandemic and regulatory decisions supporting other CDK4/6 medications negatively influence recruitment; thus, a small sample for each arm only detected large differences between the two arms regarding effectiveness. Feasibility analysis was not conducted due to insufficient data, but the participants frequently used their smartphones for text messaging. Although the survey data were limited, participants provided anecdotal information supporting the use of text messaging as a positive method to remind them to take their medication, have their labs drawn, and attend MD visits. Participants would have liked text messages at the exact time they took their medications as a simple reminder.</p><p><strong>Conclusions: </strong>Given the importance of cancer treatments and the difficulties patients experience during these treatments, text messages using smartphones can actively improve patients' engagement and their ability to manage their treatment regimens.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov; ID: NCT04216576.</p>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"11 12","pages":"100604"},"PeriodicalIF":2.4,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of the self-report symptom inventory of immune-related adverse events in patients with lung cancer 肺癌患者免疫相关不良事件自我报告症状清单的开发与验证

IF 2.4 3区医学 Q1 NURSING

Asia-Pacific Journal of Oncology Nursing

Pub Date : 2024-10-12 DOI: 10.1016/j.apjon.2024.100603

Tiantian Fan , Siying Zhu , Hong Wang , Yan Dong , Ying Zhou , Yalan Song , Shan Pan , Qiujuan Wu , Graeme Drummond Smith , Yumei Li , Yuan Han

Objective

This study aims to develop and validate the Self-Report Symptom Inventory of immune-related Adverse Events in Patients with Lung Cancer (SRSI-irAEs-LC) to allow for systematic assessment of symptomatic irAEs in patients with lung cancer treated with programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) immune checkpoint inhibitors (ICIs).

Methods

A sequential two-phase mixed-methods study was conducted. In phase I, a draft version of the SRSI-irAEs-LC was constructed through item generation and draft inventory construction. Delphi expert consultation, cognitive interviews and a pilot study were conducted to evaluate the content validity and refine the scale. In phase II, psychometric testing was performed on 512 patients with lung cancer treated with PD-1/PD-L1 ICIs using item analysis, exploratory factor analysis (EFA), confirmatory factor analysis (CFA), criterion validity, discriminant validity, and reliability evaluations.

Results

Through 5 sequential steps in phase I, the preliminary version of the SRSI-irAEs-LC comprised 10 dimensions with 41 items. Through EFA, the final version of the SRSI-irAEs-LC included 8 dimensions and 26 items that explained 62.33% of the variance. The CFA model showed that the 8-factor model fitted the data well. Good criteria validity and known-groups discriminant validity were demonstrated. Cronbach's alpha, split-half reliability, and test-retest reliability of the scale were 0.824, 0.725, and 0.851, respectively.

Conclusions

Preliminarily, the SRSI-irAEs-LC is a valid and reliable instrument for assessing symptomatic irAEs in patients with lung cancer treated with PD-1/PD-L1 ICIs. Further research is needed to confirm its generalizability to a broader population as well as its validity and reliability.

目的本研究旨在开发和验证肺癌患者免疫相关不良事件症状自评量表（SRSI-irAEs-LC），以便对接受程序性细胞死亡蛋白1（PD-1）/程序性死亡配体1（PD-L1）免疫检查点抑制剂（ICIs）治疗的肺癌患者的症状性irAEs进行系统评估。在第一阶段，通过项目生成和构建清单草案，构建了SRSI-irAEs-LC的草案版本。通过德尔菲专家咨询、认知访谈和试点研究，对量表的内容效度进行了评估和完善。在第二阶段，采用项目分析、探索性因子分析（EFA）、确证性因子分析（CFA）、标准效度、判别效度和信度评价等方法，对512名接受PD-1/PD-L1 ICIs治疗的肺癌患者进行了心理测验。通过 EFA，SRSI-irAEs-LC 的最终版本包括 8 个维度和 26 个项目，解释了 62.33% 的方差。CFA 模型显示，8 因子模型很好地拟合了数据。良好的标准效度和已知组别判别效度也得到了证实。量表的Cronbach's alpha、分裂半信度和测试-再测信度分别为0.824、0.725和0.851。结论初步认为，SRSI-irAEs-LC是评估接受PD-1/PD-L1 ICIs治疗的肺癌患者症状性irAEs的有效、可靠的工具。还需要进一步的研究来确认其在更广泛人群中的通用性及其有效性和可靠性。

{"title":"Development and validation of the self-report symptom inventory of immune-related adverse events in patients with lung cancer","authors":"Tiantian Fan , Siying Zhu , Hong Wang , Yan Dong , Ying Zhou , Yalan Song , Shan Pan , Qiujuan Wu , Graeme Drummond Smith , Yumei Li , Yuan Han","doi":"10.1016/j.apjon.2024.100603","DOIUrl":"10.1016/j.apjon.2024.100603","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to develop and validate the Self-Report Symptom Inventory of immune-related Adverse Events in Patients with Lung Cancer (SRSI-irAEs-LC) to allow for systematic assessment of symptomatic irAEs in patients with lung cancer treated with programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) immune checkpoint inhibitors (ICIs).</div></div><div><h3>Methods</h3><div>A sequential two-phase mixed-methods study was conducted. In phase I, a draft version of the SRSI-irAEs-LC was constructed through item generation and draft inventory construction. Delphi expert consultation, cognitive interviews and a pilot study were conducted to evaluate the content validity and refine the scale. In phase II, psychometric testing was performed on 512 patients with lung cancer treated with PD-1/PD-L1 ICIs using item analysis, exploratory factor analysis (EFA), confirmatory factor analysis (CFA), criterion validity, discriminant validity, and reliability evaluations.</div></div><div><h3>Results</h3><div>Through 5 sequential steps in phase I, the preliminary version of the SRSI-irAEs-LC comprised 10 dimensions with 41 items. Through EFA, the final version of the SRSI-irAEs-LC included 8 dimensions and 26 items that explained 62.33% of the variance. The CFA model showed that the 8-factor model fitted the data well. Good criteria validity and known-groups discriminant validity were demonstrated. Cronbach's <em>alpha</em>, split-half reliability, and test-retest reliability of the scale were 0.824, 0.725, and 0.851, respectively.</div></div><div><h3>Conclusions</h3><div>Preliminarily, the SRSI-irAEs-LC is a valid and reliable instrument for assessing symptomatic irAEs in patients with lung cancer treated with PD-1/PD-L1 ICIs. Further research is needed to confirm its generalizability to a broader population as well as its validity and reliability.</div></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"11 12","pages":"Article 100603"},"PeriodicalIF":2.4,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142698889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between breast radiation dermatitis and post-mastectomy pain syndrome in patients with breast cancer: A multicenter retrospective study 乳腺癌患者乳房放射性皮炎与乳房切除术后疼痛综合征之间的关系：一项多中心回顾性研究

IF 2.4 3区医学 Q1 NURSING

Asia-Pacific Journal of Oncology Nursing

Pub Date : 2024-10-05 DOI: 10.1016/j.apjon.2024.100602

Yinpeng Ren , Ran Gao , Shuguang Zhang , Xiaoli Geng , Qingheng Yang , Liquan Ouyang , Ye Zhao , Jing Zhao , Hua Kang , Jing Wang

Objective

This study explores the relationship between breast radiation dermatitis (BRD) and post-mastectomy pain syndrome (PMPS) among patients with breast cancer. Both BRD and PMPS significantly impact quality of life, yet their correlation and risk factors require further investigation.

Methods

We conducted a multicenter retrospective analysis of 784 patients with breast cancer who underwent postoperative radiotherapy between 2017 and 2023. Clinical data on BRD and PMPS were collected through patient questionnaires and hospital records, examining risk factors and evaluating the prevalence of PMPS among those with BRD.

Results

BRD affected 81.25% of patients, with higher incidence among older and obese individuals. PMPS was observed in 23.4% of the BRD group versus 13.6% in non-BRD patients (P=0.009). Early BRD onset during radiotherapy (P=0.004) and larger dermatitis areas (P=0.000) were strongly associated with increased PMPS risk.

Conclusions

This study highlights the significant relationship between BRD and PMPS, underscoring the need for early interventions to manage BRD and reduce chronic pain risk. Tailored care strategies could improve outcomes for high-risk patients.

目的：本研究探讨了乳腺癌患者中乳腺放射性皮炎（BRD）和乳房切除术后疼痛综合征（PMPS）之间的关系。BRD和PMPS都会严重影响患者的生活质量，但它们之间的相关性和风险因素还需要进一步研究。方法我们对2017年至2023年间接受术后放疗的784名乳腺癌患者进行了多中心回顾性分析。通过患者问卷和住院记录收集了有关BRD和PMPS的临床数据，研究了风险因素，并评估了PMPS在BRD患者中的患病率。23.4%的BRD患者出现了PMPS，而非BRD患者中只有13.6%出现了PMPS（P=0.009）。该研究强调了BRD与PMPS之间的重要关系，强调了早期干预以管理BRD和降低慢性疼痛风险的必要性。量身定制的护理策略可改善高风险患者的治疗效果。

{"title":"Associations between breast radiation dermatitis and post-mastectomy pain syndrome in patients with breast cancer: A multicenter retrospective study","authors":"Yinpeng Ren , Ran Gao , Shuguang Zhang , Xiaoli Geng , Qingheng Yang , Liquan Ouyang , Ye Zhao , Jing Zhao , Hua Kang , Jing Wang","doi":"10.1016/j.apjon.2024.100602","DOIUrl":"10.1016/j.apjon.2024.100602","url":null,"abstract":"<div><h3>Objective</h3><div>This study explores the relationship between breast radiation dermatitis (BRD) and post-mastectomy pain syndrome (PMPS) among patients with breast cancer. Both BRD and PMPS significantly impact quality of life, yet their correlation and risk factors require further investigation.</div></div><div><h3>Methods</h3><div>We conducted a multicenter retrospective analysis of 784 patients with breast cancer who underwent postoperative radiotherapy between 2017 and 2023. Clinical data on BRD and PMPS were collected through patient questionnaires and hospital records, examining risk factors and evaluating the prevalence of PMPS among those with BRD.</div></div><div><h3>Results</h3><div>BRD affected 81.25% of patients, with higher incidence among older and obese individuals. PMPS was observed in 23.4% of the BRD group versus 13.6% in non-BRD patients (P=0.009). Early BRD onset during radiotherapy (P=0.004) and larger dermatitis areas (P=0.000) were strongly associated with increased PMPS risk.</div></div><div><h3>Conclusions</h3><div>This study highlights the significant relationship between BRD and PMPS, underscoring the need for early interventions to manage BRD and reduce chronic pain risk. Tailored care strategies could improve outcomes for high-risk patients.</div></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"11 12","pages":"Article 100602"},"PeriodicalIF":2.4,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142698887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and associated factors of post-traumatic stress symptoms in hospitalised children with cancer and their parents in South China: A multicentred cross-sectional study 华南地区住院癌症患儿及其父母的创伤后应激症状的患病率及相关因素：多中心横断面研究

IF 2.4 3区医学 Q1 NURSING

Asia-Pacific Journal of Oncology Nursing

Pub Date : 2024-10-01 DOI: 10.1016/j.apjon.2024.100568

Yunyun Peng , Lin Xu , Can Gu , Guiyuan Ma , Zitong Zhang , Yilin Zhang , Li Liu , Jianhui Xie , Sulan Lin , Stanley Kam Ki Lam

Objective

This study aimed to examine the prevalence and risk factors of Post-Traumatic Stress Symptoms (PTSS) in hospitalised children with cancer and their parents and explore the PTSS correlation between parents and children.

Methods

Data were collected using the University of California at Los Angeles (UCLA) Posttraumatic Stress Disorder-Reaction Index for DSM-IV and the Chinese version of the Impact of Event Scale-Revised Questionnaire.

Results

Out of 203 families with hospitalised children with cancer, 77.3% of parents and 7.9% of children experienced PTSS. Time since diagnosis of less than 3 months (β = −0.063, P < 0.001), actively seeking financial help (β = −0.190, P = 0.031), children living in rural areas (β = 0.166, P = 0.023) and having a daughter with cancer (β = 0.135, P = 0.040) were risk factors for parental PTSS. At the early stages of diagnosis (β = 0.118, P = 0.017), recurrence (β = 0.140, P = 0.042) and low monthly household income (β = −0.283, P = 0.003) were risk factors for children's PTSS. No significant correlation between parental PTSS and children's PTSS (r = −0.06, P > 0.05).

Conclusions

The hospitalised children with cancer had a low prevalence of PTSS, but their parents' PTSS prevalence was high. No significant correlation was observed between parental and children's PTSS. Attention should be given to the mental health of families with hospitalised children with cancer. Early psychosocial support should be provided, especially to families with poor economic situations and a newly diagnosed or relapsed child.

方法采用美国加州大学洛杉矶分校（UCLA）创伤后应激障碍反应指数（DSM-IV）和事件影响量表-修订版问卷（中文版）收集数据。确诊时间少于 3 个月（β = -0.063，P < 0.001）、积极寻求经济帮助（β = -0.190，P = 0.031）、子女居住在农村地区（β = 0.166，P = 0.023）和女儿患有癌症（β = 0.135，P = 0.040）是父母出现 PTSS 的风险因素。诊断早期（β = 0.118，P = 0.017）、复发（β = 0.140，P = 0.042）和家庭月收入低（β = -0.283，P = 0.003）是儿童 PTSS 的危险因素。结论住院癌症患儿的 PTSS 患病率较低，但其父母的 PTSS 患病率较高。在父母和儿童的 PTSS 之间没有观察到明显的相关性。应关注住院癌症患儿家庭的心理健康。应及早提供社会心理支持，尤其是对经济状况不佳、患儿刚刚确诊或复发的家庭。

{"title":"Prevalence and associated factors of post-traumatic stress symptoms in hospitalised children with cancer and their parents in South China: A multicentred cross-sectional study","authors":"Yunyun Peng , Lin Xu , Can Gu , Guiyuan Ma , Zitong Zhang , Yilin Zhang , Li Liu , Jianhui Xie , Sulan Lin , Stanley Kam Ki Lam","doi":"10.1016/j.apjon.2024.100568","DOIUrl":"10.1016/j.apjon.2024.100568","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to examine the prevalence and risk factors of Post-Traumatic Stress Symptoms (PTSS) in hospitalised children with cancer and their parents and explore the PTSS correlation between parents and children.</div></div><div><h3>Methods</h3><div>Data were collected using the University of California at Los Angeles (UCLA) Posttraumatic Stress Disorder-Reaction Index for DSM-IV and the Chinese version of the Impact of Event Scale-Revised Questionnaire.</div></div><div><h3>Results</h3><div>Out of 203 families with hospitalised children with cancer, 77.3% of parents and 7.9% of children experienced PTSS. Time since diagnosis of less than 3 months (<em>β</em> = −0.063, <em>P</em> < 0.001), actively seeking financial help (<em>β</em> = −0.190, <em>P</em> = 0.031), children living in rural areas (<em>β</em> = 0.166, <em>P</em> = 0.023) and having a daughter with cancer (<em>β</em> = 0.135, <em>P</em> = 0.040) were risk factors for parental PTSS. At the early stages of diagnosis (<em>β</em> = 0.118, <em>P</em> = 0.017), recurrence (<em>β</em> = 0.140, <em>P</em> = 0.042) and low monthly household income (<em>β</em> = −0.283, <em>P</em> = 0.003) were risk factors for children's PTSS. No significant correlation between parental PTSS and children's PTSS (<em>r</em> = −0.06, <em>P</em> > 0.05).</div></div><div><h3>Conclusions</h3><div>The hospitalised children with cancer had a low prevalence of PTSS, but their parents' PTSS prevalence was high. No significant correlation was observed between parental and children's PTSS. Attention should be given to the mental health of families with hospitalised children with cancer. Early psychosocial support should be provided, especially to families with poor economic situations and a newly diagnosed or relapsed child.</div></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"11 10","pages":"Article 100568"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When clinical advances outpace knowledge: The role of nurses in precision oncology 当临床进步超过知识进步：护士在精准肿瘤学中的作用

IF 2.4 3区医学 Q1 NURSING

Asia-Pacific Journal of Oncology Nursing

Pub Date : 2024-10-01 DOI: 10.1016/j.apjon.2024.100566

Celia Díez de los Ríos de la Serna, Paz Fernández-Ortega

引用次数: 0

What Judith L. Johnson brought to us 朱迪斯-约翰逊为我们带来了什么

IF 2.4 3区医学 Q1 NURSING

Asia-Pacific Journal of Oncology Nursing

Pub Date : 2024-10-01 DOI: 10.1016/j.apjon.2024.100547

Asuko Sekimoto

引用次数: 0

Benefit finding and its influencing factors in patients with thyroid cancer: A retrospective study 甲状腺癌患者的获益发现及其影响因素：回顾性研究

IF 2.4 3区医学 Q1 NURSING

Asia-Pacific Journal of Oncology Nursing

Pub Date : 2024-09-06 DOI: 10.1016/j.apjon.2024.100584

Yingjia Qian , Lei Zheng , Jian Li

Objective

To understand the level of benefit finding in patients with thyroid cancer and identify its influencing factors.

Methods

This retrospective study included 241 patients with thyroid cancer who underwent surgical treatment at a tertiary hospital in Shanghai from October to December 2022. Data were collected using the General Information Questionnaire, the Chinese Benefit Finding Scale, the Social Support Revalued Scale, and the Medical Coping Modes Questionnaire. Logistic regression analysis was performed to explore factors influencing benefit finding.

Results

The total benefit finding score among patients with thyroid cancer was 89.00 (76.00, 101.50). Logistic regression analysis indicated that social support (OR = 1.08, 95% CI: 1.02–1.14) and avoidance coping mode (OR = 1.17, 95% CI: 1.00–1.37) significantly impacted benefit finding (P < 0.05).

Conclusions

Patients with thyroid cancer demonstrated a high level of benefit finding. Social support and medical coping modes were identified as key factors influencing benefit finding. Healthcare professionals should focus on enhancing these aspects to improve benefit finding in patients with thyroid cancer.

Trial registration

EC REFERENCE No. 2024-133.

方法本回顾性研究纳入了2022年10月至12月在上海一家三级甲等医院接受手术治疗的241例甲状腺癌患者。研究采用一般信息问卷、中国利益寻找量表、社会支持重估量表和医疗应对模式问卷收集数据。结果甲状腺癌患者的获益总分为 89.00（76.00，101.50）。逻辑回归分析表明，社会支持（OR = 1.08，95% CI：1.02-1.14）和回避应对模式（OR = 1.17，95% CI：1.00-1.37）对受益发现有显著影响（P <0.05）。社会支持和医疗应对模式被认为是影响受益发现的关键因素。医护人员应重点加强这些方面的工作，以提高甲状腺癌患者的获益发现率。

{"title":"Benefit finding and its influencing factors in patients with thyroid cancer: A retrospective study","authors":"Yingjia Qian , Lei Zheng , Jian Li","doi":"10.1016/j.apjon.2024.100584","DOIUrl":"10.1016/j.apjon.2024.100584","url":null,"abstract":"<div><h3>Objective</h3><div>To understand the level of benefit finding in patients with thyroid cancer and identify its influencing factors.</div></div><div><h3>Methods</h3><div>This retrospective study included 241 patients with thyroid cancer who underwent surgical treatment at a tertiary hospital in Shanghai from October to December 2022. Data were collected using the General Information Questionnaire, the Chinese Benefit Finding Scale, the Social Support Revalued Scale, and the Medical Coping Modes Questionnaire. Logistic regression analysis was performed to explore factors influencing benefit finding.</div></div><div><h3>Results</h3><div>The total benefit finding score among patients with thyroid cancer was 89.00 (76.00, 101.50). Logistic regression analysis indicated that social support (OR = 1.08, 95% CI: 1.02–1.14) and avoidance coping mode (OR = 1.17, 95% CI: 1.00–1.37) significantly impacted benefit finding (<em>P</em> < 0.05).</div></div><div><h3>Conclusions</h3><div>Patients with thyroid cancer demonstrated a high level of benefit finding. Social support and medical coping modes were identified as key factors influencing benefit finding. Healthcare professionals should focus on enhancing these aspects to improve benefit finding in patients with thyroid cancer.</div></div><div><h3>Trial registration</h3><div>EC REFERENCE No. 2024-133.</div></div>","PeriodicalId":8569,"journal":{"name":"Asia-Pacific Journal of Oncology Nursing","volume":"11 11","pages":"Article 100584"},"PeriodicalIF":2.4,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0