Xue Li, Jiafeng Yu, Xian-Ling Wu, Cui Hu, Xiaoqing Wang
Based on the structure of the natural product andrographolide, a series of novel 12-quinoline substituted derivatives 9 were designed and synthesized. In preliminary biological evaluation, these synthesized compounds showed prominent anti-platelet aggregation activities in response to thrombin and adenosine diphosphate (ADP) agonists. Among them, compound 9o (inhibition rate 55.73%, IC50 0.36 µM/L) had the highest anti-platelet aggregation activity induced by ADP. Compound 9q (inhibition rate 54.31%, IC50 0.30 µM/L) showed the highest anti-platelet aggregation activity induced by thrombin. Most of the derivatives had no significant cytotoxicity. Our research results provide a novel candidate drug structure for anti-platelet aggregation and enrich the scope of application of andrographolide derivatives.
{"title":"Synthesis of 12-quinoline substituted andrographolide derivatives and their preliminary evaluation as anti-aggregation drugs","authors":"Xue Li, Jiafeng Yu, Xian-Ling Wu, Cui Hu, Xiaoqing Wang","doi":"10.1071/ch22248","DOIUrl":"https://doi.org/10.1071/ch22248","url":null,"abstract":"Based on the structure of the natural product andrographolide, a series of novel 12-quinoline substituted derivatives 9 were designed and synthesized. In preliminary biological evaluation, these synthesized compounds showed prominent anti-platelet aggregation activities in response to thrombin and adenosine diphosphate (ADP) agonists. Among them, compound 9o (inhibition rate 55.73%, IC50 0.36 µM/L) had the highest anti-platelet aggregation activity induced by ADP. Compound 9q (inhibition rate 54.31%, IC50 0.30 µM/L) showed the highest anti-platelet aggregation activity induced by thrombin. Most of the derivatives had no significant cytotoxicity. Our research results provide a novel candidate drug structure for anti-platelet aggregation and enrich the scope of application of andrographolide derivatives.","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":"9 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82708220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kolsoum Dalvand, Alireza Ghiasvand, Sepideh Keshan-Balavandy, Feng Li, Michael Breadmore
Point-of-care testing (POCT) technology allows scientists to monitor and diagnose diseases at the patient site, much faster than classical lab-based methods. Herein, a rapid, simple, and sensitive 3D printed microfluidic device integrated with smartphone-based on-chip detection is described for POCT quantification of urinary uric acid. The device includes two circular inputs each connected to a microliter-scale chamber, separated by an integrated porous membrane, located between the sample and reagent chambers. The microfluidic device was fabricated from a transparent photopolymer using a 3D printer, in a single run. The concentration of uric acid was determined based on a chromogenic reaction in which ferrous ion, produced via the reduction of ferric ion by the analyte, complexed with 1,10-phenanthroline, and the color was recorded by a smartphone. Response surface methodology including a central composed design was utilized to evaluate the experimental parameters and subsequent introduction of a multivariate model to describe the experimental conditions. Under the optimum conditions, the calibration curve was linear over the concentration range of 30–600 mg L−1. The limit of detection was determined to be 10.5 mg L−1. The microfluidic device was successfully utilized for the recovery and quantification of uric acid in the urine, with recoveries ranging from 91.7 to 99.7%.
{"title":"A simple 3D printed microfluidic device for point-of-care analysis of urinary uric acid","authors":"Kolsoum Dalvand, Alireza Ghiasvand, Sepideh Keshan-Balavandy, Feng Li, Michael Breadmore","doi":"10.1071/ch22180","DOIUrl":"https://doi.org/10.1071/ch22180","url":null,"abstract":"Point-of-care testing (POCT) technology allows scientists to monitor and diagnose diseases at the patient site, much faster than classical lab-based methods. Herein, a rapid, simple, and sensitive 3D printed microfluidic device integrated with smartphone-based on-chip detection is described for POCT quantification of urinary uric acid. The device includes two circular inputs each connected to a microliter-scale chamber, separated by an integrated porous membrane, located between the sample and reagent chambers. The microfluidic device was fabricated from a transparent photopolymer using a 3D printer, in a single run. The concentration of uric acid was determined based on a chromogenic reaction in which ferrous ion, produced via the reduction of ferric ion by the analyte, complexed with 1,10-phenanthroline, and the color was recorded by a smartphone. Response surface methodology including a central composed design was utilized to evaluate the experimental parameters and subsequent introduction of a multivariate model to describe the experimental conditions. Under the optimum conditions, the calibration curve was linear over the concentration range of 30–600 mg L−1. The limit of detection was determined to be 10.5 mg L−1. The microfluidic device was successfully utilized for the recovery and quantification of uric acid in the urine, with recoveries ranging from 91.7 to 99.7%.","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136052313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reactive intermediates and unusual molecules at Heron Island","authors":"C. Wentrup","doi":"10.1071/chv76n1_fo","DOIUrl":"https://doi.org/10.1071/chv76n1_fo","url":null,"abstract":"","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":"40 11","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72367004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katie D. Lewis, Glenn A Pullella, H. Loh, B. Skelton, G. Flematti, M. Piggott
{"title":"Synthesis of R- and S-MDMA via nucleophilic ring-opening of homochiral N-tosylaziridines","authors":"Katie D. Lewis, Glenn A Pullella, H. Loh, B. Skelton, G. Flematti, M. Piggott","doi":"10.1071/ch23064","DOIUrl":"https://doi.org/10.1071/ch23064","url":null,"abstract":"","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":"93 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86251928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Identification of NQO1 as a target of herbal drug agrimol B in hepatocellular carcinoma","authors":"Dingyue Zhang, Lixia Dong, Wenyong Yang, Kui Wang","doi":"10.1071/ch22255","DOIUrl":"https://doi.org/10.1071/ch22255","url":null,"abstract":"","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":"14 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84868780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rong Li, Thomas N. G. Handley, Wenyi Li, N. O’Brien-Simpson, M. Hossain, J. Wade
{"title":"Directed chemical dimerisation enhances the antibacterial activity of the antimicrobial peptide MSI-78(4–20)","authors":"Rong Li, Thomas N. G. Handley, Wenyi Li, N. O’Brien-Simpson, M. Hossain, J. Wade","doi":"10.1071/ch23022","DOIUrl":"https://doi.org/10.1071/ch23022","url":null,"abstract":"","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74373787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neanne Alnafta, Marlowe S Graham, N. Proschogo, C. McErlean
{"title":"Chemical constituents of lawang root oil","authors":"Neanne Alnafta, Marlowe S Graham, N. Proschogo, C. McErlean","doi":"10.1071/ch23013","DOIUrl":"https://doi.org/10.1071/ch23013","url":null,"abstract":"","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":"9 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73714505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Efficient solid-state luminescent materials are critical components in varied optoelectronic devices. Here, we report three metal–organic frameworks combining calcium(II) with heteroleptic iridium(III) metalloligands containing the same 1,2-diimine ancillary ligand but different cyclometalating ligands. The synthesised frameworks exhibit similar supramolecular structure but different emission properties depending on the cyclometalating ligand. Binding calcium(II) to the metalloligands further affects framework emission depending on the relative contribution of triplet charge transfer (3MLLCT) or ligand-centred (3LC) transitions to the emissive excited state.
{"title":"Controlling emission energy in metal–organic frameworks featuring cyclometalated iridium(III) linkers","authors":"Carol Hua, Timothy U. Connell","doi":"10.1071/ch23127","DOIUrl":"https://doi.org/10.1071/ch23127","url":null,"abstract":"Efficient solid-state luminescent materials are critical components in varied optoelectronic devices. Here, we report three metal–organic frameworks combining calcium(II) with heteroleptic iridium(III) metalloligands containing the same 1,2-diimine ancillary ligand but different cyclometalating ligands. The synthesised frameworks exhibit similar supramolecular structure but different emission properties depending on the cyclometalating ligand. Binding calcium(II) to the metalloligands further affects framework emission depending on the relative contribution of triplet charge transfer (3MLLCT) or ligand-centred (3LC) transitions to the emissive excited state.","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135550393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charlène Lucas-Valmalle, G. Subra, P. Verdié, M. Kemel, V. Daugé, Karine Puget, Jean Martinez
{"title":"The C-terminal pentapeptide acein analogue (JMV3315) stimulates dopamine release in the brain","authors":"Charlène Lucas-Valmalle, G. Subra, P. Verdié, M. Kemel, V. Daugé, Karine Puget, Jean Martinez","doi":"10.1071/ch22232","DOIUrl":"https://doi.org/10.1071/ch22232","url":null,"abstract":"","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":"28 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72820587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Yuan, Yun-Xia Liang, Yi He, Hui-Qing Deng, Haiting Wu, Bohong Lin, Jing Zhang
{"title":"Fast protodeboronation of arylboronic acids and esters with AlCl3 at room temperature","authors":"Z. Yuan, Yun-Xia Liang, Yi He, Hui-Qing Deng, Haiting Wu, Bohong Lin, Jing Zhang","doi":"10.1071/ch23028","DOIUrl":"https://doi.org/10.1071/ch23028","url":null,"abstract":"","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":"141 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77234816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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