{"title":"The supramolecular chemistry of protein cages and viruses","authors":"Y. H. Lau","doi":"10.1071/ch23102","DOIUrl":"https://doi.org/10.1071/ch23102","url":null,"abstract":"","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":"48 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85706088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel G. Anstis, Jessica Liyu, Emma K. Davison, J. Sperry
{"title":"Alkaloids from the entheogenic plant Peganum harmala","authors":"Daniel G. Anstis, Jessica Liyu, Emma K. Davison, J. Sperry","doi":"10.1071/ch23038","DOIUrl":"https://doi.org/10.1071/ch23038","url":null,"abstract":"","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":"395 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76759333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Perspectives and opinions from scientific leaders on the evolution of data-independent acquisition for quantitative proteomics and novel biological applications","authors":"C. Hunter, J. Bons, B. Schilling","doi":"10.1071/ch23039","DOIUrl":"https://doi.org/10.1071/ch23039","url":null,"abstract":"","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":"33 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91296983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Majbrit Frøsig-Jørgensen, Jing Ji, Declan M. Gorman, Meng-Wei Kan, David J. Craik
A specimen of the marine cone snail Conus victoriae collected from a beach in Broome, Western Australia, by a group from The University of Melbourne led to the discovery of the α-conotoxin Vc1.1, which was found to have analgesic activity in rodents. The discovery of this venom-derived peptide led to a series of structural, mechanistic and pharmacological studies directed towards the development of a new analgesic for neuropathic pain by groups in Australia and internationally. Solid-phase peptide synthesis played an important role in developing structure–activity relationships. Studies in a rat model of neuropathic pain showed that a cyclic analogue of the peptide, cVc1.1, had comparable analgesic activity with that of gabapentin, one of the foremost clinically used drugs for neuropathic pain, with cVc1.1 delivered orally at a 120-fold lower dose than gabapentin. Originally, Vc1.1 was believed to act primarily through nicotinic acetylcholine receptors, but evidence for a mechanism mediated through γ-aminobutyric acid B (GABAB) receptors later emerged. Efforts to optimise the binding and pharmacological properties of analogues of Vc1.1 revealed that the affinity towards either receptor can be modulated by sequence mutations, disulfide bond modifications and backbone cyclisation. This Account describes the discovery, structure, chemistry and pharmacology of Vc1.1, with a focus on studies carried out in Australian laboratories.
{"title":"Discovery and optimisation of conotoxin Vc1.1 and analogues with analgesic properties","authors":"Majbrit Frøsig-Jørgensen, Jing Ji, Declan M. Gorman, Meng-Wei Kan, David J. Craik","doi":"10.1071/ch23155","DOIUrl":"https://doi.org/10.1071/ch23155","url":null,"abstract":"A specimen of the marine cone snail Conus victoriae collected from a beach in Broome, Western Australia, by a group from The University of Melbourne led to the discovery of the α-conotoxin Vc1.1, which was found to have analgesic activity in rodents. The discovery of this venom-derived peptide led to a series of structural, mechanistic and pharmacological studies directed towards the development of a new analgesic for neuropathic pain by groups in Australia and internationally. Solid-phase peptide synthesis played an important role in developing structure–activity relationships. Studies in a rat model of neuropathic pain showed that a cyclic analogue of the peptide, cVc1.1, had comparable analgesic activity with that of gabapentin, one of the foremost clinically used drugs for neuropathic pain, with cVc1.1 delivered orally at a 120-fold lower dose than gabapentin. Originally, Vc1.1 was believed to act primarily through nicotinic acetylcholine receptors, but evidence for a mechanism mediated through γ-aminobutyric acid B (GABAB) receptors later emerged. Efforts to optimise the binding and pharmacological properties of analogues of Vc1.1 revealed that the affinity towards either receptor can be modulated by sequence mutations, disulfide bond modifications and backbone cyclisation. This Account describes the discovery, structure, chemistry and pharmacology of Vc1.1, with a focus on studies carried out in Australian laboratories.","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135953869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BiographiesGo To >>TopConflicts of interestReferences Curt Wentrup graduated Candidatus Scientiarum under K. A. Jensen, University of Copenhagen and PhD at the Australian National University with W. D. Crow, undertook post-doctorates with Hans Dahn (Univeristé de Lausanne), W. M. Jones (Gainesville) and Maitland Jones Jr (Princeton), became Maître-Assistant and Privat-Docent at Lausanne and Professor at Universität Marburg before returning to The University of Queensland as Chair of Organic Chemistry in 1985. He received a DSc from Copenhagen, an honorary doctorate from Pau, France, a Fellowship of the Australian Academy of Science, and the Australian Centenary, Craig, Birch and Leighton Medals. As emeritus professor, he continues research in organic, physical and historical chemistry.
Curt Wentrup毕业于哥本哈根大学K. A. Jensen教授的科学研究生和澳大利亚国立大学W. D. Crow教授的博士学位，并与Hans Dahn(洛桑大学)，W. M. Jones(盖恩斯维尔)和Maitland Jones Jr(普林斯顿)一起进行博士后研究。在1985年回到昆士兰大学担任有机化学系主任之前，他曾在洛桑担任首席助理和私人讲解员，并在Universität Marburg担任教授。他获得了哥本哈根大学的科学博士学位，法国波城大学的荣誉博士学位，澳大利亚科学院的奖学金，以及澳大利亚百年纪念、克雷格、伯奇和莱顿奖章。作为名誉教授，他继续从事有机化学、物理化学和历史化学的研究。
{"title":"Celebrating RACI and Academy of Science awards 2022–23","authors":"Curt Wentrup","doi":"10.1071/ch23183","DOIUrl":"https://doi.org/10.1071/ch23183","url":null,"abstract":"BiographiesGo To >>TopConflicts of interestReferences Curt Wentrup graduated Candidatus Scientiarum under K. A. Jensen, University of Copenhagen and PhD at the Australian National University with W. D. Crow, undertook post-doctorates with Hans Dahn (Univeristé de Lausanne), W. M. Jones (Gainesville) and Maitland Jones Jr (Princeton), became Maître-Assistant and Privat-Docent at Lausanne and Professor at Universität Marburg before returning to The University of Queensland as Chair of Organic Chemistry in 1985. He received a DSc from Copenhagen, an honorary doctorate from Pau, France, a Fellowship of the Australian Academy of Science, and the Australian Centenary, Craig, Birch and Leighton Medals. As emeritus professor, he continues research in organic, physical and historical chemistry.","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":"113 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136258308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Walker, Glenn A Pullella, M. Piggott, P. Duggan
{"title":"Introduction to the chemistry and pharmacology of psychedelic drugs","authors":"S. Walker, Glenn A Pullella, M. Piggott, P. Duggan","doi":"10.1071/ch23050","DOIUrl":"https://doi.org/10.1071/ch23050","url":null,"abstract":"","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":"64 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74777055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manjeet Kumar, Cristina Cantarutti, David C Thorn, V. Bellotti, G. Esposito, M. Wilson, H. Ecroyd, J. Carver
{"title":"The extracellular chaperone clusterin prevents primary and secondary nucleation of an amyloidogenic variant of β2-microglobulin","authors":"Manjeet Kumar, Cristina Cantarutti, David C Thorn, V. Bellotti, G. Esposito, M. Wilson, H. Ecroyd, J. Carver","doi":"10.1071/ch23082","DOIUrl":"https://doi.org/10.1071/ch23082","url":null,"abstract":"","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":"78 1 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82890512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the present study, we have examined the utility of counterpoise (CP) corrections, the zero-cost geometric counterpoise (gCP) correction, and the double-ζ vDZP basis set, in representative examples of computational chemistry investigations. The tests include reaction energies and barriers in mechanisms of catalysis, and binding of substrates with enzyme active sites. Drawbacks of the CP approach include: it is more costly than calculations with the same basis set without applying CP corrections, multiple computations may be required where a single species is used in multiple instances, and it is only applicable to intermolecular interactions. In comparison, using gCP or vDZP is less costly. Their overall accuracy is comparable to CP, although the three approaches show variable performances for different systems. Thus, the use of a large basis set remains more consistent in obtaining results that are closer to the basis-set limit. Where the computational cost poses a challenge, the use of gCP or vDZP would be more advantageous than CP in terms of cost and simplicity.
{"title":"Counterpoise correction from a practical perspective: is the result worth the cost?","authors":"Bun Chan, Junming Ho","doi":"10.1071/ch23101","DOIUrl":"https://doi.org/10.1071/ch23101","url":null,"abstract":"In the present study, we have examined the utility of counterpoise (CP) corrections, the zero-cost geometric counterpoise (gCP) correction, and the double-ζ vDZP basis set, in representative examples of computational chemistry investigations. The tests include reaction energies and barriers in mechanisms of catalysis, and binding of substrates with enzyme active sites. Drawbacks of the CP approach include: it is more costly than calculations with the same basis set without applying CP corrections, multiple computations may be required where a single species is used in multiple instances, and it is only applicable to intermolecular interactions. In comparison, using gCP or vDZP is less costly. Their overall accuracy is comparable to CP, although the three approaches show variable performances for different systems. Thus, the use of a large basis set remains more consistent in obtaining results that are closer to the basis-set limit. Where the computational cost poses a challenge, the use of gCP or vDZP would be more advantageous than CP in terms of cost and simplicity.","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135401149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kinitra L. Hutchinson, B. Z. Poliquit, Andrew J. Clulow, P. Burn, I. Gentle, P. Shaw
{"title":"Correlating vapour uptake with the luminescence quenching of poly(dendrimer)s for the detection of nitro group-containing explosives","authors":"Kinitra L. Hutchinson, B. Z. Poliquit, Andrew J. Clulow, P. Burn, I. Gentle, P. Shaw","doi":"10.1071/ch23131","DOIUrl":"https://doi.org/10.1071/ch23131","url":null,"abstract":"","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":"62 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73887564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In view of the increasingly serious problem of oil–water separation, it is a convenient and practical method to introduce a hydrogel coating on the surface of materials to make super-wetting materials. Nowadays, researchers of super-wetting materials pay more attention to the research and development of responsive materials. Here, a thermal and magnetic dual-responsive superhydrophilicity/underwater superoleophobicity switchable device (Fe3O4@PNIPAM-Cu) was simply fabricated using the Fe3O4 nanoparticles, poly-N-isopropylacrylamide (PNIPAM) hydrogel as the functional coating and copper foam as the skeleton through a one-step solution immersion method. The separation efficiency of the benzene-water mixture of this dual-responsive device can reach up to 99.98%. Even after 10 separation cycles, it maintained an efficiency of more than 99.90%. At temperatures above ~34°C, the device can stop oil–water separation. The experiments presented here demonstrate this dual-responsive device possesses excellent superhydrophilicity/underwater superoleophobicity, thermal-responsive property and magnetic navigation function.
{"title":"Thermal and magnetic dual-responsive switchable device with superhydrophilicity/underwater superoleophobicity and excellent targeted oil–water separation performance","authors":"Congcong Li, H. Feng, Furong Tao, Tiantian Yang, Nali Chen, Baiyi Chen","doi":"10.1071/ch22160","DOIUrl":"https://doi.org/10.1071/ch22160","url":null,"abstract":"In view of the increasingly serious problem of oil–water separation, it is a convenient and practical method to introduce a hydrogel coating on the surface of materials to make super-wetting materials. Nowadays, researchers of super-wetting materials pay more attention to the research and development of responsive materials. Here, a thermal and magnetic dual-responsive superhydrophilicity/underwater superoleophobicity switchable device (Fe3O4@PNIPAM-Cu) was simply fabricated using the Fe3O4 nanoparticles, poly-N-isopropylacrylamide (PNIPAM) hydrogel as the functional coating and copper foam as the skeleton through a one-step solution immersion method. The separation efficiency of the benzene-water mixture of this dual-responsive device can reach up to 99.98%. Even after 10 separation cycles, it maintained an efficiency of more than 99.90%. At temperatures above ~34°C, the device can stop oil–water separation. The experiments presented here demonstrate this dual-responsive device possesses excellent superhydrophilicity/underwater superoleophobicity, thermal-responsive property and magnetic navigation function.","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":"39 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84437877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：