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Letter to the Editor: Author reply to Letter to the Editor regarding 'A revisionist model for treatment-resistant and difficult-to-treat depression'. 致编辑的信:作者就 "治疗耐药和难治抑郁症的修正主义模式 "致编辑的回信。
IF 4 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-11-01 Epub Date: 2024-09-08 DOI: 10.1177/00048674241276419
Gordon Parker
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引用次数: 0
Do compulsory mental health patients have a right to receive a second opinion on their treatment under Australian mental health legislation? 根据澳大利亚精神健康立法,强制精神疾病患者是否有权就其治疗获得第二意见?
IF 4 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-11-01 Epub Date: 2024-08-02 DOI: 10.1177/00048674241267219
Sam Boyle, Emma Cockburn, Bianca Mandeville

We reviewed Australian mental health legislation to determine what obligations it places on psychiatrists to facilitate second opinions for compulsory patients who request them. Only four jurisdictions-Australian Capital Territory, Queensland, Victoria, and Western Australia-have legislated for 'patient-initiated' second opinions. Within these four regimes, there is variation in important aspects of the second opinion process, and there is a general absence of direction given to the second opinion providers. Based on research showing the variability of second opinion provision under New Zealand mental health legislation, we argue that this absence is likely to result in significant variation in the quality and depth of second opinions provided in Australia. We argue that New South Wales, the Northern Territory, South Australia, and Tasmania should consider formal provision for patient-initiated second opinions in their mental health legislation. We believe that such legislation ought to be aware of the barriers patients may face in accessing second opinions, and avoid exacerbating these barriers as Queensland's legislation appears to. Also, we argue that research on current practice in Australia should be conducted to better understand the effects of legislation on second opinions, and to help determine what amounts to best practice.

我们审查了澳大利亚的精神健康立法,以确定精神科医生有哪些义务为提出申请的强制病人提供第二意见。只有四个辖区--澳大利亚首都地区、昆士兰州、维多利亚州和西澳大利亚州--对 "患者主动提出的 "第二意见进行了立法。在这四种制度中,第二意见程序的重要方面存在差异,而且普遍缺乏对第二意见提供者的指导。研究表明,新西兰精神卫生立法对第二意见提供的规定存在差异,基于此,我们认为,这种缺失很可能导致澳大利亚提供的第二意见在质量和深度上存在显著差异。我们认为,新南威尔士州、北部地区、南澳大利亚州和塔斯马尼亚州应考虑在其精神健康立法中正式规定由患者主动提出的第二意见。我们认为,此类立法应意识到患者在获取第二意见时可能面临的障碍,并避免像昆士兰州的立法那样加剧这些障碍。此外,我们还认为应该对澳大利亚的现行做法进行研究,以更好地了解立法对第二意见的影响,并帮助确定什么是最佳做法。
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引用次数: 0
Letter to the Editor: Letter to the Editor regarding 'A revisionist model for treatment-resistant and difficult-to-treat depression'. 致编辑的信:致编辑的信,关于 "治疗耐药和难治抑郁症的修正主义模式"。
IF 4 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-11-01 Epub Date: 2024-09-03 DOI: 10.1177/00048674241271020
Dusan Kolar, Michael V Kolar
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引用次数: 0
Glutamatergic neurotransmission in schizophrenia: A systematic review and quantitative synthesis of proton magnetic resonance spectroscopy studies across schizophrenia spectrum disorders. 精神分裂症中的谷氨酸能神经传递:精神分裂症谱系障碍质子磁共振波谱研究的系统回顾和定量综合。
IF 4 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-11-01 Epub Date: 2024-05-29 DOI: 10.1177/00048674241254216
Jamie J Lopes, Sean P Carruthers, Denny Meyer, Brian Dean, Susan L Rossell

Objective: Studies using proton magnetic resonance spectroscopy reveal substantial inconsistencies in the levels of brain glutamate, glutamine and glutamate + glutamine across schizophrenia spectrum disorders. This systematic review employs qualitative and quantitative methods to analyse the patterns and relationships between glutamatergic metabolites, schizophrenia spectrum disorders and brain regions.

Methods: A literature search was conducted using various databases with keywords including glutamate, glutamine, schizophrenia, psychosis and proton magnetic resonance spectroscopy. Inclusion criteria were limited to case-control studies that reported glutamatergic metabolite levels in adult patients with a schizophrenia spectrum disorder diagnosis - i.e. first-episode psychosis, schizophrenia, treatment-resistant schizophrenia and/or ultra-treatment-resistant schizophrenia - using proton magnetic resonance spectroscopy at 3 T or above. Pooled study data were synthesized and analysed.

Results: A total of 92 studies met the inclusion criteria, including 2721 healthy controls and 2822 schizophrenia spectrum disorder participants. Glu levels were higher in the basal ganglia, frontal cortex and medial prefrontal of first-episode psychosis participants, contrasting overall lower levels in schizophrenia participants. For Gln, strong differences in metabolite levels were evident in the basal ganglia, dorsolateral prefrontal cortex and frontal cortex, with first-episode psychosis showing significantly higher levels in the basal ganglia. In glutamate + glutamine, higher metabolite levels were found across schizophrenia spectrum disorder groups, particularly in the basal ganglia and dorsolateral prefrontal cortex of treatment-resistant schizophrenia participants. Significant relationships were found between metabolite levels and medication status, clinical measures and methodological variables.

Conclusion: The review highlights abnormal glutamatergic metabolite levels throughout schizophrenia spectrum disorders and in specific brain regions. The review underscores the importance of standardized future research assessing glutamatergic metabolites using proton magnetic resonance spectroscopy due to considerable literature heterogeneity.

目的:利用质子磁共振波谱进行的研究显示,精神分裂症谱系障碍患者大脑中谷氨酸、谷氨酰胺和谷氨酸+谷氨酰胺的水平存在很大差异。本系统综述采用定性和定量方法分析谷氨酸代谢物、精神分裂症谱系障碍和脑区之间的模式和关系:使用各种数据库进行文献检索,关键词包括谷氨酸、谷氨酰胺、精神分裂症、精神病和质子磁共振波谱。纳入标准仅限于使用 3 T 或以上质子磁共振波谱对诊断为精神分裂症谱系障碍(即首发精神病、精神分裂症、耐药精神分裂症和/或超耐药精神分裂症)的成年患者的谷氨酸代谢物水平进行报告的病例对照研究。对汇总的研究数据进行了综合分析:共有 92 项研究符合纳入标准,其中包括 2721 名健康对照者和 2822 名精神分裂症谱系障碍患者。首发精神病患者的基底节、额叶皮层和内侧前额叶的Glu水平较高,而精神分裂症患者的整体水平较低。至于 Gln,基底节、背外侧前额叶皮层和额叶皮层的代谢物水平明显不同,首发精神病患者的基底节水平显著较高。在谷氨酸+谷氨酰胺中,各精神分裂症谱系障碍组的代谢物水平较高,尤其是在耐药精神分裂症患者的基底节和背外侧前额叶皮层。研究发现代谢物水平与药物治疗状态、临床措施和方法学变量之间存在显著关系:综述强调了整个精神分裂症谱系障碍和特定脑区的谷氨酸代谢物水平异常。综述强调,由于文献中存在大量异质性,因此未来使用质子磁共振波谱评估谷氨酸代谢物的标准化研究非常重要。
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引用次数: 0
The impact of childhood abuse on future military sexual assault and PTSD symptomology in Australian veterans. 童年虐待对澳大利亚退伍军人未来军事性侵犯和创伤后应激障碍症状的影响。
IF 4 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-28 DOI: 10.1177/00048674241289027
Katelyn Kerr, Rebecca Mellor, Darcy Bennett, Richard Wellauer, Violette McGaw

Introduction: The trauma most commonly associated with the military is combat-related trauma. It is increasingly recognised that childhood sexual and physical abuse and military sexual assault may influence or exacerbate posttraumatic stress disorder (PTSD) when military members are exposed to combat.

Aims: The study aimed to determine whether a history of childhood sexual and physical abuse would increase the likelihood of military sexual assault (MSA) and determine whether a history of sexual abuse (childhood or military) impacted the incidence and severity of post-trauma sequelae compared to veterans without this history.

Method: A retrospective correlational analysis was performed on baseline data collected from clinical case records of a cohort of 134 Australian veterans with PTSD who had attended an outpatient Military Service Trauma Recovery Day Programme between October 2020 and May 2022.

Results: Almost half (48.5%) of veterans reported a history of abuse. Prevalence rates of military sexual abuse, child sexual abuse and child physical abuse were 14.9%, 13.4% and 23.1% respectively. The relationship between those who experienced childhood abuse and those who experienced military sexual abuse was not significant. No significant differences were observed between those who experienced any sexual abuse and those who did not on intake scores of psychological symptoms.

Conclusion: This is the first Australian study to investigate the prevalence of childhood abuse and military sexual abuse and its impact on PTSD and associated psychopathology in a sample of veterans seeking mental health treatment. No additional risks of experiencing military sexual assault were found for those who had survived childhood sexual abuse.

简介军队中最常见的创伤是与战斗有关的创伤。研究目的:本研究旨在确定童年性虐待和身体虐待史是否会增加军队性侵犯(MSA)的可能性,并确定与无此病史的退伍军人相比,性虐待史(童年或军队)是否会影响创伤后遗症的发生率和严重程度:对从临床病例记录中收集到的基线数据进行了回顾性相关分析,这些数据来自2020年10月至2022年5月期间参加过军人创伤恢复日门诊项目的134名患有创伤后应激障碍的澳大利亚退伍军人:近一半(48.5%)的退伍军人报告有虐待史。军队性虐待、儿童性虐待和儿童身体虐待的发生率分别为 14.9%、13.4% 和 23.1%。经历过童年虐待的退伍军人与经历过军队性虐待的退伍军人之间的关系并不显著。在心理症状的摄入评分方面,经历过任何性虐待的人与没有经历过性虐待的人之间没有明显差异:这是澳大利亚的第一项研究,调查了寻求心理健康治疗的退伍军人样本中童年虐待和军队性虐待的发生率及其对创伤后应激障碍和相关心理病理学的影响。研究没有发现童年遭受过性虐待的退伍军人遭受军队性侵犯的额外风险。
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引用次数: 0
Development of a framework of the skills and attributes needed by mental health professionals to provide optimal clinical care to people experiencing complex psychosis: A Delphi consensus study. 制定精神卫生专业人员为复杂性精神病患者提供最佳临床护理所需的技能和特质框架:德尔菲共识研究。
IF 4 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-26 DOI: 10.1177/00048674241289032
Sarah Grattan, Kimberley Davies, Janelle Weise, Nicholas Burns, Robyn Murray, Jennifer Weldon, Robin Ellis, Julia M Lappin

Background: Complex psychosis is associated with high social and economic costs. The key skills and attributes needed by mental health professionals to provide optimal clinical care to people experiencing complex psychosis have not previously been defined. A framework detailing these skills and attributes is needed to support the identification of training needs for those working with this population.

Methods: A modified online Delphi method was used to reach consensus on the skills and attributes essential for mental health professionals to deliver optimal clinical care to people experiencing complex psychosis. Participants were international healthcare professionals and academic researchers who self-identified as experts in complex psychosis. Participants were asked to rate their level of agreement with each item on a five-point Likert-type scale and to provide comments. Qualitative feedback was used to modify existing, or create new, items for subsequent rounds.

Results: 64 responses were received across three Delphi rounds. 167 items reached consensus and were endorsed (132 in Round 1, 31 in Round 2 and 4 in Round 3). Median score range for endorsed items was 4.5/5, with 88.6% scoring 5/5. All 167 endorsed items were included in the framework, categorised into 14 overarching domains.

Conclusion: Multiple skills and attributes were identified as being core components required in the delivery of optimal care by mental health professionals to people experiencing complex psychosis. The resulting framework provides a benchmark for training and skill development of mental health clinicians at both individual and team levels to optimise effective working with this high-needs population.

背景:复杂性精神病与高昂的社会和经济成本有关。精神卫生专业人员为复杂性精神病患者提供最佳临床护理所需的关键技能和特质以前尚未确定。我们需要一个详细说明这些技能和特质的框架,以支持确定从事此类人群工作的人员的培训需求:方法:我们采用了一种经过修改的在线德尔菲法,以就精神卫生专业人员为复杂性精神病患者提供最佳临床护理所必需的技能和特质达成共识。参与者是自认为是复杂性精神病专家的国际医疗保健专业人士和学术研究人员。我们要求参与者用李克特(Likert)五点量表对每个项目的同意程度进行评分,并提出意见。定性反馈用于修改现有项目或为后续项目创建新项目:三轮德尔菲共收到 64 份回复。167 个项目达成共识并获得认可(第一轮 132 个,第二轮 31 个,第三轮 4 个)。认可项目的中位分数范围为 4.5/5,88.6%的项目得分为 5/5。所有 167 个认可项目均被纳入框架,分为 14 个总体领域:结论:多种技能和属性被认为是精神卫生专业人员为复杂性精神病患者提供最佳护理所需的核心要素。由此产生的框架为心理健康临床医生在个人和团队层面的培训和技能发展提供了一个基准,以优化与这一高需求人群的有效合作。
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引用次数: 0
Letter to the Editor: Letter to the Editor regarding 'Do compulsory mental health patients have a right to receive a second psychiatric opinion on their treatment under Australian mental health legislation?' 致编辑的信致编辑的信,内容涉及 "根据澳大利亚精神健康立法,强制精神疾病患者是否有权就其治疗接受第二精神病学意见?
IF 4 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-26 DOI: 10.1177/00048674241291320
Simon Katterl
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引用次数: 0
Exploring the reliability and profile of frequent mental health presentations using different methods: An observational study using statewide ambulance data over a 4-year period. 使用不同方法探索频繁出现的精神疾病的可靠性和概况:利用全州救护车 4 年间的数据进行观察研究。
IF 4 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-26 DOI: 10.1177/00048674241289016
Anthony Hew, Jesse T Young, Bosco Rowland, Debbie Scott, Ziad Nehme, Shalini Arunogiri, Dan I Lubman

Introduction: A disproportionate number of mental health presentations to emergency services are made by frequent presenters. No current consensus definition of a frequent presenter exists. Using a statewide population-based ambulance database, this study (i) applied previous statistical methods to determine thresholds for frequent presenters, (ii) explored characteristics of the identified frequent presenter groups compared to non-frequent presenters and (iii) assessed the reliability of these methods in predicting continued frequent presenter status over time.

Methods: Statistical methods utilised in previous studies to identify frequent presenters were applied to all ambulance attendances for mental health symptoms, self-harm and alcohol and other drug issues between 1 January 2017 and 31 December 2020 in Victoria, Australia. Differences in characteristics between identified frequent and non-frequent presenter groups were determined by logistic regression analysis. The consistency of agreement of frequent presenter status over time was assessed using intraclass correlation coefficients.

Results: Thresholds for frequent presenters ranged from a mean of 5 to 39 attendances per calendar year, with groups differing in size, service use and characteristics. Compared to non-frequent presenters, frequent presenters had greater odds of being female, presenting with self-harm, experiencing social disadvantage or housing issues, involving police co-attendance and being transported to hospital. All frequent presenter definitions had poor reliability in predicting ongoing frequent presentations over time.

Conclusion: A range of methods can define frequent presenters according to thresholds of yearly service use. Reasons for identifying frequent presenters may influence the method chosen. Future studies should explore definitions that capture the dynamic nature of presentations by this group.

导言:在向急诊服务机构求助的精神疾病患者中,经常求助者所占的比例过高。目前还没有关于频繁出现者的一致定义。本研究利用全州范围内以人口为基础的救护车数据库,(i) 应用以前的统计方法来确定频繁求助者的阈值,(ii) 与非频繁求助者相比,探讨已确定的频繁求助者群体的特征,(iii) 评估这些方法在预测长期频繁求助者状态方面的可靠性:对澳大利亚维多利亚州2017年1月1日至2020年12月31日期间所有因精神健康症状、自残以及酒精和其他药物问题出诊的救护车采用了以往研究中用于识别频繁出诊者的统计方法。通过逻辑回归分析确定了频繁和非频繁出现者群体之间的特征差异。使用类内相关系数评估了在一段时间内频繁演讲者身份的一致性:结果:经常演讲者的阈值从平均每年 5 次到 39 次不等,各群体的规模、服务使用情况和特征各不相同。与非频繁求助者相比,频繁求助者中女性、自残、社会处境不利或住房问题、警方共同参与和被送往医院的几率更高。所有频繁出现者的定义在预测长期频繁出现方面的可靠性都很差:结论:根据每年使用服务的阈值,有一系列方法可以定义频繁出现者。识别频繁就诊者的原因可能会影响所选择的方法。未来的研究应探索能捕捉到这一群体就诊动态性质的定义。
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引用次数: 0
Youth suicidality risk relative to ambient temperature and heatwaves across climate zones: A time series analysis of emergency department presentations in New South Wales, Australia. 不同气候带的青少年自杀风险与环境温度和热浪的关系:澳大利亚新南威尔士州急诊科就诊情况的时间序列分析。
IF 4 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-23 DOI: 10.1177/00048674241290449
Cybele Dey, Jianyun Wu, John Uesi, Grant Sara, Michael Dudley, Katherine Knight, James G Scott, Ollie Jay, Michael Bowden, Iain E Perkes

Objective: Youth suicidality prevalence continues to rise alongside hot weather severity. Links between these two variables are underexplored. We examined associations between daily temperature and emergency department suicidality presentations by young people. We assessed these associations for five regions covering New South Wales as determined by 'climate zone' and analysed for heatwave effects as well as based on demographic subgroups.

Methods: Daily emergency department presentations for suicidality by people aged 12-24 years across New South Wales, Australia, during warmer months (November to March) from 2012 to 2019 were examined in relation to daily mean temperature and heatwaves (⩾3 consecutive days ⩾ 95th percentile of long-term daily mean temperature) and by climate zone, using a generalised additive model with negative binomial distribution. Risks for age- and sex-based subgroups were also calculated.

Results: New South Wales youth suicidality presentation rates were significantly higher on hotter days. For every 1°C rise above average daily mean temperature, youth suicidality presentations to New South Wales emergency departments increased by 1.3%. Heatwaves did not increase presentation rates beyond single-day daily mean temperature effects. These findings were predominantly replicated across climate zones and demographic subgroups, though the association between suicidality and ambient temperature was weaker in coastal regions including Eastern Sydney.

Conclusion: There is a positive linear association between ambient temperature and youth suicidality presentations to emergency departments. Risks are increased on single hot days, not only during heatwaves. Public health, broader societal approaches to heat and health system planning should consider impacts on youth suicidality of predicted increases in hot weather severity and frequency.

目的:青少年自杀率随着炎热天气的严重程度而持续上升。这两个变量之间的联系尚未得到充分研究。我们研究了每日气温与急诊科青少年自杀率之间的关联。我们根据 "气候区 "评估了新南威尔士州五个地区的这些关联,并根据热浪效应和人口亚群进行了分析:采用负二项分布的广义加法模型,研究了2012年至2019年澳大利亚新南威尔士州12-24岁人群在较热月份(11月至次年3月)因自杀而到急诊科就诊的情况与日平均气温和热浪(⩾连续3天⩾长期日平均气温的第95百分位数)的关系以及各气候区的关系。此外,还计算了基于年龄和性别分组的风险:结果:新南威尔士州青少年自杀率在高温天明显较高。日平均气温每升高1°C,到新南威尔士州急诊科就诊的青少年自杀率就会增加1.3%。除单日日平均气温的影响外,热浪并不会增加就诊率。这些发现主要在不同气候带和人口亚群中得到重复,但在包括悉尼东部在内的沿海地区,自杀与环境温度之间的关联较弱:结论:环境温度与急诊科接诊的青少年自杀率呈正线性关系。不仅在热浪期间,单个高温日的风险也会增加。公共卫生、应对热浪的更广泛的社会方法以及卫生系统规划应考虑炎热天气严重程度和频率的预计增加对青少年自杀率的影响。
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引用次数: 0
Trauma, resilience and significant relationships: Sex differences in protective factors for military mental health. 创伤、复原力和重要关系:军人心理健康保护因素的性别差异。
IF 4 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-11 DOI: 10.1177/00048674241286818
Lisa Dell, Kelsey Madden, Jenelle Baur, Alyssa Sbisa, Alexander McFarlane, Miranda VanHooff, Richard Bryant, Ellie Lawrence-Wood

Background: Military service is historically a male-dominated occupation, as such, the majority of research examining the development of mental disorder in Australian Defence Force members has had primarily male samples. While there have been mixed findings internationally regarding sex differences in rates of mental disorder and subthreshold symptoms among military personnel, across studies, the evidence tends to suggest that female military members are at least as likely as males to experience subthreshold mental health symptoms and have similar or higher rates of posttraumatic stress disorder despite the differences in roles during service. What is less understood is the impact of sex differences in symptom emergence over time and in predictors of clinical disorder.

Method: The sample included a longitudinal cohort of Australian Defence Force members (N = 8497) surveyed at Time 1 (2010) and followed up at Time 2 (2015) on measures of anger, self-perceived resilience, trauma exposure, deployment exposure, suicidality, help-seeking, relationship satisfaction and mental health disorder symptoms. Outcomes included Subthreshold Disorder (above the optimal screening cut-off on the 10-item Kessler distress scale or posttraumatic stress disorder checklist) and Probable Disorder (above the epidemiological cut-off on the 10-item Kessler distress scale or posttraumatic stress disorder checklist).

Results: Results found that while lifetime trauma exposure remained the strongest predictor of later probable disorder emergence among both males and females, for females specifically, self-reported resilience was also a significant protective factor. In contrast, being in a significant relationship at Time 1 was a protective factor against the development of subthreshold disorder in males.

Conclusion: For the first time, sex differences in mental health symptom emergence over time have been explored in a large Australian cohort of military members. The capacity to adapt and bounce back after adversity emerged as a proactive factor against poor mental health for females in the military and could be addressed as part of routine skills training. Social support from significant relationship was particularly important for males' mental health, suggesting that maintaining positive relationships and supporting military spouses and partners are critical for males' mental health.

背景:服兵役历来是男性占主导地位的职业,因此,大多数有关澳大利亚国防军成员精神障碍发展的研究主要以男性为样本。尽管国际上关于军人精神障碍和阈下症状发生率的性别差异的研究结果不一,但在各项研究中,有证据倾向于表明,尽管在服役期间的角色不同,但女性军人至少和男性一样有可能出现阈下精神健康症状,并且有类似或更高的创伤后应激障碍发生率。目前还不太清楚的是,随着时间的推移,性别差异对症状出现的影响以及对临床障碍预测的影响:样本包括澳大利亚国防军成员的纵向队列(N = 8497),在时间 1(2010 年)进行调查,并在时间 2(2015 年)对愤怒、自我感觉复原力、创伤暴露、部署暴露、自杀倾向、求助、人际关系满意度和心理健康障碍症状进行随访。结果包括阈下障碍(高于凯斯勒十项痛苦量表或创伤后应激障碍检查表的最佳筛查临界值)和可能障碍(高于凯斯勒十项痛苦量表或创伤后应激障碍检查表的流行病学临界值):结果发现,在男性和女性中,终生遭受创伤仍然是日后可能出现障碍的最有力预测因素,而对于女性而言,自我报告的复原力也是一个重要的保护因素。与此相反,在时间1时处于重要关系中的男性是阈下障碍发展的保护因素:结论:这是首次在一个大型澳大利亚军人队列中对心理健康症状随时间变化的性别差异进行研究。逆境后的适应能力和反弹能力是防止女性军人心理健康状况不佳的一个积极因素,可作为日常技能培训的一部分加以解决。来自重要关系的社会支持对男性的心理健康尤为重要,这表明保持积极的关系以及支持军人配偶和伴侣对男性的心理健康至关重要。
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引用次数: 0
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Australian and New Zealand Journal of Psychiatry
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