首页 > 最新文献

Australian and New Zealand Journal of Obstetrics and Gynaecology最新文献

英文 中文
Extending the new era of genomic testing into pregnancy management: A proposed model for Australian prenatal services 将基因组检测的新时代延伸到孕期管理中:澳大利亚产前服务的建议模式
Pub Date : 2024-04-05 DOI: 10.1111/ajo.13814
Alice Rogers, Lucas De Jong, Wendy Waters, Lesley H. Rawlings, Keryn Simons, Song Gao, Julien Soubrier, Rosalie Kenyon, Ming Lin, Rob King, David M. Lawrence, Peter Muller, Shannon Leblanc, Lesley McGregor, Suzanne C. E. H. Sallevelt, Jan Liebelt, Tristan S. E. Hardy, Janice M. Fletcher, Hamish S. Scott, Abhi Kulkarni, Christopher P. Barnett, Karin S. Kassahn
BackgroundTrio exome sequencing can be used to investigate congenital abnormalities identified on pregnancy ultrasound, but its use in an Australian context has not been assessed.AimsAssess clinical outcomes and changes in management after expedited genomic testing in the prenatal period to guide the development of a model for widespread implementation.Materials and methodsForty‐three prospective referrals for whole exome sequencing, including 40 trios (parents and pregnancy), two singletons and one duo were assessed in a tertiary hospital setting with access to a state‐wide pathology laboratory. Diagnostic yield, turn‐around time (TAT), gestational age at reporting, pregnancy outcome, change in management and future pregnancy status were assessed for each family.ResultsA clinically significant genomic diagnosis was made in 15/43 pregnancies (35%), with an average TAT of 12 days. Gestational age at time of report ranged from 16 + 5 to 31 + 6 weeks (median 21 + 3 weeks). Molecular diagnoses included neuromuscular and skeletal disorders, RASopathies and a range of other rare Mendelian disorders. The majority of families actively used the results in pregnancy decision making as well as in management of future pregnancies.ConclusionsRapid second trimester prenatal genomic testing can be successfully delivered to investigate structural abnormalities in pregnancy, providing crucial guidance for current and future pregnancy management. The time‐sensitive nature of this testing requires close laboratory and clinical collaboration to ensure appropriate referral and result communication. We found the establishment of a prenatal coordinator role and dedicated reporting team to be important facilitators. We propose this as a model for genomic testing in other prenatal services.
目的评估产前快速基因组检测后的临床结果和管理变化,以指导制定广泛实施的模式。材料和方法在一家可使用全州病理实验室的三级医院中,对 43 例转诊的全外显子组测序患者进行了评估,其中包括 40 例三胞胎(父母和孕妇)、2 例单胎和 1 例双胎。对每个家庭的诊断率、周转时间(TAT)、报告时的胎龄、妊娠结局、管理变化和未来妊娠状况进行了评估。结果 15/43 例孕妇(35%)获得了有临床意义的基因组诊断,平均周转时间为 12 天。报告时的胎龄从 16+5 周到 31+6 周不等(中位数为 21+3 周)。分子诊断包括神经肌肉和骨骼疾病、RAS 病和一系列其他罕见孟德尔疾病。结论第二孕期产前基因组快速检测可成功用于调查妊娠结构异常,为当前和未来的妊娠管理提供重要指导。这种检测的时效性要求实验室和临床密切合作,以确保适当的转诊和结果沟通。我们发现,设立产前协调员和专门的报告小组是重要的促进因素。我们建议将此作为其他产前服务机构基因组检测的一种模式。
{"title":"Extending the new era of genomic testing into pregnancy management: A proposed model for Australian prenatal services","authors":"Alice Rogers, Lucas De Jong, Wendy Waters, Lesley H. Rawlings, Keryn Simons, Song Gao, Julien Soubrier, Rosalie Kenyon, Ming Lin, Rob King, David M. Lawrence, Peter Muller, Shannon Leblanc, Lesley McGregor, Suzanne C. E. H. Sallevelt, Jan Liebelt, Tristan S. E. Hardy, Janice M. Fletcher, Hamish S. Scott, Abhi Kulkarni, Christopher P. Barnett, Karin S. Kassahn","doi":"10.1111/ajo.13814","DOIUrl":"https://doi.org/10.1111/ajo.13814","url":null,"abstract":"BackgroundTrio exome sequencing can be used to investigate congenital abnormalities identified on pregnancy ultrasound, but its use in an Australian context has not been assessed.AimsAssess clinical outcomes and changes in management after expedited genomic testing in the prenatal period to guide the development of a model for widespread implementation.Materials and methodsForty‐three prospective referrals for whole exome sequencing, including 40 trios (parents and pregnancy), two singletons and one duo were assessed in a tertiary hospital setting with access to a state‐wide pathology laboratory. Diagnostic yield, turn‐around time (TAT), gestational age at reporting, pregnancy outcome, change in management and future pregnancy status were assessed for each family.ResultsA clinically significant genomic diagnosis was made in 15/43 pregnancies (35%), with an average TAT of 12 days. Gestational age at time of report ranged from 16 + 5 to 31 + 6 weeks (median 21 + 3 weeks). Molecular diagnoses included neuromuscular and skeletal disorders, RASopathies and a range of other rare Mendelian disorders. The majority of families actively used the results in pregnancy decision making as well as in management of future pregnancies.ConclusionsRapid second trimester prenatal genomic testing can be successfully delivered to investigate structural abnormalities in pregnancy, providing crucial guidance for current and future pregnancy management. The time‐sensitive nature of this testing requires close laboratory and clinical collaboration to ensure appropriate referral and result communication. We found the establishment of a prenatal coordinator role and dedicated reporting team to be important facilitators. We propose this as a model for genomic testing in other prenatal services.","PeriodicalId":8599,"journal":{"name":"Australian and New Zealand Journal of Obstetrics and Gynaecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140567467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outpatient hysteroscopy: Suitable for all? A retrospective cohort study of safety, success and acceptability in Australia 门诊宫腔镜检查:适合所有人吗?在澳大利亚进行的安全性、成功率和可接受性回顾性队列研究
Pub Date : 2024-04-04 DOI: 10.1111/ajo.13816
Rebecca Nash, Samir Saidi
BackgroundIn Australia, gynaecologists continue to assess and investigate abnormal uterine bleeding with inpatient hysteroscopy despite evidence validating outpatient hysteroscopy services.AimThis retrospective cohort study assessed the safety, success and acceptability of office hysteroscopy in a gynae‐oncology rapid‐access clinic over six years in Sydney, Australia, and included all women without an age or body mass index (BMI) cut‐off using a ‘see and treat’ concept.MethodsA database was created and analysed retrospectively for patients who attended office hysteroscopy service between January 2016 and March 2021 (63 months, 481 eligible). An anonymous modified PAT‐32 patient satisfaction questionnaire was also offered to an initial cohort after their procedure to gauge insightful feedback about acceptability.ResultsA total of 92% of patients had successful outpatient hysteroscopic access; 24% of cases required hysteroscopy under general anaesthesia (GA) despite pathology in over 50% of cases; 68% of the total were able to be managed with outpatient hysteroscopy and did not require a follow‐up GA hysteroscopy. This paper is also the first of its kind to our knowledge to incorporate patients >65 years, those with a BMI >35 and those with a history of cervical stenosis. This study suggests that age and BMI do not impact the success rate of the procedure.ConclusionThis study demonstrates that outpatient hysteroscopy is an acceptable, safe procedure that is well tolerated by patients. Considering our rapid‐access hysteroscopy service allowed 68% of the patient cohort to avoid hysteroscopy under GA, we estimate conservatively ~$63 million per year in Australia could be saved by performing office hysteroscopies.
背景在澳大利亚,尽管有证据表明门诊宫腔镜检查服务是有效的,但妇科医生仍继续使用住院宫腔镜检查来评估和调查异常子宫出血。这项回顾性队列研究评估了澳大利亚悉尼一家妇科肿瘤快速诊疗中心六年来门诊宫腔镜检查的安全性、成功率和可接受性,并采用 "即看即治 "的理念,纳入了所有没有年龄或体重指数(BMI)分界线的妇女。结果92%的患者在门诊成功接受了宫腔镜检查;24%的病例需要在全身麻醉(GA)下进行宫腔镜检查,尽管有超过50%的病例存在病变;68%的患者可以在门诊接受宫腔镜检查,不需要进行后续的GA宫腔镜检查。据我们所知,本文也是首例将 65 岁患者、体重指数(BMI)为 35 的患者和有宫颈狭窄病史的患者纳入其中的研究。本研究表明,年龄和体重指数不会影响手术的成功率。结论本研究表明,门诊宫腔镜手术是一种可接受的、安全的手术,患者的耐受性良好。考虑到我们的快速宫腔镜检查服务让68%的患者避免了在全麻下进行宫腔镜检查,我们保守估计,在澳大利亚,每年可通过在门诊进行宫腔镜检查节省约6,300万澳元。
{"title":"Outpatient hysteroscopy: Suitable for all? A retrospective cohort study of safety, success and acceptability in Australia","authors":"Rebecca Nash, Samir Saidi","doi":"10.1111/ajo.13816","DOIUrl":"https://doi.org/10.1111/ajo.13816","url":null,"abstract":"BackgroundIn Australia, gynaecologists continue to assess and investigate abnormal uterine bleeding with inpatient hysteroscopy despite evidence validating outpatient hysteroscopy services.AimThis retrospective cohort study assessed the safety, success and acceptability of office hysteroscopy in a gynae‐oncology rapid‐access clinic over six years in Sydney, Australia, and included all women without an age or body mass index (BMI) cut‐off using a ‘see and treat’ concept.MethodsA database was created and analysed retrospectively for patients who attended office hysteroscopy service between January 2016 and March 2021 (63 months, 481 eligible). An anonymous modified PAT‐32 patient satisfaction questionnaire was also offered to an initial cohort after their procedure to gauge insightful feedback about acceptability.ResultsA total of 92% of patients had successful outpatient hysteroscopic access; 24% of cases required hysteroscopy under general anaesthesia (GA) despite pathology in over 50% of cases; 68% of the total were able to be managed with outpatient hysteroscopy and did not require a follow‐up GA hysteroscopy. This paper is also the first of its kind to our knowledge to incorporate patients >65 years, those with a BMI >35 and those with a history of cervical stenosis. This study suggests that age and BMI do not impact the success rate of the procedure.ConclusionThis study demonstrates that outpatient hysteroscopy is an acceptable, safe procedure that is well tolerated by patients. Considering our rapid‐access hysteroscopy service allowed 68% of the patient cohort to avoid hysteroscopy under GA, we estimate conservatively ~$63 million per year in Australia could be saved by performing office hysteroscopies.","PeriodicalId":8599,"journal":{"name":"Australian and New Zealand Journal of Obstetrics and Gynaecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140567575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID‐19 lockdowns affected birthing outcomes in a regional New South Wales Health District COVID-19 封锁影响了新南威尔士一个地区卫生区的分娩结果
Pub Date : 2024-04-03 DOI: 10.1111/ajo.13812
Pierre Hofstee, Bridie Mulholland, Megan Kelly, Warren Davis, Kate Curtis
IntroductionThe 400 000 residents of the Illawarra Shoalhaven Local Health District (ISLHD) experienced two distinct lockdowns aimed at mitigating the transmission of severe acute respiratory syndrome coronavirus 2 infection. Analysing effects of these lockdowns on maternal and neonatal outcomes presents a valuable opportunity to assess the impact of pandemic‐level restrictions on maternal and neonatal outcomes.AimEvaluate the impacts of restrictions from two lockdown periods on maternal, birthing, and neonatal outcomes within a regional local health district.Materials and MethodsThe study included 22 166 women who gave birth within ISLHD between 2017 and 2022. Groups included for analysis: Control Group – mothers pregnant before the pandemic (conception before 3 April 2019); Exposure Group 1 – mothers pregnant during the first lockdown (conception date 22 January 2020 to 5 May 2020); and Exposure Group 2 – mothers pregnant during the second lockdown (conception date 30 April 2021 to 13 Sep 2021).ResultsOdds of adverse birthing outcomes including non‐reassuring fetal status (odds ratio (OR) 1.34; 95% CI 1.14–1.56 and OR 1.20; 95% CI 1.03–1.40), and postpartum haemorrhage (OR 2.04; 95% CI 1.73–2.41 and OR 1.74; 95% CI 1.48–2.05) were substantially increased in Exposure Groups 1 and 2, respectively. Gestational diabetes, gestational hypertension, low birth weight and admission to neonatal intensive care rates improved.ConclusionsPregnant women exposed to pandemic restrictions within ISLHD had decreased odds of adverse antenatal and neonatal outcomes, but increased odds of poor peripartum outcomes.
引言伊拉瓦拉肖尔港地方卫生区(Illawarra Shoalhaven Local Health District,ISLHD)的 40 万居民经历了两次不同的封锁,旨在减少严重急性呼吸系统综合征冠状病毒 2 感染的传播。分析这两次封锁对孕产妇和新生儿预后的影响为评估大流行病级别的限制措施对孕产妇和新生儿预后的影响提供了宝贵的机会.AimEvaluate the impacts of restrictions from two lockdown periods on maternal, birthing, and neonatal outcomes within a regional local health district.材料与方法该研究纳入了2017年至2022年期间在ISLHD内分娩的22 166名妇女。分析对象包括对照组--大流行前怀孕的母亲(2019 年 4 月 3 日前受孕);暴露组 1--第一次封锁期间怀孕的母亲(受孕日期为 2020 年 1 月 22 日至 2020 年 5 月 5 日);暴露组 2--第二次封锁期间怀孕的母亲(受孕日期为 2021 年 4 月 30 日至 2021 年 9 月 13 日)。结果暴露组 1 和暴露组 2 的不良分娩结果,包括胎儿无保障(几率比(OR)1.34;95% CI 1.14-1.56 和 OR 1.20;95% CI 1.03-1.40)和产后出血(OR 2.04;95% CI 1.73-2.41 和 OR 1.74;95% CI 1.48-2.05)的几率分别大幅增加。妊娠糖尿病、妊娠高血压、低出生体重和新生儿重症监护入院率均有所改善。
{"title":"COVID‐19 lockdowns affected birthing outcomes in a regional New South Wales Health District","authors":"Pierre Hofstee, Bridie Mulholland, Megan Kelly, Warren Davis, Kate Curtis","doi":"10.1111/ajo.13812","DOIUrl":"https://doi.org/10.1111/ajo.13812","url":null,"abstract":"IntroductionThe 400 000 residents of the Illawarra Shoalhaven Local Health District (ISLHD) experienced two distinct lockdowns aimed at mitigating the transmission of severe acute respiratory syndrome coronavirus 2 infection. Analysing effects of these lockdowns on maternal and neonatal outcomes presents a valuable opportunity to assess the impact of pandemic‐level restrictions on maternal and neonatal outcomes.AimEvaluate the impacts of restrictions from two lockdown periods on maternal, birthing, and neonatal outcomes within a regional local health district.Materials and MethodsThe study included 22 166 women who gave birth within ISLHD between 2017 and 2022. Groups included for analysis: Control Group – mothers pregnant before the pandemic (conception before 3 April 2019); Exposure Group 1 – mothers pregnant during the first lockdown (conception date 22 January 2020 to 5 May 2020); and Exposure Group 2 – mothers pregnant during the second lockdown (conception date 30 April 2021 to 13 Sep 2021).ResultsOdds of adverse birthing outcomes including non‐reassuring fetal status (odds ratio (OR) 1.34; 95% CI 1.14–1.56 and OR 1.20; 95% CI 1.03–1.40), and postpartum haemorrhage (OR 2.04; 95% CI 1.73–2.41 and OR 1.74; 95% CI 1.48–2.05) were substantially increased in Exposure Groups 1 and 2, respectively. Gestational diabetes, gestational hypertension, low birth weight and admission to neonatal intensive care rates improved.ConclusionsPregnant women exposed to pandemic restrictions within ISLHD had decreased odds of adverse antenatal and neonatal outcomes, but increased odds of poor peripartum outcomes.","PeriodicalId":8599,"journal":{"name":"Australian and New Zealand Journal of Obstetrics and Gynaecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140567476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Journal Editorial Board 期刊编辑委员会
Pub Date : 2023-04-01 DOI: 10.1111/ajo.13564
{"title":"Journal Editorial Board","authors":"","doi":"10.1111/ajo.13564","DOIUrl":"https://doi.org/10.1111/ajo.13564","url":null,"abstract":"","PeriodicalId":8599,"journal":{"name":"Australian and New Zealand Journal of Obstetrics and Gynaecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84059457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Journal Editorial Board 期刊编辑委员会
Pub Date : 2022-08-01 DOI: 10.1111/ajo.13388
{"title":"Journal Editorial Board","authors":"","doi":"10.1111/ajo.13388","DOIUrl":"https://doi.org/10.1111/ajo.13388","url":null,"abstract":"","PeriodicalId":8599,"journal":{"name":"Australian and New Zealand Journal of Obstetrics and Gynaecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85163714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal deaths in Australia from ruptured splenic artery aneurysms 澳大利亚脾动脉瘤破裂导致的产妇死亡
Pub Date : 2022-06-02 DOI: 10.1111/ajo.13537
G. Lawson
The rupture of a splenic artery aneurysm (SAA) in pregnancy is a highly lethal condition, but so rare that most obstetricians would not encounter it during their career. In the seven official ‘Maternal Deaths in Australia’ reports, that covered 21 years from 1997 to 2017, among a total of 449 direct and indirect deaths, there were nine deaths (2%) from a ruptured SAA. These cases, and other cases from the literature and the Cochrane Library, are reviewed. The aim of the review is to raise awareness among clinicians of this potentially fatal condition.
妊娠期脾动脉瘤(SAA)破裂是一种高度致命的疾病,但非常罕见,大多数产科医生在其职业生涯中都不会遇到这种情况。在1997年至2017年21年间的7份官方“澳大利亚孕产妇死亡”报告中,在449例直接和间接死亡中,有9例(2%)死于SAA破裂。本文回顾了这些病例,以及文献和Cochrane图书馆中的其他病例。该综述的目的是提高临床医生对这种潜在致命疾病的认识。
{"title":"Maternal deaths in Australia from ruptured splenic artery aneurysms","authors":"G. Lawson","doi":"10.1111/ajo.13537","DOIUrl":"https://doi.org/10.1111/ajo.13537","url":null,"abstract":"The rupture of a splenic artery aneurysm (SAA) in pregnancy is a highly lethal condition, but so rare that most obstetricians would not encounter it during their career. In the seven official ‘Maternal Deaths in Australia’ reports, that covered 21 years from 1997 to 2017, among a total of 449 direct and indirect deaths, there were nine deaths (2%) from a ruptured SAA. These cases, and other cases from the literature and the Cochrane Library, are reviewed. The aim of the review is to raise awareness among clinicians of this potentially fatal condition.","PeriodicalId":8599,"journal":{"name":"Australian and New Zealand Journal of Obstetrics and Gynaecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80460332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of obesity on cost of total laparoscopic hysterectomy 肥胖对腹腔镜全子宫切除术费用的影响
Pub Date : 2022-04-15 DOI: 10.1111/ajo.13520
V. A. Rajadurai, E. Nathan, J. Pontré, B. Mcelhinney, K. Karthigasu, R. Hart
To test for the association between increasing patient body mass index (BMI) and the cost of total laparoscopic hysterectomy (TLH). Secondary outcomes include the relationship between increasing BMI and both peri‐ and post‐operative morbidity.
检验患者体重指数(BMI)的增加与腹腔镜全子宫切除术(TLH)费用之间的关系。次要结局包括BMI升高与手术前后发病率的关系。
{"title":"The effect of obesity on cost of total laparoscopic hysterectomy","authors":"V. A. Rajadurai, E. Nathan, J. Pontré, B. Mcelhinney, K. Karthigasu, R. Hart","doi":"10.1111/ajo.13520","DOIUrl":"https://doi.org/10.1111/ajo.13520","url":null,"abstract":"To test for the association between increasing patient body mass index (BMI) and the cost of total laparoscopic hysterectomy (TLH). Secondary outcomes include the relationship between increasing BMI and both peri‐ and post‐operative morbidity.","PeriodicalId":8599,"journal":{"name":"Australian and New Zealand Journal of Obstetrics and Gynaecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89678637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Adverse perinatal outcomes in the Australian Indigenous population, the role of asthma 不良围产期结局在澳大利亚土著人口,哮喘的作用
Pub Date : 2022-04-01 DOI: 10.1111/ajo.13468
Bronwyn K Brew
Asthma in pregnancy has been shown in a number of studies to be associated with adverse perinatal outcomes including low birth weight and perinatal death.1– 4 However, the majority of studies in this area have been in general populations in the US, Europe and Australia. It is therefore of interest that Clifton et al.5 recently published a study on perinatal outcomes in an Australian Indigenous population, especially as adverse perinatal outcomes in this population remain high, (although declining), with mortality and low birth weight rates double that of nonIndigenous rates.6 However, I do have some concerns about the results presented and their interpretation, namely around the choices of control group and confounders. In the abstract and results section the authors have stated they observed a twofold increase in neonatal deaths in Indigenous babies whose mothers had asthma compared to nonIndigenous women who did not have asthma. However, in Table 2 where odds ratios of Indigenous women with asthma have been presented the reference group is referred to as being ‘nonIndigenous women without asthma’. Given the existing risk of adverse perinatal outcomes in the Australian Indigenous population it is therefore not possible to tell what role asthma plays in these findings or whether the reported associations are in fact driven by Indigenous status (or rather, the risk factors and behaviours as a results of colonisation and racism that continue to drive Indigenous health outcomes). Further, the findings in Table 2 that asthma does not show any added effect on perinatal outcomes in nonIndigenous women supports the argument, that at least in this dataset, asthma may not be making a difference on perinatal outcomes. The other possible source of confounding is socioeconomic status. The authors have stated that the inclusion of confounders was determined by the univariate associations between covariates and outcomes. Table 1 shows that socioeconomic status measured as attained education level was significantly different between Indigenous and nonIndigenous mothers, P < 0.001. Given these findings and that it is well recognised that socioeconomic determinants are a strong driver of health,7 it is unclear then why the multivariate associations were not adjusted for education level. Although no other similar studies exist for Indigenous groups, studies comparing Black, Hispanic and White American women found that although Black women had a higher prevalence of asthma and were more likely to have lower socioeconomic determinants, asthma was not able to explain the increase in adverse perinatal outcomes in Black populations.8 These authors concluded that asthma does not contribute to racial disparities in obstetric and neonatal complications. It is therefore my suspicion that the results from Clifton et al. are driven in large part by Indigenous status and socioeconomic differences rather than by asthma. It may be that asthma is an effect modifier of the impact
许多研究表明,妊娠期哮喘与不良的围产期结局有关,包括低出生体重和围产期死亡。然而,这一领域的大多数研究都是在美国、欧洲和澳大利亚的普通人群中进行的。因此,Clifton等人最近发表了一项关于澳大利亚土著人口围产期结局的研究,特别是由于该人口的不良围产期结局仍然很高(尽管有所下降),死亡率和低出生体重率是非土著人口的两倍,这一点令人感兴趣然而,我确实对所呈现的结果及其解释有一些担忧,即围绕对照组和混杂因素的选择。在摘要和结果部分,作者指出,他们观察到,与没有哮喘的非土著妇女相比,母亲患有哮喘的土著婴儿的新生儿死亡率增加了两倍。然而,在表2中,土著妇女患哮喘的优势比被列出,参照组被称为“非土著妇女无哮喘”。鉴于澳大利亚土著人口存在不良围产期结果的风险,因此不可能判断哮喘在这些发现中起什么作用,或者报告的关联是否实际上是由土著身份驱动的(或者更确切地说,殖民和种族主义导致的风险因素和行为继续推动土著健康结果)。此外,表2中的发现表明,哮喘对非土著妇女的围产期结局没有任何额外的影响,这支持了这一论点,即至少在本数据集中,哮喘可能不会对围产期结局产生影响。另一个可能的混淆来源是社会经济地位。作者指出,混杂因素的纳入是由协变量和结果之间的单变量关联决定的。表1显示,以达到的教育水平衡量的社会经济地位在土著母亲和非土著母亲之间存在显著差异,P < 0.001。鉴于这些发现,以及人们普遍认识到社会经济决定因素是健康的强大驱动因素7,那么不清楚为什么没有根据教育水平调整多变量关联。虽然没有其他针对土著群体的类似研究,但比较黑人、西班牙裔和白人美国妇女的研究发现,尽管黑人妇女有更高的哮喘患病率,而且更有可能具有较低的社会经济决定因素,但哮喘不能解释黑人人群中不良围产期结局的增加这些作者得出结论,哮喘不会导致产科和新生儿并发症的种族差异。因此,我怀疑Clifton等人的结果在很大程度上是由土著地位和社会经济差异驱动的,而不是由哮喘驱动的。可能哮喘是土著身份对围产期结果影响的一个影响调节因素,但目前的分析没有提供足够的信息来进行评估,这使人们对作者强调需要改进哮喘护理模式的问题产生了疑问。
{"title":"Adverse perinatal outcomes in the Australian Indigenous population, the role of asthma","authors":"Bronwyn K Brew","doi":"10.1111/ajo.13468","DOIUrl":"https://doi.org/10.1111/ajo.13468","url":null,"abstract":"Asthma in pregnancy has been shown in a number of studies to be associated with adverse perinatal outcomes including low birth weight and perinatal death.1– 4 However, the majority of studies in this area have been in general populations in the US, Europe and Australia. It is therefore of interest that Clifton et al.5 recently published a study on perinatal outcomes in an Australian Indigenous population, especially as adverse perinatal outcomes in this population remain high, (although declining), with mortality and low birth weight rates double that of nonIndigenous rates.6 However, I do have some concerns about the results presented and their interpretation, namely around the choices of control group and confounders. In the abstract and results section the authors have stated they observed a twofold increase in neonatal deaths in Indigenous babies whose mothers had asthma compared to nonIndigenous women who did not have asthma. However, in Table 2 where odds ratios of Indigenous women with asthma have been presented the reference group is referred to as being ‘nonIndigenous women without asthma’. Given the existing risk of adverse perinatal outcomes in the Australian Indigenous population it is therefore not possible to tell what role asthma plays in these findings or whether the reported associations are in fact driven by Indigenous status (or rather, the risk factors and behaviours as a results of colonisation and racism that continue to drive Indigenous health outcomes). Further, the findings in Table 2 that asthma does not show any added effect on perinatal outcomes in nonIndigenous women supports the argument, that at least in this dataset, asthma may not be making a difference on perinatal outcomes. The other possible source of confounding is socioeconomic status. The authors have stated that the inclusion of confounders was determined by the univariate associations between covariates and outcomes. Table 1 shows that socioeconomic status measured as attained education level was significantly different between Indigenous and nonIndigenous mothers, P < 0.001. Given these findings and that it is well recognised that socioeconomic determinants are a strong driver of health,7 it is unclear then why the multivariate associations were not adjusted for education level. Although no other similar studies exist for Indigenous groups, studies comparing Black, Hispanic and White American women found that although Black women had a higher prevalence of asthma and were more likely to have lower socioeconomic determinants, asthma was not able to explain the increase in adverse perinatal outcomes in Black populations.8 These authors concluded that asthma does not contribute to racial disparities in obstetric and neonatal complications. It is therefore my suspicion that the results from Clifton et al. are driven in large part by Indigenous status and socioeconomic differences rather than by asthma. It may be that asthma is an effect modifier of the impact","PeriodicalId":8599,"journal":{"name":"Australian and New Zealand Journal of Obstetrics and Gynaecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74372046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Time to make some noise about a quiet revolution 是时候为一场安静的革命发出一些声音了
Pub Date : 2022-04-01 DOI: 10.1111/ajo.13530
Katrina Calvert, S. Leathersich, P. Howat, Sarah Van Der Wal
‘Tomorrow belongs to those who can hear it coming’ David Bowie. Language is a living entity that moves and changes. Use of gender‐neutral language in medical literature is increasingly common. It is time for obstetricians and gynaecologists in Australia and New Zealand to interrogate their own bias and desire to maintain the status quo, and to consider reasons for change.
“明天属于那些能听到它到来的人”——大卫·鲍伊。语言是一个动态变化的生命体。在医学文献中使用中性语言越来越普遍。对于澳大利亚和新西兰的妇产科医生来说,是时候审视他们自己的偏见和维持现状的愿望,并考虑改变的原因了。
{"title":"Time to make some noise about a quiet revolution","authors":"Katrina Calvert, S. Leathersich, P. Howat, Sarah Van Der Wal","doi":"10.1111/ajo.13530","DOIUrl":"https://doi.org/10.1111/ajo.13530","url":null,"abstract":"‘Tomorrow belongs to those who can hear it coming’ David Bowie. Language is a living entity that moves and changes. Use of gender‐neutral language in medical literature is increasingly common. It is time for obstetricians and gynaecologists in Australia and New Zealand to interrogate their own bias and desire to maintain the status quo, and to consider reasons for change.","PeriodicalId":8599,"journal":{"name":"Australian and New Zealand Journal of Obstetrics and Gynaecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79212445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to Letter to the Editor ‘Adverse perinatal outcomes in the Australian Indigenous population, the role of asthma’ 对致编辑的信“澳大利亚土著人口的不良围产期结局,哮喘的作用”的回应
Pub Date : 2022-04-01 DOI: 10.1111/ajo.13480
Vicki L. Clifton, J. Das, V. Flenady, Kym Rae
6. Australian Institute of Health and Welfare & National Indigenous Australians Agency. Aboriginal and Torres Strait Islander Health Performance Framework; 2020. Available from URL: https://www. indig enous hpf.gov.au/. Accessed 16/08/2021. 7. Marmot M. The Health Gap. London: Bloomsbury Publishing, 2016. 8. Flores KF, Robledo CA, Hwang BS et al. Does maternal asthma contribute to racial/ethnic disparities in obstetrical and neonatal complications? Ann Epidemiol 2015; 25: 392– 397.e1.
6. 澳大利亚卫生和福利研究所和澳大利亚土著国家机构。土著和托雷斯海峡岛民保健绩效框架;2020. 可从URL: https://www。土著hpf.gov.au/。16/08/2021访问。7. Marmot M.健康差距。伦敦:布鲁姆斯伯里出版社,2016。8. Flores KF, Robledo CA, Hwang BS等。产妇哮喘是否会导致产科和新生儿并发症的种族差异?安流行病学杂志2015;[25]: 392 - 397.e1。
{"title":"Response to Letter to the Editor ‘Adverse perinatal outcomes in the Australian Indigenous population, the role of asthma’","authors":"Vicki L. Clifton, J. Das, V. Flenady, Kym Rae","doi":"10.1111/ajo.13480","DOIUrl":"https://doi.org/10.1111/ajo.13480","url":null,"abstract":"6. Australian Institute of Health and Welfare & National Indigenous Australians Agency. Aboriginal and Torres Strait Islander Health Performance Framework; 2020. Available from URL: https://www. indig enous hpf.gov.au/. Accessed 16/08/2021. 7. Marmot M. The Health Gap. London: Bloomsbury Publishing, 2016. 8. Flores KF, Robledo CA, Hwang BS et al. Does maternal asthma contribute to racial/ethnic disparities in obstetrical and neonatal complications? Ann Epidemiol 2015; 25: 392– 397.e1.","PeriodicalId":8599,"journal":{"name":"Australian and New Zealand Journal of Obstetrics and Gynaecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80491434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Australian and New Zealand Journal of Obstetrics and Gynaecology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1