Wen Li, Qinge Zhang, Gabor S. Ungvari, Seon-Cheol Park, Lian-Yu Chen, Kok Yoon Chee, Roy Abraham Kallivayalil, Kang Sim, Yan-Ling He, Norman Sartorius, Naotaka Shinfuku, Shih-Ku Lin, Ajit Avasthi, Sandeep Grover, Takahiro A. Kato, Chee H. Ng, Yu-Tao Xiang
Objectives
Antipsychotic polypharmacy (APP) is prevalent among patients with schizophrenia across countries in Asia. This study aimed to explore the relationships between psychiatric symptoms and APP using network analysis.
Methods
Data on nine major psychiatric symptoms and the number of prescribed antipsychotics were extracted from the fourth survey of the Research on Asian Psychotropic Prescription Patterns (REAP-AP). A network model of the nine psychiatric symptoms was constructed for patients treated with APP and antipsychotic monotherapy (APM) respectively. The interconnections between psychiatric symptoms and APP use were further analyzed using network analysis.
Results
A total of 1528 patients with schizophrenia treated with APP were matched with 1528 patients treated with APM in Asia. The top three central psychiatric symptoms in the networks of psychiatric symptoms were consistent, but in different orders for APP-treated patients (verbal aggression, hallucinations, and social/occupational dysfunction) and APM-treated patients (social/occupational dysfunction, verbal aggression, and hallucinations). Network analysis of APP and psychiatric symptoms revealed that disorganized/catatonic behavior was strongly linked with APP, followed by delusions, hallucinations, and verbal aggression.
Conclusion
Psychiatric symptoms closely associated with APP included verbal aggression, grossly disorganized/catatonic behavior, delusions, and hallucinations. For patients with schizophrenia who are primarily exhibiting such symptoms, alternative appropriate treatment strategies should be considered.
{"title":"A Network Analysis of Psychiatric Symptoms in Patients With Schizophrenia Treated With Antipsychotic Polypharmacy Using Propensity Score Matching: Findings From the Research on Asian Psychotropic Prescription Patterns (REAP) Study","authors":"Wen Li, Qinge Zhang, Gabor S. Ungvari, Seon-Cheol Park, Lian-Yu Chen, Kok Yoon Chee, Roy Abraham Kallivayalil, Kang Sim, Yan-Ling He, Norman Sartorius, Naotaka Shinfuku, Shih-Ku Lin, Ajit Avasthi, Sandeep Grover, Takahiro A. Kato, Chee H. Ng, Yu-Tao Xiang","doi":"10.1111/appy.70005","DOIUrl":"https://doi.org/10.1111/appy.70005","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Antipsychotic polypharmacy (APP) is prevalent among patients with schizophrenia across countries in Asia. This study aimed to explore the relationships between psychiatric symptoms and APP using network analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data on nine major psychiatric symptoms and the number of prescribed antipsychotics were extracted from the fourth survey of the Research on Asian Psychotropic Prescription Patterns (REAP-AP). A network model of the nine psychiatric symptoms was constructed for patients treated with APP and antipsychotic monotherapy (APM) respectively. The interconnections between psychiatric symptoms and APP use were further analyzed using network analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 1528 patients with schizophrenia treated with APP were matched with 1528 patients treated with APM in Asia. The top three central psychiatric symptoms in the networks of psychiatric symptoms were consistent, but in different orders for APP-treated patients (verbal aggression, hallucinations, and social/occupational dysfunction) and APM-treated patients (social/occupational dysfunction, verbal aggression, and hallucinations). Network analysis of APP and psychiatric symptoms revealed that disorganized/catatonic behavior was strongly linked with APP, followed by delusions, hallucinations, and verbal aggression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Psychiatric symptoms closely associated with APP included verbal aggression, grossly disorganized/catatonic behavior, delusions, and hallucinations. For patients with schizophrenia who are primarily exhibiting such symptoms, alternative appropriate treatment strategies should be considered.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8618,"journal":{"name":"Asia‐Pacific Psychiatry","volume":"17 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yi Hu, Qian Hui Chew, Shih-Ku Lin, Wen-Chen Ouyang, Chih-Ken Chen, Seon-Cheol Park, Ok-Jin Jang, Kok-Yoon Chee, Kwong Sen Ding, Jamaline Chong, Ling Zhang, Keqing Li, Xiaomin Zhu, Chonnakarn Jatchavala, Pornjira Pariwatcharakul, Roy A. Kallivayalil, Sandeep Grover, Ajit Avasthi, Moin Ansari, Margarita M. Maramis, Phyo Aung Paing, Chay Hoon Tan, Yu-Tao Xiang, Mian-Yoon Chong, Yong Chon Park, Takahiro A. Kato, Naotaka Shinfuku, Ross J. Baldessarini, Kang Sim
Introduction
Adjunctive antidepressant (AD) use is prevalent for the treatment of bipolar disorder (BD) in many countries, but there is little information about this practice in Asia. Accordingly, we addressed the prevalence, dosing, and clinical correlates of adjunctive AD use with BD in a large Asian sample.
Methods
Patients with BD were recruited across 13 Asian sites (PR China, Hong Kong, India, Indonesia, Japan, South Korea, Malaysia, Myanmar, Pakistan, Singapore, Sri Lanka, Taiwan, and Thailand) for this cross-sectional study. We examined differences between patients with versus without adjunctive AD treatment. Multivariable logistic regression was used to identify factors associated with the use of adjunctive AD.
Results
Among a total of 2114 adult participants (47.7% men; age 42.4 years [CI: 41.8–43.0]; BMI 25.0 kg/m2 [24.8–25.2]), the prevalence of AD use averaged 19.8% [18.1–21.6], at a mean imipramine-equivalent dose of 113 [110–116] mg/day. Adjunctive AD use was associated with factors including older age, outpatient status, more depression, suicidal behavior, rapid cycling, and lower doses of MS and antipsychotics (APs).
Discussion
Usage of AD treatment for BD in Asia was less than half that reported in Western samples. Such use of AD treatment appeared to be well tolerated but underscores the need for close clinical follow-up to avoid risks of excessive elevation of mood or behavior.
{"title":"Adjunctive Antidepressant Use in Bipolar Disorder and Its Clinical Correlates: An Asian Psychotropic Prescription Patterns Consortium Study","authors":"Yi Hu, Qian Hui Chew, Shih-Ku Lin, Wen-Chen Ouyang, Chih-Ken Chen, Seon-Cheol Park, Ok-Jin Jang, Kok-Yoon Chee, Kwong Sen Ding, Jamaline Chong, Ling Zhang, Keqing Li, Xiaomin Zhu, Chonnakarn Jatchavala, Pornjira Pariwatcharakul, Roy A. Kallivayalil, Sandeep Grover, Ajit Avasthi, Moin Ansari, Margarita M. Maramis, Phyo Aung Paing, Chay Hoon Tan, Yu-Tao Xiang, Mian-Yoon Chong, Yong Chon Park, Takahiro A. Kato, Naotaka Shinfuku, Ross J. Baldessarini, Kang Sim","doi":"10.1111/appy.70004","DOIUrl":"https://doi.org/10.1111/appy.70004","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Adjunctive antidepressant (AD) use is prevalent for the treatment of bipolar disorder (BD) in many countries, but there is little information about this practice in Asia. Accordingly, we addressed the prevalence, dosing, and clinical correlates of adjunctive AD use with BD in a large Asian sample.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with BD were recruited across 13 Asian sites (PR China, Hong Kong, India, Indonesia, Japan, South Korea, Malaysia, Myanmar, Pakistan, Singapore, Sri Lanka, Taiwan, and Thailand) for this cross-sectional study. We examined differences between patients with versus without adjunctive AD treatment. Multivariable logistic regression was used to identify factors associated with the use of adjunctive AD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among a total of 2114 adult participants (47.7% men; age 42.4 years [CI: 41.8–43.0]; BMI 25.0 kg/m<sup>2</sup> [24.8–25.2]), the prevalence of AD use averaged 19.8% [18.1–21.6], at a mean imipramine-equivalent dose of 113 [110–116] mg/day. Adjunctive AD use was associated with factors including older age, outpatient status, more depression, suicidal behavior, rapid cycling, and lower doses of MS and antipsychotics (APs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Usage of AD treatment for BD in Asia was less than half that reported in Western samples. Such use of AD treatment appeared to be well tolerated but underscores the need for close clinical follow-up to avoid risks of excessive elevation of mood or behavior.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8618,"journal":{"name":"Asia‐Pacific Psychiatry","volume":"17 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Non-suicidal self-injury (NSSI) and suicidal ideation (SI) are prevalent and co-occurring among adolescents, serving as critical predictors of suicide. This study aimed to develop a predictive model and nomogram for suicide attempts (SA) in Chinese adolescents with mood disorders exhibiting NSSI and SI.
Methods
Data were collected from 134 participants. Predictors were selected via LASSO regression from data collected using the Self-Injurious Thoughts and Behaviors Interview-Revised and self-report scales, followed by multivariate logistic regression to build the nomogram. Model performance was assessed through discriminatory ability, calibration curves, and clinical decision analysis.
Results
Adolescents with SA history had fewer education years, higher prevalence and future likelihood of self-injurious thoughts and behaviors, earlier NSSI onset, more frequent and severe NSSI, and more intense and persistent SI compared to those without SA. Three key predictors for SA were identified: NSSI emotion regulation scores, average SI persistence duration, and history of interrupted attempts. The developed nomogram exhibited robust predictive accuracy with an AUC of 0.756.
Discussion
This study presents a predictive model for suicide risk in adolescents with mood disorders exhibiting NSSI and SI. The model demonstrates high predictive accuracy and clinical applicability, offering a practical tool for clinicians to prioritize high-risk cases and guide personalized interventions.
导言：非自杀性自伤（NSSI）和自杀意念（SI）在青少年中普遍存在并同时出现，是预测自杀的关键因素。本研究旨在为有情绪障碍的中国青少年建立一个自杀企图（SA）的预测模型和提名图。 方法 收集了 134 名参与者的数据。根据自伤想法和行为访谈-修订版及自我报告量表收集的数据，通过LASSO回归筛选出预测因子，然后通过多元逻辑回归建立提名图。通过判别能力、校准曲线和临床决策分析对模型性能进行评估。 结果 与无 SA 史的青少年相比，有 SA 史的青少年受教育年限更短、自伤想法和行为的发生率和未来可能性更高、NSSI 开始得更早、NSSI 更频繁和更严重、SI 更强烈和更持久。研究发现了三个预测 SA 的关键因素：NSSI情绪调节评分、SI持续平均持续时间和中断尝试史。所开发的提名图具有很高的预测准确性，AUC 为 0.756。 讨论 本研究提出了一种情绪障碍青少年自杀风险预测模型，该模型表现出 NSSI 和 SI。该模型具有很高的预测准确性和临床适用性，为临床医生优先处理高风险病例和指导个性化干预提供了实用工具。
{"title":"A Predictive Nomogram for Suicide Attempts in Chinese Adolescents With Both Non-Suicidal Self-Injury and Suicidal Ideation","authors":"Yi-Hui Liu, Ming Chen, Hao-Zhang Huang, Jia-Rong Liang, Yong-Yi He, Jia-Hui Hu, Ting-Ting Zhang, Fu-Jun Jia, Cai-Lan Hou","doi":"10.1111/appy.70003","DOIUrl":"https://doi.org/10.1111/appy.70003","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Non-suicidal self-injury (NSSI) and suicidal ideation (SI) are prevalent and co-occurring among adolescents, serving as critical predictors of suicide. This study aimed to develop a predictive model and nomogram for suicide attempts (SA) in Chinese adolescents with mood disorders exhibiting NSSI and SI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data were collected from 134 participants. Predictors were selected via LASSO regression from data collected using the Self-Injurious Thoughts and Behaviors Interview-Revised and self-report scales, followed by multivariate logistic regression to build the nomogram. Model performance was assessed through discriminatory ability, calibration curves, and clinical decision analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Adolescents with SA history had fewer education years, higher prevalence and future likelihood of self-injurious thoughts and behaviors, earlier NSSI onset, more frequent and severe NSSI, and more intense and persistent SI compared to those without SA. Three key predictors for SA were identified: NSSI emotion regulation scores, average SI persistence duration, and history of interrupted attempts. The developed nomogram exhibited robust predictive accuracy with an AUC of 0.756.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>This study presents a predictive model for suicide risk in adolescents with mood disorders exhibiting NSSI and SI. The model demonstrates high predictive accuracy and clinical applicability, offering a practical tool for clinicians to prioritize high-risk cases and guide personalized interventions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8618,"journal":{"name":"Asia‐Pacific Psychiatry","volume":"17 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Emergence of a New Threat in East Asia: Severe Agitation and Suicide Attempts Linked to Etomidate-Infused E-Cigarettes","authors":"Chun-I Liu, I-Ming Chen, Szu-Yung Wang, Chi Chen","doi":"10.1111/appy.70001","DOIUrl":"https://doi.org/10.1111/appy.70001","url":null,"abstract":"","PeriodicalId":8618,"journal":{"name":"Asia‐Pacific Psychiatry","volume":"17 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rapid cycling (RC) is a special subtype of bipolar disorder (BD). Previous studies have rarely involved the investigation of neurological soft signs (NSS) and emotional intelligence (EI) in rapid cycling patients.
Object
This study aims to compare the differences in NSS and EI between patients with RC and non-rapid cycling (NRC) in BD.
Methods
The Cambridge Neurological Inventory and The Mayer–Salovey–Caruso Emotional Intelligence Test were used to assess the NSS and EI levels of euthymic patients with BD and healthy controls (HC). Patients were divided into RC and NRC groups.
Results
In terms of NSS, both the RC and NRC groups scored significantly higher than the HC group in the Motor coordination subdomain and total scores. In the Sensory integration subdomain, there was a significant trend of RC group scoring higher than the NRC group, which in turn scored higher than the HC group. In terms of EI, there was a trend of RC group scoring lower than the NRC group, which scored lower than the HC group in the understanding emotions subdomain and MSCEIT total score. In the managing emotions subdomain, the RC group scored lower than the HC group.
Conclusion
Compared to the NRC group, the RC group exhibited higher NSS levels, mainly manifesting in more severe sensory integration impairment. The RC group scored lower in EI, primarily reflected in understanding and managing emotions, and the managing emotions subdomain may serve as a more sensitive indicator to distinguish between the two groups.
{"title":"A Comparative Analysis of Neurological Soft Signs and Emotional Intelligence in Rapid Cycling and Non-Rapid Cycling Bipolar Disorder","authors":"Feng Yingying, Yang Bo, Zhao Jun","doi":"10.1111/appy.70000","DOIUrl":"https://doi.org/10.1111/appy.70000","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Rapid cycling (RC) is a special subtype of bipolar disorder (BD). Previous studies have rarely involved the investigation of neurological soft signs (NSS) and emotional intelligence (EI) in rapid cycling patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Object</h3>\u0000 \u0000 <p>This study aims to compare the differences in NSS and EI between patients with RC and non-rapid cycling (NRC) in BD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The Cambridge Neurological Inventory and The Mayer–Salovey–Caruso Emotional Intelligence Test were used to assess the NSS and EI levels of euthymic patients with BD and healthy controls (HC). Patients were divided into RC and NRC groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In terms of NSS, both the RC and NRC groups scored significantly higher than the HC group in the Motor coordination subdomain and total scores. In the Sensory integration subdomain, there was a significant trend of RC group scoring higher than the NRC group, which in turn scored higher than the HC group. In terms of EI, there was a trend of RC group scoring lower than the NRC group, which scored lower than the HC group in the understanding emotions subdomain and MSCEIT total score. In the managing emotions subdomain, the RC group scored lower than the HC group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Compared to the NRC group, the RC group exhibited higher NSS levels, mainly manifesting in more severe sensory integration impairment. The RC group scored lower in EI, primarily reflected in understanding and managing emotions, and the managing emotions subdomain may serve as a more sensitive indicator to distinguish between the two groups.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8618,"journal":{"name":"Asia‐Pacific Psychiatry","volume":"16 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
No research to date has examined cross-cultural differences in the pathways to internet gaming disorder (IGD). The current study aimed to address this limitation by examining the relationships between nationality (Singaporeans vs. Australians), culture orientation, gaming motivations, and IGD.
Methods
Participants were 101 Singaporeans (55.4% males) and 98 Australians (52.0% males). They completed the Culture Orientation Scale, the Motives for Online Gaming Questionnaire, and the Internet Gaming Disorder Scale-Short-Form.
Results
A series of mediational analyses showed that Singaporeans tend to be more collectivistic (both horizontally and vertically). In turn, this culture orientation motivates them to play games for social reasons, increasing the risk for IGD. In contrast, Australians tend to be more individualistic (vertically only). In turn, this culture orientation motivates them to play games for competitive reasons, increasing the risk for IGD.
Conclusion
Limitations include the use of samples from two countries only, precluding a generalization of the results. Future research directions include examining the role of game genres as a mediator in the nationality-IGD relationship.
{"title":"Cross-Cultural Differences in the Pathways to Internet Gaming Disorder","authors":"Peter K. H. Chew, Patrick K. F. Lin, Yong Jie Yow","doi":"10.1111/appy.12565","DOIUrl":"10.1111/appy.12565","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>No research to date has examined cross-cultural differences in the pathways to internet gaming disorder (IGD). The current study aimed to address this limitation by examining the relationships between nationality (Singaporeans vs. Australians), culture orientation, gaming motivations, and IGD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants were 101 Singaporeans (55.4% males) and 98 Australians (52.0% males). They completed the Culture Orientation Scale, the Motives for Online Gaming Questionnaire, and the Internet Gaming Disorder Scale-Short-Form.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A series of mediational analyses showed that Singaporeans tend to be more collectivistic (both horizontally and vertically). In turn, this culture orientation motivates them to play games for social reasons, increasing the risk for IGD. In contrast, Australians tend to be more individualistic (vertically only). In turn, this culture orientation motivates them to play games for competitive reasons, increasing the risk for IGD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Limitations include the use of samples from two countries only, precluding a generalization of the results. Future research directions include examining the role of game genres as a mediator in the nationality-IGD relationship.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8618,"journal":{"name":"Asia‐Pacific Psychiatry","volume":"16 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/appy.12565","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhen Gui PhD, Qinge Zhang MD, Sha Sha MD, Xiao-Hong Li MD, Zhaohui Su PhD, Teris Cheung PhD, Xi-Ling Cui PhD, Gabor S. Ungvari MD, PhD, Katrine K. Wong PhD, Chee H. Ng MBBS, MD, Feng Yuan MD, Yu-Tao Xiang MD, PhD
Objective
Accumulating evidence indicates that oxidative stress and the disruption of antioxidant defenses play an important role in the neurobiology of bipolar disorder (BD). Studies have found that increased oxidative stress may be associated with cell apoptosis and neuronal damage in BD patients. Hence, this study explored the research field related to BD and oxidative stress from a bibliometrics perspective.
Methods
Literature search and relevant data retrieval based on the Web of Sciences Core Collection (WoSCC). R software (version 4.2.2), VOSviewer software (version 1.6.18), and CiteSpace (version 6.1.6) were used in this bibliometric analysis.
Results
A total of 2081 publications related to BD and oxidative stress were published between 1986 and 2024. Bipolar Disorders was the journal that had the most publications in this area (72; 3.46%; IF = 5.9), while the United States (1285; 61.7%) and the University of Toronto (377; 18.1%) were the most productive country and institution, respectively. Apart from “oxidative stress” and “bipolar disorder,” the most frequently used keywords were “schizophrenia,” “prefrontal cortex,” and “nitric oxide.”
Conclusions
The growing number of publications related to BD and oxidative stress in recent years highlights the importance of this research field. Hot topics in research related to BD and oxidative stress included animal experiments and molecular mechanisms, psychiatric-related inflammation and biomarkers, neurodegenerative diseases, and metabolism. Furthermore, the biological mechanisms of BD, particularly biomarkers and inflammation, may be the emerging research priority area in the future.
{"title":"Bipolar disorder and oxidative stress: A bibliometric perspective","authors":"Zhen Gui PhD, Qinge Zhang MD, Sha Sha MD, Xiao-Hong Li MD, Zhaohui Su PhD, Teris Cheung PhD, Xi-Ling Cui PhD, Gabor S. Ungvari MD, PhD, Katrine K. Wong PhD, Chee H. Ng MBBS, MD, Feng Yuan MD, Yu-Tao Xiang MD, PhD","doi":"10.1111/appy.12564","DOIUrl":"10.1111/appy.12564","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Accumulating evidence indicates that oxidative stress and the disruption of antioxidant defenses play an important role in the neurobiology of bipolar disorder (BD). Studies have found that increased oxidative stress may be associated with cell apoptosis and neuronal damage in BD patients. Hence, this study explored the research field related to BD and oxidative stress from a bibliometrics perspective.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Literature search and relevant data retrieval based on the Web of Sciences Core Collection (WoSCC). R software (version 4.2.2), VOSviewer software (version 1.6.18), and CiteSpace (version 6.1.6) were used in this bibliometric analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 2081 publications related to BD and oxidative stress were published between 1986 and 2024. <i>Bipolar Disorders</i> was the journal that had the most publications in this area (72; 3.46%; IF = 5.9), while the United States (1285; 61.7%) and the University of Toronto (377; 18.1%) were the most productive country and institution, respectively. Apart from “oxidative stress” and “bipolar disorder,” the most frequently used keywords were “schizophrenia,” “prefrontal cortex,” and “nitric oxide.”</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The growing number of publications related to BD and oxidative stress in recent years highlights the importance of this research field. Hot topics in research related to BD and oxidative stress included animal experiments and molecular mechanisms, psychiatric-related inflammation and biomarkers, neurodegenerative diseases, and metabolism. Furthermore, the biological mechanisms of BD, particularly biomarkers and inflammation, may be the emerging research priority area in the future.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8618,"journal":{"name":"Asia‐Pacific Psychiatry","volume":"16 3","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/appy.12564","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lien-Chung Wei MD, MPH, Happy Kuy-Lok Tan MD, MPH, MHS
{"title":"Letter to the editor—Reflections on “Total valproate versus free valproate in therapeutic drug monitoring for bipolar disorder: A cross-sectional study”","authors":"Lien-Chung Wei MD, MPH, Happy Kuy-Lok Tan MD, MPH, MHS","doi":"10.1111/appy.12562","DOIUrl":"10.1111/appy.12562","url":null,"abstract":"","PeriodicalId":8618,"journal":{"name":"Asia‐Pacific Psychiatry","volume":"16 2","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141417584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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