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Symptom Complexity Subtypes Show Distinct Individualism–Collectivism Orientations in Adolescents With Depressive Episodes, With Loneliness Mediating Their Relationship 青少年抑郁症状复杂性亚型表现出明显的个人主义-集体主义倾向,孤独感在其关系中起中介作用。
IF 3.4 3区 医学 Q2 PSYCHIATRY Pub Date : 2026-01-06 DOI: 10.1111/appy.70011
Rui Zhou, Yi-Hui Liu, Yong-Yi He, Jia-Rong Liang, Mu-Tong Chen, Nan Chen, Fu-Jun Jia, Cai-Lan Hou

Introduction

Adolescent depressive episodes exhibit significant symptom complexity and heterogeneity, necessitating an integrated approach to identify distinct subtypes. Cultural orientations (individualism and collectivism) and loneliness are crucial factors impacting adolescent mental health. This study identifies symptom complexity subtypes in Chinese adolescents with depressive episodes, investigates cultural orientation differences between these subtypes, and explores the role of loneliness.

Methods

A total of 110 adolescents were included. K-means clustering was used to generate symptom complexity subtypes based on disease duration, self-injury, mood disorder, depressive, and anxiety symptoms. Cultural orientations were assessed using the Individualism–Collectivism Scale, loneliness using the UCLA Loneliness Scale, and other relevant variables were collected via self-report. Structural equation modeling (SEM) was used to explore associations among cultural orientations, loneliness, and symptom complexity.

Results

Two subtypes were identified: low-complexity and high-complexity. The high-complexity subtype exhibited elevated loneliness levels (t = −6.16, p < 0.001), more severe childhood trauma and bullying, and greater social media addiction. This group also reported higher vertical individualism (t = −2.02, p = 0.046) and lower vertical collectivism (t = 2.05, p = 0.043). SEM revealed a significant indirect association between higher individualism tendency and increased symptom complexity mediated by loneliness (β = 0.21, p < 0.001 and β = 0.53, p < 0.001, respectively).

Discussion

Incorporating cultural orientation assessments into clinical practice may improve treatment outcomes for adolescents with depressive episodes by identifying those at risk for complex symptom presentations and informing subsequent culturally-tailored therapeutic interventions.

青少年抑郁发作表现出显著的症状复杂性和异质性,需要一个综合的方法来识别不同的亚型。文化取向(个人主义和集体主义)和孤独感是影响青少年心理健康的关键因素。本研究确定了中国青少年抑郁发作的症状复杂性亚型,研究了这些亚型之间的文化取向差异,并探讨了孤独的作用。方法:对110名青少年进行调查。基于病程、自伤、情绪障碍、抑郁和焦虑症状,采用k均值聚类方法生成症状复杂性亚型。文化取向采用个人主义-集体主义量表,孤独感采用UCLA孤独感量表,其他相关变量通过自我报告收集。采用结构方程模型(SEM)探讨文化取向、孤独感和症状复杂性之间的关系。结果:鉴定出两种亚型:低复杂性和高复杂性。讨论:将文化取向评估纳入临床实践,可以通过识别那些有复杂症状表现风险的青少年,并为随后的文化定制治疗干预提供信息,从而改善患有抑郁症发作的青少年的治疗效果。
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引用次数: 0
Major Depressive Disorder With Psychiatric Emergency in Hong Kong: A Review and Practice Recommendation of the Asian Association of Neuropsychopharmacology 香港重度抑郁症伴精神急症:亚洲神经精神药理学协会回顾与实践建议。
IF 3.4 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-11-20 DOI: 10.1111/appy.70010
Ho Bun Lam, Tak Lam Lo, Kwok Leung Au Yeung, Ngo Cheung, Eric Yat-Wo Cheung, Chi Kin Fu, Chun Lam, Yiu Ki Lee, Ronnie Sze-Yuan Pao, Wing Kuen Sung, Sik Chuen Ting, Fan Kwong Tsang, Chi Keung Wong, Ting-Chi Vanessa Wong, Ming Cheuk Wong, Pui-Lam Isaac Yip, Ki Yan Mak

Psychiatric emergency (PE) as related to major depressive disorder (MDD) is most commonly understood as the presentation of suicidality or a risk of violence to others. However, MDD-PE can have a wide variety of clinical presentations. The challenges in treating PE arise from the difficulty in fully defining and diagnosing this condition, especially by emergency department and non-psychiatric medical personnel. Additionally, determining the appropriate level of care, as well as resource and other constraints, further complicates the management of MDD-PE. This manuscript reviews the definition, diagnosis, and management of MDD-PE globally, and provides recommendations for clinicians in the context of Hong Kong clinical practice. It reflects the outcomes of a meeting of psychiatrists in Hong Kong convened by the Asian Association of Neuropsychopharmacology. The primary goal of the diagnostic process is to determine a patient's level of risk to themselves and others. The main recommendations include educating clinicians on the diverse presentation of MDD-PE and non-clinical factors that may contribute to risk assessment—emphasizing contextual factors during history-taking. The recommendations also include the stratification of patients into three categories depending on (1) whether hospitalization is warranted and (2) the urgency and intensity of required intervention, with the aim of optimizing resources. Finally, the role of novel interventions, such as fast-acting or non-invasive ones, is discussed.

与重度抑郁症(MDD)相关的精神急症(PE)最常被理解为出现自杀或对他人施暴的风险。然而,MDD-PE可能有各种各样的临床表现。治疗PE的挑战来自于难以完全定义和诊断这种情况,特别是急诊室和非精神科医务人员。此外,确定适当的护理水平,以及资源和其他限制因素,使MDD-PE的管理进一步复杂化。本文回顾了全球MDD-PE的定义、诊断和管理,并在香港临床实践的背景下为临床医生提供建议。它反映了由亚洲神经精神药理学协会在香港召集的精神科医生会议的结果。诊断过程的主要目标是确定患者对自己和他人的风险水平。主要建议包括教育临床医生MDD-PE的不同表现和可能有助于风险评估的非临床因素,强调病史记录时的背景因素。这些建议还包括根据(1)是否需要住院治疗和(2)所需干预的紧迫性和强度将患者分为三类,目的是优化资源。最后,讨论了新型干预措施的作用,如速效或非侵入性干预措施。
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引用次数: 0
The Effect of Hope on Functional Recovery in Patients With Schizophrenia: A Cross-Sectional Study 希望对精神分裂症患者功能恢复的影响:一项横断面研究
IF 3.4 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-11-10 DOI: 10.1111/appy.70009
Eda Ay, Hatice Polat

Objective

To determine the effect of hope on functional recovery in individuals diagnosed with schizophrenia.

Materials and Methods

This correlational, cross-sectional study was conducted at the Psychiatry Outpatient Clinic of a hospital in eastern Türkiye between June 2022 and January 2023. Data were collected using a personal information form, the Herth Hope Index (HHI), and the Functional Remission of General Schizophrenia (FROGS) scale. The study included 136 patients diagnosed with schizophrenia according to the DSM-5 diagnostic criteria. Data were analyzed using percentage distributions and mean values, as well as Pearson correlation and regression analyses.

Results

The mean total FROGS score of the patients was found to be 47.25 ± 15.2, while the mean total HHS score was 45.22 ± 22.63. A statistically significant positive correlation was identified between the mean scores of all subscales of the FROGS and HHS, as well as between their total scores (p < 0.05). Regression analysis revealed that the level of hope in patients with schizophrenia had a 60% effect on functional recovery (F = 203.61; R2 = 0.603; p ≤ 0.001).

Conclusion

The findings of this study indicated that patients diagnosed with schizophrenia had moderate levels of hope but low functional recovery scores. Additionally, a significant and positive relationship was observed between hope and functional recovery, demonstrating that hope is an influential factor in enhancing functional recovery. Therefore, it is recommended that interventions aimed at increasing levels of hope be planned and implemented within treatment and rehabilitation programs.

目的探讨希望对精神分裂症患者功能恢复的影响。材料和方法这项相关的横断面研究于2022年6月至2023年1月在乌克兰东部一家医院的精神病学门诊进行。使用个人信息表、赫斯希望指数(HHI)和一般性精神分裂症功能缓解(frog)量表收集数据。该研究包括136名根据DSM-5诊断标准诊断为精神分裂症的患者。数据分析采用百分比分布和平均值,Pearson相关分析和回归分析。结果患者的frog总分平均为47.25±15.2分,HHS总分平均为45.22±22.63分。frog和HHS各分量表的平均分及总分之间存在显著的正相关(p < 0.05)。回归分析显示,精神分裂症患者的希望水平对功能恢复有60%的影响(F = 203.61; R2 = 0.603; p≤0.001)。结论精神分裂症患者的希望程度中等,但功能恢复评分较低。此外,希望与功能恢复之间存在显著的正相关关系,表明希望是促进功能恢复的影响因素。因此,建议在治疗和康复方案中计划和实施旨在提高希望水平的干预措施。
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引用次数: 0
Associations of Square Dancing With Depression and Anxiety: Nationwide Study Findings From a Network Perspective 广场舞与抑郁和焦虑的关联:网络视角下的全国性研究结果。
IF 3.4 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-09-23 DOI: 10.1111/appy.70008
Meng-Yi Chen, Wei Bai, Ling Zhang, Sha Sha, Zhaohui Su, Teris Cheung, Robert D. Smith, Gabor S. Ungvari, Todd Jackson, Qinge Zhang, Yu-Tao Xiang

Background

Depression and anxiety are global public health challenges among older adults. Square dancing, a popular activity for older Chinese adults, is believed to relieve these disturbances. This study compared the prevalence, severity, and network structures of depression and anxiety among older square dancers versus non-dancers (i.e., those who do not engage in square dancing).

Methods

Propensity score matching (PSM) created square dancer and non-dancer groups using data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Depressive and anxiety symptoms were assessed with the 10-item Center for Epidemiological Studies Depression Scale (CESD-10) and the 7-item Generalized Anxiety Disorder Scale (GAD-7), respectively. Central symptoms and bridge symptoms were estimated in each group using expected influence (EI) and bridge EI, respectively.

Results

The study included 401 square dancers and a matched sample of 1163 non-dancers. The prevalence and severity of depression and anxiety were significantly lower among square dancers compared to non-dancers. In contrast, network structures of depressive and anxiety symptoms were similar between the two groups. “Uncontrollable worrying” and “Felt sadness” were the most central symptoms, and “Nervousness”, “Bothered by things” and “Felt nervous/fearful” were key bridge symptoms across both groups.

Conclusion

Participation in square dancing is associated with reduced overall prevalence and severity of depression and anxiety among older adults, but is not associated with a unique network structure of these syndromes compared to non-participation. Consequently, psychosocial interventions developed for depression and anxiety based on the network structure of non-dancers may also be applicable for square dancers who experience anxiety and depression.

背景:抑郁和焦虑是老年人面临的全球性公共卫生挑战。广场舞是中国老年人的一种流行活动,被认为可以缓解这些干扰。本研究比较了老年广场舞者与非广场舞者(即不参与广场舞的人)抑郁和焦虑的患病率、严重程度和网络结构。方法:使用中国健康寿命纵向调查(CLHLS)的数据,采用倾向评分匹配法(PSM)创建广场舞组和非广场舞组。抑郁和焦虑症状分别用10项流行病学研究中心抑郁量表(csd -10)和7项广泛性焦虑障碍量表(GAD-7)进行评估。分别用预期影响(EI)和桥式EI估计各组的中心症状和桥式症状。结果:该研究包括401名广场舞者和1163名非广场舞者。广场舞者抑郁和焦虑的患病率和严重程度明显低于非广场舞者。相比之下,抑郁和焦虑症状的网络结构在两组之间相似。“无法控制的担忧”和“感到悲伤”是最核心的症状,“紧张”、“被事物困扰”和“感到紧张/恐惧”是两组之间的关键桥梁症状。结论:参加广场舞与老年人抑郁和焦虑的总体患病率和严重程度降低有关,但与不参加广场舞相比,与这些综合征的独特网络结构无关。因此,基于非舞者的网络结构开发的抑郁和焦虑的社会心理干预也可能适用于经历焦虑和抑郁的广场舞者。
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引用次数: 0
Call to Enhance Pediatricians' Capacity in Delivering Child and Adolescent Mental Health Services in China 呼吁提高儿科医生在中国提供儿童和青少年心理健康服务的能力
IF 3.4 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-09-07 DOI: 10.1111/appy.70007
Meirong Pan, Ni Tang, Jianguang Qi, Zhengjie Zhu, Qingjiu Cao, Tianmei Si
<p>Mental disorders are leading causes of disability in children and adolescents in China, affecting 30.8 million individuals (Dong et al. <span>2025</span>). Despite escalating needs, China's child and adolescent mental health services (CAMHS) face severe workforce shortages, exacerbated by systemic inefficiencies with unmet lower-tier services demands (Jiang et al. <span>2024</span>). Strengthening pediatricians' CAMHS capacity is a viable solution aligned with WHO's stepped-care model (WHO Team <span>2021</span>). Despite global consensus on essential mental health competencies among pediatricians (Foy et al. <span>2019</span>), significant gaps persist in China, both in targeted surveys and policy frameworks, specifically addressing child and adolescent psychiatry (CAP) competency development among pediatricians.</p><p>Our national survey of 537 pediatricians highlights urgency: 496 (92.36%) encountered pediatric mental health cases. Of these, 75.60% reported moderate-to-high stress when delivering CAMHS, primarily due to insufficient CAP skills. Only 32.77% received CAP-specific training, primarily through self-directed learning (<i>n</i> = 84, 47.73%) and conferences (<i>n</i> = 82, 46.59%). Strong consensus existed for CAMHS competency development (<i>n</i> = 517, 96.27%), prioritizing communication skills, early recognition of mental health conditions, and multidisciplinary teamwork (Figure 1).</p><p>To address the gaps, we urgently call for immediate actions, including: (1) mandatory CAP training adapting best practices to local needs focusing on communication skills and early disorder recognition to boost pediatricians' willingness and competence in CAMHS; (2) a national CAP e-library, grounded on foundational resources like mhGAP (World Health Organization <span>2017</span>), to provide standardized content, reduce geographic disparities, and integrate guidelines, lectures, case studies, and regional resources for referrals; and (3) support from the National Health Commission and academic leadership, including policy directives, increased CAMHS funding, and CAP rotation quality assessment.</p><p>Enhancing pediatricians' CAMHS capacity through these steps will help China build a sustainable CAMHS workforce for youth needs, improve outcomes, and offer a scalable model for other Asia-Pacific nations facing similar workforce shortages and seeking to expand CAMHS within primary care frameworks.</p><p>Meirong Pan conceived the study design and performed data collection, extraction, and analysis, and drafted the paper. Ni Tang conceived the study design and performed data collection, extraction, and analysis. Jianguang Qi conceived the study design and performed data extraction. Zhengjie Zhu performed data extraction. Tianmei Si conceived the study design and performed data collection, extraction, and analysis; drafted and reviewed the paper. All authors reviewed the final manuscript.</p><p>The authors have nothing to report.</p><p>This study
精神障碍是中国儿童和青少年致残的主要原因,影响了3080万人(Dong et al. 2025)。尽管需求不断升级,但中国的儿童和青少年心理健康服务(CAMHS)面临严重的劳动力短缺,而低层次服务需求未得到满足的系统性效率低下加剧了这一问题(Jiang et al. 2024)。加强儿科医生的CAMHS能力是符合世卫组织阶梯式护理模式的可行解决方案(世卫组织2021年小组)。尽管全球对儿科医生的基本心理健康能力有共识(Foy et al. 2019),但中国在针对性调查和政策框架方面仍然存在显著差距,特别是在儿科医生的儿童和青少年精神病学(CAP)能力发展方面。我们对537名儿科医生的全国调查强调了紧迫性:496名(92.36%)遇到了儿童心理健康病例。其中,75.60%的人在提供CAMHS时报告了中等到高度的压力,主要是由于CAP技能不足。只有32.77%的人接受过cap专项培训,主要是通过自主学习(n = 84, 47.73%)和会议(n = 82, 46.59%)。对于CAMHS的能力发展(n = 517, 96.27%),优先考虑沟通技巧,早期识别心理健康状况和多学科团队合作(图1),存在强烈的共识。为了解决这些差距,我们迫切呼吁立即采取行动,包括:(1)强制性CAP培训,使最佳实践适应当地需求,重点关注沟通技巧和早期疾病识别,以提高儿科医生参与CAMHS的意愿和能力;(2)建立国家CAP电子图书馆,以mhGAP(世界卫生组织2017年)等基础资源为基础,提供标准化内容,减少地域差异,并整合指南、讲座、案例研究和区域资源,以供转诊;(3)国家卫生健康委员会和学术领导的支持,包括政策指示、增加CAMHS资金和CAP轮转质量评估。通过这些步骤提高儿科医生的CAMHS能力,将有助于中国建立一支可持续的CAMHS劳动力队伍,以满足青少年需求,改善结果,并为其他面临类似劳动力短缺并寻求在初级保健框架内扩大CAMHS的亚太国家提供可扩展的模式。潘美荣构思了研究设计,进行了数据收集、提取和分析,并撰写了论文。倪唐构思了研究设计,并进行了数据收集、提取和分析。齐建光构思研究设计并进行数据提取。朱正杰进行数据提取。司天美构思研究设计,进行数据收集、提取和分析;起草并审阅论文。所有作者都审阅了定稿。作者没有什么可报告的。本研究已获得北京大学第六医院伦理与临床研究委员会[(2024)伦理审查号(68)]批准,并按照赫尔辛基宣言和《涉及人体受试者的医学研究法案》(WMO)进行。作者声明无利益冲突。
{"title":"Call to Enhance Pediatricians' Capacity in Delivering Child and Adolescent Mental Health Services in China","authors":"Meirong Pan,&nbsp;Ni Tang,&nbsp;Jianguang Qi,&nbsp;Zhengjie Zhu,&nbsp;Qingjiu Cao,&nbsp;Tianmei Si","doi":"10.1111/appy.70007","DOIUrl":"https://doi.org/10.1111/appy.70007","url":null,"abstract":"&lt;p&gt;Mental disorders are leading causes of disability in children and adolescents in China, affecting 30.8 million individuals (Dong et al. &lt;span&gt;2025&lt;/span&gt;). Despite escalating needs, China's child and adolescent mental health services (CAMHS) face severe workforce shortages, exacerbated by systemic inefficiencies with unmet lower-tier services demands (Jiang et al. &lt;span&gt;2024&lt;/span&gt;). Strengthening pediatricians' CAMHS capacity is a viable solution aligned with WHO's stepped-care model (WHO Team &lt;span&gt;2021&lt;/span&gt;). Despite global consensus on essential mental health competencies among pediatricians (Foy et al. &lt;span&gt;2019&lt;/span&gt;), significant gaps persist in China, both in targeted surveys and policy frameworks, specifically addressing child and adolescent psychiatry (CAP) competency development among pediatricians.&lt;/p&gt;&lt;p&gt;Our national survey of 537 pediatricians highlights urgency: 496 (92.36%) encountered pediatric mental health cases. Of these, 75.60% reported moderate-to-high stress when delivering CAMHS, primarily due to insufficient CAP skills. Only 32.77% received CAP-specific training, primarily through self-directed learning (&lt;i&gt;n&lt;/i&gt; = 84, 47.73%) and conferences (&lt;i&gt;n&lt;/i&gt; = 82, 46.59%). Strong consensus existed for CAMHS competency development (&lt;i&gt;n&lt;/i&gt; = 517, 96.27%), prioritizing communication skills, early recognition of mental health conditions, and multidisciplinary teamwork (Figure 1).&lt;/p&gt;&lt;p&gt;To address the gaps, we urgently call for immediate actions, including: (1) mandatory CAP training adapting best practices to local needs focusing on communication skills and early disorder recognition to boost pediatricians' willingness and competence in CAMHS; (2) a national CAP e-library, grounded on foundational resources like mhGAP (World Health Organization &lt;span&gt;2017&lt;/span&gt;), to provide standardized content, reduce geographic disparities, and integrate guidelines, lectures, case studies, and regional resources for referrals; and (3) support from the National Health Commission and academic leadership, including policy directives, increased CAMHS funding, and CAP rotation quality assessment.&lt;/p&gt;&lt;p&gt;Enhancing pediatricians' CAMHS capacity through these steps will help China build a sustainable CAMHS workforce for youth needs, improve outcomes, and offer a scalable model for other Asia-Pacific nations facing similar workforce shortages and seeking to expand CAMHS within primary care frameworks.&lt;/p&gt;&lt;p&gt;Meirong Pan conceived the study design and performed data collection, extraction, and analysis, and drafted the paper. Ni Tang conceived the study design and performed data collection, extraction, and analysis. Jianguang Qi conceived the study design and performed data extraction. Zhengjie Zhu performed data extraction. Tianmei Si conceived the study design and performed data collection, extraction, and analysis; drafted and reviewed the paper. All authors reviewed the final manuscript.&lt;/p&gt;&lt;p&gt;The authors have nothing to report.&lt;/p&gt;&lt;p&gt;This study","PeriodicalId":8618,"journal":{"name":"Asia‐Pacific Psychiatry","volume":"17 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/appy.70007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145012302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentary on “Cross-Cultural Differences in the Pathways to Internet Gaming Disorder” 《网络游戏成瘾途径的跨文化差异》评论
IF 3.4 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-08-31 DOI: 10.1111/appy.70006
Mei-Yun Lu, Lien-Chung Wei
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引用次数: 0
A Network Analysis of Psychiatric Symptoms in Patients With Schizophrenia Treated With Antipsychotic Polypharmacy Using Propensity Score Matching: Findings From the Research on Asian Psychotropic Prescription Patterns (REAP) Study 使用倾向评分匹配的抗精神病药物治疗精神分裂症患者精神症状网络分析:来自亚洲精神药物处方模式(REAP)研究的结果
IF 3.4 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-08-18 DOI: 10.1111/appy.70005
Wen Li, Qinge Zhang, Gabor S. Ungvari, Seon-Cheol Park, Lian-Yu Chen, Kok Yoon Chee, Roy Abraham Kallivayalil, Kang Sim, Yan-Ling He, Norman Sartorius, Naotaka Shinfuku, Shih-Ku Lin, Ajit Avasthi, Sandeep Grover, Takahiro A. Kato, Chee H. Ng, Yu-Tao Xiang

Objectives

Antipsychotic polypharmacy (APP) is prevalent among patients with schizophrenia across countries in Asia. This study aimed to explore the relationships between psychiatric symptoms and APP using network analysis.

Methods

Data on nine major psychiatric symptoms and the number of prescribed antipsychotics were extracted from the fourth survey of the Research on Asian Psychotropic Prescription Patterns (REAP-AP). A network model of the nine psychiatric symptoms was constructed for patients treated with APP and antipsychotic monotherapy (APM) respectively. The interconnections between psychiatric symptoms and APP use were further analyzed using network analysis.

Results

A total of 1528 patients with schizophrenia treated with APP were matched with 1528 patients treated with APM in Asia. The top three central psychiatric symptoms in the networks of psychiatric symptoms were consistent, but in different orders for APP-treated patients (verbal aggression, hallucinations, and social/occupational dysfunction) and APM-treated patients (social/occupational dysfunction, verbal aggression, and hallucinations). Network analysis of APP and psychiatric symptoms revealed that disorganized/catatonic behavior was strongly linked with APP, followed by delusions, hallucinations, and verbal aggression.

Conclusion

Psychiatric symptoms closely associated with APP included verbal aggression, grossly disorganized/catatonic behavior, delusions, and hallucinations. For patients with schizophrenia who are primarily exhibiting such symptoms, alternative appropriate treatment strategies should be considered.

目的抗精神病药物多药(APP)在亚洲各国精神分裂症患者中普遍存在。本研究旨在通过网络分析探讨精神症状与APP之间的关系。方法从亚洲精神药物处方模式研究(REAP-AP)第四次调查中提取9种主要精神症状和抗精神病药物处方数量的数据。应用APP和单药抗精神病治疗分别建立九种精神症状的网络模型。应用网络分析进一步分析精神症状与APP使用之间的相互关系。结果亚洲地区共1528例应用APP治疗的精神分裂症患者与1528例应用APM治疗的精神分裂症患者相匹配。在精神症状网络中,前三名的中心精神症状是一致的,但app治疗的患者(言语攻击、幻觉、社会/职业功能障碍)和apm治疗的患者(社会/职业功能障碍、言语攻击、幻觉)的顺序不同。APP与精神症状的网络分析显示,紊乱/紧张性行为与APP密切相关,其次是妄想、幻觉和言语攻击。结论与APP密切相关的精神症状包括言语攻击、严重紊乱/紧张性行为、妄想和幻觉。对于主要表现出这些症状的精神分裂症患者,应考虑其他适当的治疗策略。
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引用次数: 0
Adjunctive Antidepressant Use in Bipolar Disorder and Its Clinical Correlates: An Asian Psychotropic Prescription Patterns Consortium Study 双相情感障碍中辅助抗抑郁药的使用及其临床相关性:一项亚洲精神药物处方模式联合研究
IF 2.8 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-06-09 DOI: 10.1111/appy.70004
Yi Hu, Qian Hui Chew, Shih-Ku Lin, Wen-Chen Ouyang, Chih-Ken Chen, Seon-Cheol Park, Ok-Jin Jang, Kok-Yoon Chee, Kwong Sen Ding, Jamaline Chong, Ling Zhang, Keqing Li, Xiaomin Zhu, Chonnakarn Jatchavala, Pornjira Pariwatcharakul, Roy A. Kallivayalil, Sandeep Grover, Ajit Avasthi, Moin Ansari, Margarita M. Maramis, Phyo Aung Paing, Chay Hoon Tan, Yu-Tao Xiang, Mian-Yoon Chong, Yong Chon Park, Takahiro A. Kato, Naotaka Shinfuku, Ross J. Baldessarini, Kang Sim

Introduction

Adjunctive antidepressant (AD) use is prevalent for the treatment of bipolar disorder (BD) in many countries, but there is little information about this practice in Asia. Accordingly, we addressed the prevalence, dosing, and clinical correlates of adjunctive AD use with BD in a large Asian sample.

Methods

Patients with BD were recruited across 13 Asian sites (PR China, Hong Kong, India, Indonesia, Japan, South Korea, Malaysia, Myanmar, Pakistan, Singapore, Sri Lanka, Taiwan, and Thailand) for this cross-sectional study. We examined differences between patients with versus without adjunctive AD treatment. Multivariable logistic regression was used to identify factors associated with the use of adjunctive AD.

Results

Among a total of 2114 adult participants (47.7% men; age 42.4 years [CI: 41.8–43.0]; BMI 25.0 kg/m2 [24.8–25.2]), the prevalence of AD use averaged 19.8% [18.1–21.6], at a mean imipramine-equivalent dose of 113 [110–116] mg/day. Adjunctive AD use was associated with factors including older age, outpatient status, more depression, suicidal behavior, rapid cycling, and lower doses of MS and antipsychotics (APs).

Discussion

Usage of AD treatment for BD in Asia was less than half that reported in Western samples. Such use of AD treatment appeared to be well tolerated but underscores the need for close clinical follow-up to avoid risks of excessive elevation of mood or behavior.

在许多国家,辅助抗抑郁药(AD)的使用普遍用于治疗双相情感障碍(BD),但在亚洲,这方面的信息很少。因此,我们在一个大的亚洲样本中研究了辅助AD与双相障碍的患病率、剂量和临床相关性。方法在13个亚洲地区(中国、香港、印度、印度尼西亚、日本、韩国、马来西亚、缅甸、巴基斯坦、新加坡、斯里兰卡、台湾和泰国)招募BD患者进行横断面研究。我们检查了接受辅助AD治疗和未接受辅助AD治疗的患者之间的差异。使用多变量逻辑回归来确定与辅助AD使用相关的因素。结果共纳入2114名成年受试者(男性47.7%;年龄42.4岁[CI: 41.8-43.0];BMI为25.0 kg/m2[24.8-25.2]),平均丙咪嗪当量剂量为113 [110-116]mg/天,AD患病率为19.8%[18.1-21.6]。辅助AD的使用与年龄较大、门诊状态、更多抑郁、自杀行为、快速循环、MS和抗精神病药物(APs)剂量较低等因素相关。在亚洲,AD治疗双相障碍的使用率不到西方样本的一半。这种使用阿尔茨海默病治疗似乎耐受性良好,但强调需要密切的临床随访,以避免情绪或行为过度升高的风险。
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引用次数: 0
A Predictive Nomogram for Suicide Attempts in Chinese Adolescents With Both Non-Suicidal Self-Injury and Suicidal Ideation 中国青少年非自杀性自伤和自杀意念自杀企图的预测Nomogram (n形图)
IF 2.8 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-04-23 DOI: 10.1111/appy.70003
Yi-Hui Liu, Ming Chen, Hao-Zhang Huang, Jia-Rong Liang, Yong-Yi He, Jia-Hui Hu, Ting-Ting Zhang, Fu-Jun Jia, Cai-Lan Hou

Introduction

Non-suicidal self-injury (NSSI) and suicidal ideation (SI) are prevalent and co-occurring among adolescents, serving as critical predictors of suicide. This study aimed to develop a predictive model and nomogram for suicide attempts (SA) in Chinese adolescents with mood disorders exhibiting NSSI and SI.

Methods

Data were collected from 134 participants. Predictors were selected via LASSO regression from data collected using the Self-Injurious Thoughts and Behaviors Interview-Revised and self-report scales, followed by multivariate logistic regression to build the nomogram. Model performance was assessed through discriminatory ability, calibration curves, and clinical decision analysis.

Results

Adolescents with SA history had fewer education years, higher prevalence and future likelihood of self-injurious thoughts and behaviors, earlier NSSI onset, more frequent and severe NSSI, and more intense and persistent SI compared to those without SA. Three key predictors for SA were identified: NSSI emotion regulation scores, average SI persistence duration, and history of interrupted attempts. The developed nomogram exhibited robust predictive accuracy with an AUC of 0.756.

Discussion

This study presents a predictive model for suicide risk in adolescents with mood disorders exhibiting NSSI and SI. The model demonstrates high predictive accuracy and clinical applicability, offering a practical tool for clinicians to prioritize high-risk cases and guide personalized interventions.

导言:非自杀性自伤(NSSI)和自杀意念(SI)在青少年中普遍存在并同时出现,是预测自杀的关键因素。本研究旨在为有情绪障碍的中国青少年建立一个自杀企图(SA)的预测模型和提名图。 方法 收集了 134 名参与者的数据。根据自伤想法和行为访谈-修订版及自我报告量表收集的数据,通过LASSO回归筛选出预测因子,然后通过多元逻辑回归建立提名图。通过判别能力、校准曲线和临床决策分析对模型性能进行评估。 结果 与无 SA 史的青少年相比,有 SA 史的青少年受教育年限更短、自伤想法和行为的发生率和未来可能性更高、NSSI 开始得更早、NSSI 更频繁和更严重、SI 更强烈和更持久。研究发现了三个预测 SA 的关键因素:NSSI情绪调节评分、SI持续平均持续时间和中断尝试史。所开发的提名图具有很高的预测准确性,AUC 为 0.756。 讨论 本研究提出了一种情绪障碍青少年自杀风险预测模型,该模型表现出 NSSI 和 SI。该模型具有很高的预测准确性和临床适用性,为临床医生优先处理高风险病例和指导个性化干预提供了实用工具。
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引用次数: 0
Sexsomnia-Like Behaviors Associated With Zolpidem 唑吡坦与嗜睡性行为有关
IF 2.8 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-02-25 DOI: 10.1111/appy.70002
Hui-Yuan Liao, Huang-Chi Lin
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引用次数: 0
期刊
Asia‐Pacific Psychiatry
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