{"title":"[Therapeutic strategies in Parkinson's disease].","authors":"I Shoulson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":"54 6","pages":"277-81"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12852158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G Sanchís, M A Mena, R Martín del Río, B Morales, M J Casarejo, M J de Yébenes, C Tabernero, A Jiménez, J G de Yébenes
Levodopa is the treatment of choice in Parkinson's disease, but a high percentage of patients develop complications in the response, including fluctuations, after some years of treatment. Although the origin of fluctuations is unknown, these could be, at least partly, attributed to pharmacokinetic factors. Aromatic aminoacids interfere in the absorption and brain penetration of levodopa, and lowering protein intake improves the quality of the response. The continuation of a low-protein diet is difficult for some patients. In this way, to know if these diet effects are noticeable in an acute period would be interesting, in order to select groups of patients who were susceptible to improve with this treatment. In this report we have studied the acute effect of a low protein diet on the pharmacological response to levodopa, and the plasmatic levels of L-Dopa, 3-OM-Dopa and large neutral aminoacids. Protein restriction improves clinical response to levodopa, although the mechanisms of this improvement remain unknown.
左旋多巴是帕金森病的首选治疗方法，但在治疗数年后，很高比例的患者在治疗反应中出现并发症，包括波动。虽然波动的来源尚不清楚，但这些可能至少部分归因于药代动力学因素。芳香族氨基酸会干扰左旋多巴的吸收和大脑渗透，降低蛋白质摄入量可以改善反应的质量。对一些病人来说，坚持低蛋白饮食是很困难的。通过这种方式，了解这些饮食效果在急性期是否明显将是有趣的，以便选择易受这种治疗改善的患者群体。在本报告中，我们研究了低蛋白饮食对左旋多巴药理学反应的急性影响，以及血浆中左旋多巴、3- om -多巴和大中性氨基酸的水平。蛋白限制改善临床对左旋多巴的反应，尽管这种改善的机制尚不清楚。
{"title":"[Effect of a controlled low-protein diet on the pharmacological response to levodopa and on the plasma levels of L-dopa and amino acids in patients with Parkinson's disease].","authors":"G Sanchís, M A Mena, R Martín del Río, B Morales, M J Casarejo, M J de Yébenes, C Tabernero, A Jiménez, J G de Yébenes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Levodopa is the treatment of choice in Parkinson's disease, but a high percentage of patients develop complications in the response, including fluctuations, after some years of treatment. Although the origin of fluctuations is unknown, these could be, at least partly, attributed to pharmacokinetic factors. Aromatic aminoacids interfere in the absorption and brain penetration of levodopa, and lowering protein intake improves the quality of the response. The continuation of a low-protein diet is difficult for some patients. In this way, to know if these diet effects are noticeable in an acute period would be interesting, in order to select groups of patients who were susceptible to improve with this treatment. In this report we have studied the acute effect of a low protein diet on the pharmacological response to levodopa, and the plasmatic levels of L-Dopa, 3-OM-Dopa and large neutral aminoacids. Protein restriction improves clinical response to levodopa, although the mechanisms of this improvement remain unknown.</p>","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":"54 6","pages":"296-302"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Therapeutic advances in Parkinson disease. Symposium of the XLII annual meeting of the Spanish Neurological Society. December 1990].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":"54 6","pages":"261-326"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12852270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J A Obeso, M R Luquín, J Artieda, M T Herrero, M A Pastor, J Guridi
{"title":"[Anatomo-functional basis for Parkinson's disease].","authors":"J A Obeso, M R Luquín, J Artieda, M T Herrero, M A Pastor, J Guridi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":"54 6","pages":"272-6"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Optimization of the treatment of Parkinson's disease using dopamine agonists].","authors":"U K Rinne","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":"54 6","pages":"282-7"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12852273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J Vilert Barnet, A Jarne Esparcia, M Aguilar Barbera
The purpose of this study is to contrast a sampling of 20 patients diagnosed as suffering from "Idiopathic Parkinson's Disease" (mean age, 54; schooling, 8.5 years; length of disease, 6.07 years) with a healthy control group, in order to detect possible correlation between intellectual impairment and depression in the individuals affected by Parkinsonism. An integrated battery of neuropsychological testing (PIEN-Test Barcelona. Peña, 1990) was used, in conjunction with "Beck's Depression Inventory". The results show significant differences in the following areas: expressive language, complex language comprehension, motor coordination, complex visuospatial factors, verbal memory and WAIS-type intelligence factors. Discriminant analysis was performed to select the most discriminating variables. The results were as follows, beginning with the most discriminating factor: motor coordination, complex comprehension, complex visuospatial factors, math skills and an overall slowing down. The patients with the highest depression levels were found to have the greatest impairment in mental control/attention and complex comprehension.
{"title":"[Cognitive deterioration in Parkinson's disease].","authors":"J Vilert Barnet, A Jarne Esparcia, M Aguilar Barbera","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of this study is to contrast a sampling of 20 patients diagnosed as suffering from \"Idiopathic Parkinson's Disease\" (mean age, 54; schooling, 8.5 years; length of disease, 6.07 years) with a healthy control group, in order to detect possible correlation between intellectual impairment and depression in the individuals affected by Parkinsonism. An integrated battery of neuropsychological testing (PIEN-Test Barcelona. Peña, 1990) was used, in conjunction with \"Beck's Depression Inventory\". The results show significant differences in the following areas: expressive language, complex language comprehension, motor coordination, complex visuospatial factors, verbal memory and WAIS-type intelligence factors. Discriminant analysis was performed to select the most discriminating variables. The results were as follows, beginning with the most discriminating factor: motor coordination, complex comprehension, complex visuospatial factors, math skills and an overall slowing down. The patients with the highest depression levels were found to have the greatest impairment in mental control/attention and complex comprehension.</p>","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":"54 6","pages":"311-7"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Search for the cause of Parkinson's disease].","authors":"J W Langston","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":"54 6","pages":"264-71"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Pergolide in Parkinson's disease].","authors":"D Parkes","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":"54 6","pages":"288-95"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Parkinson's disease: advances in the decade of the brain].","authors":"E Tolosa, J Chacón","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":"54 6","pages":"261-3"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R Astarloa, B Morales, V Sánchez, N Peñafiel, J Rábano, J Oliván, J García de Yébenes
We report the results of the treatment of 80 patients with various idiopathic focal dystonia and essential hemifacial spasm with Botulinum A toxin. A statistically significant improvement was obtained in our 34 patients with blepharospasm, 19 patients with hemifacial spasm, 59% of 22 patients with cervical dystonia and 60% of 5 patients with hand dystonia. Mean duration of the benefit of each injection was 15.3, 16.3, 7.6 and 8.7 weeks respectively. Adverse effects were local and transient. We concluded that botulinum A toxin is a safe and effective therapy for patients with focal dystonia and hemifacial spasm.
{"title":"[Focal dystonias and facial hemispasm: treatment with botulinum A toxin].","authors":"R Astarloa, B Morales, V Sánchez, N Peñafiel, J Rábano, J Oliván, J García de Yébenes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report the results of the treatment of 80 patients with various idiopathic focal dystonia and essential hemifacial spasm with Botulinum A toxin. A statistically significant improvement was obtained in our 34 patients with blepharospasm, 19 patients with hemifacial spasm, 59% of 22 patients with cervical dystonia and 60% of 5 patients with hand dystonia. Mean duration of the benefit of each injection was 15.3, 16.3, 7.6 and 8.7 weeks respectively. Adverse effects were local and transient. We concluded that botulinum A toxin is a safe and effective therapy for patients with focal dystonia and hemifacial spasm.</p>","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":"54 5","pages":"210-7"},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12966000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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