Pub Date : 1972-10-31DOI: 10.20772/CANCERSCI1959.63.5_605
S. Fujii, M. Muramatsu
In 1948, Nakahara and Fukuoka15) first isolated toxohormone from a tumor as a factor depressing liver catalase. Subsequently, it was reported that injection of the toxohormone fraction caused thymus involution,6) anemia,6,7,11) depression of liver tryptophan pyrrolase,10) DPN synthetase,18,20) and the plasma iron level14) as well as reduction of liver catalase activity. Fujii et al.4) obtained a basic protein fraction with toxohormone activities from Rhodamine sarcoma. They subjected it to carboxymethylcellulose column chromatography and separated a plasma iron-depressing factor from factors depressing liver catalase and tryptophan pyrrolase. Accordingly, Fujii et al.5) proposed the "toxohormone complex theory." The present paper reports further purification of the plasma iron-depressing factor and analysis of its chemical composition.
1948年，中原和福冈首次从肿瘤中分离出弓形激素，作为抑制肝脏过氧化氢酶的因子。随后，有报道称注射弓形激素部分引起胸腺退化，6)贫血，6、7、11)肝脏色氨酸吡啶酶，10)DPN合成酶，18、20)和血浆铁水平下降，14)肝脏过氧化氢酶活性降低。Fujii et al.4)从罗丹明肉瘤中获得了具有弓形激素活性的碱性蛋白组分。他们对其进行羧甲基纤维素柱层析，并从抑制肝脏过氧化氢酶和色氨酸吡咯酶的因子中分离出血浆铁抑制因子。据此，Fujii et al.5)提出了“弓形激素复合物理论”。本文报道了等离子体降铁因子的进一步纯化及其化学成分分析。
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{"title":"[ASSOCIATION OF AUTOIMMUNITY IN VARIOUS DISEASES].","authors":"H SUZUKI","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":86869,"journal":{"name":"Sogo igaku. Medicine","volume":"21 ","pages":"209-13"},"PeriodicalIF":0.0,"publicationDate":"1964-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23719289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[TRANSPLANTATION IMMUNITY. ON THE MECHANISM OF ANTIGENS IN HOMOGRAFTS].","authors":"G FUJII","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":86869,"journal":{"name":"Sogo igaku. Medicine","volume":"21 ","pages":"215-20"},"PeriodicalIF":0.0,"publicationDate":"1964-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23719290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[AUTOIMMUNE HEMOLYTIC DISEASE (ANEMIA) WITH SPECIAL REFERENCE TO CLINICAL OBSERVATIONS].","authors":"M FUKASE","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":86869,"journal":{"name":"Sogo igaku. Medicine","volume":"21 ","pages":"159-69"},"PeriodicalIF":0.0,"publicationDate":"1964-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23719283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[RHEUMATOID ARTHRITIS WITH SPECIAL REFERENCE TO THE RHEUMATOID FACTOR].","authors":"Y HORIUCHI, T MISHIMA, T ADACHI","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":86869,"journal":{"name":"Sogo igaku. Medicine","volume":"21 ","pages":"187-95"},"PeriodicalIF":0.0,"publicationDate":"1964-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23719286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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