Pub Date : 2024-01-01DOI: 10.32598/bcn.2022.4292.1
Dina Gholipour, Mansour Shahraki, Mohsen Saravani, Abolfazl Payandeh, Hadi Eslahi
{"title":"The Effect of Omega-3 Supplementation on Serum Levels of Antioxidant Status in Patients With Bipolar Disease: A Randomized Double-blind Controlled Clinical Trial","authors":"Dina Gholipour, Mansour Shahraki, Mohsen Saravani, Abolfazl Payandeh, Hadi Eslahi","doi":"10.32598/bcn.2022.4292.1","DOIUrl":"https://doi.org/10.32598/bcn.2022.4292.1","url":null,"abstract":"","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"158 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140523140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-29DOI: 10.32598/bcn.2023.5693.1
Seyyed Mohammad Taghi Razavi-Toosi, Yasin Asadi, N. Aboutaleb, Masoumeh Faezi
Introduction: Stem cells isolated from amniotic membrane can produce and freedom substances that have the ability to regenerate damaged tissues and contain proteins and other factors that apply via numerous major and minor mechanisms leading to increasing angiogenesis and tissue survival. The research was conducted to prove the defensive characteristics of the secretome in the face of temporary focal cerebral ischemia in mouse stroke models. Methods: Cerebral ischemia protocol in a specific area was implemented in rats with middle cerebral artery occlusion for 60 minutes and then reperfusion was given for 6, 20 and 30 minutes. Within 30 minutes after the start of reperfusion, conditioned medium derived from human amniotic membrane (AMSC-CM) was poured into the right ventricle (ICV) with a dose of 0.5 microliters. Finally, the volume of the injury, cerebral tissue water, sensorimotor activity and the strength of the blood-brain barrier integrity were evaluated 24 hours after drug injection. Results: ICV injection of conditioned medium at the start of reperfusion phase considerably decrease the volume of the injury in 6, 20, and 30 hours after reperfusion compared MCAO operated group (p < 0.01), cerebral tissue water in the treatment group decreased considerably after intervention in comparison with the MCAO group in core and penumbral area not in the subcortical area (p < 0.05), Also, the Evans Blue penetration rate in all times in the core and penumbral area in AMSC-CM group considerably decreased paralleled with the MCAO group (p < 0.05). Conclusion: The results show that treatment with AMSC-CM during 6-30 h after ischemia-reperfusion insult exerts some beneficial effects against ischemia-reperfusion injury. These findings provide an important vision for more complementary research and treatment of stroke.
{"title":"Conditioned Medium Derived from the Human Amniotic Membrane Prevents Brain Damage against Cerebral Ischemia/Reperfusion in Three Phases, Subacute, Acute, and Chronic in a Stroke Model in Rats","authors":"Seyyed Mohammad Taghi Razavi-Toosi, Yasin Asadi, N. Aboutaleb, Masoumeh Faezi","doi":"10.32598/bcn.2023.5693.1","DOIUrl":"https://doi.org/10.32598/bcn.2023.5693.1","url":null,"abstract":"Introduction: Stem cells isolated from amniotic membrane can produce and freedom substances that have the ability to regenerate damaged tissues and contain proteins and other factors that apply via numerous major and minor mechanisms leading to increasing angiogenesis and tissue survival. The research was conducted to prove the defensive characteristics of the secretome in the face of temporary focal cerebral ischemia in mouse stroke models. Methods: Cerebral ischemia protocol in a specific area was implemented in rats with middle cerebral artery occlusion for 60 minutes and then reperfusion was given for 6, 20 and 30 minutes. Within 30 minutes after the start of reperfusion, conditioned medium derived from human amniotic membrane (AMSC-CM) was poured into the right ventricle (ICV) with a dose of 0.5 microliters. Finally, the volume of the injury, cerebral tissue water, sensorimotor activity and the strength of the blood-brain barrier integrity were evaluated 24 hours after drug injection. Results: ICV injection of conditioned medium at the start of reperfusion phase considerably decrease the volume of the injury in 6, 20, and 30 hours after reperfusion compared MCAO operated group (p < 0.01), cerebral tissue water in the treatment group decreased considerably after intervention in comparison with the MCAO group in core and penumbral area not in the subcortical area (p < 0.05), Also, the Evans Blue penetration rate in all times in the core and penumbral area in AMSC-CM group considerably decreased paralleled with the MCAO group (p < 0.05). Conclusion: The results show that treatment with AMSC-CM during 6-30 h after ischemia-reperfusion insult exerts some beneficial effects against ischemia-reperfusion injury. These findings provide an important vision for more complementary research and treatment of stroke.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139213099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.32598/bcn.2022.2297.1
H. Ghazvini, F. Tirgar, Mehdi Khodamoradi, Seyedeh Masoumeh Seyedhosseini Tamijani, Saba Niknamfar, E. Akbari, Mohammad Nekahi, Nabiollah Tarjani, Hossein Ghalehnoei, Motahareh Rouhi Ardeshiri
Introduction: It has long been known that Methamphetamine (MA), as a psychostimulant, leads to long-lasting cognitive deficits. Previous studies have shown that lithium, a mood stabilizer, could facilitate cognitive ability in most of brain diseases. In current study the effects of lithium on spatial memory, hippocampal apoptosis and brain edema in METH-exposed rats are investigated. Methods: The present study 32 Wistar rats were used to examine the effects of lithium on spatial memory by the Morris water maze, hippocampal apoptosis using the TUNEL assay, and brain edema following MA administrations. Results: The findings indicated that treatment with lithium significantly ameliorated spatial learning and memory impairment in MA-treated rats. In addition, the findings showed that treatment with lithium significantly reduced brain edema and apoptosis in the CA1 neurons in MA -exposed rats. Conclusion: The results show that treatment with lithium can partially ameliorate the MA –induced neurocognitive deficits in rats, which may be related to its protective effect in the hippocampus.
导言：众所周知，甲基苯丙胺（MA）作为一种精神兴奋剂，会导致长期的认知障碍。以往的研究表明，锂作为一种情绪稳定剂，可促进大多数脑部疾病患者的认知能力。本研究探讨了锂对暴露于 METH 的大鼠的空间记忆、海马凋亡和脑水肿的影响。研究方法本研究使用 32 只 Wistar 大鼠来研究锂对 Morris 水迷宫空间记忆、TUNEL 法检测海马凋亡以及 MA 给药后脑水肿的影响。结果研究结果表明，锂治疗能明显改善 MA 治疗大鼠的空间学习和记忆损伤。此外，研究结果表明，锂治疗能明显减轻 MA 暴露大鼠的脑水肿和 CA1 神经元的凋亡。结论研究结果表明，锂能部分改善 MA 诱导的大鼠神经认知缺陷，这可能与锂对海马的保护作用有关。
{"title":"Investigating Facilitatory Effects of Lithium on Methamphetamine-induced Spatial Memory Impairments in Rat","authors":"H. Ghazvini, F. Tirgar, Mehdi Khodamoradi, Seyedeh Masoumeh Seyedhosseini Tamijani, Saba Niknamfar, E. Akbari, Mohammad Nekahi, Nabiollah Tarjani, Hossein Ghalehnoei, Motahareh Rouhi Ardeshiri","doi":"10.32598/bcn.2022.2297.1","DOIUrl":"https://doi.org/10.32598/bcn.2022.2297.1","url":null,"abstract":"Introduction: It has long been known that Methamphetamine (MA), as a psychostimulant, leads to long-lasting cognitive deficits. Previous studies have shown that lithium, a mood stabilizer, could facilitate cognitive ability in most of brain diseases. In current study the effects of lithium on spatial memory, hippocampal apoptosis and brain edema in METH-exposed rats are investigated. Methods: The present study 32 Wistar rats were used to examine the effects of lithium on spatial memory by the Morris water maze, hippocampal apoptosis using the TUNEL assay, and brain edema following MA administrations. Results: The findings indicated that treatment with lithium significantly ameliorated spatial learning and memory impairment in MA-treated rats. In addition, the findings showed that treatment with lithium significantly reduced brain edema and apoptosis in the CA1 neurons in MA -exposed rats. Conclusion: The results show that treatment with lithium can partially ameliorate the MA –induced neurocognitive deficits in rats, which may be related to its protective effect in the hippocampus.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.32598/bcn.2022.3830.2
Mohammad Saleh Khajeh Hosseini, Mohammad Pourmir Firoozabadi, Kambiz Badie, Parviz Azad Fallah
Introduction: The study explores the use of Electroencephalograph (EEG) signals as a means to uncover various states of the human brain, with a specific focus on emotion classification. Despite the potential of EEG signals in this domain, existing methods face challenges. Features extracted from EEG signals may not accurately represent an individual's emotional patterns due to interference from time-varying factors and noise. Additionally, higher-level cognitive factors, such as personality, mood, and past experiences, further complicate emotion recognition. The dynamic nature of EEG data in terms of time series introduces variability in feature distribution and interclass discrimination across different time stages. Methods: To address these challenges, the paper proposes a novel adaptive ensemble classification method. The study introduces a new method for providing emotional stimuli, categorizing them into three groups (sadness, neutral, and happiness) based on their valence-arousal (VA) scores. The experiment involved 60 participants aged 19–30 years, and the proposed method aimed to mitigate the limitations associated with conventional classifiers. Results: The results demonstrate a significant improvement in the performance of emotion classifiers compared to conventional methods. The classification accuracy achieved by the proposed adaptive ensemble classification method is reported at 87.96%. This suggests a promising advancement in the ability to accurately classify emotions using EEG signals, overcoming the limitations outlined in the introduction. Conclusion: In conclusion, the paper introduces an innovative approach to emotion classification based on EEG signals, addressing key challenges associated with existing methods. By employing a new adaptive ensemble classification method and refining the process of providing emotional stimuli, the study achieves a noteworthy improvement in classification accuracy. This advancement is crucial for enhancing our understanding of the complexities of emotion recognition through EEG signals, paving the way for more effective applications in fields such as neuroinformatics and affective computing.
{"title":"Electroencephalograph Emotion Classification Using a Novel Adaptive Ensemble Classifier Considering Personality Traits","authors":"Mohammad Saleh Khajeh Hosseini, Mohammad Pourmir Firoozabadi, Kambiz Badie, Parviz Azad Fallah","doi":"10.32598/bcn.2022.3830.2","DOIUrl":"https://doi.org/10.32598/bcn.2022.3830.2","url":null,"abstract":"Introduction: The study explores the use of Electroencephalograph (EEG) signals as a means to uncover various states of the human brain, with a specific focus on emotion classification. Despite the potential of EEG signals in this domain, existing methods face challenges. Features extracted from EEG signals may not accurately represent an individual's emotional patterns due to interference from time-varying factors and noise. Additionally, higher-level cognitive factors, such as personality, mood, and past experiences, further complicate emotion recognition. The dynamic nature of EEG data in terms of time series introduces variability in feature distribution and interclass discrimination across different time stages. Methods: To address these challenges, the paper proposes a novel adaptive ensemble classification method. The study introduces a new method for providing emotional stimuli, categorizing them into three groups (sadness, neutral, and happiness) based on their valence-arousal (VA) scores. The experiment involved 60 participants aged 19–30 years, and the proposed method aimed to mitigate the limitations associated with conventional classifiers. Results: The results demonstrate a significant improvement in the performance of emotion classifiers compared to conventional methods. The classification accuracy achieved by the proposed adaptive ensemble classification method is reported at 87.96%. This suggests a promising advancement in the ability to accurately classify emotions using EEG signals, overcoming the limitations outlined in the introduction. Conclusion: In conclusion, the paper introduces an innovative approach to emotion classification based on EEG signals, addressing key challenges associated with existing methods. By employing a new adaptive ensemble classification method and refining the process of providing emotional stimuli, the study achieves a noteworthy improvement in classification accuracy. This advancement is crucial for enhancing our understanding of the complexities of emotion recognition through EEG signals, paving the way for more effective applications in fields such as neuroinformatics and affective computing.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-26DOI: 10.32598/bcn.2023.4724.1
J. Mehvari, Zeinab Jaafari, Mohamad Zare, N. Tabrizi, Alireza Khosravi Farsani
Introduction: Sudden unexpected death in epilepsy (SUDEP) is the substantial cause of death in patients with epilepsy (PWE). Electroconductive disorders leading to life-threatening arrhythmia are mostly hypothesized to play a crucial role; however, there is paucity of knowledge in variable among the patients with drug-resistant temporal lobe epilepsy (TLE) compared to the healthy controls. Methods: The current case-control study has been conducted on 50 drug-resistant TLE patients as the cases and 50 age- and gender-matched healthy subjects selected from their first-degree family members. ECGs were taken when admitted at the hospital (base line), immediately after a seizure incidence and within an hour after the end of the seizure from the cases compared with a random ECG of the controls considering parameters including PR-, RR-, and corrected QT interval (QTc), P wave duration and heart rate (HR) variability. Results: Shorter corrected QTc interval was notified among the drug-resistant TLE patients compared to the controls (P-value=0.017) in the base line taken ECGs, while the assessments immediately after the seizure revealed significant differences in terms of RR-interval (P-value=0.005) and heart rate (P-value=0.005). Post-ictal ECGs did not differ between the groups (P-value>0.05). Conclusion: According to the findings of this study, shortened QTc interval at base line ECGs, shortened RR interval and increased HR during the seizure were the ECG elements affected in drug-resistant TLE patients; however, to generalize the outcomes, further studies are required.
{"title":"The Assessments of Electrocardiographic Parameters in the Patients with Drug-Resistant Temporal Lobe Epilepsy; A Case-Control Study","authors":"J. Mehvari, Zeinab Jaafari, Mohamad Zare, N. Tabrizi, Alireza Khosravi Farsani","doi":"10.32598/bcn.2023.4724.1","DOIUrl":"https://doi.org/10.32598/bcn.2023.4724.1","url":null,"abstract":"Introduction: Sudden unexpected death in epilepsy (SUDEP) is the substantial cause of death in patients with epilepsy (PWE). Electroconductive disorders leading to life-threatening arrhythmia are mostly hypothesized to play a crucial role; however, there is paucity of knowledge in variable among the patients with drug-resistant temporal lobe epilepsy (TLE) compared to the healthy controls. Methods: The current case-control study has been conducted on 50 drug-resistant TLE patients as the cases and 50 age- and gender-matched healthy subjects selected from their first-degree family members. ECGs were taken when admitted at the hospital (base line), immediately after a seizure incidence and within an hour after the end of the seizure from the cases compared with a random ECG of the controls considering parameters including PR-, RR-, and corrected QT interval (QTc), P wave duration and heart rate (HR) variability. Results: Shorter corrected QTc interval was notified among the drug-resistant TLE patients compared to the controls (P-value=0.017) in the base line taken ECGs, while the assessments immediately after the seizure revealed significant differences in terms of RR-interval (P-value=0.005) and heart rate (P-value=0.005). Post-ictal ECGs did not differ between the groups (P-value>0.05). Conclusion: According to the findings of this study, shortened QTc interval at base line ECGs, shortened RR interval and increased HR during the seizure were the ECG elements affected in drug-resistant TLE patients; however, to generalize the outcomes, further studies are required.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75660581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-12DOI: 10.32598/bcn.2022.4037.1
R. Mosaed, Arash Akhavan Rezayat, Behnaz Rohani, Aida Ayati Afin, F. Najmeddin, Shahideh Amini, Maryam Taghizadeh-Ghehi, Mohamad Afshar Ardalan, A. Najafi, M. Mojtahedzadeh
Introduction: Intracranial pressure (ICP) elevation leading to cerebral edema is a critical condition that should be identified and treated immediately. In this study, we systematically reviewed the articles investigating the role of hypertonic sodium lactate (HSL) in patients with traumatic brain injury. Method: PubMed, Scopus, EMBASE, and Web of Science were searched to find published articles on the effects of HSL on ICP in patients with a traumatic brain injury until December 2020. Animal studies, case reports, and studies, including liver and renal failure patients, cardiac dysfunction, or hypovolemic shock, were excluded. The Newcastle–Ottawa Scale checklist was used to assess the methodological quality of eligible articles. Information was gathered based on the following: Demographic data, methods, intervention, and outcomes. Results: Our initial search with the predefined search strategy proceeded 113 studies. Finally, seven studies were eligible for systematic review, which three of them were eligible for meta-analysis. A random meta-analysis of three articles comparing ICP before and after the infusion of HSL showed a reduced ICP following the use of HSL in traumatic brain injuries (P=0.015). Conclusion: Our study demonstrated hypertonic sodium lactate's undeniable role in managing increased ICP in patients with brain injury. Nevertheless, conducting more clinical studies for assessing the possible side effects of HSL seems crucial.
颅内压(ICP)升高导致脑水肿是一种危重疾病，应立即发现并治疗。在本研究中，我们系统地回顾了研究高渗乳酸钠(HSL)在创伤性脑损伤患者中的作用的文章。方法:检索PubMed、Scopus、EMBASE和Web of Science，查找截至2020年12月关于HSL对颅脑损伤患者ICP影响的已发表文章。排除了动物研究、病例报告和研究，包括肝肾衰竭患者、心功能障碍或低血容量性休克。使用纽卡斯尔-渥太华量表检查表评估符合条件的文章的方法学质量。收集的信息基于以下方面:人口统计数据、方法、干预措施和结果。结果:我们使用预定义的搜索策略进行了113项研究。最后，有7项研究符合系统评价的要求，其中3项符合荟萃分析的要求。对三篇比较HSL输注前后颅内压的随机荟萃分析显示，颅内压在颅脑外伤中使用HSL后降低(P=0.015)。结论:我们的研究证明了高渗乳酸钠在处理颅脑损伤患者颅内压增高中不可否认的作用。然而，进行更多的临床研究来评估HSL可能的副作用似乎至关重要。
{"title":"Effects of Hypertonic Sodium Lactate on Intracranial Pressure in Patients with Traumatic Brain Injury: A Systematic Review and Metanalysis on Clinical Trial Studies","authors":"R. Mosaed, Arash Akhavan Rezayat, Behnaz Rohani, Aida Ayati Afin, F. Najmeddin, Shahideh Amini, Maryam Taghizadeh-Ghehi, Mohamad Afshar Ardalan, A. Najafi, M. Mojtahedzadeh","doi":"10.32598/bcn.2022.4037.1","DOIUrl":"https://doi.org/10.32598/bcn.2022.4037.1","url":null,"abstract":"Introduction: Intracranial pressure (ICP) elevation leading to cerebral edema is a critical condition that should be identified and treated immediately. In this study, we systematically reviewed the articles investigating the role of hypertonic sodium lactate (HSL) in patients with traumatic brain injury. Method: PubMed, Scopus, EMBASE, and Web of Science were searched to find published articles on the effects of HSL on ICP in patients with a traumatic brain injury until December 2020. Animal studies, case reports, and studies, including liver and renal failure patients, cardiac dysfunction, or hypovolemic shock, were excluded. The Newcastle–Ottawa Scale checklist was used to assess the methodological quality of eligible articles. Information was gathered based on the following: Demographic data, methods, intervention, and outcomes. Results: Our initial search with the predefined search strategy proceeded 113 studies. Finally, seven studies were eligible for systematic review, which three of them were eligible for meta-analysis. A random meta-analysis of three articles comparing ICP before and after the infusion of HSL showed a reduced ICP following the use of HSL in traumatic brain injuries (P=0.015). Conclusion: Our study demonstrated hypertonic sodium lactate's undeniable role in managing increased ICP in patients with brain injury. Nevertheless, conducting more clinical studies for assessing the possible side effects of HSL seems crucial.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89763033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background:Dyslexia is a typical learning disability that does not affect intelligence but causes problems with reading, writing, and spelling. It is influenced by certain genes, due to which several researchers have attempted to identify the susceptible gene. Dyslexia is incurable and diagnosis is difficult because it always overlaps with other learning disabilities. Hence, timely assessment and intervention consequently give the best results. Therefore, our aim was to find the relation between dyslexia and single nucleotide polymorphisms (SNPs) in several candidate genes like DYX1C1, KIAA0319, and DCDC2 in Indian population. Methods:In the present study, 103 individuals with dyslexia and 100 controls in the age group between 6 to 15 years were taken. Thirteen SNPs in the KIAA gene, seven SNPs of DCDC2, and three SNPs of the DYX1C1 gene were analysed by the Mass Array technique. Results:The association of dyslexia with SNPs rs3756821, rs6935076, rs4576240 of the KIAA gene was found significant. A significant association was found with rs600753 of the DYX1C1 gene and dyslexia and we could not find any association of the DCDC2 gene with dyslexia. Conclusions:Prerequisite genetic analysis is necessary for the diagnosis of dyslexia as it is a crucial educational barrier. Treatment is known to be most effective if dyslexia is identified in the early stages for effective intervention for children before they experience prolonged reading failure. Further, it helps in prenatal diagnosis for early intervention.
{"title":"Study of KIAA0319, DYXIC1 and DCDC2 Gene Polymorphisms in Children with Dyslexia in Indian Population","authors":"Shilpa Reddy Ganasyam, Manaswini Namilakonda, Sujatha Madireddy, V. Ananthapur, Srinadh Buragadda, Sunitha Tella","doi":"10.32598/bcn.2022.3258.1","DOIUrl":"https://doi.org/10.32598/bcn.2022.3258.1","url":null,"abstract":"Background:Dyslexia is a typical learning disability that does not affect intelligence but causes problems with reading, writing, and spelling. It is influenced by certain genes, due to which several researchers have attempted to identify the susceptible gene. Dyslexia is incurable and diagnosis is difficult because it always overlaps with other learning disabilities. Hence, timely assessment and intervention consequently give the best results. Therefore, our aim was to find the relation between dyslexia and single nucleotide polymorphisms (SNPs) in several candidate genes like DYX1C1, KIAA0319, and DCDC2 in Indian population. Methods:In the present study, 103 individuals with dyslexia and 100 controls in the age group between 6 to 15 years were taken. Thirteen SNPs in the KIAA gene, seven SNPs of DCDC2, and three SNPs of the DYX1C1 gene were analysed by the Mass Array technique. Results:The association of dyslexia with SNPs rs3756821, rs6935076, rs4576240 of the KIAA gene was found significant. A significant association was found with rs600753 of the DYX1C1 gene and dyslexia and we could not find any association of the DCDC2 gene with dyslexia. Conclusions:Prerequisite genetic analysis is necessary for the diagnosis of dyslexia as it is a crucial educational barrier. Treatment is known to be most effective if dyslexia is identified in the early stages for effective intervention for children before they experience prolonged reading failure. Further, it helps in prenatal diagnosis for early intervention.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81817417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-07DOI: 10.32598/bcn.2022.3683.2
M. Ashtiyani, Parmida Moradi Birgani, M. Soleimani, Seyed Behnamedin Jameie, A. Shahrokhi, Mohammad Reze Deevband, Mohammad Mehdi Mirbagheri
Introduction: Cerebral Palsy (CP) is one of the most common causes of motor disability in childhood. Since CP is a corollary to brain damage, persistent treatment should accompany an alteration in brain functional activity in line with clinical improvements. Methods: Fourteen children with spastic hemiplegia CP were randomly divided into 2 groups. The study group (8yrs-5mos) underwent 45min AlterG training sessions 3 times/week for 8 weeks, while the control group (8yrs-2mos) received the same amount of occupational therapy (OT). Functional magnetic resonance imaging (fMRI) was conducted to quantify brain activation during the performance of passive tasks including ankle plantarflexion to dorsiflexion and knee flexion to extension over the range of motion. Walking capacity was assessed using the Timed-Up-and-Go, 10-meter, and 6-minute walk tests. All evaluations were performed before and after training and compared between the two groups. Results: We were able to detect the signatures of ankle and knee passive movement tasks in the fMRI and characterize them in terms of activated voxels. The pre-post activation changes following the completion of training course showed that the elicited motor cortex activation was greater for the ankle than the knee tasks. For the ankle, primary motor cortex, precentral gyrus and corpus callosum showed significant enhancement in most study participants. The results indicated 16.1% more active voxels in the study than control groups. Similarly, clinical outcome measures improved over twice as much in this group. Conclusions: AlterG training could be a potentially effective therapeutic intervention for improving gait and balance impairments in children with CP.
脑瘫(CP)是儿童运动障碍最常见的原因之一。由于CP是脑损伤的必然结果，持续治疗应伴随脑功能活动的改变，以符合临床改善。方法:将14例痉挛性偏瘫患儿随机分为两组。研究组(8岁-5岁)接受45分钟的AlterG训练，每周3次，持续8周，而对照组(8岁-2岁)接受相同量的职业治疗(OT)。功能磁共振成像(fMRI)用于量化被动任务执行过程中的大脑激活，包括踝关节跖屈到背屈和膝关节屈曲到运动范围内的延伸。步行能力通过time - up -and- go、10米和6分钟步行测试进行评估。在训练前后进行各项评估，并进行两组间比较。结果:我们能够在fMRI中检测到踝关节和膝关节被动运动任务的特征，并根据激活体素对其进行表征。训练课程完成后的前后激活变化表明，踝关节的运动皮层激活比膝关节的运动皮层激活更大。对于脚踝，初级运动皮层、中央前回和胼胝体在大多数研究参与者中显示出显著的增强。结果显示，研究中的活跃体素比对照组多16.1%。同样，临床结果测量在这一组改善了两倍多。结论:交替训练可能是一种潜在有效的治疗干预措施，可改善CP患儿的步态和平衡障碍。
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Pub Date : 2022-02-06DOI: 10.32598/bcn.2022.2559.1
R. Jain, Rahul Raghav, M. Waseem, A. Jabin, Sonali Jhanjee
This study evaluates the effects of hydro-alcoholic root extract of Delphinium denudatum Wall (Jadwar, family; Ranunculaceae) for its ability to attenuate the nicotine-withdrawal in nicotine-dependent rats. The physical dependence on nicotine was induced in male adult Wistar albino rats (175-250 g) by subcutaneous implantation of Alzet mini osmotic pumps which supplied nicotine at 9.0mg/kg/day, while control rats received saline via osmotic pumps. For seven days four separate test doses of hydro-alcoholic root extract of Delphinium denudatum Wall (200, 400, 800, 1600 mg/kg) were given orally. On the 7th day, a mecamylamine injection (1 mg/kg, s.c.) was given to precipitate nicotine-withdrawal. The global Gellert’s–Holtzman rating scale was used to rate somatic signs of withdrawal for 15 minutes, followed by a measurement of motor activity. Drug Bupropion was used as a positive control. Serum levels of nicotine (cotinine) and corticosterone were done by ELISA. In nicotine-dependent rats, oral administration of Delphinium denudatum Wall root extract suppressed the hyper-locomotion and decreased the corticosterone levels at all dosages. Higher doses (800 and 1600 mg/kg) of extract, significantly attenuated nicotine withdrawal whereas, lower doses (200 and 400 mg/kg) had no significant effect. These results suggest that hydro-alcoholic root extract of Delphinium denudatum Wall may prove to be a potential therapeutic agent to attenuate nicotine dependence and facilitate tobacco smoking cessation.
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