Pub Date : 2022-05-06DOI: 10.37191/mapsci-2582-4937-4(1)-024
D. S. Rashid
Human papilloma virus (HPV) infection is one of the major causes of cervical cancer which is one of the common causes of death in women across the globe and is the fourth most prevalent cancer in women representing 7.5% of female cancer deaths globally and more than 85% of these occur in underdeveloped regions. In India, cervical cancer is responsible for the highest cancer deaths among women which can be attributed to multiple pregnancies, open relationships, inadequate sanitation and cleanliness, behavioral habit and lifestyle, smoking, poor nutrition, and long-term contraceptive use. These factors have been associated as risk factors for cervical cancer. This review discusses issues faced by women in tribal and rural areas of India due to poor economic conditions, different lifestyles to mainstream population, sociocultural behavior and lack of access to healthcare facilities. The review also focusses on the tribal populations of the world and the prevalence rates in these tribal groups. The current initiatives taken by government and non-government organizations (NGOs) to prevent and control the HPV infection and reduce the cervical cancer burden have also been highlighted. The review emphasizes the urgent need for preferential care for women in rural and tribal communities of the world.
{"title":"Human Papillomavirus (Hpv) Infection In Rural And Tribal Populations Of The World With A Special Focus On The Prevalence In India","authors":"D. S. Rashid","doi":"10.37191/mapsci-2582-4937-4(1)-024","DOIUrl":"https://doi.org/10.37191/mapsci-2582-4937-4(1)-024","url":null,"abstract":"Human papilloma virus (HPV) infection is one of the major causes of cervical cancer which is one of the common causes of death in women across the globe and is the fourth most prevalent cancer in women representing 7.5% of female cancer deaths globally and more than 85% of these occur in underdeveloped regions. In India, cervical cancer is responsible for the highest cancer deaths among women which can be attributed to multiple pregnancies, open relationships, inadequate sanitation and cleanliness, behavioral habit and lifestyle, smoking, poor nutrition, and long-term contraceptive use. These factors have been associated as risk factors for cervical cancer. This review discusses issues faced by women in tribal and rural areas of India due to poor economic conditions, different lifestyles to mainstream population, sociocultural behavior and lack of access to healthcare facilities. The review also focusses on the tribal populations of the world and the prevalence rates in these tribal groups. The current initiatives taken by government and non-government organizations (NGOs) to prevent and control the HPV infection and reduce the cervical cancer burden have also been highlighted. The review emphasizes the urgent need for preferential care for women in rural and tribal communities of the world.","PeriodicalId":87293,"journal":{"name":"Journal of biomedical and allied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43931810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.37191/mapsci-2582-4937-4(1)-023
E. D. Barç
Introduction: Epidemics are infectious diseases. Pandemic is defined as epidemic diseases that spread to many continents and cause fatal cases on humans and animals. Although most infectious diseases can be transmitted to humans or animals in one or more ways, the priority in the fight against Covid-19 is to avoid contact and contamination routes, to protect the areas of the body that are open to contamination, and to effectively disinfect. The quarantine environment, which is taken as a precautionary measure to protect against Covid-19, affects human psychology and leads to the emergence of some situations. It is aimed to examine the relationship between the depression and anxiety levels seen in university students and the measures taken with the Covid-19 pandemic, taking into account the demographic variables. Materials and Methods: It was conducted as a descriptive study at a foundation university in Ankara between July-December 2020. “Sociodemographic Data Collection Form”, “Covid-19 Isolation Process Examining Questionnaire” and “Hospital Anxiety and Depression Scale” were used to collect data. Due to the Covid-19 street restrictions and to reduce contact, data were collected by using "Google Forms" and sharing links to students via mail and WhatsApp groups. Data analysis was done using SPSS 25.0 package program, p<0.05 was considered significant. Results: In the results of the study, it was observed that the anxiety levels of the students were 15.45 ± 4.50, and the depression levels were 10.85 ± 3.06. The level of being affected by Covid-19 was found to be 68.43 ± 11.91. It was determined that there was a weak and negative significant relationship between the level of being affected by Covid-19 and anxiety levels (p=0.01). It was determined that there was a weak and negative significant relationship between the students' level of being affected by Covid-19 and their depression levels (p=0.01). Conclusion: It can be stated that students who are less affected by Covid-19 will have higher levels of anxiety and depression. Due to the uncertainty when the Covid-19 pandemic first emerged, it was thought that there was a weak negative significant relationship between Covid-19 and anxiety and depression levels. It is recommended that the study be conducted with more students in similar sample groups.
{"title":"The Effects Of The Covid-19 Pandemic And Covid-19 Measures On University Students Related To Levels Of Anxiety And Depression","authors":"E. D. Barç","doi":"10.37191/mapsci-2582-4937-4(1)-023","DOIUrl":"https://doi.org/10.37191/mapsci-2582-4937-4(1)-023","url":null,"abstract":"Introduction: Epidemics are infectious diseases. Pandemic is defined as epidemic diseases that spread to many continents and cause fatal cases on humans and animals. Although most infectious diseases can be transmitted to humans or animals in one or more ways, the priority in the fight against Covid-19 is to avoid contact and contamination routes, to protect the areas of the body that are open to contamination, and to effectively disinfect. The quarantine environment, which is taken as a precautionary measure to protect against Covid-19, affects human psychology and leads to the emergence of some situations. It is aimed to examine the relationship between the depression and anxiety levels seen in university students and the measures taken with the Covid-19 pandemic, taking into account the demographic variables.\u0000\u0000Materials and Methods: It was conducted as a descriptive study at a foundation university in Ankara between July-December 2020. “Sociodemographic Data Collection Form”, “Covid-19 Isolation Process Examining Questionnaire” and “Hospital Anxiety and Depression Scale” were used to collect data. Due to the Covid-19 street restrictions and to reduce contact, data were collected by using \"Google Forms\" and sharing links to students via mail and WhatsApp groups. Data analysis was done using SPSS 25.0 package program, p<0.05 was considered significant.\u0000\u0000Results: In the results of the study, it was observed that the anxiety levels of the students were 15.45 ± 4.50, and the depression levels were 10.85 ± 3.06. The level of being affected by Covid-19 was found to be 68.43 ± 11.91. It was determined that there was a weak and negative significant relationship between the level of being affected by Covid-19 and anxiety levels (p=0.01). It was determined that there was a weak and negative significant relationship between the students' level of being affected by Covid-19 and their depression levels (p=0.01).\u0000\u0000Conclusion: It can be stated that students who are less affected by Covid-19 will have higher levels of anxiety and depression. Due to the uncertainty when the Covid-19 pandemic first emerged, it was thought that there was a weak negative significant relationship between Covid-19 and anxiety and depression levels. It is recommended that the study be conducted with more students in similar sample groups.","PeriodicalId":87293,"journal":{"name":"Journal of biomedical and allied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44182091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-14DOI: 10.37191/mapsci-2582-4937-2(2)-020
Jose Leonel Almonte-Saviñón
Aerobic granular sludge (granules) is an innovative wastewater treatment, where dense biomass is in granular form. The problem of applying this technology at full scale is the granulation process time, which takes several months. In this paper, in an attempt to quicken this process, a biofilm was tested using several candidates as biodegradable support (BDS) for granulation. In this study, it was found that not only the granulation process was accelerated using sesame seeds as BDS (10, 15 and 21 days, compared to 2 months proposed by other studies), but also a new phenomenon was observed where new granules were generated from mature granules, enhancing the granulation process. This paper offers an enhanced option for granulation process.
{"title":"Developing Aerobic Granular Sludge With Sesame Like Biodegradable Support","authors":"Jose Leonel Almonte-Saviñón","doi":"10.37191/mapsci-2582-4937-2(2)-020","DOIUrl":"https://doi.org/10.37191/mapsci-2582-4937-2(2)-020","url":null,"abstract":"Aerobic granular sludge (granules) is an innovative wastewater treatment, where dense biomass is in granular form. The problem of applying this technology at full scale is the granulation process time, which takes several months. In this paper, in an attempt to quicken this process, a biofilm was tested using several candidates as biodegradable support (BDS) for granulation. In this study, it was found that not only the granulation process was accelerated using sesame seeds as BDS (10, 15 and 21 days, compared to 2 months proposed by other studies), but also a new phenomenon was observed where new granules were generated from mature granules, enhancing the granulation process. This paper offers an enhanced option for granulation process.","PeriodicalId":87293,"journal":{"name":"Journal of biomedical and allied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43853391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-08DOI: 10.37191/mapsci-2582-4937-2(2)-019
R. P. Saxena
Aim of study to assess the knowledge and practices regarding prevention of pre-eclampsia among antenatal mothers. The objectives of study to assess the knowledge regarding prevention of pre-eclampsia, to assess the practices regarding prevention of pre-eclampsia, to find out co-relation between knowledge and practice regarding prevention of pre-eclampsia, to find out the relationship of knowledge score and practices with selected demographic variables and to develop information booklets on prevention of pre-eclampsia by selecting a sample of 100 antenatal mothers by simple random sampling technique. Maximum number 67 (67%) antenatal mothers had average knowledge followed by 24 (24%) antenatal mothers had below average knowledge and minimum number 9 (9%) antenatal mothers had good knowledge regarding prevention of preeclampsia. Maximum number 93 (93%) antenatal mothers had satisfactory practice and minimum number 7 (7%) antenatal mothers had unsatisfactory practice regarding prevention of preeclampsia. There was fair co-relation between knowledge and practices of antenatal mothers regarding pre-eclampsia
{"title":"A Descriptive Study To Assess The Knowledge And Practices Regarding Prevention Of Pre-eclampsia Among Antenatal Mothers In Selected Hospitals Of Moga, Punjab","authors":"R. P. Saxena","doi":"10.37191/mapsci-2582-4937-2(2)-019","DOIUrl":"https://doi.org/10.37191/mapsci-2582-4937-2(2)-019","url":null,"abstract":"Aim of study to assess the knowledge and practices regarding prevention of pre-eclampsia among antenatal mothers. The objectives of study to assess the knowledge regarding prevention of pre-eclampsia, to assess the practices regarding prevention of pre-eclampsia, to find out co-relation between knowledge and practice regarding prevention of pre-eclampsia, to find out the relationship of knowledge score and practices with selected demographic variables and to develop information booklets on prevention of pre-eclampsia by selecting a sample of 100 antenatal mothers by simple random sampling technique. Maximum number 67 (67%) antenatal mothers had average knowledge followed by 24 (24%) antenatal mothers had below average knowledge and minimum number 9 (9%) antenatal mothers had good knowledge regarding prevention of preeclampsia. Maximum number 93 (93%) antenatal mothers had satisfactory practice and minimum number 7 (7%) antenatal mothers had unsatisfactory practice regarding prevention of preeclampsia. There was fair co-relation between knowledge and practices of antenatal mothers regarding pre-eclampsia","PeriodicalId":87293,"journal":{"name":"Journal of biomedical and allied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45567095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-08DOI: 10.37191/mapsci-2582-4937-2(2)-022
F. Shireen
Probiotics are important to guarantee the food production of many people all over the world, particularly those who are oppressed and highly susceptible. Some of this will be enhanced by increasing the number of natural resources that can be used to make consumable food products and minimizing generally pro components to generate food that is safe to eat and rich in nutrients. Lactobacillus, a carboxylic acid bacterium, was isolated primarily from decaying vegetables, fruits, and room trash. Genus Lactobacillus belong cluster of carboxylic bacterium that is represented as a gaggle of heterogeneous, regular non-spore-forming, gram-positive rods that have numerous habitats like plants and duct tracts and throughout the surroundings. Lactobacilli strains, often known as probiotics, are beneficial bacteria that improve digestion, combat disease, and promote digestion in humans and animals. Some species like true bacteria Plantarum, true bacteria casei, and true bacteria bulgaricus are typically isolated from farm. A natural protection exists in a number of fruits. Organic acids in fruits are sufficient to generate a pH of four or lower on the pH scale. The most essential determinant in defining the dominant microflora in fruits is the pH scale, and consequently the type of acid. A pH scale cannot support the growth of food-borne bacteria that are harmful to human health. The carboxylic acid bacterium performs a critical role in protecting the host against hazardous pathogens while also strengthening the system. Carboxylic acid bacteria are great sources of probiotics with potential qualities that, when administered in sufficient levels, can benefit the host's health.
{"title":"Antibacterial Approach Of Lactobacillus Species Isolated From Exterior Of Fruits","authors":"F. Shireen","doi":"10.37191/mapsci-2582-4937-2(2)-022","DOIUrl":"https://doi.org/10.37191/mapsci-2582-4937-2(2)-022","url":null,"abstract":"Probiotics are important to guarantee the food production of many people all over the world, particularly those who are oppressed and highly susceptible. Some of this will be enhanced by increasing the number of natural resources that can be used to make consumable food products and minimizing generally pro components to generate food that is safe to eat and rich in nutrients. Lactobacillus, a carboxylic acid bacterium, was isolated primarily from decaying vegetables, fruits, and room trash. Genus Lactobacillus belong cluster of carboxylic bacterium that is represented as a gaggle of heterogeneous, regular non-spore-forming, gram-positive rods that have numerous habitats like plants and duct tracts and throughout the surroundings. Lactobacilli strains, often known as probiotics, are beneficial bacteria that improve digestion, combat disease, and promote digestion in humans and animals. Some species like true bacteria Plantarum, true bacteria casei, and true bacteria bulgaricus are typically isolated from farm. A natural protection exists in a number of fruits. Organic acids in fruits are sufficient to generate a pH of four or lower on the pH scale. The most essential determinant in defining the dominant microflora in fruits is the pH scale, and consequently the type of acid. A pH scale cannot support the growth of food-borne bacteria that are harmful to human health. The carboxylic acid bacterium performs a critical role in protecting the host against hazardous pathogens while also strengthening the system. Carboxylic acid bacteria are great sources of probiotics with potential qualities that, when administered in sufficient levels, can benefit the host's health.","PeriodicalId":87293,"journal":{"name":"Journal of biomedical and allied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46879946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-09DOI: 10.37191/mapsci-2582-4937-2(2)-021
Blossom Samuel Affia
Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), front temporal dementia (FTD) and Huntington’s disease (HD show some clinical, morbid and molecular overlapping [1]. PD is one of the most common neurodegenerative disorders. Dopaminergic neurons in the substantia nigra pars compacta degenerate and die, which forms the basis of the disease [2]. As the disease intensifies with the passage of time, many people develop dementia, and other mental abilities in later stages [3]. Loss of dopaminergic neurons causes prominent and projecting symptoms like involuntary tremor, rigidity, postural instability, gait, speech problems and akinesia [4]. One accepted and efficient convention for generating dopaminergic neurons in vitro is the combination of several pharmacological compounds and molecules. A broad general evaluation of neurodegeneration is discussed in this article.
{"title":"Neurodegeneration- Disease And Dementia","authors":"Blossom Samuel Affia","doi":"10.37191/mapsci-2582-4937-2(2)-021","DOIUrl":"https://doi.org/10.37191/mapsci-2582-4937-2(2)-021","url":null,"abstract":"Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), front temporal dementia (FTD) and Huntington’s disease (HD show some clinical, morbid and molecular overlapping [1]. PD is one of the most common neurodegenerative disorders. Dopaminergic neurons in the substantia nigra pars compacta degenerate and die, which forms the basis of the disease [2]. As the disease intensifies with the passage of time, many people develop dementia, and other mental abilities in later stages [3]. Loss of dopaminergic neurons causes prominent and projecting symptoms like involuntary tremor, rigidity, postural instability, gait, speech problems and akinesia [4]. One accepted and efficient convention for generating dopaminergic neurons in vitro is the combination of several pharmacological compounds and molecules. A broad general evaluation of neurodegeneration is discussed in this article.","PeriodicalId":87293,"journal":{"name":"Journal of biomedical and allied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42953067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-07DOI: 10.37191/mapsci-2582-4937-2(2)-018
Jaspal Kaur Oberoi
Medical ethics has been followed in most nations for decades. But during COVID 19 pandemic situation, again every nation has to deal with the ethics related to categorizing patients and health care distribution while maintaining community health. To solve the dilemma of consequentialist and non-consequentialist theories, the major focus was driven on community health. But while looking at the rate of infected, cured, and death, it’s an alarming sign to India to strengthen the medical resources and follow the common good approach. Every Indian citizen has the right to get proper treatment and funerals after death. Considering the problem associated with the spreading of the virus through dead bodies, cremation was done by medical staff. Due to the limited availability of medical staff and lack of an electric furnace, many dead bodies were cremated after a long time. Due to inadequate medical professionals and technical constraints, the infectivity rate is increasing which is affecting the economy, mental strength, and social values. Hence, now we have to start thinking and working on strengthening hospitals, diagnostic labs, and sophisticated cremation centers to avoid negligence and to follow ethics.
{"title":"Coronavirus and Medical Ethics","authors":"Jaspal Kaur Oberoi","doi":"10.37191/mapsci-2582-4937-2(2)-018","DOIUrl":"https://doi.org/10.37191/mapsci-2582-4937-2(2)-018","url":null,"abstract":"Medical ethics has been followed in most nations for decades. But during COVID 19 pandemic situation, again every nation has to deal with the ethics related to categorizing patients and health care distribution while maintaining community health. To solve the dilemma of consequentialist and non-consequentialist theories, the major focus was driven on community health. But while looking at the rate of infected, cured, and death, it’s an alarming sign to India to strengthen the medical resources and follow the common good approach. Every Indian citizen has the right to get proper treatment and funerals after death. Considering the problem associated with the spreading of the virus through dead bodies, cremation was done by medical staff. Due to the limited availability of medical staff and lack of an electric furnace, many dead bodies were cremated after a long time. Due to inadequate medical professionals and technical constraints, the infectivity rate is increasing which is affecting the economy, mental strength, and social values. Hence, now we have to start thinking and working on strengthening hospitals, diagnostic labs, and sophisticated cremation centers to avoid negligence and to follow ethics.","PeriodicalId":87293,"journal":{"name":"Journal of biomedical and allied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47637255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37191/MAPSCI-2582-4937-2(2)-017
Yunusa Hassan
Emerged from the Chinese city of Wuhan, Coronavirus Disease 2019 (COVID-19) becomes the novel scenario to the face of the Earth where people must learn to live with. This paper reviewed some indispensable environmental management issues during the post-COVID-19 pandemic in Africa with specific reference to hospital waste management in Nigeria. Though not exhaustible, the study assesses how hospital waste and other environmental priorities will adversely help the restraining of the COVID-19 pandemic. In most West African communities where financial and technological challenges are evident, the management of these essential environmental issues requires a coordinated and prompt response from various authorities. Moreover, the provision of sufficient funding is central to every aspect of hospital waste management, therefore, this study suggests the need for thorough informative awareness programs as a panacea since the success of managing these key environmental issues is directly connected to the containment of this pandemic to a minimal level.
{"title":"Restraining COVID-19: Management of Hospital Waste in Post Pandemic Setting in West Africa","authors":"Yunusa Hassan","doi":"10.37191/MAPSCI-2582-4937-2(2)-017","DOIUrl":"https://doi.org/10.37191/MAPSCI-2582-4937-2(2)-017","url":null,"abstract":"Emerged from the Chinese city of Wuhan, Coronavirus Disease 2019 (COVID-19) becomes the novel scenario to the face of the Earth where people must learn to live with. This paper reviewed some indispensable environmental management issues during the post-COVID-19 pandemic in Africa with specific reference to hospital waste management in Nigeria. Though not exhaustible, the study assesses how hospital waste and other environmental priorities will adversely help the restraining of the COVID-19 pandemic. In most West African communities where financial and technological challenges are evident, the management of these essential environmental issues requires a coordinated and prompt response from various authorities. Moreover, the provision of sufficient funding is central to every aspect of hospital waste management, therefore, this study suggests the need for thorough informative awareness programs as a panacea since the success of managing these key environmental issues is directly connected to the containment of this pandemic to a minimal level.","PeriodicalId":87293,"journal":{"name":"Journal of biomedical and allied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47274333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-01Epub Date: 2020-03-16DOI: 10.37191/mapsci-2582-4937-2(1)-013
Mujib Ullah
Stem cells are currently being used in many clinical trials for regenerative purposes. These are promising results for stem cells in the treatment of several diseases, including cancer. Nevertheless, there are still many variables which should be addressed before the application of stem cells for cancer treatment. One approach should be to establish well-characterized therapeutic stem cell banks to minimize the variation in results from different clinical trials and facilitate their effective use in basic and translational research.
{"title":"Need for Specialized Therapeutic Stem Cells Banks Equipped with Tumor Regression Enzymes and Anti-Tumor Genes.","authors":"Mujib Ullah","doi":"10.37191/mapsci-2582-4937-2(1)-013","DOIUrl":"https://doi.org/10.37191/mapsci-2582-4937-2(1)-013","url":null,"abstract":"<p><p>Stem cells are currently being used in many clinical trials for regenerative purposes. These are promising results for stem cells in the treatment of several diseases, including cancer. Nevertheless, there are still many variables which should be addressed before the application of stem cells for cancer treatment. One approach should be to establish well-characterized therapeutic stem cell banks to minimize the variation in results from different clinical trials and facilitate their effective use in basic and translational research.</p>","PeriodicalId":87293,"journal":{"name":"Journal of biomedical and allied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/76/94/nihms-1640885.PMC7861576.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25342798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-14DOI: 10.37191/mapsci-2582-4937-1(2)-009
Leonardo Hernández-Hernández
The influence of Ca2+ and other divalent cations on contractile responses of slow skeletal muscle fibers of the frog (Rana pipiens) under conditions of chronic denervation was investigated.Isometric tension was recorded from slow bundles of normal and denervated cruralis muscle in normal solution and in solutions with free calcium concentration solution or in solutions where other divalent cations (Sr2+, Ni2+, Co2+ or Mn2+) substituted for calcium. In the second week after nerve section, in Ca2+-free solutions, we observed that contractures (evoked from 40 to 80 mM-K+) of non-denervated muscles showed significantly higher tensions (p<0.05), than those from denervated bundles. Likewise, in solutions where calcium was substituted by all divalent cations tested, with exception of Mn2+, the denervated bundles displayed lower tension than non-denervated, also in the second week of denervation. In this case, the Ca2+ substitution by Sr2+ caused the higher decrease in tension, followed by Co2+ and Ni2+, which were different to non-denervated bundles, as the lowest tension was developed by Mn2+, followed by Co2+, and then Ni2+ and Sr2+. After the third week, we observed a recovery in tension. These results suggest that denervation altering the binding capacity to divalent cations of the voltage sensor.
{"title":"Effect of External Calcium and other Divalent Cations on K+ Contractures in Denervated Slow Skeletal Muscle Fibers of the Frog","authors":"Leonardo Hernández-Hernández","doi":"10.37191/mapsci-2582-4937-1(2)-009","DOIUrl":"https://doi.org/10.37191/mapsci-2582-4937-1(2)-009","url":null,"abstract":"The influence of Ca2+ and other divalent cations on contractile responses of slow skeletal muscle fibers of the frog (Rana pipiens) under conditions of chronic denervation was investigated.Isometric tension was recorded from slow bundles of normal and denervated cruralis muscle in normal solution and in solutions with free calcium concentration solution or in solutions where other divalent cations (Sr2+, Ni2+, Co2+ or Mn2+) substituted for calcium. In the second week after nerve section, in Ca2+-free solutions, we observed that contractures (evoked from 40 to 80 mM-K+) of non-denervated muscles showed significantly higher tensions (p<0.05), than those from denervated bundles. Likewise, in solutions where calcium was substituted by all divalent cations tested, with exception of Mn2+, the denervated bundles displayed lower tension than non-denervated, also in the second week of denervation. In this case, the Ca2+ substitution by Sr2+ caused the higher decrease in tension, followed by Co2+ and Ni2+, which were different to non-denervated bundles, as the lowest tension was developed by Mn2+, followed by Co2+, and then Ni2+ and Sr2+. After the third week, we observed a recovery in tension. These results suggest that denervation altering the binding capacity to divalent cations of the voltage sensor.","PeriodicalId":87293,"journal":{"name":"Journal of biomedical and allied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43749572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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