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April 2021 Critical Care Case of the Month: Abnormal Acid-Base Balance in a Post-Partum Woman 2021年4月本月重症监护病例:产后妇女酸碱平衡异常
Pub Date : 2021-04-01 DOI: 10.13175/SWJPCC007-21
Mohammad T. Mahmoud
No abstract available. Article truncated after first page. History of Present Illness: A 29-year-old healthy woman, who is 8 weeks postpartum, presented to the emergency department with severe shortness of breath, fast shallow breathing, nausea, several episodes of nonbloody nonbilious emesis, abdominal pain and malaise for 1 week. The patient delivered a healthy boy at full-term by spontaneous vaginal delivery. Her pregnancy was uneventful. She denied smoking or use of alcohol. Physical Exam: On presentation to the emergency department her blood pressure was found to be 121/71, temperature 36.8°C, pulse 110 beats per minute, respiratory rate 20 breaths per minute and SpO2 saturation of 99% while breathing ambient air. Physical exam was remarkable except for dry mucous membranes, sinus tachycardia, and tachypnea with mild epigastric tenderness with light palpation. Which of the following should be done? 1. Complete blood count (CBC) 2. Metabolic panel 3. Chest x-ray 4. Arterial blood gases (ABGs) 5. All of the above …
没有可用的摘要。文章在第一页后被截断。现有疾病史:一名29岁的健康女性,产后8周,因严重呼吸急促、浅呼吸快、恶心、几次非血液性非胆汁性呕吐、腹痛和不适症状到急诊科就诊1周。患者在足月时通过自然阴道分娩产下一名健康男孩。她的怀孕平安无事。她否认吸烟或饮酒。体检:在急诊科就诊时,发现她的血压为121/71,温度为36.8°C,脉搏每分钟110次,呼吸频率为每分钟20次,呼吸环境空气时血氧饱和度为99%。体格检查除粘膜干燥、窦性心动过速、呼吸急促伴轻度上腹部压痛伴轻度触诊外,其余均显著。应执行以下哪项操作?1.全血细胞计数(CBC)2。代谢小组3。胸部x光片4。动脉血气(ABG)5。以上所有…
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引用次数: 0
Medical Image of the Month: Pulmonary Aspergillus Overlap Syndrome Presenting with ABPA, Multiple Bilateral Aspergillomas 本月医学影像:肺曲霉菌重叠综合征伴ABPA,多发性双侧曲霉菌瘤
Pub Date : 2021-03-02 DOI: 10.13175/SWJPCC002-21
Bharath Janapati, Anil Jain, Priya G. Sharma
No abstract available. Article truncated after 150 words. Introduction. Aspergillus is a ubiquitous fungal organism that causes a variety of pulmonary manifestations, both in immune-competent and immune-compromised patients. It can vary from simple colonization, Aspergilloma, ABPA to Chronic Pulmonary Aspergillosis (CPA) and Invasive Pulmonary Aspergillosis (IPA) (1). ABPA is the most frequently recognized manifestation of allergic aspergillosis, caused by the immunological reactions mounted against Asp. fumigatus. Aspergillomas are rounded conglomerates of fungal hyphae, fibrin, mucus and cellular debris that arise in pulmonary cavities, as a late manifestation of CPA. Chronic pulmonary aspergillosis (CPA) is a long-term aspergillus infection of the lung. The most common form of CPA is chronic cavitary pulmonary aspergillosis (CCPA), which untreated may progress to chronic fibrosing pulmonary aspergillosis. Aspergillus overlap syndrome is defined as the occurrence of more than one form of aspergillus disease (e.g., ABPA with Aspergilloma, ABPA progressing to IPA etc.) in a single individual. Case Report. A 58-year-old woman, resident of …
没有可用的摘要。文章在150字后被截断。介绍曲霉菌是一种普遍存在的真菌,在免疫能力强和免疫受损的患者中都会引起各种肺部表现。它可以从简单定植、曲霉菌瘤、ABPA到慢性肺曲霉菌病(CPA)和侵袭性肺曲霉菌症(IPA)(1)。ABPA是过敏性曲霉菌病最常见的表现,由对Asp的免疫反应引起。烟曲霉。Aspergillomas是由真菌菌丝、纤维蛋白、粘液和细胞碎片组成的圆形聚集体,出现在肺部,是CPA的晚期表现。慢性肺曲霉菌病(CPA)是一种长期肺部曲霉菌感染。CPA最常见的形式是慢性空洞性肺曲霉菌病(CCPA),未经治疗可能发展为慢性纤维化肺曲霉病。曲霉菌重叠综合征被定义为在单个个体中发生一种以上形式的曲霉菌疾病(例如,伴有曲霉菌瘤的ABPA、进展为IPA的ABPA等)。病例报告。一个58岁的女人,住在…
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引用次数: 0
March 2021 Pulmonary Case of the Month: Transfer for ECMO Evaluation 2021年3月当月肺部病例:转为ECMO评估
Pub Date : 2021-03-01 DOI: 10.13175/SWJPCC069-20
N. Blackstone, April Olson, A. Gibbs, B. Natt, J. Campion
A 31-year-old male fire fighter with a history of recurrent “atypical pneumonia,” environmental and drug allergies, nasal polyps, asthma, and Crohn's disease (not on immunosuppressants) was transferred from an outside hospital for management of acute hypoxic respiratory failure with peripheral eosinophilia. Prior to admission he reported a 2-week history of worsening dyspnea, productive cough and wheezing, prompting an urgent care visit where he was prescribed amoxicillin-clavulanate for suspected community acquired pneumonia. Despite multiple days on this medication, his symptoms significantly worsened until he was unable to lie flat without coughing or wheezing. He was ultimately admitted to an outside hospital where his labs were notable for a leukocytosis to 22,000 and peripheral eosinophilia with an absolute eosinophil count of 9700 cells/microL. His blood cultures and urine cultures were negative, and a radiograph of the chest demonstrated bilateral nodular infiltrates. With these imaging findings combined with the peripheral eosinophilia there was a concern for Coccidioidomycosis infection and he was subsequentially started on empirical fluconazole in addition to ceftriaxone and azithromycin. Bronchoalveolar lavage (BAL) was performed revealing 80% eosinophils, 14% polymorphic nuclear cells (PMNs), 4% monocytes and 2% lymphocytes, no pathogens were identified. The patient’s clinical status continued to decline despite antimicrobial therapy, and he was intubated for refractory hypoxia. At this point, the patient was transferred to our hospital for further care.
一名31岁的男性消防队员,有反复发作的“非典型肺炎”、环境和药物过敏、鼻息肉、哮喘和克罗恩病病史(不使用免疫抑制剂),被从外部医院转移,用于治疗伴有外周嗜酸性粒细胞增多的急性缺氧性呼吸衰竭。入院前,他报告有2周的呼吸困难、生产性咳嗽和喘息恶化史,促使他进行了紧急护理,为他开了阿莫西林-克拉维酸盐治疗疑似社区获得性肺炎。尽管服用了多日这种药物,但他的症状明显恶化,直到他无法平躺而不咳嗽或喘息。他最终住进了一家外部医院,在那里,他的实验室以白细胞增多至22000和外周嗜酸性粒细胞增多而闻名,嗜酸性细胞绝对计数为9700个细胞/微升。他的血液和尿液培养均为阴性,胸部X线片显示双侧结节性浸润。这些影像学检查结果与外周嗜酸性粒细胞增多症相结合,有人担心球虫病感染,随后他开始服用经验性氟康唑以及头孢曲松和阿奇霉素。支气管肺泡灌洗(BAL)显示80%的嗜酸性粒细胞、14%的多态性核细胞、4%的单核细胞和2%的淋巴细胞,未发现病原体。尽管进行了抗菌治疗,但患者的临床状况仍在持续下降,并因顽固性缺氧而插管。这时,病人被转移到我们医院接受进一步的治疗。
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引用次数: 0
Medical Image of the Month: Diffuse White Matter Microhemorrhages Secondary to SARS-CoV-2 (COVID-19) Infection 本月医学影像:SARS-CoV-2 (COVID-19)感染继发的弥漫性白质微出血
Pub Date : 2021-02-02 DOI: 10.13175/SWJPCC001-21
K. Wickstrom, N. Blackstone, A. Sam, Tammer El-Aini
No abstract available. Article truncated after 150 words. Clinical Scenario: A 59-year-old woman with hypothyroidism presented to the emergency room with progressive shortness of breath for 2 weeks. Upon arrival, she was markedly hypoxic necessitating use of a non-rebreather to maintain her oxygen saturations above 88%. A chest radiograph demonstrated extensive, bilateral airspace disease. She was diagnosed with SARS-CoV-2 (COVID-19) pneumonia and started on the appropriate therapies. Approximately 48 hours into her hospitalization, she required intubation with mechanical ventilation due to her progressive hypoxemic respiratory failure. She was intubated for approximately 5 weeks with a gradual improvement in her respiratory status, but not to the point where she was a candidate for a tracheostomy. Despite being off sedation for an extended period, she remained unresponsive. A CT of the head without contrast did not demonstrate any significant abnormalities. An MRI of the brain was subsequently performed and demonstrated diffuse juxtacortical and callosal white matter microhemorrhages (Figure 1). Given …
没有可用的摘要。文章在150字后被截断。临床场景:一名患有甲状腺功能减退症的59岁女性因渐进性呼吸急促进入急诊室2周。抵达后,她明显缺氧,需要使用非再呼吸器将氧饱和度维持在88%以上。胸部X光片显示广泛的双侧空域疾病。她被诊断为严重急性呼吸系统综合征冠状病毒2型(新冠肺炎)肺炎,并开始接受适当的治疗。住院约48小时后,由于进行性低氧性呼吸衰竭,她需要插管并进行机械通气。她插管了大约5周,呼吸状况逐渐改善,但还没有到可以进行气管造口的程度。尽管她长时间处于镇静状态,但仍然没有反应。头部CT检查未显示任何明显异常。随后对大脑进行了核磁共振成像,并显示弥漫性皮质旁和胼胝体白质微出血(图1)。给定…
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引用次数: 0
February 2021 Imaging Case of the Month: An Indeterminate Solitary Nodule 本月影像病例:不确定孤立性结节
Pub Date : 2021-02-01 DOI: 10.13175/SWJPCC006-21
P. Panse, C. Jokerst, M. Gotway
No abstract available. Article truncated after first page. Clinical History: A 43 -year-old woman with no past medical history presented to the Emergency Room with complaints of right chest wall pain extending into the right upper quadrant. The patient was a non-smoker, denied any allergies, and was not taking any prescription medications. Physical examination showed the patient to be afebrile with normal heart and respiratory rates and blood pressure = 110/75 mmHg. Her room air oxygen saturation was 99%. The patient’s complete blood count and serum chemistries showed normal values. Her liver function testing and renal function testing parameters were also within normal limits. Which of the following represents an appropriate next step for the patient’s management? 1. Perform abdominal ultrasound 2. Perform chest radiography 3. Perform unenhanced chest CT 4. More than one of the above 5. None of the above …
没有可用的摘要。文章在第一页后被截断。临床病史:一名43岁的女性,既往无病史,因右胸壁疼痛延伸至右上象限而被送入急诊室。该患者不吸烟,否认有任何过敏反应,也没有服用任何处方药。体格检查显示患者无热,心率和呼吸频率正常,血压=110/75毫米汞柱。她的房间空气氧饱和度为99%。病人的全血细胞计数和血清化学成分显示正常。她的肝功能测试和肾功能测试参数也在正常范围内。以下哪一项代表了患者管理的适当下一步?1.进行腹部超声检查2。进行胸部射线照相术3。进行未增强胸部CT 4。以上5项中的一项以上。以上都不是…
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引用次数: 0
First-Attempt Endotracheal Intubation Success Rate Using A Telescoping Steel Bougie 伸缩式钢支架首次气管插管成功率分析
Pub Date : 2021-01-25 DOI: 10.13175/SWJPCC004-21
Evan D Schmitz, CA Usa La Jolla
Background There has been a renewed interest in using the plastic intubation bougie to facilitate first-attempt endotracheal intubation success. The sterile single-use telescopic steel bougie (AIROD) was invented to overcome the limitations of the plastic bougie which is easily deformed during storage. Methods This is a retrospective study involving critically ill patients who were intubated with the AIROD in the intensive care unit at a single institution. The purpose of this case series is to compare the success rate of the AIROD to the generally accepted success rate for the traditional plastic bougie of 96%. Results A total of 54 patients were enrolled at a single ICU over a 10 months period. All patients were critically ill with 76% having a difficult airway, Cormack-Lehane grade view 2 or greater in 60%, and ARDS secondary to COVID-19 in 54%. The primary outcome of first-attempt intubation success in critically ill patients intubated in the ICU with the AIROD was 97% with a 95% confidence interval of 0.89 to 0.99. The average time for intubation of all airway classifications was 15 seconds. Conclusion The AIROD first-attempt intubation success rate was found to be similar to the rate for the traditional plastic bougie.
背景:人们对使用塑料插管弓来促进气管插管首次尝试的成功重新产生了兴趣。无菌一次性伸缩钢蹦床(AIROD)是为了克服塑料蹦床在储存过程中容易变形的缺点而发明的。方法本研究是一项回顾性研究,涉及在单一机构重症监护病房插管使用AIROD的危重患者。本案例系列的目的是将AIROD的成功率与传统塑料支架的96%的普遍接受的成功率进行比较。结果在10个月的时间内,共有54例患者在单个ICU登记。所有患者均为危重患者,76%的患者气道困难,60%的患者Cormack-Lehane分级为2级或以上,54%的患者继发于COVID-19的ARDS。使用AIROD在ICU插管的危重患者首次插管成功率为97%,95%可信区间为0.89 ~ 0.99。所有气道分类插管的平均时间为15秒。结论AIROD首次插管成功率与传统的塑料支槽相似。
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引用次数: 1
The Best Laid Plans of Mice and Men 老鼠和人的最佳计划
Pub Date : 2021-01-13 DOI: 10.13175/SWJPCC003-21
R. Robbins, Phoenix Pulmonary, P. Harber, Allen Thomas
No abstract available. Article truncated after 150 words. When writing a grant proposal, many of us do a power analysis to ensure that we will have a sufficient number or “n” to detect a statistically significant difference between two populations. We estimate the number needed in each group by considering the likely intergroup difference and then add additional subjects depending on the number who will not give informed consent, refuse, die, are lost to follow up, etc. Often the number of nonparticipants is estimated based on previous experience, but sometimes a small study is done first called a feasibility study which tests the assumptions about recruitment. For both clinical trials and epidemiologic studies, a pilot or feasibility study also helps assure that participants will be representative of the relevant population (1). (For examples, will only the most seriously ill participate in a drug trial, or will the most vulnerable workers decline participation in a study. Will some drugs …
没有可用的摘要。文章在150字后被截断。在撰写拨款提案时,我们中的许多人都会进行幂分析,以确保我们有足够的数字或“n”来检测两个群体之间的统计显著差异。我们通过考虑可能的组间差异来估计每组所需的人数,然后根据不给予知情同意、拒绝、死亡、无法随访等的人数增加额外的受试者。通常,非受试者的人数是根据以前的经验估计的,但有时会先进行一项小型研究,称为可行性研究,以测试招聘的假设。对于临床试验和流行病学研究,试点或可行性研究也有助于确保参与者能够代表相关人群(1)。(例如,只有病情最严重的人才会参加药物试验,或者最脆弱的工作人员会拒绝参加研究…
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引用次数: 0
Clinical Care of COVID-19 Patients in a Front-line ICU 一线ICU新冠肺炎患者的临床护理
Pub Date : 2021-01-04 DOI: 10.13175/swjpcc070-20
R. Raschke, Tyler J Glenn, K. Josen
No abstract available. Article truncated after 150 words. These are some clinical observations made after over the past 10 months, working in a busy COVID-19 ICU unit in Scottsdale, AZ. The opinions expressed here are those of the private practice authors. Overview of triage and rounding on large numbers of COVID-19 patients in the ICU service. Our approach to bedside care of our ICU service has required abbreviation for the sake of efficiency in the face of more than a doubling of our census. Our approach to rounding is opinion-based. We’ve been forced to cut corners where we can in order to survive. Our hospital uses the Abbott ID-Now® rapid point-of -are test for screening all COVID-19-asymptomatic patients admitted to our hospital, but due to its low sensitivity in hospitalized patients (1). We do not trust it to rule-out COVID-19 in patients with pneumonia being admitted to the ICU and also order an in-house PCR for such patients …
没有可用的摘要。文章在150字后被截断。这些是在亚利桑那州斯科茨代尔一家繁忙的新冠肺炎重症监护室工作了10个多月后得出的一些临床观察结果。这里表达的意见是私人执业作者的意见。ICU服务中大量新冠肺炎患者的分诊和舍入概述。在我们的人口普查增加了一倍多的情况下,为了提高效率,我们的ICU服务的床边护理方法需要缩写。我们四舍五入的方法是基于意见的。为了生存,我们不得不在力所能及的地方偷工减料。我们的医院使用Abbott ID-Now®快速定点检测来筛查所有入院的新冠肺炎症状患者,但由于其在住院患者中的敏感性较低(1)。我们不相信它能排除入住重症监护室的肺炎患者中的新冠肺炎,并为这些患者订购内部PCR…
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引用次数: 0
Medical image of the month: mucinous adenocarcinoma of the lung mimicking pneumonia 本月医学影像:肺粘液腺癌样肺炎
Pub Date : 2021-01-02 DOI: 10.13175/swjpcc072-20
N. Blackstone, Tammer El-Aini
No abstract available. Article truncated after 150 words. Clinical Scenario: A 60-year-old man with a history of chronic obstructive pulmonary disease presented to the hospital with worsening shortness of breath over a period of 3 days. He had a 50-pack-year history of smoking, coronary artery disease, and a previous history of a left lung mass of unknown pathology status post left upper lobectomy. He was bought to the emergency room via ambulance after being found at home with oxygen saturations in the 60s. Upon arrival to the emergency room, he required continuous oxygen at 15 L/min to maintain his oxygen saturations above 88%. He had a progressive, markedly productive cough over the last few weeks prior to presentation. He had been treated for pneumonia with multiple courses of antibiotics over the last two months without any significant improvement. His blood work was significant for a leukocytosis with neutrophilia and an elevated D-dimer. He underwent a CTA of the …
没有摘要。文章在150字后被删节。临床情况:60岁男性,有慢性阻塞性肺疾病病史,3天内呼吸急促加重。患者有50年的吸烟史,冠状动脉疾病,左上肺叶切除术后有左肺肿块病史,病理状况不详。他在家中被发现,血氧饱和度为60多岁,随后被救护车送至急诊室。到达急诊室后,他需要以15l /min的速度持续吸氧,以维持血氧饱和度在88%以上。在就诊前的最后几周,他有进行性明显咳嗽。在过去的两个月里,他因肺炎接受了多个疗程的抗生素治疗,但没有任何明显的改善。他的血液检查显示白细胞增多伴中性粒细胞增多和d -二聚体升高。他接受了CTA…
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引用次数: 1
A Population-Based Feasibility Study of Occupation and Thoracic Malignancies in New Mexico. 新墨西哥州职业与胸部恶性肿瘤基于人群的可行性研究
Pub Date : 2021-01-01 Epub Date: 2021-08-13 DOI: 10.13175/swjpcc067-20
Claire R Pestak, Tawny W Boyce, Orrin B Myers, L Olivia Hopkins', Charles L Wiggins, Bruce R Wissore, Akshay Sood, Linda S Cook

Background: Occupational exposures in mining and oil/gas extraction are known risk factors for thoracic malignancies (TMs). Given the relatively high proportion of these industries in New Mexico (NM), we conducted a feasibility study of adult lifetime occupational history among TM cases. We hypothesized a higher proportion of occupational TM in NM relative to the estimated national average of 10-14%.

Methods: We identified incident TM cases through the population-based New Mexico Tumor Registry (NMTR), from 2017-2018. Cases completed a telephone interview. An adjudication panel reviewed case histories and classified cancers as probable, possible, or non-occupational related, taking into account the presence, duration, and latency of exposures. We characterized recruitment and describe job titles and exposures among those with occupational TMs. We also compared the distributions of industry between those with and without occupational TM.

Results: The NMTR identified 400 eligible TM cases, 290 of which were available to be recruited (n=285 lung/bronchial cancer; n=5 mesotheliomas). Of the latter, 60% refused and 18% were deceased, 9% had invalid addresses, 11% were unable to be reached by telephone, and 3% were too ill to participate. The 43 cases who completed an interview held 236 jobs. A total of 33% of cases were classified as probable occupational TM and 5% as possible occupational TM.

Conclusions: High rates of early mortality and refusals were significant barriers to study participation. Nonetheless, the proportion of probable occupational TMs greatly exceeded the estimated national average, highlighting the need for further study of occupational TM in the state.

背景:采矿和油气开采中的职业暴露是已知的胸部恶性肿瘤(TMs)的危险因素。鉴于这些行业在新墨西哥州(NM)的比例相对较高,我们对TM病例的成人终身职业史进行了可行性研究。我们假设,相对于估计的全国平均水平10-14%,NM中职业TM的比例更高。方法:我们通过基于人群的新墨西哥州肿瘤登记处(NMTR)确定2017-2018年的TM病例。个案完成电话访谈。考虑到暴露的存在、持续时间和潜伏期,评审小组回顾了病例史并将癌症分类为可能、可能或非职业相关。我们描述了招聘特征,并描述了职业TMs患者的职称和暴露情况。我们还比较了有和没有职业TM的人群的行业分布。结果:NMTR确定了400例符合条件的TM病例,其中290例可供招募(n=285例肺癌/支气管癌;n = 5间皮瘤能够)。在后者中,60%的人拒绝了,18%的人已经去世,9%的人地址无效,11%的人无法通过电话联系到,3%的人病得太重而无法参加。完成面试的43个案例中有236个职位。33%的病例归为可能的职业性TM, 5%归为可能的职业性TM。结论:高早期死亡率和拒绝率是参与研究的重要障碍。尽管如此,可能的职业TM比例大大超过了估计的全国平均水平,突出了该州职业TM进一步研究的必要性。
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引用次数: 0
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Southwest journal of pulmonary & critical care
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