Joop J A van Loon, Qingbo Tang, Honglei Wang, Chenzhu Wang, Dongsheng Zhou, Hans M Smid
{"title":"Tasting in plant-feeding insects: from single compounds to complex natural stimuli.","authors":"Joop J A van Loon, Qingbo Tang, Honglei Wang, Chenzhu Wang, Dongsheng Zhou, Hans M Smid","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87484,"journal":{"name":"SEB experimental biology series","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27951063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Redox metabolism and longevity relationships in animals and plants. Preface.","authors":"C. Foyer, R. Faragher, P. Thornalley","doi":"10.4324/9780203866740","DOIUrl":"https://doi.org/10.4324/9780203866740","url":null,"abstract":"","PeriodicalId":87484,"journal":{"name":"SEB experimental biology series","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70598859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Álvarez-Buylla, Enrique Balleza, M. Benítez, C. Espinosa-Soto, P. Padilla-Longoria
{"title":"Gene regulatory network models: a dynamic and integrative approach to development.","authors":"E. Álvarez-Buylla, Enrique Balleza, M. Benítez, C. Espinosa-Soto, P. Padilla-Longoria","doi":"10.4324/9780203967195-8","DOIUrl":"https://doi.org/10.4324/9780203967195-8","url":null,"abstract":"","PeriodicalId":87484,"journal":{"name":"SEB experimental biology series","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70601187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Damian C Crowther, Richard Page, Thomas Rival, Dhianjali S Chandraratna, David A Lomas
{"title":"Using a Drosophila model of Alzheimer's disease.","authors":"Damian C Crowther, Richard Page, Thomas Rival, Dhianjali S Chandraratna, David A Lomas","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87484,"journal":{"name":"SEB experimental biology series","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27295188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laurence A Brown, Christopher J Mee, Jacqueline F Kidd, David B Sattelle
{"title":"Amyloid peptides and ion channel function in Drosophila models of Alzheimer's disease.","authors":"Laurence A Brown, Christopher J Mee, Jacqueline F Kidd, David B Sattelle","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87484,"journal":{"name":"SEB experimental biology series","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27295189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Drosophila melanogaster in the study of epilepsy.","authors":"Nara I Muraro, Richard A Baines","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87484,"journal":{"name":"SEB experimental biology series","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27295192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Several models have been suggested above, describing possible modes of spindle checkpoint action: 1. Cdc20 sequestration (by Mad2-Cdc20 and/or MCC). 2. Stable MCC-APC/C association. 3. Cdc20 turnover (in budding yeast). 4. Cdc20-APC/C modification (by Mps1, Bub1, MAPK, Aurora B or BubR1 kinases). Several of these mechanisms could affect APC/C activity by modifying, competing for, and/or blocking the binding site(s) for its substrates. Alternatively, they could reduce the processivity of ubiquitination of substrates, or prevent the release of substrates and thereby reduce substrate turnover. Indeed, the processivity of ubiquitination can determine the order of destruction of APC/C substrates (Rape et al., 2006). Most substrates require multiple APC/C binding events in order to build polyubiquitin chains, and only polyubiquitinated substrates are recognised by the 26S proteasome for destruction. Thus, if the processivity of ubiquitination or the turnover of APC/C substrates were impaired in mitosis, the degradation of securin and cyclin would no longer take place, which would result in mitotic arrest. Our results have highlighted the importance of Mad3 as an anaphase inhibitor, and suggest that it usually acts in concert with Mad2 to efficiently inhibit Cdc20-APC/C. Further experiments are necessary to fully understand their mechanism of action, and this will require a wide range of approaches including dynamic studies of the 'flux' of Mad2 and BubR1 through signalling scaffolds, further structural insights, the identification of important phosphorylation sites on both the checkpoint proteins and Cdc20-APC/C, and an in vitro reconstitution of MCC inhibition of the APC/C. We look forward to seeing the complex regulation of mitotic progression being described over the coming years.
上面提出了几种模型，描述了纺锤体检查点作用的可能模式:Cdc20封存(通过Mad2-Cdc20和/或MCC)。2. 稳定的MCC-APC/C关联。3.Cdc20的周转(在出芽酵母中)。4. Cdc20-APC/C修饰(Mps1, Bub1, MAPK, Aurora B或BubR1激酶)。其中一些机制可以通过改变、竞争和/或阻断其底物的结合位点来影响APC/C的活性。或者，它们可以降低底物泛素化的进程，或阻止底物的释放，从而减少底物的周转。事实上，泛素化的进程可以决定APC/C底物的破坏顺序(Rape et al.， 2006)。大多数底物需要多个APC/C结合事件才能构建多泛素链，只有多泛素化底物才能被26S蛋白酶体识别并破坏。因此，如果在有丝分裂过程中泛素化的进程或APC/C底物的周转被破坏，securin和cyclin的降解将不再发生，这将导致有丝分裂停滞。我们的研究结果强调了Mad3作为后期抑制剂的重要性，并表明它通常与Mad2协同作用以有效抑制Cdc20-APC/C。为了充分了解它们的作用机制，还需要进一步的实验，这将需要广泛的方法，包括通过信号支架对Mad2和BubR1的“通量”进行动态研究，进一步的结构洞察，鉴定检查点蛋白和Cdc20-APC/C上重要的磷酸化位点，以及体外重建MCC对APC/C的抑制。我们期待在未来几年看到有丝分裂过程的复杂调控被描述。
{"title":"The spindle checkpoint: how do cells delay anaphase onset?","authors":"Matylda M Sczaniecka, Kevin G Hardwick","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Several models have been suggested above, describing possible modes of spindle checkpoint action: 1. Cdc20 sequestration (by Mad2-Cdc20 and/or MCC). 2. Stable MCC-APC/C association. 3. Cdc20 turnover (in budding yeast). 4. Cdc20-APC/C modification (by Mps1, Bub1, MAPK, Aurora B or BubR1 kinases). Several of these mechanisms could affect APC/C activity by modifying, competing for, and/or blocking the binding site(s) for its substrates. Alternatively, they could reduce the processivity of ubiquitination of substrates, or prevent the release of substrates and thereby reduce substrate turnover. Indeed, the processivity of ubiquitination can determine the order of destruction of APC/C substrates (Rape et al., 2006). Most substrates require multiple APC/C binding events in order to build polyubiquitin chains, and only polyubiquitinated substrates are recognised by the 26S proteasome for destruction. Thus, if the processivity of ubiquitination or the turnover of APC/C substrates were impaired in mitosis, the degradation of securin and cyclin would no longer take place, which would result in mitotic arrest. Our results have highlighted the importance of Mad3 as an anaphase inhibitor, and suggest that it usually acts in concert with Mad2 to efficiently inhibit Cdc20-APC/C. Further experiments are necessary to fully understand their mechanism of action, and this will require a wide range of approaches including dynamic studies of the 'flux' of Mad2 and BubR1 through signalling scaffolds, further structural insights, the identification of important phosphorylation sites on both the checkpoint proteins and Cdc20-APC/C, and an in vitro reconstitution of MCC inhibition of the APC/C. We look forward to seeing the complex regulation of mitotic progression being described over the coming years.</p>","PeriodicalId":87484,"journal":{"name":"SEB experimental biology series","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27345987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Grammenoudi, M. Anezaki, Stylianos Kosmidis, E. Skoulakis
{"title":"Modelling cell and isoform type specificity of tauopathies in Drosophila.","authors":"S. Grammenoudi, M. Anezaki, Stylianos Kosmidis, E. Skoulakis","doi":"10.1201/9781003060796-4","DOIUrl":"https://doi.org/10.1201/9781003060796-4","url":null,"abstract":"","PeriodicalId":87484,"journal":{"name":"SEB experimental biology series","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65950679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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