Pub Date : 2022-10-01DOI: 10.14235/bas.galenos.2021.6026
H. İkiışık, Merve Kirlangiç, Hasan Huseyin Mutlu, I. Maral
Objective: We aimed to reveal the opinions of students and faculty members about the educational process in the distance education provided in a medical school during the pandemic period, the problems they encounter and their relationship with digital literacy levels. Methods: The design of the study is cross-sectional. An online survey including demographic information, positive and negative aspects of distance education, opinions about the process, and digital literacy scale was administered to 1st, 2nd, 3rd, 4th and 5th year medical students and faculty members. A p-value of < 0.05 was considered significant in the data analysis. Results: A total of 513 individuals (52.9%) responded to the questionnaires. The mean digital literacy score was 3.42 +/- 0.84 for students and 3.57 +/- 0.82 for faculty members. For faculty members, age (B=-0.041, t=-2.72 p=0.009) and having no previous distance education experience (B=-0.813, t=-2.32 p=0.025), and for students, female gender (B=-0.287, t=-3.65 p < 0.001) and having no previous distance education experience (B=-0.343, t=-2.53 p=0.011). Conclusion: Distance education, which gained speed with the pandemic, will continue to exist in education in the coming years. Although the digital literacy scores of students and faculty members in the medical faculty are above average, advanced digital literacy will enable better and accurate use of digital technologies and a more effective and efficient education.
{"title":"Being a Student and Faculty Member in the Faculty of Medicine During Pandemic: An Evaluation of Distance Education","authors":"H. İkiışık, Merve Kirlangiç, Hasan Huseyin Mutlu, I. Maral","doi":"10.14235/bas.galenos.2021.6026","DOIUrl":"https://doi.org/10.14235/bas.galenos.2021.6026","url":null,"abstract":"Objective: We aimed to reveal the opinions of students and faculty members about the educational process in the distance education provided in a medical school during the pandemic period, the problems they encounter and their relationship with digital literacy levels. Methods: The design of the study is cross-sectional. An online survey including demographic information, positive and negative aspects of distance education, opinions about the process, and digital literacy scale was administered to 1st, 2nd, 3rd, 4th and 5th year medical students and faculty members. A p-value of < 0.05 was considered significant in the data analysis. Results: A total of 513 individuals (52.9%) responded to the questionnaires. The mean digital literacy score was 3.42 +/- 0.84 for students and 3.57 +/- 0.82 for faculty members. For faculty members, age (B=-0.041, t=-2.72 p=0.009) and having no previous distance education experience (B=-0.813, t=-2.32 p=0.025), and for students, female gender (B=-0.287, t=-3.65 p < 0.001) and having no previous distance education experience (B=-0.343, t=-2.53 p=0.011). Conclusion: Distance education, which gained speed with the pandemic, will continue to exist in education in the coming years. Although the digital literacy scores of students and faculty members in the medical faculty are above average, advanced digital literacy will enable better and accurate use of digital technologies and a more effective and efficient education.","PeriodicalId":8757,"journal":{"name":"Bezmialem Science","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44248115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-19DOI: 10.14235/bas.galenos.2021.6301
Nazlı Batar, Seda Kermen, Sezen Sevdin, Aybuke Ersin, Duygu Güçlü
Objective: This study aimed to evaluate the changes in the body composition of individuals who fasted and did Pilates at least twice a week during Ramadan versus those who fasted but did no Pilates. Methods: This was an experimental study conducted on 60 healthy women who were admitted to the Noi Pilates in İstanbul Turkey, which was a private Pilates studio. The study was carried out on 60 grown-up, healthy women between 18 and 65 years of age who fasted in Ramadan 2019, some of whom did Pilates and some who did not. The women involved in the study had been doing Pilates for 6 months prior to Ramadan and did Pilates at least 3 times a week during Ramadan. Results: Significant increases were observed in body mass index (BMI), triceps skin-fold thickness (SFT), muscle mass and fat percentage in the fasting and non-pilates group (p<0.05). Our study found the change in the percentage of triceps SFT and fat in women who did Pilates to be more than those who did not. BMI, muscle mass, waist circumference and hip circumference of women who did Pilates and who did not do Pilates during Ramadan did not differ compared to the first measurements, and neither of the two methods dominated in terms of these variables. Conclusion: While a long period of fasting in Ramadan leads people to inactivity, personalized exercise and nutrition programs planned by experts may result in weight loss, especially for obese and slightly overweight people.
{"title":"Effect of Pilates Exercises on the Body Composition of Fasting Females","authors":"Nazlı Batar, Seda Kermen, Sezen Sevdin, Aybuke Ersin, Duygu Güçlü","doi":"10.14235/bas.galenos.2021.6301","DOIUrl":"https://doi.org/10.14235/bas.galenos.2021.6301","url":null,"abstract":"Objective: This study aimed to evaluate the changes in the body composition of individuals who fasted and did Pilates at least twice a week during Ramadan versus those who fasted but did no Pilates. Methods: This was an experimental study conducted on 60 healthy women who were admitted to the Noi Pilates in İstanbul Turkey, which was a private Pilates studio. The study was carried out on 60 grown-up, healthy women between 18 and 65 years of age who fasted in Ramadan 2019, some of whom did Pilates and some who did not. The women involved in the study had been doing Pilates for 6 months prior to Ramadan and did Pilates at least 3 times a week during Ramadan. Results: Significant increases were observed in body mass index (BMI), triceps skin-fold thickness (SFT), muscle mass and fat percentage in the fasting and non-pilates group (p<0.05). Our study found the change in the percentage of triceps SFT and fat in women who did Pilates to be more than those who did not. BMI, muscle mass, waist circumference and hip circumference of women who did Pilates and who did not do Pilates during Ramadan did not differ compared to the first measurements, and neither of the two methods dominated in terms of these variables. Conclusion: While a long period of fasting in Ramadan leads people to inactivity, personalized exercise and nutrition programs planned by experts may result in weight loss, especially for obese and slightly overweight people.","PeriodicalId":8757,"journal":{"name":"Bezmialem Science","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42696486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-19DOI: 10.14235/bas.galenos.2020.4483
D. Yıldırım, Meryem Erceylan
This systematic review was conducted to demonstrate the effectiveness of the use of reiki therapy in cancer pain management and to draw attention to the availability of this application in palliative care units. The studies on cancer pain management, both in English and Turkish, of which full text versions were accessible, were systematically analyzed, and the studies without full text and ongoing studies were not included. The study was conducted by reviewing Cumulative Index to Nursing and Allied Health Literature, EBSCOhost, MEDLINE, ScienceDirect, Ovid, ProQuest, Web of Science, and ULAKBİM National DataBases. There were no year restrictions in screening. Keywords such as “cancer pain”, “cancer pain management”, “reiki” and “palliative care” were used to access the studies. Nineteen research papers were accessed and 5 of them were found to be compatible with the inclusion criteria of our study. Cohrane was established as the guideline to determine levels of evidence. Of the included studies, one was a randomized controlled study, three were experimental studies, the other one was a systematic review. In our day, randomized controlled studies examining the effect of reiki therapy on pain in cancer patients who receive palliative care are limited. In particular, studies have shown that reiki is even more effective in reducing pain when used in addition to pharmacological treatment and conventional nursing care. It is observed that the studies are carried out with a small sample number and generally with a single group. Pain assessments are usually performed with care” were used to access the studies. Also, the reference list of all randomized clinical trials and review papers were checked to find suitable studies that were not identified by electronic search. After the abstracts of the papers were scanned, 19 papers were reached. It was determined that 5 of these studies met the criteria of inclusion in the research. These studies were analyzed separately When we examine the effect of reiki on physical and psychological recovery in cancer patients treated in palliative care, it is reported that reiki has a positive effect on reducing pain. However, there are gaps in matters such as which hand position to use in reiki therapy, the duration and frequency of the reiki session, and the application period. For this reason, it is recommended to conduct randomized controlled studies with a large sample group.
本系统综述是为了证明灵气疗法在癌症疼痛管理中的有效性，并引起人们对这种应用在姑息治疗单位的关注。系统分析了英文和土耳其文的癌症疼痛管理研究，其中全文可查，不包括没有全文的研究和正在进行的研究。本研究通过查阅护理和相关健康文献累积索引、EBSCOhost、MEDLINE、ScienceDirect、Ovid、ProQuest、Web of Science和ULAKBİM国家数据库进行。筛查没有年份限制。使用“癌症疼痛”、“癌症疼痛管理”、“灵气”和“姑息治疗”等关键词访问研究。共检索到19篇研究论文，其中5篇符合本研究的纳入标准。Cohrane被确立为确定证据水平的指南。在纳入的研究中，一项是随机对照研究，三项是实验研究，另一项是系统综述。在我们这个时代，随机对照研究检验灵气疗法对接受姑息治疗的癌症患者疼痛的影响是有限的。特别是，研究表明，在药物治疗和传统护理之外，灵气在减轻疼痛方面甚至更有效。值得注意的是，这些研究的样本数很少，而且通常只有一个群体。疼痛评估通常是谨慎进行的”。此外，我们还检查了所有随机临床试验和综述论文的参考文献列表，以找到没有通过电子检索确定的合适研究。扫描论文摘要后，共收到19篇论文。确定其中5项研究符合纳入本研究的标准。当我们研究灵气对姑息治疗癌症患者的生理和心理恢复的影响时，据报道，灵气对减轻疼痛有积极的作用。然而，在灵气治疗中使用的手部位置，灵气疗程的持续时间和频率以及应用周期等问题上存在差距。因此，建议进行大样本的随机对照研究。
{"title":"The Effect of Reiki Therapy on Cancer Pain Management in Palliative Care Patients: A Systematic Review","authors":"D. Yıldırım, Meryem Erceylan","doi":"10.14235/bas.galenos.2020.4483","DOIUrl":"https://doi.org/10.14235/bas.galenos.2020.4483","url":null,"abstract":"This systematic review was conducted to demonstrate the effectiveness of the use of reiki therapy in cancer pain management and to draw attention to the availability of this application in palliative care units. The studies on cancer pain management, both in English and Turkish, of which full text versions were accessible, were systematically analyzed, and the studies without full text and ongoing studies were not included. The study was conducted by reviewing Cumulative Index to Nursing and Allied Health Literature, EBSCOhost, MEDLINE, ScienceDirect, Ovid, ProQuest, Web of Science, and ULAKBİM National DataBases. There were no year restrictions in screening. Keywords such as “cancer pain”, “cancer pain management”, “reiki” and “palliative care” were used to access the studies. Nineteen research papers were accessed and 5 of them were found to be compatible with the inclusion criteria of our study. Cohrane was established as the guideline to determine levels of evidence. Of the included studies, one was a randomized controlled study, three were experimental studies, the other one was a systematic review. In our day, randomized controlled studies examining the effect of reiki therapy on pain in cancer patients who receive palliative care are limited. In particular, studies have shown that reiki is even more effective in reducing pain when used in addition to pharmacological treatment and conventional nursing care. It is observed that the studies are carried out with a small sample number and generally with a single group. Pain assessments are usually performed with care” were used to access the studies. Also, the reference list of all randomized clinical trials and review papers were checked to find suitable studies that were not identified by electronic search. After the abstracts of the papers were scanned, 19 papers were reached. It was determined that 5 of these studies met the criteria of inclusion in the research. These studies were analyzed separately When we examine the effect of reiki on physical and psychological recovery in cancer patients treated in palliative care, it is reported that reiki has a positive effect on reducing pain. However, there are gaps in matters such as which hand position to use in reiki therapy, the duration and frequency of the reiki session, and the application period. For this reason, it is recommended to conduct randomized controlled studies with a large sample group.","PeriodicalId":8757,"journal":{"name":"Bezmialem Science","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42334926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-19DOI: 10.14235/bas.galenos.2021.6224
S. Serel Arslan, Çiğdem Ulukaya Durakbaşa, T. Soyer
Objective: The study examined the clinical practice and knowledge of pediatric surgeons regarding diagnosis and treatment of eosinophilic esophagitis (EoE) in children with esophageal atresia (EA). Methods: Pediatric surgeons who were involved in diagnosis and treatment of EA from Turkey were included. An online survey, which included 26 questions related to clinical practice and knowledge of pediatric surgeons was administered via Google forms. The survey included questions regarding descriptive information of participants, diagnosis, treatment, and knowledge about EoE in children with EA. Results: Fifty seven pediatric surgeons responded to the study. Reflux symptoms resistant to treatment and recurrent anastomotic strictures were most commonly reported as symptoms of EoE. Endoscopy biopsies was the most commonly selected diagnostic method for EoE with nearly half of the surgeons obtaining appropriate biopsies. Diet elimination, proton pump inhibitors and systemic steroids were most commonly reported to be used in the of EoE. pediatric surgeons low-level knowledge, occupational experience, the number of children with EA in annual follow-up and the number of children with EA who had EoE. In the diagnosis section, there were questions related to consultations in the long-term follow-up, the endoscopy applications and the diagnosis of EoE. There were two questions related to the treatment of GERD and two questions regarding the treatment of EoE. In the knowledge section, participants were asked to state “yes” or “no” for the statements. Only one practice and knowledge regarding diagnosis and treatment of EoE in children with EA. Therefore, improvement in the care of these children could be achieved by increasing awareness and knowledge of pediatric surgeons, decreasing heterogeneous nature of practice patterns and creating a consensus in clinical settings.
{"title":"Clinical Practice and Knowledge of Pediatric Surgeons about Eosinophilic Esophagitis in Children with Esophageal Atresia","authors":"S. Serel Arslan, Çiğdem Ulukaya Durakbaşa, T. Soyer","doi":"10.14235/bas.galenos.2021.6224","DOIUrl":"https://doi.org/10.14235/bas.galenos.2021.6224","url":null,"abstract":"Objective: The study examined the clinical practice and knowledge of pediatric surgeons regarding diagnosis and treatment of eosinophilic esophagitis (EoE) in children with esophageal atresia (EA). Methods: Pediatric surgeons who were involved in diagnosis and treatment of EA from Turkey were included. An online survey, which included 26 questions related to clinical practice and knowledge of pediatric surgeons was administered via Google forms. The survey included questions regarding descriptive information of participants, diagnosis, treatment, and knowledge about EoE in children with EA. Results: Fifty seven pediatric surgeons responded to the study. Reflux symptoms resistant to treatment and recurrent anastomotic strictures were most commonly reported as symptoms of EoE. Endoscopy biopsies was the most commonly selected diagnostic method for EoE with nearly half of the surgeons obtaining appropriate biopsies. Diet elimination, proton pump inhibitors and systemic steroids were most commonly reported to be used in the of EoE. pediatric surgeons low-level knowledge, occupational experience, the number of children with EA in annual follow-up and the number of children with EA who had EoE. In the diagnosis section, there were questions related to consultations in the long-term follow-up, the endoscopy applications and the diagnosis of EoE. There were two questions related to the treatment of GERD and two questions regarding the treatment of EoE. In the knowledge section, participants were asked to state “yes” or “no” for the statements. Only one practice and knowledge regarding diagnosis and treatment of EoE in children with EA. Therefore, improvement in the care of these children could be achieved by increasing awareness and knowledge of pediatric surgeons, decreasing heterogeneous nature of practice patterns and creating a consensus in clinical settings.","PeriodicalId":8757,"journal":{"name":"Bezmialem Science","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43073001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-19DOI: 10.14235/bas.galenos.2021.5875
Sinan Demircioğlu, Ömer Ekinci, Ali Doğan, T. Ulaş
Objective: Chromosomal abnormalities are one of the most important prognostic factors in acute myeloid leukemia (AML). However, not all patients may have such informative chromosomal abnormalities. Although there are many studies on the prognostic value of immunophenotyping in AML, it is still not used as a prognostic marker. In this study, we aimed to investigate the effects of CD13, CD33, CD34, CD117, MPO and HLADR expressions on prognosis of non-acute promyelocytic leukemia AML. Methods: One hundred thirteen patients diagnosed as having non-acute promyelocytic leukemia AML and followed up between 2010 and 2018 were included in this study. The associations of CD13, CD33, CD34, CD117, MPO and HLA DR expressions with chemotherapy response, progression free survival (PFS) and overall survival (OS) were statistically analyzed. Results: It was seen that response to chemotherapy decitabine were evaluated for response after 4-6 cycles. Treatment was continued with responders until progression. Flow cytometric immunophenotyping was performed on bone marrow aspirate. Specimen processing was performed according to a routine red cell lysis protocol. Single cell suspensions were stained with various 4 fluorochrome-conjugated antibody combinations and analyzed in reference to isotype-matched fluorochrome-conjugated control antibodies. Immunophenotypic properties were evaluated with Multiparametric Cytometry MPO expression was shown to be an independent risk factor for PFS and OS in our own patient population.
{"title":"Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia","authors":"Sinan Demircioğlu, Ömer Ekinci, Ali Doğan, T. Ulaş","doi":"10.14235/bas.galenos.2021.5875","DOIUrl":"https://doi.org/10.14235/bas.galenos.2021.5875","url":null,"abstract":"Objective: Chromosomal abnormalities are one of the most important prognostic factors in acute myeloid leukemia (AML). However, not all patients may have such informative chromosomal abnormalities. Although there are many studies on the prognostic value of immunophenotyping in AML, it is still not used as a prognostic marker. In this study, we aimed to investigate the effects of CD13, CD33, CD34, CD117, MPO and HLADR expressions on prognosis of non-acute promyelocytic leukemia AML. Methods: One hundred thirteen patients diagnosed as having non-acute promyelocytic leukemia AML and followed up between 2010 and 2018 were included in this study. The associations of CD13, CD33, CD34, CD117, MPO and HLA DR expressions with chemotherapy response, progression free survival (PFS) and overall survival (OS) were statistically analyzed. Results: It was seen that response to chemotherapy decitabine were evaluated for response after 4-6 cycles. Treatment was continued with responders until progression. Flow cytometric immunophenotyping was performed on bone marrow aspirate. Specimen processing was performed according to a routine red cell lysis protocol. Single cell suspensions were stained with various 4 fluorochrome-conjugated antibody combinations and analyzed in reference to isotype-matched fluorochrome-conjugated control antibodies. Immunophenotypic properties were evaluated with Multiparametric Cytometry MPO expression was shown to be an independent risk factor for PFS and OS in our own patient population.","PeriodicalId":8757,"journal":{"name":"Bezmialem Science","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47189967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-19DOI: 10.14235/bas.galenos.2021.5883
M. Arslan, İshak Aydemir, Nurcan Yabancı Ayhan
Objective: The most common psychological health problems are depression and stress. Depressive symptoms and stress are increasing day by day in university youth. Since depression and stress negatively affect the health of the young population, it is important that it contribute to the increase of the healthy population. The objective of the study was to evaluate the relationship of depression and stress with tryptophan consumption among university students. Methods: A questionnaire which included descriptive questions, amounts of tryptophan consumption, “Beck depression” inventory and “perceived stress (PS) scale” were conducted voluntarily to 900 undergraduate students studying at İstanbul Aydın University in this correlation study. Results: There was no statistically significant difference was found between students’ depression levels and tryptophan consumption levels (p>0.05). A statistically significant difference was found between the perceived coping level and the mean tryptophan consumption level (p<0.05). As tryptophan consumption increases, stress decreases and coping with PS increases. There was no relationship between tryptophan consumption and depression, but there was a relationship between tryptophan consumption and stress.
{"title":"The Relationship of Depression and Stress with Tryptophan Consumption among University Youth","authors":"M. Arslan, İshak Aydemir, Nurcan Yabancı Ayhan","doi":"10.14235/bas.galenos.2021.5883","DOIUrl":"https://doi.org/10.14235/bas.galenos.2021.5883","url":null,"abstract":"Objective: The most common psychological health problems are depression and stress. Depressive symptoms and stress are increasing day by day in university youth. Since depression and stress negatively affect the health of the young population, it is important that it contribute to the increase of the healthy population. The objective of the study was to evaluate the relationship of depression and stress with tryptophan consumption among university students. Methods: A questionnaire which included descriptive questions, amounts of tryptophan consumption, “Beck depression” inventory and “perceived stress (PS) scale” were conducted voluntarily to 900 undergraduate students studying at İstanbul Aydın University in this correlation study. Results: There was no statistically significant difference was found between students’ depression levels and tryptophan consumption levels (p>0.05). A statistically significant difference was found between the perceived coping level and the mean tryptophan consumption level (p<0.05). As tryptophan consumption increases, stress decreases and coping with PS increases. There was no relationship between tryptophan consumption and depression, but there was a relationship between tryptophan consumption and stress.","PeriodicalId":8757,"journal":{"name":"Bezmialem Science","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48449694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-19DOI: 10.14235/bas.galenos.2021.6123
S. Şener, M. Badem, U. Özgen, N. Korkmaz, Ş. Kanbolat, G. Kerimoğlu, R. Aliyazicioglu, E. Yeni̇lmez, Esen Sezen Karaoğlan
Objective: Lysimachia genus has been recorded to be used in diabetes, traditionally and to have antidiabetic effect and antioxidant effects. The aim of this study was to evaluate the antidiabetic and antioxidant effects of aqueous extract of Lysimachia verticillaris (LV) and its isolated compounds, the percentage of apoptosis and histological changes in pancreatic β -cells in rats with streptozotocin (STZ)-induced type 1 diabetes mellitus. Male Spraque Dawley rats were into 6 groups. STZ (40 mg/kg) induced diabetic rats were treated orally with aqueous extract (400 mg/kg) and isolated compounds (20 mg/ kg). To interpret antidiabetic effect, serum glucose and insulin levels were measured and morphological changes of pancreas were examined. Serum samples were analysed for catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPX) levels to investigate antioxidant effect. The terminal deoxynucleotidyl transferase (TDT)-mediated dUTP-biotin nick end-labeling (TUNEL) assays were performed to reveal apoptosis of pancreatic β -cells. its phenolic compounds isolated (27). Present study aims to investigate the antidiabetic effects of the aqueous extract of the aerial parts of LV and its phenolic compounds gallic acid, myrcetin 3-O- α -rhamnopyranoside and quercetin 3-O- β -glucopyranoside isolated in our previous Results: Oral administration of the extract and isolated compounds reduced high blood glucose levels (p<0.005). Morever, the treatments were resulted in increased serum insulin (p≤0.05), CAT (p≤0.05), SOD (p≤0.05) and GPX (p≤0.05). All applications with compounds, especially with quercetin 3-O- β -glucopyranoside reduced the morphological impairment of pancreas. The percentage of TUNEL positive cells was higher (p≤0.05) in the pancreatic islets of untreated diabetic group than others groups. Conclusion: According to results, the extract and isolated compounds of LV displayed antidiabetic effect, while quercetin 3-O- β -glucopyranoside showed the highest antidiabetic effect. The antidiabetic effects of LV and phenolic compounds may be due to their antioxidant effects. Thus, LV and isolated compounds can be a potential source of herbal medicine for DM. However, it requires further investigations such as toxicological analysis studies and clinical trials.
{"title":"Antidiabetic and Antioxidant Effect of the Aerial Parts of Lysimachia verticillaris and its Isolated Phenolic Compounds on Streptozotocin-induced Diabetic Rats","authors":"S. Şener, M. Badem, U. Özgen, N. Korkmaz, Ş. Kanbolat, G. Kerimoğlu, R. Aliyazicioglu, E. Yeni̇lmez, Esen Sezen Karaoğlan","doi":"10.14235/bas.galenos.2021.6123","DOIUrl":"https://doi.org/10.14235/bas.galenos.2021.6123","url":null,"abstract":"Objective: Lysimachia genus has been recorded to be used in diabetes, traditionally and to have antidiabetic effect and antioxidant effects. The aim of this study was to evaluate the antidiabetic and antioxidant effects of aqueous extract of Lysimachia verticillaris (LV) and its isolated compounds, the percentage of apoptosis and histological changes in pancreatic β -cells in rats with streptozotocin (STZ)-induced type 1 diabetes mellitus. Male Spraque Dawley rats were into 6 groups. STZ (40 mg/kg) induced diabetic rats were treated orally with aqueous extract (400 mg/kg) and isolated compounds (20 mg/ kg). To interpret antidiabetic effect, serum glucose and insulin levels were measured and morphological changes of pancreas were examined. Serum samples were analysed for catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPX) levels to investigate antioxidant effect. The terminal deoxynucleotidyl transferase (TDT)-mediated dUTP-biotin nick end-labeling (TUNEL) assays were performed to reveal apoptosis of pancreatic β -cells. its phenolic compounds isolated (27). Present study aims to investigate the antidiabetic effects of the aqueous extract of the aerial parts of LV and its phenolic compounds gallic acid, myrcetin 3-O- α -rhamnopyranoside and quercetin 3-O- β -glucopyranoside isolated in our previous Results: Oral administration of the extract and isolated compounds reduced high blood glucose levels (p<0.005). Morever, the treatments were resulted in increased serum insulin (p≤0.05), CAT (p≤0.05), SOD (p≤0.05) and GPX (p≤0.05). All applications with compounds, especially with quercetin 3-O- β -glucopyranoside reduced the morphological impairment of pancreas. The percentage of TUNEL positive cells was higher (p≤0.05) in the pancreatic islets of untreated diabetic group than others groups. Conclusion: According to results, the extract and isolated compounds of LV displayed antidiabetic effect, while quercetin 3-O- β -glucopyranoside showed the highest antidiabetic effect. The antidiabetic effects of LV and phenolic compounds may be due to their antioxidant effects. Thus, LV and isolated compounds can be a potential source of herbal medicine for DM. However, it requires further investigations such as toxicological analysis studies and clinical trials.","PeriodicalId":8757,"journal":{"name":"Bezmialem Science","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45230901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-19DOI: 10.14235/bas.galenos.2021.6708
A. Çi̇ftçi̇, M. Gök, M. Kafadar
Objective: We aimed to evaluate the patients who were hospitalized, followed up and treated in our clinic with the diagnosis of acute biliary pancreatitis (ABP) after cholecystectomy. Methods: The electronic records of 18 patients with a history of cholecystectomy were reviewed retrospectively. The demographic findings of the patients, time passed after cholecystectomy, methods used in diagnosis, amylase levels, treatment choices, clinical follow-ups, mortality and morbidity rates, and length of hospital stay were evaluated. The Ranson criteria and Apache II score were used to determine the severity of pancreatitis. Results: Thirteen (72.2%) were female and 5 (27.8%) were male. The mean age was 57.83±12.59 (34-77). The mean time elapsed after cholecystectomy was 72.11±38.12 (5-130) months. The mean diameter of the common bile duct (CBD) was measured as 12.39±2.30 (8-15) mm. The average level of amylase was 986.50±323.29 (350-1530) U/L. Fifteen (83.33%) patients had mild, and 3 (16.67%) patients had moderately severe acute biliary pancreatitis. Endoscopic sphincterotomy (ES) was performed on 16 patients during endoscopic retrograde cholangiopancreatography (ERCP). Two patients were operated due to failure of ERCP. Choledochotomy, transduodenal sphincteroplasty and The T-tube drainage were performed on 1 patient. The other underwent choledochotomy and choledochoduodenostomy. The average length of stay in hospital was 7.89±4.91 (5-25) days. (5-130) months. The rate of incidence of patients with cholecystectomy in the etiology of ABP was found to be 3.08%. Intravenous contrast-enhanced abdominal tomography (CT) was performed on all patients to evaluate the pancreas. CT was repeated 48 and 96 hours later when patients’ clinical conditions had not changed. MRCP was performed on all patients to show the CBD diameter and the presence of stones. The mean diameter of the CBD was measured as 12.39±2.30 (8-15) mm by MRCP. The average level of amylase was 986.50±323.29 (350-1530) U/L. Fifteen (83.33%) patients had mild, and 3 (16.67%) patients had moderately severe ABP according to the Ranson’s criteria and Apache II score. None of the patients had severe ABP. Patients with moderately severe ABP responded to medical therapy. None of the patients needed intensive care unit. All patients underwent endoscopic retrograde ERCP. ES was performed on 16 of the 18 patients during ERCP. Two patients were operated due to failure of ERCP. CBD exploration was performed on both patients surgically. Four to five stones were removed from the CBD in one patient. The transition from CBD to duodenum was controlled with dilators. Transduodenal sphincteroplasty was performed because there was stenosis in the Oddi sphincter. A T-tube was inserted into the CBD. T-tube cholangiography was executed on the 14 th day. The T-tube was removed since no pathology was found in the for acute pancreatitis caused by CBD stones in patients with cholecystectomy are ERCP and ES. In patients with
{"title":"Management of Acute Biliary Pancreatitis in Cholecystectomized Patients","authors":"A. Çi̇ftçi̇, M. Gök, M. Kafadar","doi":"10.14235/bas.galenos.2021.6708","DOIUrl":"https://doi.org/10.14235/bas.galenos.2021.6708","url":null,"abstract":"Objective: We aimed to evaluate the patients who were hospitalized, followed up and treated in our clinic with the diagnosis of acute biliary pancreatitis (ABP) after cholecystectomy. Methods: The electronic records of 18 patients with a history of cholecystectomy were reviewed retrospectively. The demographic findings of the patients, time passed after cholecystectomy, methods used in diagnosis, amylase levels, treatment choices, clinical follow-ups, mortality and morbidity rates, and length of hospital stay were evaluated. The Ranson criteria and Apache II score were used to determine the severity of pancreatitis. Results: Thirteen (72.2%) were female and 5 (27.8%) were male. The mean age was 57.83±12.59 (34-77). The mean time elapsed after cholecystectomy was 72.11±38.12 (5-130) months. The mean diameter of the common bile duct (CBD) was measured as 12.39±2.30 (8-15) mm. The average level of amylase was 986.50±323.29 (350-1530) U/L. Fifteen (83.33%) patients had mild, and 3 (16.67%) patients had moderately severe acute biliary pancreatitis. Endoscopic sphincterotomy (ES) was performed on 16 patients during endoscopic retrograde cholangiopancreatography (ERCP). Two patients were operated due to failure of ERCP. Choledochotomy, transduodenal sphincteroplasty and The T-tube drainage were performed on 1 patient. The other underwent choledochotomy and choledochoduodenostomy. The average length of stay in hospital was 7.89±4.91 (5-25) days. (5-130) months. The rate of incidence of patients with cholecystectomy in the etiology of ABP was found to be 3.08%. Intravenous contrast-enhanced abdominal tomography (CT) was performed on all patients to evaluate the pancreas. CT was repeated 48 and 96 hours later when patients’ clinical conditions had not changed. MRCP was performed on all patients to show the CBD diameter and the presence of stones. The mean diameter of the CBD was measured as 12.39±2.30 (8-15) mm by MRCP. The average level of amylase was 986.50±323.29 (350-1530) U/L. Fifteen (83.33%) patients had mild, and 3 (16.67%) patients had moderately severe ABP according to the Ranson’s criteria and Apache II score. None of the patients had severe ABP. Patients with moderately severe ABP responded to medical therapy. None of the patients needed intensive care unit. All patients underwent endoscopic retrograde ERCP. ES was performed on 16 of the 18 patients during ERCP. Two patients were operated due to failure of ERCP. CBD exploration was performed on both patients surgically. Four to five stones were removed from the CBD in one patient. The transition from CBD to duodenum was controlled with dilators. Transduodenal sphincteroplasty was performed because there was stenosis in the Oddi sphincter. A T-tube was inserted into the CBD. T-tube cholangiography was executed on the 14 th day. The T-tube was removed since no pathology was found in the for acute pancreatitis caused by CBD stones in patients with cholecystectomy are ERCP and ES. In patients with ","PeriodicalId":8757,"journal":{"name":"Bezmialem Science","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45259896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-19DOI: 10.14235/bas.galenos.2021.6479
Mehmet Kapıcıoğlu, Anıl Pulatkan, Vahdet Uçan, Okan Tezgel, K. Bilsel
Objective: The purpose of this study was to compare the complications and functional outcomes of single versus double-incision repair techniques for the treatment of distal biceps brachii tendon rupture Methods: Between 2012 and 2018, patients with distal biceps brachii tendon rupture who were treated with a single or double-incision repair technique were included in this retrospective study. Range of motion (ROM) and Mayo elbow performance scores (MEPS) were evaluated. Results: Seventeen patients with a mean age of 45.6±6.4 years (range: 34-58 years) who underwent single (n=9) and double (n=8) incision techniques were included in this study. The mean follow-up was 33±10.5 months (range: 24-62 months). Preoperative and postoperative ROM and MEPS were similar between two groups (p>0.05). In the single incision repair technique group, 3 patients had lateral antebrachial cutaneous nerve (LACN) palsy and 1 patient was re-operated due to re-rupture. In the double incision repair technique group, 1 patient had posterior interosseous nerve (PIN) palsy and 1 patient had hematoma that did not require surgical drainage. No significant differences were detected in terms of complications (p=0.62). Conclusion: Good functional results were obtained after both single and double incision techniques for the treatment of distal biceps brachii tendon rupture. Both single and double incision techniques were reliable however LACN was at risk in single incision technique and PIN in double incision technique.
{"title":"Comparison of Single and Double Incision Repair Techniques in Distal Biceps Tendon Rupture","authors":"Mehmet Kapıcıoğlu, Anıl Pulatkan, Vahdet Uçan, Okan Tezgel, K. Bilsel","doi":"10.14235/bas.galenos.2021.6479","DOIUrl":"https://doi.org/10.14235/bas.galenos.2021.6479","url":null,"abstract":"Objective: The purpose of this study was to compare the complications and functional outcomes of single versus double-incision repair techniques for the treatment of distal biceps brachii tendon rupture Methods: Between 2012 and 2018, patients with distal biceps brachii tendon rupture who were treated with a single or double-incision repair technique were included in this retrospective study. Range of motion (ROM) and Mayo elbow performance scores (MEPS) were evaluated. Results: Seventeen patients with a mean age of 45.6±6.4 years (range: 34-58 years) who underwent single (n=9) and double (n=8) incision techniques were included in this study. The mean follow-up was 33±10.5 months (range: 24-62 months). Preoperative and postoperative ROM and MEPS were similar between two groups (p>0.05). In the single incision repair technique group, 3 patients had lateral antebrachial cutaneous nerve (LACN) palsy and 1 patient was re-operated due to re-rupture. In the double incision repair technique group, 1 patient had posterior interosseous nerve (PIN) palsy and 1 patient had hematoma that did not require surgical drainage. No significant differences were detected in terms of complications (p=0.62). Conclusion: Good functional results were obtained after both single and double incision techniques for the treatment of distal biceps brachii tendon rupture. Both single and double incision techniques were reliable however LACN was at risk in single incision technique and PIN in double incision technique.","PeriodicalId":8757,"journal":{"name":"Bezmialem Science","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47104251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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