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Feasibility Study and Design of the ICU Infection Registry System for Patients Admitted to the Alzahra University Hospital in Isfahan: A Methodology Study. 伊斯法罕阿尔扎赫拉大学医院重症监护室感染登记系统的可行性研究与设计:方法论研究。
Pub Date : 2023-08-31 eCollection Date: 2023-01-01 DOI: 10.4103/abr.abr_267_22
Soodabeh Rostami, Setayesh Sindarreh, Amirhossein Akhavan Sigari, Marzieh Salimi Bani, Behjat Taheri, Saeed Abbasi

Background: Data gathering and bioinformatics play a significant role in the management and treatment of patients, especially of critically ill patients. This study assesses the feasibility and design of a registration system for nosocomial infections and sepsis in the intensive care unit of Alzahra university hospital in Isfahan.

Methods: The members of the registration system consisting of physicians and nurses of the ICU, infectious disease and pulmonary specialists, microbiologists, infection control supervisors, and librarians. The data collection tool was a researcher-made checklist. To design the framework of the tool, researchers investigated various tools and indices in references and databases such as PubMed, Scopus, Web of Science, and national databases regarding ICU infection and disease registration systems. Essential items in this field were selected and a preliminary draft was prepared to record the data of patients with ICU-related infections. After applying experts' opinions, the checklist was reviewed, and the final approval of the checklist was obtained.

Results: The final version of the checklist is prepared in three parts consisting of demographic data, principle variables (data required for registration of a patient), and the extended variables including details of the principle variables, and the data used to diagnose and treat.

Conclusion: The ICU infection registration system can predict the prevalence of infection, monitor services and treatment of patients, analyze survival, assess clinical care outcomes, and investigate drug-related interventions. Reducing hospitalization costs by stratifying patients, providing a database for research studies, assessing the cost-effectiveness of interventions, are other advantages that resulted from the design of this system.

背景:数据收集和生物信息学在患者,尤其是重症患者的管理和治疗中发挥着重要作用。本研究评估了伊斯法罕市阿尔扎赫拉大学医院重症监护室院内感染和败血症登记系统的可行性和设计:登记系统的成员包括重症监护室的医生和护士、传染病和肺病专家、微生物学家、感染控制主管和图书管理员。数据收集工具是研究人员自制的核对表。为了设计该工具的框架,研究人员调查了参考文献和数据库(如 PubMed、Scopus、Web of Science 和有关 ICU 感染和疾病登记系统的国家数据库)中的各种工具和指数。筛选出该领域的基本项目,并编写了记录 ICU 相关感染患者数据的初稿。在征求专家意见后,对核对表进行了审核,并最终通过了核对表:最终版本的核对表由三部分组成,包括人口统计学数据、主要变量(患者登记所需的数据)、扩展变量(包括主要变量的详细信息)以及用于诊断和治疗的数据:重症监护室感染登记系统可以预测感染的发生率、监测患者的服务和治疗情况、分析存活率、评估临床护理效果以及研究与药物相关的干预措施。通过对患者进行分层、为研究提供数据库、评估干预措施的成本效益,从而降低住院费用,这些都是设计该系统的其他优势。
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引用次数: 0
Is L-Glutamate Toxic to Neurons and Thereby Contributes to Neuronal Loss and Neurodegeneration? A Systematic Review. L-谷氨酸是否对神经元有毒并因此导致神经元丢失和神经退行性变?系统综述。
IF 2.7 Pub Date : 2022-04-29 DOI: 10.3390/brainsci12050577
Maryam N Al-Nasser, Ian R Mellor, Wayne G Carter

L-glutamate (L-Glu) is a nonessential amino acid, but an extensively utilised excitatory neurotransmitter with critical roles in normal brain function. Aberrant accumulation of L-Glu has been linked to neurotoxicity and neurodegeneration. To investigate this further, we systematically reviewed the literature to evaluate the effects of L-Glu on neuronal viability linked to the pathogenesis and/or progression of neurodegenerative diseases (NDDs). A search in PubMed, Medline, Embase, and Web of Science Core Collection was conducted to retrieve studies that investigated an association between L-Glu and pathology for five NDDs: Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD). Together, 4060 studies were identified, of which 71 met eligibility criteria. Despite several inadequacies, including small sample size, employment of supraphysiological concentrations, and a range of administration routes, it was concluded that exposure to L-Glu in vitro or in vivo has multiple pathogenic mechanisms that influence neuronal viability. These mechanisms include oxidative stress, reduced antioxidant defence, neuroinflammation, altered neurotransmitter levels, protein accumulations, excitotoxicity, mitochondrial dysfunction, intracellular calcium level changes, and effects on neuronal histology, cognitive function, and animal behaviour. This implies that clinical and epidemiological studies are required to assess the potential neuronal harm arising from excessive intake of exogenous L-Glu.

L-谷氨酸(L-Glu)是一种非必需氨基酸,但却是一种被广泛利用的兴奋性神经递质,在正常大脑功能中起着至关重要的作用。L-Glu 的异常积累与神经毒性和神经变性有关。为了进一步研究这个问题,我们系统地查阅了相关文献,以评估 L-Glu 对神经元活力的影响,这些影响与神经退行性疾病(NDDs)的发病和/或进展有关。我们在 PubMed、Medline、Embase 和 Web of Science Core Collection 中进行了搜索,检索了研究 L-Glu 与五种神经退行性疾病病理学之间关联的研究:阿尔茨海默病(AD)、帕金森病(PD)、多发性硬化症(MS)、肌萎缩侧索硬化症(ALS)和亨廷顿病(HD)。共确定了 4060 项研究,其中 71 项符合资格标准。尽管存在一些不足之处,包括样本量较小、采用了超生理浓度和一系列给药途径,但得出的结论是,体外或体内暴露于 L-Glu 有多种致病机制,会影响神经元的活力。这些机制包括氧化应激、抗氧化防御能力下降、神经炎症、神经递质水平改变、蛋白质蓄积、兴奋毒性、线粒体功能障碍、细胞内钙水平变化,以及对神经元组织学、认知功能和动物行为的影响。这意味着需要进行临床和流行病学研究,以评估过量摄入外源性 L-Glu 可能对神经元造成的危害。
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引用次数: 0
The Window Opens 窗户打开了
Pub Date : 2017-10-02 DOI: 10.1080/1556035X.2017.1397406
J. Roth
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引用次数: 0
The Effectiveness of Cognitive Group Therapy Based on Schema-Focused Approach on Self-Esteem and Emotion Regulation in Drug Addicted Prisoners Under the Methadone Maintenance Treatment (MMT) 基于图式聚焦法的认知团体治疗对美沙酮维持治疗下吸毒人员自尊和情绪调节的有效性
Pub Date : 2017-10-02 DOI: 10.1080/1556035X.2017.1337532
F. Jalali, S. Hashemi, A. Hasani, Niloofar Fakoor Sharghi
ABSTRACT This study's purpose is to determine the effectiveness of cognitive group therapy based on schema-focused approach on self-esteem and emotion regulation in drug-addicted prisoners under methadone maintenance treatment (MMT). The research population comprised addicted male prisoners under the MMT in Chenaran Prison. The experimental group received cognitive group therapy based on schema-focused approach, whereas the control group received no treatment. The instruments used for measurement in this research were the Coopersmith Self-Esteem Inventory and the Cognitive Emotion Regulation Questionnaire. Results revealed that cognitive group therapy based on schema-focused approach increase self-esteem and regulate emotions in addicted prisoners who are under the MMT.
摘要本研究的目的是确定基于图式集中方法的认知小组治疗对接受美沙酮维持治疗(MMT)的吸毒囚犯自尊和情绪调节的有效性。研究人群包括Chenaran监狱MMT下的成瘾男性囚犯。实验组接受了基于图式聚焦方法的认知小组治疗,而对照组没有接受任何治疗。本研究采用库珀史密斯自尊量表和认知情绪调节问卷进行测量。研究结果表明,基于图式聚焦方法的认知小组治疗可以提高MMT下成瘾囚犯的自尊并调节情绪。
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引用次数: 9
Assessing the Impact of American Indian Peer Recovery Support on Substance Use and Health 评估美国印第安人同伴康复支持对药物使用和健康的影响
Pub Date : 2017-10-02 DOI: 10.1080/1556035X.2017.1337531
Allyson Kelley, Dyani Bingham, E. Brown, Lita Pepion
ABSTRACT Peer Recovery Support (PRS) is emerging as a key intervention for communities and individuals as they address high rates of substance abuse and limited recovery resources. American Indian populations were among the first people to use concepts of PRS through abstinence-based revitalization movements and ceremonies. The present study examined the impact of PRS on substance use, emotional and psychological problems, and social connections among urban and reservation American Indian peers involved in a 3-year PRS program. A total of 224 individuals, 110 male and 114 female completed baseline GPRA. Of these, 65 peers completed baseline and 6-month follow-up GPRAs. Involvement in PRS decreased substance use significantly among peers. Peer attendance at voluntary self-help groups and support from family and friends increased as a result of PRS.
摘要同伴康复支持(PRS)正在成为社区和个人的一项关键干预措施,因为它们解决了药物滥用率高和康复资源有限的问题。美国印第安人是最早通过基于禁欲的振兴运动和仪式使用PRS概念的人之一。本研究调查了PRS对参与3年PRS计划的城市和保留地美国印第安人同龄人的物质使用、情绪和心理问题以及社会联系的影响。共有224人,110名男性和114名女性完成了基线GPRA。其中,65名同龄人完成了基线和6个月的GPRA随访。参与PRS显著降低了同龄人的药物使用。由于PRS,参加自愿自助团体的同伴人数以及家人和朋友的支持有所增加。
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引用次数: 10
Rolling Psychodynamic Group for Cocaine Use Disorder: A Single-Group Study Using Multilevel Models 可卡因使用障碍的滚动心理动力学组:一项使用多水平模型的单组研究
Pub Date : 2017-10-02 DOI: 10.1080/1556035X.2017.1313148
L. Pavia, C. Tosto, A. Cinquegrana, Ernesto Scioti, Tiziana Bussola, Paola Cavani
ABSTRACT Cocaine disorder has been shown to have an important impact on the success of treatments because it is often associated with social or occupational impairment, high relapse incidences and poor treatment outcomes. Many community group treatment programs for cocaine disorders use a rolling admissions structure, in which a group member who drops out or successfully completes therapy is replaced by another individual. Despite the common use, little is known about the effectiveness of this group. The study involved 18 patients who started a group therapy for cocaine abuse disorder. Outpatients group therapy take place into Clinical Center of Cocaine Addicts in Brescia, Italy. The measures used are DAST-20, OQ-45, GMLCS. The analysis conducted by the Multilevel Models show improvements compared to the symptom that is reliable with respect to psychological functioning. Patients who remain in treatment longer experience a greater quality of relationships within the group.
可卡因障碍已被证明对治疗的成功具有重要影响,因为它通常与社会或职业障碍、高复发率和不良治疗结果相关。许多社区团体治疗可卡因疾病的项目采用滚动入院结构,其中一个团体成员退出或成功完成治疗,由另一个人代替。尽管普遍使用,但对该组的有效性知之甚少。这项研究涉及18名开始接受可卡因滥用障碍团体治疗的患者。门诊病人集体治疗在布雷西亚,意大利的可卡因成瘾者临床中心进行。使用的测量方法是DAST-20, OQ-45, GMLCS。由多层模型进行的分析显示,与可靠的心理功能症状相比,症状有所改善。治疗时间越长,患者在小组内的关系质量越高。
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引用次数: 1
EOV editorial board page EOV编委会页面
Pub Date : 2017-10-02 DOI: 10.1080/1556035x.2017.1406720
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引用次数: 0
A Revised Multifamily Group Curriculum: The Need for Family Member Recovery from Addiction 修订后的多家庭小组课程:家庭成员从成瘾中恢复的必要性
Pub Date : 2017-10-02 DOI: 10.1080/1556035X.2017.1348281
Sterling T. Shumway, Sarah Schonian, Spencer D. Bradshaw, Nicholas D. Hayes
ABSTRACT This article presents a revised curriculum for a family program developed for family members who are participating in a family program at a residential treatment for addiction. The article consists of a comprehensive overview of the modules developed for the program, inclusive of multifamily groups, psychoeducational components, and other family therapy modalities. In addition, preliminary results are presented demonstrating the positive effects of the program, while simultaneously building a foundation for the development and necessity of family member recovery.
摘要本文介绍了一个家庭项目的修订课程,该课程是为在戒毒所参加家庭项目的家庭成员开发的。本文全面概述了为该项目开发的模块,包括多家庭群体、心理教育组成部分和其他家庭治疗模式。此外,初步结果表明了该计划的积极效果,同时为家庭成员康复的发展和必要性奠定了基础。
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引用次数: 9
Progress: Things are Good and Getting Better 进展:一切都很好,而且越来越好
Pub Date : 2017-10-02 DOI: 10.1080/1556035X.2017.1397407
L. B. Young
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引用次数: 0
Bridging the Gap Between Research and Practice in Therapeutic Communities (TCs) for Addictions 弥合成瘾治疗社区(TCs)研究与实践之间的差距
Pub Date : 2017-06-23 DOI: 10.1080/1556035X.2017.1331598
W. Vanderplasschen, Rowdy Yates, M. Miovský
Therapeutic communities (TCs) are well-known as a treatment modality and can be found in a variety of populations and settings, including addicts, as well as children and young people, individuals with personality disorders and learning disabilities, prisons and hospitals (see Boyling, 2009; De Leon, 2000; Kennard, 1998; Vanderplasschen, Vandevelde, & Broekaert, 2014). The term therapeutic community was first used by the British psychiatrist TomMain (1946), who was involved in the so-called Northfield Experiments (see Vanderplasschen, Vandevelde, De Ruysscher, Vandevelde, & Broekaert, 2017), where soldiers suffering from shell shock and war neuroses after the Second World War were treated by using group processes therapeutically (Harrison & Clarck, 1992). From that time forwards, the term therapeutic community has been linked to a range of treatment traditions and approaches that essentially share the “idea of using all the relationships and activities of a residential psychiatric centre to aid the therapeutic task” (Bridger, 1985, p. 60). One of these traditions is commonly referred to as drug-free or hierarchical TCs, also called concept(-based) TCs or TCs for addictions (Vanderplasschen et al., 2014). These TCs were developed in the 1960s as intensive inpatient-type programs to get people off drugs and to provide a complete break from their past lifestyle. Numerous residential programs for addicts have been modelled after this original concept and also drug-free TCs themselves have evolved and beenmodified to address the needs of specific groups, such as adolescents, mothers with young children, incarcerated substance abusers, or persons with co-occurring mental disorders. Community as method has been identified as the core and common mechanism across TCs (De Leon, 1997). It has been described as “teaching individuals to use the context of community life to learn about themselves” (De Leon, 2000, p. 93) and refers to peer and staff relationships, social roles, the social structure, group process and daily activities. Two years ago we agreed to prepare a special issue of the Journal of Groups in Addiction and Recovery (JGAR) on TCs. This decision was inspired by a series of
治疗社区是一种众所周知的治疗模式,可以在各种人群和环境中找到,包括瘾君子、儿童和年轻人、有人格障碍和学习障碍的人、监狱和医院(见Boyling,2009;德莱昂,2000年;肯纳德,1998年;Vanderplaschen、Vandevelde和Broekert,2014)。“治疗群体”一词最早由英国精神病学家TomMain(1946)使用,他参与了所谓的Northfield实验(见Vanderplaschen、Vandevelde、De Ruysscher、Vandevilde和Broekert,2017),在该实验中,第二次世界大战后患有炮弹休克和战争神经症的士兵通过使用群体治疗过程进行治疗(Harrison和Clarck,1992)。从那时起,“治疗社区”一词与一系列治疗传统和方法联系在一起,这些传统和方法基本上共享“利用寄宿精神病中心的所有关系和活动来帮助治疗任务的想法”(Bridger,1985,第60页)。其中一种传统通常被称为无药物或分级TC,也称为基于概念的TC或成瘾TC(Vanderplaschen等人,2014)。这些TC是在20世纪60年代作为强化住院型项目开发的,目的是让人们远离毒品,并彻底摆脱过去的生活方式。许多针对吸毒者的寄宿计划都是以这一原始概念为蓝本的,而且无毒品TC本身也经过了发展和修改,以满足特定群体的需求,如青少年、有幼儿的母亲、被监禁的药物滥用者或同时患有精神障碍的人。社区作为方法已被确定为TC的核心和共同机制(De Leon,1997)。它被描述为“教个人利用社区生活的背景来了解自己”(De Leon,2000,p.93),并指的是同伴和员工关系、社会角色、社会结构、群体过程和日常活动。两年前,我们同意为《成瘾与康复群体杂志》(JGAR)准备一期关于TC的特刊。这一决定的灵感来自于
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引用次数: 4
期刊
Journal of groups in addiction & recovery
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