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Automatic landmark identification for surgical 3d-navigation - A proposed method for marker-free dental surgical navigation systems. 用于外科手术3d导航的自动地标识别-一种用于无标记牙科手术导航系统的建议方法。
IF 1.7 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2022-07-04 Print Date: 2022-10-26 DOI: 10.1515/bmt-2021-0307
Micha Bischofberger, Stephan Böhringer, Erik Schkommodau

This paper proposes a conceptual method to calculate the pose of a stereo-vision camera relative to an artificial mandible without additional markers. The general method for marker-free navigation has four steps: 1) parallel image acquisition by a stereo-vision camera, 2) automatic identification of 2d point pairs (landmark pairs) in a left and a right image, 3) calculation of related 3d points in the joint camera coordinate system and 4) matching of 3d points generated to a preoperative 3d model (i.e., CT data based). To identify and compare landmarks in the acquired stereo images, well-known algorithms for landmark detection, description and matching were compared within the developed approach. Finally, the BRISK algorithm (Leutenegger S, Chli M, Siegwart RY. BRISK: Binary Robust invariant scalable keypoints. Proceedings of the IEEE International Conference on Computer Vision; 2011: 2548-2555) was used. The proposed method was implemented in MATLAB® and validated in vitro with one artificial mandible. The accuracy evaluation of the camera positions calculated resulted in an average deviation error of 1.45 mm ± 0.76 mm to the real camera displacement. This value was calculated using only stereo images with over 100 reconstructed landmark pairs each. This provides the basis for marker-free navigation.

本文提出了一种不需要附加标记来计算立体视觉相机相对于人工下颌骨的姿态的概念方法。无标记导航的一般方法有四个步骤:1)由立体视觉相机获取平行图像,2)自动识别左右图像中的二维点对(地标对),3)在联合相机坐标系中计算相关的三维点,4)将生成的三维点与术前三维模型(即基于CT数据)进行匹配。为了识别和比较获得的立体图像中的地标,在开发的方法中比较了已知的地标检测,描述和匹配算法。Leutenegger S, Chli M, Siegwart RY. BRISK:二值鲁棒不变可伸缩关键点。IEEE计算机视觉国际会议论文集;2011: 2548-2555)。在MATLAB®中实现了该方法,并在一个人工下颌骨上进行了体外验证。计算得到的摄像机位置精度评价结果与摄像机实际位移的平均偏差为1.45 mm±0.76 mm。该值仅使用具有100多个重建地标对的立体图像来计算。这为无标记导航提供了基础。
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引用次数: 0
Analysis of pilots' EEG map in take-off and landing tasks. 起降任务中飞行员脑电图分析。
IF 1.7 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2022-06-28 Print Date: 2022-10-26 DOI: 10.1515/bmt-2021-0418
Li Ji, Chen Zhang, Haiwei Li, Ningning Zhang, Peng Zheng, Changhao Guo, Yong Zhang, Xiaoyu Tang

The take-off and landing phases are considered the critical stages of aircraft flight. To ensure flight efficiency and safety in the critical stages, this research proposes a method for analyzing and monitoring pilot flight status by β-wave. The focus of the study is β potential changes on the EEG map. First, the proportion of β-wave in the electroencephalogram (EEG) of pilots during take-off and landing increases significantly. Second, the EEG map accurately and intuitively reflects the spatial distribution of potential changes in brain regions. Finally, correlation and machine learning are used for further research of β-wave. The conclusions show that the significant changes in the β-wave caused by take-off and landing can be seen in the EEG map to identify and adjust the pilot's state. Therefore, this research provides more accurate and effective reference information (like the EEG map, correlation and machine learning) for efficient and safe flight training in the critical stages.

起飞和降落阶段被认为是飞机飞行的关键阶段。为了保证关键阶段的飞行效率和安全,本研究提出了一种利用β波分析和监测飞行员飞行状态的方法。研究的重点是脑电图图上β电位的变化。首先,飞行员在起飞和降落时脑电图中β波的比例显著增加。其次,脑电图准确直观地反映了脑区电位变化的空间分布。最后,利用相关和机器学习对β波进行进一步研究。结论表明,在脑电图图中可以看到起飞和降落引起的β波的显著变化,从而识别和调整飞行员的状态。因此,本研究为关键阶段的高效安全飞行训练提供了更准确有效的参考信息(如EEG图、相关性、机器学习等)。
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引用次数: 0
Automatic sleep scoring with LSTM networks: impact of time granularity and input signals LSTM网络的自动睡眠评分:时间粒度和输入信号的影响
IF 1.7 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2022-06-06 DOI: 10.1515/bmt-2021-0408
Alexandra-Maria Tăuțan, A. C. Rossi, B. Ionescu
Abstract Supervised automatic sleep scoring algorithms are usually trained using sleep stage labels manually annotated on 30 s epochs of PSG data. In this study, we investigate the impact of using shorter epochs with various PSG input signals for training and testing a Long Short Term Memory (LSTM) neural network. An LSTM model is evaluated on the provided 30 s epoch sleep stage labels from a publicly available dataset, as well as on 10 s subdivisions. Additionally, three independent scorers re-labeled a subset of the dataset on shorter time windows. The automatic sleep scoring experiments were repeated on the re-annotated subset.The highest performance is achieved on features extracted from 30 s epochs of a single channel frontal EEG. The resulting accuracy, precision and recall were of 92.22%, 67.58% and 66.00% respectively. When using a shorter epoch as input, the performance decreased by approximately 20%. Re-annotating a subset of the dataset on shorter time epochs did not improve the results and further altered the sleep stage detection performance. Our results show that our feature-based LSTM classification algorithm performs better on 30 s PSG epochs when compared to 10 s epochs used as input. Future work could be oriented to determining whether varying the epoch size improves classification outcomes for different types of classification algorithms.
有监督的自动睡眠评分算法通常使用人工标注睡眠阶段标签的PSG数据进行训练。在这项研究中,我们研究了使用不同PSG输入信号的较短时间对长短期记忆(LSTM)神经网络的训练和测试的影响。LSTM模型在公共数据集提供的30秒epoch睡眠阶段标签以及10秒细分上进行评估。此外,三个独立的评分者在较短的时间窗口上重新标记数据集的子集。在重新标注的子集上重复自动睡眠评分实验。在单通道额叶脑电图的30 s epoch特征提取上,获得了最高的性能。准确度、精密度和召回率分别为92.22%、67.58%和66.00%。当使用较短的epoch作为输入时,性能下降了大约20%。在较短的时间点上重新标注数据集的子集并没有改善结果,反而进一步改变了睡眠阶段检测性能。结果表明,基于特征的LSTM分类算法在30秒的PSG epoch上的表现优于10秒的PSG epoch。未来的工作可能是确定不同epoch大小是否会改善不同类型分类算法的分类结果。
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引用次数: 1
Layer recurrent neural network-based diagnosis of Parkinson’s disease using voice features 基于层递归神经网络的帕金森病语音特征诊断
IF 1.7 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2022-06-03 DOI: 10.1515/bmt-2022-0022
Z. Senturk
Abstract Parkinson’s disease (PD), a slow-progressing neurological disease, affects a large percentage of the world’s elderly population, and this population is expected to grow over the next decade. As a result, early detection is crucial for community health and the future of the globe in order to take proper safeguards and have a less arduous treatment procedure. Recent research has begun to focus on the motor system deficits caused by PD. Because practically most of the PD patients suffer from voice abnormalities, researchers working on automated diagnostic systems investigate vocal impairments. In this paper, we undertake extensive experiments with features extracted from voice signals. We propose a layer Recurrent Neural Network (RNN) based diagnosis for PD. To prove the efficiency of the model, different network models are compared. To the best of our knowledge, several neural network topologies, namely RNN, Cascade Forward Neural Networks (CFNN), and Feed Forward Neural Networks (FFNN), are used and compared for voice-based PD detection for the first time. In addition, the impacts of data normalization and feature selection (FS) are thoroughly examined. The findings reveal that normalization increases classifier performance and Laplacian-based FS outperforms. The proposed RNN model with 300 voice features achieves 99.74% accuracy.
帕金森病(PD)是一种进展缓慢的神经系统疾病,影响着世界上很大比例的老年人口,预计在未来十年内,这一人口将继续增长。因此,早期发现对社区健康和全球的未来至关重要,以便采取适当的保障措施并减少繁重的治疗程序。最近的研究开始关注帕金森病引起的运动系统缺陷。由于实际上大多数PD患者都患有声音异常,因此从事自动诊断系统的研究人员对声音障碍进行了调查。在本文中,我们对从语音信号中提取的特征进行了大量的实验。提出了一种基于分层递归神经网络(RNN)的PD诊断方法。为了证明该模型的有效性,对不同的网络模型进行了比较。据我们所知,几种神经网络拓扑,即RNN,级联前向神经网络(CFNN)和前馈神经网络(FFNN),首次用于基于语音的PD检测并进行了比较。此外,对数据归一化和特征选择(FS)的影响进行了深入的研究。研究结果表明,归一化提高了分类器的性能,基于拉普拉斯的FS优于分类器。所提出的RNN模型具有300个语音特征,准确率达到99.74%。
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引用次数: 3
Frontmatter
IF 1.7 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2022-06-01 DOI: 10.1515/bmt-2022-frontmatter3
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引用次数: 0
Fetal phonocardiogram signals denoising using improved complete ensemble (EMD) with adaptive noise and optimal thresholding of wavelet coefficients 利用改进的全系综(EMD)自适应噪声和最佳小波系数阈值对胎儿心音信号进行降噪
IF 1.7 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2022-06-01 DOI: 10.1515/bmt-2022-0006
Fethi Cheikh, Nasser Edinne Benhassine, S. Sbaa
Abstract Although fetal phonocardiogram (fPCG) signals have become a good indicator for discovered heart disease, they may be contaminated by various noises that reduce the signals quality and the final diagnosis decision. Moreover, the noise may cause the risk of the data to misunderstand the heart signal and to misinterpret it. The main objective of this paper is to effectively remove noise from the fPCG signal to make it clinically feasible. So, we proposed a novel noise reduction method based on Improved Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (ICEEMDAN), wavelet threshold and Crow Search Algorithm (CSA). This noise reduction method, named ICEEMDAN-DWT-CSA, has three major advantages. They were, (i) A better suppress of mode mixing and a minimized number of IMFs, (ii) A choice of wavelet corresponding to the study signal proven by the literature and (iii) Selection of the optimal threshold value. Firstly, the noisy fPCG signal is decomposed into Intrinsic Mode Functions (IMFs) by the (ICEEMDAN). Each noisy IMFs were decomposed by the Discrete Wavelet Transform (DWT). Then, the optimal threshold value using the (CSA) technique is selected and the thresholding function is carried out in the detail’s coefficients. Secondly, each denoised (IMFs) is reconstructed by applying the Inverse Discrete Wavelet Transform (IDWT). Finally, all these denoised (IMFs) are combined to get the denoised fPCG signal. The performance of the proposed method has been evaluated by Signal to Noise Ratio (SNR), Mean Square Error (MSE) and the Correlation Coefficient (COR). The experiment gave a better result than some standard methods.
虽然胎儿心音图(fPCG)信号已成为发现心脏病的良好指标,但它们可能受到各种噪声的污染,从而降低信号质量,影响最终的诊断决策。此外,噪声可能会导致数据误解心脏信号和误解它的风险。本文的主要目的是有效去除fPCG信号中的噪声,使其具有临床可行性。为此,提出了一种基于改进的全集成经验模态分解自适应噪声(ICEEMDAN)、小波阈值和Crow搜索算法(CSA)的降噪方法。这种降噪方法被命名为ICEEMDAN-DWT-CSA,它有三个主要优点。它们是:(i)更好地抑制模态混合和最小化IMFs数量;(ii)选择与文献证明的研究信号对应的小波;(iii)选择最优阈值。首先,利用icemdan将含噪fPCG信号分解为内禀模态函数(IMFs);利用离散小波变换(DWT)对各噪声imf进行分解。然后,利用(CSA)技术选择最优阈值,并在细节系数中进行阈值函数。其次,利用离散小波逆变换(IDWT)对每个去噪后的图像进行重构。最后,将这些去噪后的信号进行组合,得到去噪后的fPCG信号。通过信噪比(SNR)、均方误差(MSE)和相关系数(COR)对该方法的性能进行了评价。实验结果优于一些标准方法。
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引用次数: 2
Non-woven textiles for medical implants: mechanical performances improvement 医用植入物用无纺布纺织品:机械性能改进
IF 1.7 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2022-05-25 DOI: 10.1515/bmt-2022-0017
Amandine Lequeux, B. Mazé, G. Laroche, F. Heim
Abstract Non-woven textile has been largely used as medical implant material over the last decades, especially for scaffold manufacturing purpose. This material presents a large surface area-to-volume ratio, which promotes adequate interaction with biological tissues. However, its strength is limited due to the lack of cohesion between the fibers. The goal of the present work was to investigate if a non-woven substrate can be reinforced by embroidery stitching towards strength increase. Non-woven samples were produced from both melt-blowing and electro-spinning techniques, reinforced with a stitching yarn and tested regarding several performances: ultimate tensile strength, burst strength and strength loss after fatigue stress. Several stitching parameters were considered: distance between stitches, number of stitch lines (1, 2 or 3) and line geometry (horizontal H, vertical L, cross X). The performance values obtained after reinforcement were compared with values obtained for control samples. Results bring out that reinforcement can increase the strength by up to 50% for a melt-blown mat and by up to 100% for an electro-spun mat with an X reinforcement pattern. However, after cyclic loading, the reinforcement yarn tends to degrade the ES mat in particular. Moreover, increasing the number of stitches tends to fragilize the mats.
摘要在过去的几十年里,无纺布被广泛用作医用植入材料,特别是用于支架的制造。这种材料具有较大的表面积体积比,可促进与生物组织的充分相互作用。然而,由于纤维之间缺乏凝聚力,其强度受到限制。本工作的目的是研究是否可以通过刺绣缝合来增强非织造基板的强度。非织造布样品采用熔喷和电纺丝两种技术生产,并用缝线加固,并测试了几种性能:极限拉伸强度、破裂强度和疲劳应力后的强度损失。我们考虑了几个缝线参数:缝线之间的距离、缝线数(1、2或3)和线形(水平H、垂直L、交叉X)。将加固后得到的性能值与对照样本得到的值进行比较。结果表明,增强筋可使熔喷毡的强度提高50%,使X型增强筋的电纺毡的强度提高100%。然而,在循环加载后,增强纱尤其倾向于降解ES垫。此外,增加针脚的数量往往会使垫子变得脆弱。
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引用次数: 0
Biomechanical comparison of different prosthetic materials and posterior implant angles in all-on-4 treatment concept by three-dimensional finite element analysis 采用三维有限元分析比较全on-4治疗概念中不同假体材料和后路种植体角度的生物力学差异
IF 1.7 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2022-05-20 DOI: 10.1515/bmt-2022-0109
Ayhan Gürbüz, Z. Güçlü, Gonca Deste Gökay, R. Durkan
Abstract The study aimed to evaluate the biomechanical behaviors of different prosthetic materials and posterior implant angles in All-on-4 implant-supported fixed maxillary prostheses with three-dimensional (3D) finite element analysis. The model of complete edentulous maxilla was created using the Rhinoceros and VRMesh Studio programs. Anterior vertical and 17°- and 30°-angled posterior implants were positioned with All-on-4 design. Straigth and angled multi-unit abutments scanned using a 3D scanner. Two different prosthetic superstructures (monolithic zirconia framework and lithium disilicate veneer (ZL) and monolithic zirconia-reinforced lithium silicate (ZLS)) were modeled. Four models designed according to the prosthetic structure and posterior implant angles. Posterior vertical bilateral loading and frontal oblique loading was performed. The principal stresses (bone tissues-Pmax and Pmin) and von Mises equivalent stresses (implant and prosthetic structures) were analyzed. In all models, the highest Pmax stress values were calculated under posterior bilateral loading in cortical bone. The highest von Mises stress levels occured in the posterior implants under posterior bilateral load (260.33 and 219.50 MPa) in the ZL-17 and ZL-30 models, respectively. Under both loads, higher stress levels in prosthetic structures were shown in the ZLS models compared with ZL models. There was no difference between posterior implant angles on stress distribution occurred in implant material and alveolar bone tissue. ZLS and ZL prosthetic structures can be reliably used in maxillary All-on-4 rehabilitation.
摘要本研究旨在通过三维有限元分析评估All-on-4种植体固定义齿不同材料和种植体后牙角度的生物力学行为。使用Rhinoceros和VRMesh Studio程序创建完整的无牙上颌骨模型。采用All-on-4设计定位前侧垂直种植体和后侧17°和30°角度种植体。使用3D扫描仪扫描直和角度多单元基台。模拟了两种不同的假体上部结构(单片氧化锆框架和二硅酸锂贴面(ZL)和单片氧化锆增强硅酸锂(ZLS))。根据假体结构和后种植体角度设计四种模型。后路垂直双侧负荷和正面斜向负荷。分析了主应力(骨组织- pmax和Pmin)和von Mises等效应力(种植体和假体结构)。在所有模型中,计算皮质骨后侧双侧载荷下的最大Pmax应力值。ZL-17和ZL-30模型在双侧后侧负荷(260.33 MPa和219.50 MPa)下,后侧种植体的von Mises应力水平最高。在两种载荷下,ZLS模型与ZL模型相比,假体结构的应力水平更高。种植体后角对种植体材料和牙槽骨组织的应力分布无显著差异。ZLS和ZL假体结构可可靠地用于上颌All-on-4修复。
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引用次数: 0
Computer-aided diagnosis system for retinal disorder classification using optical coherence tomography images 基于光学相干断层成像的视网膜疾病分类计算机辅助诊断系统
IF 1.7 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2022-05-18 DOI: 10.1515/bmt-2021-0330
N. Saleh, Manal Abdel Wahed, A. M. Salaheldin
Abstract The incidence of vision impairment is rapidly increasing. Diagnosis and classifying retinal abnormalities in ophthalmological applications is a significant challenge. Using Optical Coherence Tomography (OCT), the study aims to develop a computer aided diagnosis system for detecting and classifying retinal disorders. Choroidal neovascularization, diabetic macular edema, drusen, and normal cases are the investigated groups. Both deep learning and machine learning are combined to build the system. The SqueezeNet neural network was modified to extract features. The Support Vector Machine (SVM), K-Nearest Neighbor (K-NN), Decision Tree (DT), and Ensemble Model (EM) algorithms were used for disorder classification. The Bayesian optimization technique was also used to determine the best hyperparameters for each model. The model’ performance was evaluated through nine criteria using 12,000 OCT images. The results have demonstrated accuracies of 97.39, 97.47, 96.98, and 95.25% for the SVM, K-NN, DT, and EM, respectively. When results are compared to relevant studies in terms of accuracy and tested samples, they show superior performance. As a result, a novel computer-aided diagnosis system for detecting and classifying retinal diseases has been developed, reducing human error while also saving time.
摘要视力障碍的发病率正在迅速上升。诊断和分类视网膜异常在眼科应用是一个重大的挑战。本研究旨在利用光学相干断层扫描(OCT)技术,开发一种检测和分类视网膜疾病的计算机辅助诊断系统。脉络膜新生血管、糖尿病性黄斑水肿、黄斑水肿和正常病例为研究组。将深度学习和机器学习结合起来构建系统。对SqueezeNet神经网络进行改进,提取特征。使用支持向量机(SVM)、k -最近邻(K-NN)、决策树(DT)和集成模型(EM)算法进行无序分类。采用贝叶斯优化技术确定各模型的最佳超参数。使用12,000张OCT图像,通过9项标准评估模型的性能。结果表明,SVM、K-NN、DT和EM的准确率分别为97.39、97.47、96.98和95.25%。当结果与相关研究在准确性和测试样本方面进行比较时,它们显示出优越的性能。因此,开发了一种用于检测和分类视网膜疾病的新型计算机辅助诊断系统,减少了人为错误,同时也节省了时间。
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引用次数: 5
Investigation of the impact of electromagnetic fields emitted close to the head by smart glasses 智能眼镜对头部附近电磁场影响的研究
IF 1.7 4区 医学 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2022-05-17 DOI: 10.1515/bmt-2021-0301
Philipp Jungk, Matthias Wienke, Christoph Schiefer, U. Hartmann, Volker Harth, C. Terschüren, Carsten Alteköster, D. Friemert
Abstract The functionality of smart glasses includes the possibility of wireless communication. For this purpose, WiFi or Bluetooth modules are integrated into the glasses. They emit electromagnetic radiation in the vicinity of the user’s head. This simulation study investigates the impact of varying positions, frequencies, and antenna types of the embedded WiFi or Bluetooth modules on different tissue types in the human head. The absorption of electromagnetic energy causes the main impact on the tissue in the head. This physical process is best described by the specific absorption rate SAR. To investigate the effects of position, frequency, and antenna type on the simulated SAR values multiple simulations have been carried out considering real-world applications of smart glasses. The results show that the type of antenna has little effect on the SAR values of the different tissues. The maximum regulated output powers explain the frequencies’ impact on the exposure. According to our findings, the greatest influence on the SAR values can be attributed to the placement of the antenna. Finally, our study reveals that positioning the antenna at the front side of the head is optimal for most tissues because of its maximal distance to the head tissues.
智能眼镜的功能包括无线通信的可能性。为此,WiFi或蓝牙模块被集成到眼镜中。它们会在使用者头部附近发射电磁辐射。这项模拟研究调查了不同位置、频率和天线类型的嵌入式WiFi或蓝牙模块对人类头部不同组织类型的影响。电磁能量的吸收对头部组织造成主要影响。这一物理过程最好用特定吸收率SAR来描述。为了研究位置、频率和天线类型对模拟SAR值的影响,考虑到智能眼镜的实际应用,进行了多次模拟。结果表明,天线类型对不同组织的SAR值影响不大。最大调节输出功率解释了频率对曝光的影响。根据我们的研究结果,对SAR值的最大影响可归因于天线的放置。最后,我们的研究表明,对于大多数组织来说,将天线定位在头部的前部是最佳的,因为它与头部组织的距离最大。
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引用次数: 0
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