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Ile105Val polymorphism in the GSTP1 gene is associated with susceptibility to acute myeloid leukemia: an updated systematic review and meta-analysis. GSTP1 基因中的 Ile105Val 多态性与急性髓性白血病的易感性相关:最新的系统综述和荟萃分析。
IF 2.6 4区 医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2024-05-01 Epub Date: 2024-03-13 DOI: 10.1080/1354750X.2024.2326538
Raphael Enrique Tiongco, Neil David Cayanan, Miljun Catacata, Michael John Dominguez

Background and objective: Several genetic variations are associated with acute myeloid leukemia (AML) susceptibility, including the GSTP1 Ile105Val polymorphism. Even with the existing meta-analysis conducted on the topic, no consensus has been reached since none of the studies available performed in-depth data analysis. Hence, we performed an updated systematic review and meta-analysis in this paper to obtain more precise estimates.

Materials and methods: We searched various databases and calculated the odds ratio (OR) and 95% confidence interval (CI) to examine whether the GSTP1 Ile105Val polymorphism is associated with AML susceptibility. Further statistical analysis was also done to obtain more accurate and reliable findings.

Results: A total of 15 studies are included in the systematic review, but only 9 were included in the meta-analysis due to the studies deviating from the Hardy-Weinberg equilibrium. The analysis showed significantly increased susceptibility to AML in the allelic, co-dominant, and recessive models. Furthermore, subgroup analysis noted increased AML susceptibility in the non-Asian population. Comparing the proportions of the genotypes and alleles showed a significantly higher proportion of the Val/Val genotype and Val allele in the non-Asian cohort.

Conclusion: The GSTP1 Ile105Val polymorphism is significantly associated with AML susceptibility, especially among non-Asians. Further investigation should be performed to strengthen the current results.

背景和目的:有几种基因变异与急性髓性白血病(AML)的易感性有关,其中包括 GSTP1 Ile105Val 多态性。即使现有的相关荟萃分析也没有达成共识,因为现有的研究都没有进行深入的数据分析。因此,我们在本文中进行了最新的系统回顾和荟萃分析,以获得更精确的估计值:我们检索了各种数据库,并计算了几率比(OR)和 95% 置信区间(CI),以研究 GSTP1 Ile105Val 多态性是否与 AML 易感性相关。此外,还进行了进一步的统计分析,以获得更准确、更可靠的结果:系统综述共纳入了 15 项研究,但由于研究偏离了 Hardy-Weinberg 平衡,只有 9 项纳入了荟萃分析。分析表明,在等位基因、共显性和隐性模型中,对急性髓细胞性白血病的易感性明显增加。此外,亚组分析还发现,非亚洲人对急性髓细胞性白血病的易感性增加。比较基因型和等位基因的比例发现,在非亚洲人群中,Val/Val 基因型和 Val 等位基因的比例明显更高:结论:GSTP1 Ile105Val多态性与急性髓细胞性白血病的易感性密切相关,尤其是在非亚洲人中。应开展进一步调查以加强当前结果。
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引用次数: 0
Date (Phoenix dactylifera L. Mill) fruit enhances sexual performance via modulation of oxido-inflammatory mediators and purinergic signaling in hypertensive male rats. 椰枣(Phoenix dactylifera L. Mill)果实通过调节高血压雄性大鼠体内的氧化-炎症介质和嘌呤能信号转导来提高性能力。
IF 2.6 4区 医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2024-05-01 Epub Date: 2024-03-21 DOI: 10.1080/1354750X.2024.2331502
Adeniyi A Adebayo, Ayokunle O Ademosun, Ganiyu Oboh

Introduction: The present study aimed at investigating the effect of dietary supplementation of Phoenix dactylifera, an important component of aphrodisiac supplements, on sexual performance, oxido-inflammatory mediators and purinergic signaling system in hypertensive rats.

Material and methods: Hypertension was induced via oral administration of 40 mg/kg L-NAME. Thereafter, the sexual performance of the experimental animals was determined and the hypertensive rats with impaired sexual activities were placed on P. dactylifera-supplemented diet for 21 days, and the effects of the treatment on the overall sexual behavior, antioxidant status, oxido-inflammatory biomarkers, and enzyme activity of the purinergic system were assessed.

Results: Hypertensive rats showed a significant (p < 0.05) decrease in sexual performance, elevated level of oxido-inflammatory mediators, and altered purinergic enzymes activity when compared with the control. However, sub-chronic feeding with P. dactylifera-supplemented diet improved sexual performance, significantly lowered oxido-inflammatory biomarkers, and enhanced the activity of purinergic enzymes in hypertensive rats.

Conclusion: Findings presented in this study suggest that dietary inclusion of P. dactylifera could be useful in managing erectile dysfunction (ED) commonly observed in subjects with hypertension. Findings highlighted in this study thus provide the scientific basis supporting the folkloric use of P. dactylifera as a key ingredient in aphrodisiac supplements.

引言材料与方法:通过口服40 mg/kg L-NAME诱导高血压。之后,测定实验动物的性能力,并将性活动受损的高血压大鼠置于添加了白头翁的饮食中 21 天,评估治疗对总体性行为、抗氧化状态、氧化-炎症生物标志物和嘌呤能系统酶活性的影响:结果:高血压大鼠在补充 P. dactylifera 的饮食后,性表现明显改善,氧化-炎症生物标志物显著降低,嘌呤能酶的活性增强:本研究的结果表明,膳食中添加 P. dactylifera 可用于治疗高血压患者常见的勃起功能障碍(ED)。因此,本研究强调的结果为支持民间将 P. dactylifera 用作壮阳补品的主要成分提供了科学依据。
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引用次数: 0
Investigating the diagnostic potential of IL-1β, IL-10, and IL-36γ in gingival crevicular fluid in patients with different periodontal conditions. 研究不同牙周病患者牙龈蠕动液中 IL-1β、IL-10 和 IL-36γ 的诊断潜力
IF 2.6 4区 医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2024-05-01 Epub Date: 2024-03-11 DOI: 10.1080/1354750X.2024.2318256
Mihtikar Gürsel, Tuba Bayat, Niyazi Dündar, Ayşegül Yabacı Tak, Burcu Karaduman

Background: The study aimed to analyze cytokine levels, including interleukin (IL)-1β, IL-10, and IL-36γ, to investigate the link between pro- and anti-inflammatory responses in periodontal conditions and assess their potential as diagnostic biomarkers for distinguishing between different types of periodontal conditions.

Methods: 80 systemically healthy non-smokers (25 periodontally healthy, 25 with gingivitis, 30 with periodontitis) were included. Clinical periodontal parameters were recorded, and gingival crevicular fluid (GCF) samples were obtained. Receiver operating characteristic (ROC) curve analysis was applied to determine the diagnostic value of cytokines.

Results: IL-36γ had the highest sensitivity for diagnosing periodontitis, although its specificity for identifying those without periodontitis was relatively low. The combination of IL-1β and IL-36γ was the most effective in differentiating periodontitis from periodontal health. IL-10 was found to be an acceptable discriminator for distinguishing gingivitis from healthy conditions. However, its sensitivity and specificity for identifying gingivitis were lower. The combination of the three cytokines showed the highest ability to distinguish between periodontitis and gingivitis.

Conclusion: The levels of IL-1β, IL-10, and IL-36γ in GCF may provide insights into periodontal health and disease status. Further studies are needed to validate these results and explore the potential of these cytokines in periodontal disease management.

研究背景该研究旨在分析细胞因子水平,包括白细胞介素(IL)-1β、IL-10和IL-36γ,以研究牙周病中促炎症反应和抗炎症反应之间的联系,并评估其作为诊断生物标志物的潜力,以区分不同类型的牙周病。记录临床牙周参数并采集牙龈缝隙液(GCF)样本。应用接收者操作特征(ROC)曲线分析确定细胞因子的诊断价值。结果IL-36γ诊断牙周炎的灵敏度最高,但其鉴别无牙周炎者的特异性相对较低。IL-1β 和 IL-36γ 的组合在区分牙周炎和牙周健康方面最为有效。研究发现,IL-10 是区分牙龈炎和健康状况的一个可接受的鉴别指标。然而,其鉴别牙龈炎的敏感性和特异性较低。三种细胞因子的组合显示出区分牙周炎和牙龈炎的最高能力:结果:IL-36γ诊断牙周炎的灵敏度最高,但其鉴别无牙周炎者的特异性相对较低。IL-1β 和 IL-36γ 的组合在区分牙周炎和牙周健康方面最为有效。研究发现,IL-10 是区分牙龈炎和健康状况的一个可接受的鉴别指标。然而,其鉴别牙龈炎的敏感性和特异性较低。三种细胞因子的组合显示出区分牙周炎和牙龈炎的最高能力:结论:GCF 中 IL-1β、IL-10 和 IL-36γ 的水平可能有助于了解牙周健康和疾病状况。还需要进一步的研究来验证这些结果,并探索这些细胞因子在牙周疾病治疗中的潜力。
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引用次数: 0
BCAT1, IKZF1 and SEPT9: methylated DNA biomarkers for detection of pan-gastrointestinal adenocarcinomas BCAT1、IKZF1 和 SEPT9:用于检测泛胃肠道腺癌的甲基化 DNA 生物标记物
IF 2.6 4区 医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2024-04-22 DOI: 10.1080/1354750x.2024.2340663
Geraldine Laven-Law, Ganessan Kichenadasse, Graeme P. Young, Erin L. Symonds, Jean M. Winter
Methylated circulating tumour DNA (ctDNA) blood tests for BCAT1/IKZF1 (COLVERA) and SEPT9 (Epi proColon) are used to detect colorectal cancer (CRC). However, there are no ctDNA assays approved for ...
针对 BCAT1/IKZF1 (COLVERA) 和 SEPT9 (Epi proColon) 的甲基化循环肿瘤 DNA (ctDNA) 血液检测可用于检测结直肠癌 (CRC)。然而,目前还没有ctDNA检测方法被批准用于...
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引用次数: 0
A prognostic risk model based on lactate metabolism and transport-related lncRNAs for gastric adenocarcinoma 基于乳酸代谢和转运相关 lncRNA 的胃腺癌预后风险模型
IF 2.6 4区 医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2024-04-17 DOI: 10.1080/1354750x.2024.2341411
Zhenyuan Qian, Fang Wu, Guoqing Feng, Wenfa Lin, Xufan Cai, Jianzhang Wu, Kun Ke, Zaiyuan Ye, Guoxi Xu
Increased lactate levels and metastasis in tumours are strongly associated with dismal outcomes. But prognostic value of lactate metabolism and transport-related lncRNAs in gastric adenocarcinoma (...
肿瘤中乳酸水平升高和转移与预后不良密切相关。但乳酸代谢和转运相关的 lncRNAs 在胃腺癌(...
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引用次数: 0
Biomarker-guided drug development provides value for patients, payers and drug developers: lessons learned from 25 years in the biomarker industry 生物标志物指导下的药物开发为患者、支付方和药物开发商带来价值:生物标志物行业 25 年的经验教训
IF 2.6 4区 医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2024-04-12 DOI: 10.1080/1354750x.2024.2342016
Alexander L. Reese-Petersen, Helene W. Breisnes, Daniel Gabor, Sarah R. Rønnow, Bruna Manoel, Mayuur Bajaj, Claus S. von Arenstorff, Elijah Aighobahi, Rune Vestermark, Morten A. Karsdal
IntroductionThere is an urgent, persistent, need for better biomarkers in clinical drug development. More informative biomarkers can increase the likelihood of drug advancement or approval, and imp...
导言在临床药物开发过程中,对更好的生物标记物的需求是迫切而持久的。信息量更丰富的生物标志物可以提高药物进步或获批的可能性,并有助于提高药物的安全性。
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引用次数: 0
The role of Matrix Metalloproteinase-2 and Galectin-3 as predictive biomarkers for all-cause mortality in patients undergoing transfemoral transcatheter aortic valve implantation 基质金属蛋白酶-2和Galectin-3作为经口经导管主动脉瓣植入术患者全因死亡率预测生物标志物的作用
IF 2.6 4区 医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2024-04-08 DOI: 10.1080/1354750x.2024.2341409
Kerstin Piayda, Julian Tim Heilemann, Stanislav Keranov, Luisa Schulz, Mani Arsalan, Christoph Liebetrau, Won-Keun Kim, Felix J. Hofmann, Pascal Bauer, Sandra Voss, Christian Troidl, Samuel T. Sossalla, Christian W. Hamm, Holger M. Nef, Oliver Dörr
Background: Currently available risk scores fail to accurately predict morbidity and mortality in patients with severe symptomatic aortic stenosis who undergo transcatheter aortic valve implantatio...
背景:目前可用的风险评分无法准确预测接受经导管主动脉瓣植入术的重度无症状主动脉瓣狭窄患者的发病率和死亡率。
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引用次数: 0
The Association Between Inflammatory Biomarkers and Low Back Disorder: A Systematic Review and Meta-analysis 炎症生物标志物与腰背痛之间的关系:系统回顾与元分析
IF 2.6 4区 医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2024-04-05 DOI: 10.1080/1354750x.2024.2339285
Stone Sima, Xiaolong Chen, Ashish D. Diwan
Introduction: Low back disorder (LBD) is a major cause of disability worldwide. Inflammation results in proliferation of cytokines or consequent degradation products (collectively known as Inflamma...
简介腰背疾病(LBD)是导致全球残疾的一个主要原因。炎症会导致细胞因子或随之而来的降解产物(统称为炎症因子)的增殖。
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引用次数: 0
Upregulation of ESPL1 is associated with poor prognostic outcomes in endometrial cancer ESPL1的上调与子宫内膜癌的不良预后有关
IF 2.6 4区 医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2024-04-03 DOI: 10.1080/1354750x.2024.2339288
Yuzhong Yang, Ying Sheng, Jinhua Zheng, Aiyu Ma, Shaohua Chen, Jing Lin, Xiaozhen Yang, Yuanna Liang, Yan Zhang, Xiang Zheng
Background: Extra spindle pole bodies-like 1 (ESPL1) is known to play a crucial role in the segregation of sister chromatids during mitosis. Overexpression of ESPL1 is considered to have oncogenic ...
背景:众所周知,纺锤体外极体-样1(ESPL1)在有丝分裂过程中姐妹染色单体的分离中起着至关重要的作用。ESPL1的过表达被认为具有致癌...
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引用次数: 0
Exocyclic DNA adducts and oxidative stress parameters: useful tools for biomonitoring exposure to aldehydes in smokers 外环 DNA 加合物和氧化应激参数:对吸烟者接触醛类物质情况进行生物监测的有用工具
IF 2.6 4区 医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2024-03-20 DOI: 10.1080/1354750x.2024.2333361
Héléna Alamil, Marie-Lise Colsoul, Natacha Heutte, Marie Van Der Schueren, Laurence Galanti, Mathilde Lechevrel
Exocyclic DNA adducts have been shown to be potential biomarkers of cancer risk related to oxidative stress and exposure to aldehydes in smokers. In fact, aldehydes potentially arise from tobacco c...
外环 DNA 加合物已被证明是与氧化应激和吸烟者接触醛类物质有关的癌症风险的潜在生物标志物。事实上,醛类物质可能来自烟草中的...
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引用次数: 0
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Biomarkers
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