Pub Date : 2013-10-09DOI: 10.1615/FORUMIMMUNDISTHER.2013008307
O. Ohno, T. Teruya, K. Suenaga, D. Uemura
{"title":"Apoptosis as a Practical Target for Identifying Anticancer Agents of Marine Origin","authors":"O. Ohno, T. Teruya, K. Suenaga, D. Uemura","doi":"10.1615/FORUMIMMUNDISTHER.2013008307","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.2013008307","url":null,"abstract":"","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"4 1","pages":"33-41"},"PeriodicalIF":0.0,"publicationDate":"2013-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67439549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-04-01DOI: 10.1615/ForumImmunDisTher.2013008408
Robert Scheinman
NF-κB has long been known to play an important role in autoimmune diseases such as rheumatoid arthritis (RA). Indeed, as our understanding of how NF-κB is utilized has increased, we have been hard put to find a process not associated with this transcription factor family in some way. However, new data originating, in part, from genome-wide association studies have demonstrated that very specific alterations in components of the NF-κB pathway are sufficient to confer increased risk of developing disease. Here we review the data which have identified specific components of the NF-κB pathway, and consider what is known of their mechanisms of action and how these mechanisms might play into the disease process. In addition, the use of genetic information to predict RA is considered.
{"title":"NF-κB and Rheumatoid Arthritis: Will Understanding Genetic Risk Lead to a Therapeutic Reward?","authors":"Robert Scheinman","doi":"10.1615/ForumImmunDisTher.2013008408","DOIUrl":"https://doi.org/10.1615/ForumImmunDisTher.2013008408","url":null,"abstract":"<p><p>NF-κB has long been known to play an important role in autoimmune diseases such as rheumatoid arthritis (RA). Indeed, as our understanding of how NF-κB is utilized has increased, we have been hard put to find a process not associated with this transcription factor family in some way. However, new data originating, in part, from genome-wide association studies have demonstrated that very specific alterations in components of the NF-κB pathway are sufficient to confer increased risk of developing disease. Here we review the data which have identified specific components of the NF-κB pathway, and consider what is known of their mechanisms of action and how these mechanisms might play into the disease process. In addition, the use of genetic information to predict RA is considered.</p>","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"4 2","pages":"93-110"},"PeriodicalIF":0.0,"publicationDate":"2013-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963006/pdf/nihms559162.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32216068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-01DOI: 10.1615/FORUMIMMUNDISTHER.2013008385
R. Haenold, A. Kretz, F. Weih
{"title":"Role of NF-κB in Neurodegenerative Diseases","authors":"R. Haenold, A. Kretz, F. Weih","doi":"10.1615/FORUMIMMUNDISTHER.2013008385","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.2013008385","url":null,"abstract":"","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"4 1","pages":"161-179"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67439719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-01DOI: 10.1615/FORUMIMMUNDISTHER.2014008421
Ozge Ilhan-Sarac, H. T. Şekeroğlu, A. Sanaç, E. Ozyar, C. Şener
{"title":"Use of Botulinum Neurotoxin in Cranial Nerve Paralysis due to Nasopharyngeal Carcinoma","authors":"Ozge Ilhan-Sarac, H. T. Şekeroğlu, A. Sanaç, E. Ozyar, C. Şener","doi":"10.1615/FORUMIMMUNDISTHER.2014008421","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.2014008421","url":null,"abstract":"","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"4 1","pages":"213-218"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67439417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-01DOI: 10.1615/FORUMIMMUNDISTHER.2013008396
M. Indira, P. Abhilash
{"title":"Role of NF-Kappa B (NF-κB) in Diabetes","authors":"M. Indira, P. Abhilash","doi":"10.1615/FORUMIMMUNDISTHER.2013008396","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.2013008396","url":null,"abstract":"","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"4 1","pages":"111-132"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67439783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-01DOI: 10.1615/FORUMIMMUNDISTHER.2013008317
M. Kawada, Shuichi Sakamoto, A. Nomoto
{"title":"Modulation of Tumor–Stromal Cell Interactions: A New Anti-Tumor Strategy Targeting the Tumor Microenvironment","authors":"M. Kawada, Shuichi Sakamoto, A. Nomoto","doi":"10.1615/FORUMIMMUNDISTHER.2013008317","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.2013008317","url":null,"abstract":"","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"4 1","pages":"53-62"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67439631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-01DOI: 10.1615/FORUMIMMUNDISTHER.2013008313
Y. Horiguchi
{"title":"Current Molecular Targets for Urological Cancer","authors":"Y. Horiguchi","doi":"10.1615/FORUMIMMUNDISTHER.2013008313","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.2013008313","url":null,"abstract":"","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"4 1","pages":"25-32"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67439590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-01DOI: 10.1615/FORUMIMMUNDISTHER.2013008386
J. Proto, A. Lu, Bing Wang, J. Huard
{"title":"The role of NF-κB in muscular dystrophy","authors":"J. Proto, A. Lu, Bing Wang, J. Huard","doi":"10.1615/FORUMIMMUNDISTHER.2013008386","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.2013008386","url":null,"abstract":"","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"4 1","pages":"149-160"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67439729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-01DOI: 10.1615/FORUMIMMUNDISTHER.2014008125
N. Oršolić
{"title":"Possible Molecular Targets of Bee Venom in the Treatment of Cancer: Application and Perspectives","authors":"N. Oršolić","doi":"10.1615/FORUMIMMUNDISTHER.2014008125","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.2014008125","url":null,"abstract":"","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"4 1","pages":"275-315"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67439825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-01DOI: 10.1615/FORUMIMMUNDISTHER.2014008152
Sudhir Kumar, Puja Sarkar, R. Jain
Cancer is one of the leading causes of death worldwide. Remarkable progress has recently been made toward understanding the proposed hallmarks of cancer development and treatment. Treatment modali- ties comprise radiation therapy, surgery, chemotherapy, immunotherapy, and hormonal therapy. The use of chemotherapeutics currently remains the predominant option for cancer therapy. One of the major problems with successful cancer therapy using chemotherapeutics is that patients often do not respond or eventually develop resistance after initial treatment. This issue has led to the increased use of anticancer drugs developed from natural resources. The biodiversity of venoms and toxins make them a unique source from which new therapeu- tics may be developed. Some molecules of venom are under clinical trials and may be utilized in anticancer drug development in the near future. This review discusses the anticancer potential of different venoms, surveys the pharmacology of venom peptides, and assesses their therapeutic prospects.
{"title":"Venoms Can Be a Boon for Cancer Patients","authors":"Sudhir Kumar, Puja Sarkar, R. Jain","doi":"10.1615/FORUMIMMUNDISTHER.2014008152","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.2014008152","url":null,"abstract":"Cancer is one of the leading causes of death worldwide. Remarkable progress has recently been made toward understanding the proposed hallmarks of cancer development and treatment. Treatment modali- ties comprise radiation therapy, surgery, chemotherapy, immunotherapy, and hormonal therapy. The use of chemotherapeutics currently remains the predominant option for cancer therapy. One of the major problems with successful cancer therapy using chemotherapeutics is that patients often do not respond or eventually develop resistance after initial treatment. This issue has led to the increased use of anticancer drugs developed from natural resources. The biodiversity of venoms and toxins make them a unique source from which new therapeu- tics may be developed. Some molecules of venom are under clinical trials and may be utilized in anticancer drug development in the near future. This review discusses the anticancer potential of different venoms, surveys the pharmacology of venom peptides, and assesses their therapeutic prospects.","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"4 1","pages":"255-273"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67439836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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