Pub Date : 2023-10-04DOI: 10.1007/s12668-023-01208-9
Xhamla Nqoro, Samson A. Adeyemi, Philemon Ubanako, Derek T. Ndinteh, Pradeep Kumar, Yahya E. Choonara, Blessing A. Aderibigbe
Abstract Wounds are usually accompanied by complications such as excessive bleeding and bacteria invasion. The design of wound dressings that rapidly stop excessive bleeding and inhibit bacterial invasion, is crucial to promoting accelerated wound healing. To meet the abovementioned requirements in wound dressings, topical gels were prepared from sodium alginate (SA) and carbopol. The wound dressings were loaded with an antifibrinolytic agent, tranexamic acid, and a variety of metal-based nanoparticles. The prepared topical gels displayed significant antibacterial efficacy against Gram-negative bacteria and moderate activity against Gram-positive bacterial strains. These gels exhibited good spreadability and viscosity, signifying suitability for skin application, and ease of application. Moreover, the prepared gels showed good cytocompatibility, promoted cell proliferation, and exhibited > 85% wound closure on day 3 compared to the untreated which showed a 38% wound reduction in vitro. Excellent blood clotting absorbance values were observed for the gels compared to the control, showing that they can promote blood clotting. Features presented by the prepared gels reveal that they are promising wound dressings for treating bleeding and infected wounds.
{"title":"A Topical Alginate-Based Wound Gel Fixated with Metal-Based Nanoparticles and Tranexamic Acid as a Hemostatic Wound Healing System","authors":"Xhamla Nqoro, Samson A. Adeyemi, Philemon Ubanako, Derek T. Ndinteh, Pradeep Kumar, Yahya E. Choonara, Blessing A. Aderibigbe","doi":"10.1007/s12668-023-01208-9","DOIUrl":"https://doi.org/10.1007/s12668-023-01208-9","url":null,"abstract":"Abstract Wounds are usually accompanied by complications such as excessive bleeding and bacteria invasion. The design of wound dressings that rapidly stop excessive bleeding and inhibit bacterial invasion, is crucial to promoting accelerated wound healing. To meet the abovementioned requirements in wound dressings, topical gels were prepared from sodium alginate (SA) and carbopol. The wound dressings were loaded with an antifibrinolytic agent, tranexamic acid, and a variety of metal-based nanoparticles. The prepared topical gels displayed significant antibacterial efficacy against Gram-negative bacteria and moderate activity against Gram-positive bacterial strains. These gels exhibited good spreadability and viscosity, signifying suitability for skin application, and ease of application. Moreover, the prepared gels showed good cytocompatibility, promoted cell proliferation, and exhibited > 85% wound closure on day 3 compared to the untreated which showed a 38% wound reduction in vitro. Excellent blood clotting absorbance values were observed for the gels compared to the control, showing that they can promote blood clotting. Features presented by the prepared gels reveal that they are promising wound dressings for treating bleeding and infected wounds.","PeriodicalId":8939,"journal":{"name":"BioNanoScience","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135592602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-04DOI: 10.1007/s12668-023-01203-0
S. Antinate Shilpa, A. J. Pavithra, G. S. Hikku, K. Jeyasubramanian, Pandiyarasan Veluswamy, Hiroya Ikeda
{"title":"Imparting Efficient Antibacterial Activity to Cotton Fabrics by Coating with Green Synthesized Nano-Ag/PMMA Composite","authors":"S. Antinate Shilpa, A. J. Pavithra, G. S. Hikku, K. Jeyasubramanian, Pandiyarasan Veluswamy, Hiroya Ikeda","doi":"10.1007/s12668-023-01203-0","DOIUrl":"https://doi.org/10.1007/s12668-023-01203-0","url":null,"abstract":"","PeriodicalId":8939,"journal":{"name":"BioNanoScience","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.1007/s12668-023-01210-1
Adil Darvesh, Manuel Sánchez-Chero, Carla Angélica Reyes Reyes, Pedro Aníbal Solís Céspedes, Marcos Timina Alvarez, Max Fernando Urbina Cárdenas, Carmen Elvira Rosas-Prado
{"title":"Mathematical Analysis of Bio-nanofluid Flow over a Nonlinear Tapering Artery with Stenosis Conditions Using Cross Fluid Viscosity Model","authors":"Adil Darvesh, Manuel Sánchez-Chero, Carla Angélica Reyes Reyes, Pedro Aníbal Solís Céspedes, Marcos Timina Alvarez, Max Fernando Urbina Cárdenas, Carmen Elvira Rosas-Prado","doi":"10.1007/s12668-023-01210-1","DOIUrl":"https://doi.org/10.1007/s12668-023-01210-1","url":null,"abstract":"","PeriodicalId":8939,"journal":{"name":"BioNanoScience","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135696654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-02DOI: 10.1007/s12668-023-01212-z
Mujeeb ur Rahman, Fazal Haq, Hassan Ali Ghazwani, Muhammad Ijaz Khan, Dilsora Abduvalieva, Shahid Ali, Sami Ullah Khan
{"title":"Darcy-Forchheimer Flow of Prandtl Nanofluid with Irreversibility Analysis and Cubic Autocatalytic Chemical Reactions","authors":"Mujeeb ur Rahman, Fazal Haq, Hassan Ali Ghazwani, Muhammad Ijaz Khan, Dilsora Abduvalieva, Shahid Ali, Sami Ullah Khan","doi":"10.1007/s12668-023-01212-z","DOIUrl":"https://doi.org/10.1007/s12668-023-01212-z","url":null,"abstract":"","PeriodicalId":8939,"journal":{"name":"BioNanoScience","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135830721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-30DOI: 10.1007/s12668-023-01207-w
Rajni Bala, Alisha Lalhall, Rohit K. Sharma, Nishima Wangoo
{"title":"Gold Nanocrystals Modified Electrochemical Aptasensor for Ultra-trace Level Detection of Malathion in Environmental Samples","authors":"Rajni Bala, Alisha Lalhall, Rohit K. Sharma, Nishima Wangoo","doi":"10.1007/s12668-023-01207-w","DOIUrl":"https://doi.org/10.1007/s12668-023-01207-w","url":null,"abstract":"","PeriodicalId":8939,"journal":{"name":"BioNanoScience","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136336909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preparation and Characterization of Core@shell Structures of Glycerin@Fe3O4, and Al2O3@Fe3O4 Nanoparticles for Use in Hyperthermia Therapy","authors":"Saleh Fallah Samakosh, Ali Bahari, Vaheed Fallah Hamidabadi, Hossain Milani Moghaddam","doi":"10.1007/s12668-023-01202-1","DOIUrl":"https://doi.org/10.1007/s12668-023-01202-1","url":null,"abstract":"","PeriodicalId":8939,"journal":{"name":"BioNanoScience","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135199710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-29DOI: 10.1007/s12668-023-01206-x
Sunil J. Kulkarni, Mahesh A. Suryawanshi, Vijay B. Mane, Gajanan Kumbhar
{"title":"Biohydrogen From Waste Feedstocks – Materials, Methods and Recent Developments","authors":"Sunil J. Kulkarni, Mahesh A. Suryawanshi, Vijay B. Mane, Gajanan Kumbhar","doi":"10.1007/s12668-023-01206-x","DOIUrl":"https://doi.org/10.1007/s12668-023-01206-x","url":null,"abstract":"","PeriodicalId":8939,"journal":{"name":"BioNanoScience","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135199446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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