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Power exercises with elastic bands combined with endurance training improve pulse pressure, systolic blood pressure, and functional parameters in older adults. 弹力带力量练习与耐力训练相结合可改善老年人的脉压、收缩压和功能参数。
IF 1.2 4区 医学 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-11-08 DOI: 10.1097/MBP.0000000000000733
Luiz Filipe Costa Chaves, Bruno Bavaresco Gambassi, Eduardo Cadore, Samir Sotão, Thiago Matheus Sousa, Danielle da Silva Dias, Paulo Adriano Schwingel, Cristiano Mostarda

Objective: This study aimed to investigate the effects of power training (PT) using elastic bands combined with endurance training (ET) on pulse pressure (PP), systolic (SBP) and diastolic blood pressures (DBP), autonomic response (AR), and functional parameters in older adults.

Methods: Thirty participants were randomly assigned to the control group (n = 15) and the intervention group (IG) (n = 15). IG participants performed PT with elastic bands combined with ET twice weekly for 8 weeks. PP, SBP, DBP, AR, and functional parameters were assessed before and after 8 weeks.

Results: PP, SBP, and functional parameters significantly improved after 8 weeks in the IG (P < 0.05). The study also found a clinically significant reduction in the SBP (Δ = -16.5 mmHg; η2p = 0.36) and DBP (Δ = -4.3 mmHg; η2p = 0.26), and a clinical reduction in the 5-Repetition Sit-To-Stand test (η2p = 0.63) and the elbow flexion test (η2p = 0.51).

Conclusion: Our findings indicate that PT with elastic bands combined with ET improves PP, SBP, and functional parameters in older adults. Hence, our combined training protocol can be an easily accessible, low-cost, nonpharmacological strategy for strength, and conditioning professionals to prescribe as an exercise intervention to older adults.

研究目的本研究旨在探讨使用弹力带进行力量训练(PT)并结合耐力训练(ET)对老年人脉压(PP)、收缩压(SBP)和舒张压(DBP)、自律神经反应(AR)和功能参数的影响:将 30 名参与者随机分配到对照组(15 人)和干预组(15 人)。干预组参与者使用弹力带结合 ET 进行 PT,每周两次,持续 8 周。在 8 周前和 8 周后对 PP、SBP、DBP、AR 和功能参数进行评估:结果:8 周后,IG 的 PP、SBP 和功能参数均有明显改善(P < 0.05)。研究还发现,SBP(Δ = -16.5 mmHg;η2p = 0.36)和 DBP(Δ = -4.3 mmHg;η2p = 0.26)的临床降幅明显,5-重复坐立测试(η2p = 0.63)和肘关节屈曲测试(η2p = 0.51)的临床降幅也明显:我们的研究结果表明,使用弹力带进行 PT 并结合 ET 可改善老年人的 PP、SBP 和功能参数。因此,我们的综合训练方案可以成为一种方便、低成本、非药物性的策略,供力量和调理专业人员作为运动干预措施用于老年人。
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引用次数: 0
Validation of the G.LAB MD6300 upper arm blood pressure monitor in different positions according to the AAMI/ESH/ISO Universal Standard (ISO81060-2:2018+AMD1:2020). 根据 AAMI/ESH/ISO 通用标准(ISO81060-2:2018+AMD1:2020),对 G.LAB MD6300 上臂血压计的不同位置进行验证。
IF 1.2 4区 医学 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-10-24 DOI: 10.1097/MBP.0000000000000732
Rui Cheng, Linyi Li, Jinfeng Chen, Jie Ren, Yi Wan

Objective: To validate the accuracy of the G.LAB MD6300 oscillometric upper arm blood pressure monitor in the sitting, supine, and right lateral decubitus position in the general population according to the Association for the Advancement of Medical Instrumentation/European Society of Hypertension/International Organization for Standardization (AAMI/ESH/ISO) Universal Standard (ISO 81060-2 : 2018+AMD1 : 2020).

Methods: The qualified participants were recruited in the study and the same left-arm sequential method was used for blood pressure measurement according to the Universal Standard. The validation results were assessed for the three positions and the Bland-Altman scatter plot was used to show the difference between the test device and reference results.

Results: A total of 85 participants were included in the analysis. The mean differences between the test device and reference readings were 0.95 ± 6.76/0.47 ± 6.71 mmHg, 0.55 ± 6.73/-0.20 ± 6.72 mmHg, and -0.71 ± 7.11/-0.86 ± 7.06 mmHg for SBP and DBP for the validation criterion 1 in the sitting position, supine with upward palm position, and right lateral decubitus position with downward left palm flat on left side position, respectively. Furthermore, the mean differences and their standard deviations for SBP and DBP calculated according to criterion 2 in the ISO81060-2 : 2018+AMD1 : 2020 were acceptable in all three positions.

Conclusion: The G.LAB MD6300 upper arm blood pressure monitor fulfilled the validation criteria of the AAMI/ESH/ISO Universal Standard (ISO 81060-2 : 2018+AMD1 : 2020) in the sitting position, and its accuracy in the supine and right lateral decubitus position was acceptable and roughly equivalent to that in the sitting position. Therefore, it can be recommended for clinical use and self-measurement in the general population.

目的根据美国医学仪器促进协会/欧洲高血压学会/国际标准化组织(AAMI/ESH/ISO)通用标准(ISO 81060-2 : 2018+AMD1 : 2020),验证 G.LAB MD6300示波上臂式血压计在普通人群中坐位、仰卧位和右侧卧位的准确性:研究招募了合格的参与者,并根据通用标准使用相同的左臂顺序法进行血压测量。对三个位置的验证结果进行评估,并使用布兰-阿尔特曼散点图来显示测试设备与参考结果之间的差异:结果:共有 85 名参与者参与了分析。对于验证标准 1,在坐位、仰卧位手掌向上、右侧卧位左手掌向下平放在左侧位置时,测试设备和参考读数的平均差分别为 0.95 ± 6.76/0.47 ± 6.71 mmHg、0.55 ± 6.73/-0.20 ± 6.72 mmHg 和 -0.71 ± 7.11/-0.86 ± 7.06 mmHg。此外,根据 ISO81060-2 : 2018+AMD1 : 2020 标准 2 计算的 SBP 和 DBP 的平均差及其标准偏差在所有三种体位下均可接受:G.LAB MD6300 上臂式血压计在坐位时符合 AAMI/ESH/ISO 通用标准 (ISO 81060-2 : 2018+AMD1 : 2020) 的验证标准,在仰卧位和右侧卧位时的准确度也可以接受,与坐位时的准确度基本相当。因此,可以建议将其用于临床和普通人群的自我测量。
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引用次数: 0
Does greater adherence to a healthy dietary pattern correspond to a better body composition and cardiorespiratory fitness in adults with overweight and primary hypertension? Data from the EXERDIET-HTA study. 在超重和原发性高血压的成年人中,更多坚持健康饮食模式是否能改善身体成分和心肺功能?来自 EXERDIET-HTA 研究的数据。
IF 1.2 4区 医学 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-10-16 DOI: 10.1097/MBP.0000000000000731
Ilargi Gorostegi-Anduaga, Mikel Tous-Espelosin, Sara Maldonado-Martín

Cardiovascular events are positively associated with primary hypertension (HTN), obesity, and low cardiorespiratory fitness (CRF) and negatively with healthy dietary patterns, such as Healthy Diet Indicator (HDI), Mediterranean diet (MD), and the Dietary Approaches to Stop Hypertension (DASH). The aim is to analyze the association between healthy dietary patterns with body composition and CRF. Body composition (bioimpedance) and CRF [peak oxygen uptake (V̇O2peak)] were assessed in 165 participants with HTN and overweight/obesity. There were (1) a positive association (unadjusted) between fat-free mass (%) with DASH and MD (P = 0.03) and a negative association between fat mass (%) and MD (P = 0.03); (2) positive associations (adjusted) between V̇O2peak (l·min-1) with DASH (P = 0.007), HDI (P = 0.017), and MD (P = 0.010) and V̇O2peak (ml·kg-1·min-1) with DASH (P = 0.005); (3) a negative relationship (unadjusted and adjusted) between energy intake and DASH (P = 0.004). In conclusion, these findings highlight the cardiovascular health protection provided by healthy dietary patterns associated with healthier CRF and body composition in people with a profile of HTN and overweight.

心血管事件与原发性高血压(HTN)、肥胖和心肺功能低下(CRF)呈正相关,而与健康饮食模式(如健康饮食指标(HDI)、地中海饮食(MD)和膳食法抗高血压(DASH))呈负相关。目的是分析健康饮食模式与身体成分和 CRF 之间的关联。对165名患有高血压和超重/肥胖症的参与者的身体成分(生物阻抗)和CRF[峰值摄氧量(VO2peak)]进行了评估。结果显示:(1) 去脂质量(%)与 DASH 和 MD 之间存在正相关(未调整)(P = 0.03),脂肪质量(%)与 MD 之间存在负相关(P = 0.03);(2) V̇O2peak (l-min-1) 与 DASH 之间存在正相关(调整后)(P = 0.007)、HDI(P = 0.017)和 MD(P = 0.010)与 DASH(P = 0.005)之间以及 V̇O2peak(ml-kg-1-min-1)与 DASH(P = 0.005)之间存在正相关;(3)能量摄入量与 DASH(P = 0.004)之间存在负相关(未调整和调整)。总之,这些研究结果突显了健康饮食模式对心血管健康的保护作用,而健康饮食模式与高血压和超重人群更健康的 CRF 和身体组成相关。
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引用次数: 0
Validation of the TMB-2296-BT blood pressure monitor in adults according to the ISO 81060-2:2018 + Amd.1:2020. 根据 ISO 81060-2:2018 + Amd.1:2020 对 TMB-2296-BT 成人血压计进行验证。
IF 1.2 4区 医学 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-10-04 DOI: 10.1097/MBP.0000000000000728
Zijian Xie, Li Zhu, Xiao Zheng, Chaoya Li, Jia Hu, Xinda Wang, Hua Deng, Xiaoqin Du, Jiahui Liang, Bin Peng

This study aimed to validate the accuracy of the test device (TMB-2296-BT) blood pressure (BP) monitor in adults according to International Standard Organization (ISO) 81060-2:2018 + Amd.1:2020 universal standard protocol, which is a digital monitor. Three trained observers used the same arm sequential method to compare the SBPs and DBPs measured by the test device with those measured by the reference device (mercury sphygmomanometer). For the test device with cuff ranging from 22 to 32 cm, there are 88 adults, with a male-to-female ratio of 35 : 53. The mean difference and SD between reference BPs and test device BPs readings were (0.21 ± 2.59)/(0.66 ± 2.12) mmHg for SBP/DBP for criterion 1, and (0.21 ± 2.07)/(0.66 ± 1.76) mmHg for SBP/DBP for criterion 2. For the test device with cuffs ranging from 22 to 42 cm, there are 87 adults, with a male-to-female ratio of 49 : 38. The mean difference and SD between reference BPs and test device BPs readings were (-1.62 ± 2.80)/(0.12 ± 3.01) mmHg for SBP/DBP for criterion 1, and (-1.62 ± 2.35)/(0.12 ± 2.60) mmHg for SBP/ DBP for criterion 2. And for the test device with cuff arm circumference sizes of 22-32 cm and 22-42 cm fulfilled both validation criterion 1 and 2 of the ISO 81060-2:2018 + Amd.1:2020 standard and can be recommended for both clinical and self/home BP measurement in adults.

本研究旨在根据国际标准化组织(ISO)81060-2:2018 + Amd.1:2020通用标准协议,验证数字式成人血压(BP)监测仪(TMB-2296-BT)的准确性。三位训练有素的观察员使用同一手臂顺序法,将测试设备测得的 SBPs 和 DBPs 与参考设备(水银血压计)测得的 SBPs 和 DBPs 进行比较。测试设备的袖带范围为 22 厘米至 32 厘米,共有 88 名成人使用,男女比例为 35:53。在标准 1 中,参考血压与测试设备血压读数的平均差和标度分别为(0.21 ± 2.59)/(0.66 ± 2.12)毫米汞柱(SBP/DBP);在标准 2 中,参考血压与测试设备血压读数的平均差和标度分别为(0.21 ± 2.07)/(0.66 ± 1.76)毫米汞柱(SBP/DBP)。在标准 1 中,参考血压与测试设备血压读数的平均差和标度分别为(-1.62 ± 2.80)/(0.12 ± 3.01)毫米汞柱(SBP/DBP);在标准 2 中,参考血压与测试设备血压读数的平均差和标度分别为(-1.62 ± 2.35)/(0.12 ± 2.60)毫米汞柱(SBP/DBP)。而袖带臂围尺寸为 22-32 厘米和 22-42 厘米的测试设备符合 ISO 81060-2:2018 + Amd.1:2020 标准的验证标准 1 和 2,可推荐用于成人临床和自我/家庭血压测量。
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引用次数: 0
Validating the accuracy of Omron HEM-7372T1-AZAZ (BP5460) in monitoring blood pressure according to the ISO 81060-2:2018+Amd 1:2020 protocol in the general population. 验证欧姆龙 HEM-7372T1-AZAZ (BP5460) 根据 ISO 81060-2:2018+Amd 1:2020 协议在普通人群中监测血压的准确性。
IF 1.2 4区 医学 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-10-01 Epub Date: 2024-05-21 DOI: 10.1097/MBP.0000000000000708
Hakuo Takahashi, Shingo Yamashita, Nobuki Yakura

Purpose: The performance of the Omron HEM-7372T1-AZAZ (BP5460) in monitoring blood pressure (BP) in the upper arm was validated in accordance with the International Organization for Standardization (ISO) 81060-2:2018 (E) and amendment (Amd)1:2020 protocol.

Methods: The device was used to assess 98 participants who fulfilled the inclusion criteria, including the range of arm circumference and systolic and diastolic BP, in accordance with the protocol. Data validation and analysis were performed according to the manufacturer's instructions.

Results: In the ISO validation procedure (criterion 1), the mean ± SD of the differences between test device readings and reference BP was 0.3 ± 6.17/3.6 ± 5.26 mmHg (systolic/diastolic). These data fulfilled the ISO requirements of ≤5±≤8 mmHg. The mean differences between the observer measurements and Omron HEM-7372T1-AZAZ (BP5460) readings were 0.3 ± 4.82 mmHg for systolic BP and 3.6 ± 4.78 mmHg for diastolic BP, fulfilling criterion 2 with SD values of ≤6.95 for SBP and ≤5.89 for DBP. Therefore, two ISO criteria were fulfilled.

Conclusion: The Omron HEM-7372T1-AZAZ BP monitor fulfilled the requirements of the ISO validation standard. This device can be recommended for home BP measurements in the general population.

目的:根据国际标准化组织(ISO)81060-2:2018(E)和修正案(Amd)1:2020 协议,对欧姆龙 HEM-7372T1-AZAZ (BP5460) 监测上臂血压(BP)的性能进行了验证:使用该设备对 98 名符合纳入标准(包括臂围范围、收缩压和舒张压)的参与者进行了评估。数据验证和分析按照制造商的说明进行:在 ISO 验证程序(标准 1)中,测试设备读数与参考血压之间差异的平均值(± SD)为 0.3 ± 6.17/3.6 ± 5.26 mmHg(收缩压/舒张压)。这些数据符合国际标准化组织的要求,即 ≤5±≤8 mmHg。观察者测量值与欧姆龙 HEM-7372T1-AZAZ (BP5460)读数的平均差为:收缩压 0.3 ± 4.82 mmHg,舒张压 3.6 ± 4.78 mmHg,符合标准 2,SBP 的 SD 值≤6.95,DBP 的 SD 值≤5.89。因此,符合 ISO 的两项标准:结论:欧姆龙 HEM-7372T1-AZAZ 血压计符合 ISO 验证标准的要求。建议将此设备用于普通人群的家庭血压测量。
{"title":"Validating the accuracy of Omron HEM-7372T1-AZAZ (BP5460) in monitoring blood pressure according to the ISO 81060-2:2018+Amd 1:2020 protocol in the general population.","authors":"Hakuo Takahashi, Shingo Yamashita, Nobuki Yakura","doi":"10.1097/MBP.0000000000000708","DOIUrl":"10.1097/MBP.0000000000000708","url":null,"abstract":"<p><strong>Purpose: </strong>The performance of the Omron HEM-7372T1-AZAZ (BP5460) in monitoring blood pressure (BP) in the upper arm was validated in accordance with the International Organization for Standardization (ISO) 81060-2:2018 (E) and amendment (Amd)1:2020 protocol.</p><p><strong>Methods: </strong>The device was used to assess 98 participants who fulfilled the inclusion criteria, including the range of arm circumference and systolic and diastolic BP, in accordance with the protocol. Data validation and analysis were performed according to the manufacturer's instructions.</p><p><strong>Results: </strong>In the ISO validation procedure (criterion 1), the mean ± SD of the differences between test device readings and reference BP was 0.3 ± 6.17/3.6 ± 5.26 mmHg (systolic/diastolic). These data fulfilled the ISO requirements of ≤5±≤8 mmHg. The mean differences between the observer measurements and Omron HEM-7372T1-AZAZ (BP5460) readings were 0.3 ± 4.82 mmHg for systolic BP and 3.6 ± 4.78 mmHg for diastolic BP, fulfilling criterion 2 with SD values of ≤6.95 for SBP and ≤5.89 for DBP. Therefore, two ISO criteria were fulfilled.</p><p><strong>Conclusion: </strong>The Omron HEM-7372T1-AZAZ BP monitor fulfilled the requirements of the ISO validation standard. This device can be recommended for home BP measurements in the general population.</p>","PeriodicalId":8950,"journal":{"name":"Blood Pressure Monitoring","volume":" ","pages":"272-275"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141074629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term blood pressure variability and risk of cardiovascular diseases in populations with different blood pressure status: an ambispective cohort study. 不同血压状态人群的长期血压变化和心血管疾病风险:一项前瞻性队列研究。
IF 1.2 4区 医学 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-10-01 Epub Date: 2024-06-21 DOI: 10.1097/MBP.0000000000000712
Jinnan Li, Ting Qu, Ying Li, Pengcheng Li, Benmai Luo, Yue Yi, Aibin Shi, Zhixin Pang, Yuting Chu, Yuxin Zhao, Li Yang, Shaopeng Xu, Juan Xie, Hong Zhu

Objective: We aimed to investigate the correlation between long-term blood pressure variability (BPV) and the risk of cardiovascular diseases (CVDs) among population with different blood pressure statuses (normotension, well-controlled hypertension, and uncontrolled hypertension).

Methods: In this ambispective cohort study, CVD-free residents aged over 50 years were consecutively enrolled from two community health service centers (CHCs) in Tianjin, China from April 2017 to May 2017. Information on blood pressure was retrospectively extracted from electronic medical records of CHCs between January 2010 and May 2017, and the occurrence of new-onset CVDs was prospectively observed during follow-up until September 2019. Long-term variation of SBP and DBP was assessed using four indicators: SD, coefficient of variation (CV), average successive variability (ASV), and average real variability (ARV). Cox proportional hazards regression model was developed to identify the potential impact of BPV on the incidence of CVDs. The receiver operating characteristic curve (ROC) was utilized to evaluate the predictive value of BPV indicators for the occurrence of CVDs.

Results: Of 1275 participants included, 412 (32.3%) experienced new CVD events during the median 7.7 years of follow-up, with an incidence density of 499/10 000 person-year in the whole cohort. Cox regression analysis revealed that almost all SBP and DBP variability indicators (except for SBP-SD) were significantly related to the risk of CVDs, especially among individuals with well-controlled hypertension. A trend toward an increased risk of CVDs across BPV quartiles was also observed. Moderate predictive abilities of BPV were observed, with the area under ROC curves ranging between 0.649 and 0.736. For SBP variability, SD had the lowest predictive ability, whereas for DBP variability, ARV had the lowest predictive ability. No significant association of CVDs with SBP-SD was found in all analyses, no matter as a continuous or categorical variable.

Conclusion: Elevated long-term BPV is associated with an increased risk of CVDs, especially among individuals with well-controlled hypertension. CV and ASV had higher predictive values than SD and ARV.

目的我们旨在研究不同血压状态(正常血压、控制良好的高血压和未控制的高血压)人群的长期血压变异性(BPV)与心血管疾病(CVDs)风险之间的相关性:在这项前瞻性队列研究中,2017年4月至2017年5月期间,中国天津市两个社区卫生服务中心(CHC)连续招募了50岁以上无心血管疾病的居民。研究人员从社区卫生服务中心的电子病历中回顾性提取了2010年1月至2017年5月期间的血压信息,并在随访至2019年9月期间对新发心血管疾病的发生情况进行了前瞻性观察。采用四项指标评估SBP和DBP的长期变化:SD、变异系数(CV)、平均连续变异系数(ASV)和平均实际变异系数(ARV)。建立了 Cox 比例危险回归模型,以确定 BPV 对心血管疾病发病率的潜在影响。利用接收器操作特征曲线(ROC)评估血压变异指标对心血管疾病发生的预测价值:结果:在纳入的 1275 名参与者中,有 412 人(32.3%)在中位 7.7 年的随访期间经历了新的心血管疾病事件,整个队列的发病密度为 499/10,000人年。Cox回归分析表明,几乎所有的SBP和DBP变异性指标(SBP-SD除外)都与心血管疾病风险显著相关,尤其是在高血压控制良好的人群中。此外,还观察到不同血压变异性四分位数的心血管疾病风险呈上升趋势。BPV 的预测能力适中,ROC 曲线下面积介于 0.649 和 0.736 之间。对于 SBP 变异,SD 的预测能力最低,而对于 DBP 变异,ARV 的预测能力最低。在所有分析中,无论是连续变量还是分类变量,均未发现心血管疾病与 SBP-SD 有明显关联:结论:长期血压变异性升高与心血管疾病风险增加有关,尤其是在高血压控制良好的人群中。CV和ASV的预测值高于SD和ARV。
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引用次数: 0
Smart solutions in hypertension diagnosis and management: a deep dive into artificial intelligence and modern wearables for blood pressure monitoring. 高血压诊断和管理的智能解决方案:深入探讨人工智能和现代可穿戴血压监测设备。
IF 1.2 4区 医学 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-10-01 Epub Date: 2024-06-17 DOI: 10.1097/MBP.0000000000000711
Anubhuti Juyal, Shradha Bisht, Mamta F Singh

Hypertension, a widespread cardiovascular issue, presents a major global health challenge. Traditional diagnosis and treatment methods involve periodic blood pressure monitoring and prescribing antihypertensive drugs. Smart technology integration in healthcare offers promising results in optimizing the diagnosis and treatment of various conditions. We investigate its role in improving hypertension diagnosis and treatment effectiveness using machine learning algorithms for early and accurate detection. Intelligent models trained on diverse datasets (encompassing physiological parameters, lifestyle factors, and genetic information) to detect subtle hypertension risk patterns. Adaptive algorithms analyze patient-specific data, optimizing treatment plans based on medication responses and lifestyle habits. This personalized approach ensures effective, minimally invasive interventions tailored to each patient. Wearables and smart sensors provide real-time health insights for proactive treatment adjustments and early complication detection.

高血压是一个普遍存在的心血管问题,对全球健康构成重大挑战。传统的诊断和治疗方法包括定期监测血压和开具降压药。智能技术在医疗保健领域的应用为优化各种疾病的诊断和治疗带来了可喜的成果。我们利用机器学习算法研究其在提高高血压诊断和治疗效果方面的作用,以实现早期准确检测。智能模型在不同的数据集(包括生理参数、生活方式因素和遗传信息)上进行训练,以检测微妙的高血压风险模式。自适应算法分析患者的特定数据,根据药物反应和生活习惯优化治疗方案。这种个性化方法可确保为每位患者量身定制有效的微创干预措施。可穿戴设备和智能传感器可提供实时健康信息,以便主动调整治疗方案和早期发现并发症。
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引用次数: 0
Inflammation-based markers, especially the uric acid/albumin ratio, are associated with non-dipper pattern in newly diagnosed treatment-naive hypertensive patients. 基于炎症的标记物,尤其是尿酸/白蛋白比值,与新诊断的接受过治疗的高血压患者的非低血压模式有关。
IF 1.2 4区 医学 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-10-01 Epub Date: 2024-05-22 DOI: 10.1097/MBP.0000000000000709
Kenan Toprak, Kaya Özen, Mesut Karataş, Ayten Dursun

Objective: Physiologically, at night, blood pressure (BP) is expected to decrease by at least 10% in hypertensive individuals. The absence of this decrease, called non-dipper hypertension, is associated with increased end-organ damage and cardiovascular mortality and morbidity in hypertensive individuals. It is known that increased inflammatory process plays an important role in the etiopathogenesis of non-dipper hypertension pattern. In recent years, it has been shown that inflammation-based markers (IBMs) obtained by combining various inflammation-related hematological and biochemical parameters in a single fraction have stronger predictive value than single inflammatory parameters. However, until now, there has not been a study investigating the relationship of these markers with dipper/non-dipper status in newly diagnosed hypertensive patients.

Methods: Based on ambulatory BP monitoring, 217 dipper and 301 non-dipper naive hypertensive subjects were included in this study. All subjects' IBM values were compared between dipper and non-dipper hypertensive individuals.

Results: IBMs [C-reactive protein/albumin ratio (CAR), monocyte/high-density lipoprotein cholesterol ratio (MHR), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio, systemic immune-inflammation index (SII), uric acid/albumin ratio (UAR)] were significantly higher in the non-dipper group. CAR, MHR, NLR, SII, and UAR were determined as independent predictors for non-dipper pattern ( P  < 0.05, for all). Also, UAR's diagnostic performance for non-dipper pattern was found to be superior to other IBMs (area under the curve: 0.783, 95% confidence interval: 0.743-0.822; P  < 0.001).

Conclusion: These findings suggest an association between elevated IBMs, particularly UAR, and the non-dipper hypertension pattern observed in our study.

目的:根据生理学原理,高血压患者夜间血压(BP)预计至少会下降 10%。如果血压没有下降,则称为非开夜车高血压,这与高血压患者的内脏损害、心血管死亡率和发病率增加有关。众所周知,炎症过程的加剧在非北斗高血压模式的发病机制中起着重要作用。近年来的研究表明,将各种与炎症相关的血液学和生化指标综合在一起得出的基于炎症的标志物(IBMs)比单一的炎症指标具有更强的预测价值。然而,到目前为止,还没有一项研究调查了这些标记物与新诊断的高血压患者的糖尿病/非糖尿病状态之间的关系:方法:本研究根据动态血压监测结果,纳入了 217 名糖尿病患者和 301 名非糖尿病患者。结果:所有受试者的 IBM 值[C-反应蛋白][C-反应蛋白][C-反应蛋白][C-反应蛋白][C-反应蛋白][C-反应蛋白结果:非慎饮组的 IBM 值[C-反应蛋白/白蛋白比值(CAR)、单核细胞/高密度脂蛋白胆固醇比值(MHR)、中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值、全身免疫炎症指数(SII)、尿酸/白蛋白比值(UAR)]明显高于慎饮组。CAR、MHR、NLR、SII 和 UAR 被确定为非北斗七星模式的独立预测因子(P 结论:非北斗七星模式与北斗七星指数的升高有关:这些发现表明,IBMs 升高(尤其是 UAR)与我们研究中观察到的非北斗星高血压模式存在关联。
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引用次数: 0
Blood pressure variability at rest and during pressor challenges in patients with acute ischemic stroke. 急性缺血性脑卒中患者静息时和加压挑战时的血压变异性。
IF 1.2 4区 医学 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-10-01 Epub Date: 2024-06-04 DOI: 10.1097/MBP.0000000000000710
Sankanika Roy, Man Y Lam, Ronney B Panerai, Thompson G Robinson, Jatinder S Minhas

Introduction: Patients with acute ischemic stroke (AIS) have elevated blood pressure (BP) variability (BPV) and reduced baroreflex sensitivity (BRS) at rest for several days after initial stroke symptoms. We aimed to assess BPV and BRS in AIS patients during pressor challenge maneuvers in the acute and subacute phases of stroke. Pressor challenge maneuvers simulate day-to-day activities and can predict the quality of life.

Methods: Continuous beat-to-beat BP and ECG in 15 AIS patients (mean age 69 ± 7.5 years) and 15 healthy controls (57 ± 16 years) were recorded at rest and during a 5-min rapid head positioning (RHP) paradigm. Patients were assessed within 24 h (acute phase) and 7 days (subacute phase) of stroke onset. Low frequency (LF) SBP power (measure of BPV), LF-α, and combined α-index (measure of BRS) were calculated from the recordings.

Results: In the acute phase, at rest, LF-SBP power was higher ( P  = 0.024) and α-index was lower ( P  = 0.006) in AIS patients than in healthy controls. There was no change in LF-SBP during RHP in the patients but in healthy controls, it increased significantly ( P  = 0.018). In the subacute phase, at rest, the alpha-index increased ( P  = 0.037) and LF-SBP decreased ( P  = 0.029) significantly in the AIS patients, however, there was still no rise in the LF-SBP power during RHP ( P  = 0.240).

Conclusion: AIS patients have a high resting BPV. High resting BPV may be responsible for blunted BPV responses during pressor challenge maneuvers such as RHP, suggesting ongoing autonomic dysfunction and compromised quality of life.

导言:急性缺血性脑卒中(AIS)患者在最初出现脑卒中症状后的数天内,静息状态下的血压(BPV)变异性(BPV)升高,气压反射敏感性(BRS)降低。我们的目的是评估 AIS 患者在中风急性期和亚急性期进行加压挑战操作时的血压变异性和血压反射敏感性。加压挑战操作模拟日常活动,可预测生活质量:方法:记录 15 名 AIS 患者(平均年龄 69 ± 7.5 岁)和 15 名健康对照者(57 ± 16 岁)在静息状态和 5 分钟快速头部定位(RHP)模式下的连续逐次血压和心电图。患者在中风发生后 24 小时内(急性期)和 7 天内(亚急性期)接受评估。根据记录计算低频(LF)SBP 功率(衡量 BPV 的指标)、LF-α 和综合 α 指数(衡量 BRS 的指标):结果:与健康对照组相比,急性期静息时,AIS 患者的 LF-SBP 功率更高(P = 0.024),α 指数更低(P = 0.006)。在 RHP 期间,患者的 LF-SBP 没有变化,但在健康对照组中,LF-SBP 显著增加(P = 0.018)。在亚急性阶段,AIS 患者静息时的α-指数明显增加(P = 0.037),低频-SBP 明显下降(P = 0.029),但在 RHP 时低频-SBP 功率仍无上升(P = 0.240):结论:AIS 患者的静息血压变压值很高。结论:AIS 患者的静息血压偏高,这可能是 RHP 等加压挑战操作时血压反应迟钝的原因,表明患者的自主神经功能持续失调,生活质量受到影响。
{"title":"Blood pressure variability at rest and during pressor challenges in patients with acute ischemic stroke.","authors":"Sankanika Roy, Man Y Lam, Ronney B Panerai, Thompson G Robinson, Jatinder S Minhas","doi":"10.1097/MBP.0000000000000710","DOIUrl":"10.1097/MBP.0000000000000710","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with acute ischemic stroke (AIS) have elevated blood pressure (BP) variability (BPV) and reduced baroreflex sensitivity (BRS) at rest for several days after initial stroke symptoms. We aimed to assess BPV and BRS in AIS patients during pressor challenge maneuvers in the acute and subacute phases of stroke. Pressor challenge maneuvers simulate day-to-day activities and can predict the quality of life.</p><p><strong>Methods: </strong>Continuous beat-to-beat BP and ECG in 15 AIS patients (mean age 69 ± 7.5 years) and 15 healthy controls (57 ± 16 years) were recorded at rest and during a 5-min rapid head positioning (RHP) paradigm. Patients were assessed within 24 h (acute phase) and 7 days (subacute phase) of stroke onset. Low frequency (LF) SBP power (measure of BPV), LF-α, and combined α-index (measure of BRS) were calculated from the recordings.</p><p><strong>Results: </strong>In the acute phase, at rest, LF-SBP power was higher ( P  = 0.024) and α-index was lower ( P  = 0.006) in AIS patients than in healthy controls. There was no change in LF-SBP during RHP in the patients but in healthy controls, it increased significantly ( P  = 0.018). In the subacute phase, at rest, the alpha-index increased ( P  = 0.037) and LF-SBP decreased ( P  = 0.029) significantly in the AIS patients, however, there was still no rise in the LF-SBP power during RHP ( P  = 0.240).</p><p><strong>Conclusion: </strong>AIS patients have a high resting BPV. High resting BPV may be responsible for blunted BPV responses during pressor challenge maneuvers such as RHP, suggesting ongoing autonomic dysfunction and compromised quality of life.</p>","PeriodicalId":8950,"journal":{"name":"Blood Pressure Monitoring","volume":" ","pages":"232-241"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141260427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-sensitivity C-reactive protein predicts microalbuminuria progression in essential hypertensive patients: a 3-year follow-up study. 高敏 C 反应蛋白可预测原发性高血压患者微量白蛋白尿的进展:一项为期 3 年的随访研究。
IF 1.2 4区 医学 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-10-01 Epub Date: 2024-06-21 DOI: 10.1097/MBP.0000000000000713
Yan Yang, Xiao-Feng Tang, Yan Wang, Jian-Zhong Xu, Ping-Jin Gao, Yan Li

Objectives: To determine the independent effect of high-sensitivity C-reactive protein (hs-CRP) and the combined effects of hs-CRP and other traditional risk factors on microalbuminuria in hypertensive patients during the 3-year follow-up period.

Methods and results: Baseline hs-CRP levels and other risk factors were measured in 280 adults in 2007. In the third year of examination, 199 patients (mean age 62.5 ± 9.5, men 59.3%) were approached for the measurement of microalbuminuria. The subjects were classified into two groups by the median of baseline hs-CRP. Compared to the patients with baseline hs-CRP below the median group ( n  = 99, 50%), the group with baseline hs-CRP above the median ( n  = 100, 50%) had higher urinary albumin-to-creatinine ratio (ACR) ( P  = 0.007) at the end of follow-up period. ACR at the end of follow-up period was significantly correlated with baseline diabetes ( β  = 0.342; P  < 0.001), baseline SBP ( β  = 0.148; P  = 0.02), and baseline log-transformed hs-CRP ( β  = 0.169; P  = 0.01), while adversely correlated with baseline estimated glomerular filtration rate (eGFR) ( β  = -0.163; P  = 0.02) in multivariate stepwise linear analysis. In addition, ACR change during follow-up period was significantly correlated with baseline diabetes ( β  = 0.359; P  < 0.001) and baseline log-transformed hs-CRP ( β  = 0.190; P  = 0.004) in multivariate stepwise linear analysis. The combined effects of baseline hs-CRP and conventional risk factors, such as male sex, diabetes, smoking status, hyperlipidemia, hyperuricemia, and mildly reduced eGFR had a greater risk for microalbuminuria progression. There was no difference in eGFR changes during the follow-up period between two groups.

Conclusion: Our findings offer a new piece of evidence on the predictive value of baseline hs-CRP for microalbuminuria progression in essential hypertensive patients, and highlight those who combined with traditional cardiovascular risk factors had a greater risk for developing microalbuminuria.

目的确定高敏 C 反应蛋白(hs-CRP)对高血压患者 3 年随访期间微量白蛋白尿的独立影响,以及 hs-CRP 和其他传统风险因素对微量白蛋白尿的联合影响:2007年,对280名成年人的hs-CRP基线水平和其他风险因素进行了测量。在检查的第三年,对 199 名患者(平均年龄为 62.5 ± 9.5 岁,男性占 59.3%)进行了微量白蛋白尿测量。受试者按基线 hs-CRP 的中位数分为两组。与基线 hs-CRP 低于中位数组(99 人,50%)相比,基线 hs-CRP 高于中位数组(100 人,50%)在随访结束时的尿白蛋白与肌酐比值(ACR)较高(P = 0.007)。随访结束时的 ACR 与基线糖尿病有显著相关性(β = 0.342;P 结论:我们的研究结果为糖尿病患者提供了新的证据:我们的研究结果为基线 hs-CRP 对本质性高血压患者微量白蛋白尿进展的预测价值提供了新的证据,并强调了那些合并有传统心血管风险因素的患者患微量白蛋白尿的风险更大。
{"title":"High-sensitivity C-reactive protein predicts microalbuminuria progression in essential hypertensive patients: a 3-year follow-up study.","authors":"Yan Yang, Xiao-Feng Tang, Yan Wang, Jian-Zhong Xu, Ping-Jin Gao, Yan Li","doi":"10.1097/MBP.0000000000000713","DOIUrl":"10.1097/MBP.0000000000000713","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the independent effect of high-sensitivity C-reactive protein (hs-CRP) and the combined effects of hs-CRP and other traditional risk factors on microalbuminuria in hypertensive patients during the 3-year follow-up period.</p><p><strong>Methods and results: </strong>Baseline hs-CRP levels and other risk factors were measured in 280 adults in 2007. In the third year of examination, 199 patients (mean age 62.5 ± 9.5, men 59.3%) were approached for the measurement of microalbuminuria. The subjects were classified into two groups by the median of baseline hs-CRP. Compared to the patients with baseline hs-CRP below the median group ( n  = 99, 50%), the group with baseline hs-CRP above the median ( n  = 100, 50%) had higher urinary albumin-to-creatinine ratio (ACR) ( P  = 0.007) at the end of follow-up period. ACR at the end of follow-up period was significantly correlated with baseline diabetes ( β  = 0.342; P  < 0.001), baseline SBP ( β  = 0.148; P  = 0.02), and baseline log-transformed hs-CRP ( β  = 0.169; P  = 0.01), while adversely correlated with baseline estimated glomerular filtration rate (eGFR) ( β  = -0.163; P  = 0.02) in multivariate stepwise linear analysis. In addition, ACR change during follow-up period was significantly correlated with baseline diabetes ( β  = 0.359; P  < 0.001) and baseline log-transformed hs-CRP ( β  = 0.190; P  = 0.004) in multivariate stepwise linear analysis. The combined effects of baseline hs-CRP and conventional risk factors, such as male sex, diabetes, smoking status, hyperlipidemia, hyperuricemia, and mildly reduced eGFR had a greater risk for microalbuminuria progression. There was no difference in eGFR changes during the follow-up period between two groups.</p><p><strong>Conclusion: </strong>Our findings offer a new piece of evidence on the predictive value of baseline hs-CRP for microalbuminuria progression in essential hypertensive patients, and highlight those who combined with traditional cardiovascular risk factors had a greater risk for developing microalbuminuria.</p>","PeriodicalId":8950,"journal":{"name":"Blood Pressure Monitoring","volume":" ","pages":"242-248"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Blood Pressure Monitoring
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