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Nutritional Status in a Patient with Gestational Diabetes Mellitus and Pregnancy Outcome 妊娠期糖尿病患者的营养状况与妊娠结局
Pub Date : 2022-12-31 DOI: 10.3329/jbcps.v41i1.63261
K. Yesmin, F. Begum, M. Islam
Introduction: Both maternal nutritional status and GDM have impact on pregnancy outcome. But, data from Bangladesh in this issue is still scarce. To design and utilize national obstetric health care, nutritional status of GDM women and its impact in the birth weight of babies should be evaluated and therefore, this study was designed.Methods: This prospective cohort study was conducted in the department of Obstetrics and Gynecology at BIRDEM General Hospital-2, Dhaka to evaluate the nutritional status of GDM women and its impact on pregnancy outcomes.Results: The mean age of the patients in the study was 29.71± 5.06 years. The mean age, Mid Upper Arm Circumference (MUAC,) and Body Mass Index (BMI) were significantly higher in GDM mothers (p <0.05). Additionally, gestational weight gain between 28 weeks and before delivery was significantly higher in GDM mothers (p <0.001). The mean birth weight of the newborns was also higher in the GDM group (3.23±0.46vs. 2.97±0.37 kg) (p <0.05). Macrosomic neonates were observed only in the GDM group (4.36%). APGAR score was significantly better in non-GDM mothers’ babies (p <0.05). Babies of GDM mothers had a significantly higher proportion of birth asphyxia, septicemia, pneumonia, Intrauterine Growth Retardation (IUGR), and Neonatal Intensive Care Unit (NICU) admissions (p <0.05). Macrosomic mothers had significantly higher BMI and higher gestational weight gain (p<0.05).Conclusion: Mothers with GDM had a higher rate of bad pregnancy outcomes and that macrosomia was linked to a higher BMI.J Bangladesh Coll Phys Surg 2023; 41: 63-74
引言:母体营养状况和GDM都对妊娠结局有影响。但是,孟加拉国在这个问题上的数据仍然很少。为了设计和利用国家产科保健,应评估GDM妇女的营养状况及其对婴儿出生体重的影响,因此,设计了本研究。方法:这项前瞻性队列研究在达卡BIRDEM综合医院2号妇产科进行,以评估GDM妇女的营养状况及其对妊娠结局的影响。结果:本研究患者的平均年龄为29.71±5.06岁。GDM母亲的平均年龄、中上臂围(MUAC)和体重指数(BMI)均显著高于GDM母亲(p<0.05),GDM母亲在28周至分娩前的妊娠期体重增加明显更高(p<0.001)。GDM组新生儿的平均出生体重也更高(3.23±0.46 vs 2.97±0.37 kg)(p<0.05)。仅在GDM组观察到宏观新生儿(4.36%)。APGAR评分在非GDM母亲的婴儿中明显更好(p<0.01)出生窒息、败血症、肺炎、宫内生长迟缓(IUGR)和新生儿重症监护室(NICU)入院的比例显著较高(p<0.05)。巨大儿母亲的BMI显著较高,妊娠期体重增加也较高(p>0.05)。结论:GDM母亲的不良妊娠结局发生率较高,巨大儿与较高的BMI有关。J Bangladesh Coll Phys Surg 2023;41:63-74
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引用次数: 0
Diabetic Nephropathy: Disease Burden, Pathophysiology and Therapeutic Approaches 糖尿病肾病:疾病负担、病理生理学和治疗方法
Pub Date : 2022-12-31 DOI: 10.3329/jbcps.v41i1.63255
Md. Anwarul Kabir
Abstract not availableJ Bangladesh Coll Phys Surg 2023; 41: 5-6
摘要不可用J Bangladesh Coll Phys Surg 2023;41:5-6
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引用次数: 0
Rosai-Dorfman Disease: A Case Report 罗赛-多夫曼病1例报告
Pub Date : 2022-10-16 DOI: 10.3329/jbcps.v40i4.61894
Amrita Lal Halder, Md. Abid Hossain Mollah
Rosai-Dorfman disease (RDD) is a type of sinus histiocytosis. It is a rare disease (1:200000), particularly in children and commonly presents with massive, painless and usually bilateral cervical lymphadenopathy along with fever and weight loss. Leukocytosis, elevated erythrocyte sedimentation rate and hypergammaglobulinemia are common. A definitive diagnosis can only be made by histological analysis of affected lymph nodes. Emperipolesis and a typical immunohistochemical pattern characterized by positivity for S-100 protein and CD68 antigen and negativity for CD1a antigen are diagnostic for RDD. Here we report a case of RDD occurring in a 10-month-old child with progressive cervical lymphadenopathy and persistent fever. Histopathological and immunohistochemistry studies of a lymph node biopsy established the diagnosis. A watchful follow-up resulted in the resolution of fever and lymphadenopathy.J Bangladesh Coll Phys Surg 2022; 40: 299-301
Rosai Dorfman病(RDD)是一种窦性组织细胞增多症。这是一种罕见的疾病(1:200000),尤其是在儿童中,通常表现为巨大、无痛的双侧颈部淋巴结病,伴有发烧和体重减轻。白细胞增多、红细胞沉降率升高和高丙种球蛋白血症是常见的。只有对受影响的淋巴结进行组织学分析才能做出明确的诊断。以S-100蛋白和CD68抗原阳性和CD1a抗原阴性为特征的典型免疫组织化学模式是RDD的诊断。在这里,我们报告了一例RDD发生在一名10个月大的儿童身上,伴有进行性颈部淋巴结病和持续发热。淋巴结活检的组织病理学和免疫组织化学研究确定了诊断。经过密切的随访,发热和淋巴结病得到了缓解。J Bangladesh Coll Phys Surg 2022;40:299-301
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引用次数: 0
Fibro Sarcoma of the Gingiva: A Rare Presentation 牙龈纤维肉瘤:一种罕见的表现
Pub Date : 2022-10-16 DOI: 10.3329/jbcps.v40i4.60306
Md Talal Mamun, Chowdhury Foyzur Rob
Fibrosarcoma is a rare malignant mesenchymal neoplasm’s of the fibroblasts which are represents 1% of all malignancies in the head and neck region. In this article we described a case of primary fibrosarcoma of the gingiva in right sided alvulas of the mandible in 16 years old male. Who was presented with a rapidly growing painful lump. Microscopically the tumor mass was composed with atypical proliferation of spindle cells arranged in intersecting fascicles and sterioform pattern. In immunohistochemically the cells showed immuno-reactivity for SAM, while negativity towards the others markers. On the basis of clinical histological and immunohistochemistry our case was diagnosed as a low grade primary fibrosarcoma of gingiva. We performed radical resection with wide margin as a primary treatment of choice without neck dissection. After primary treatment there is no signs of recurrence and metastasis was observed last 3 years follow up.J Bangladesh Coll Phys Surg 2022; 40: 310-313
纤维肉瘤是一种罕见的纤维母细胞间质恶性肿瘤,占头颈部所有恶性肿瘤的1%。在这篇文章中,我们描述了一个16岁的男性下颌骨右侧外翻牙龈原发性纤维肉瘤的病例。他出现了一个快速增长的疼痛肿块。镜下肿瘤肿块由非典型增生的梭形细胞组成,梭形细胞呈交叉束状排列。在免疫组织化学中,细胞对SAM表现出免疫反应性,而对其他标记物呈阴性。经临床组织学及免疫组化检查,我们的病例被诊断为低级别原发性牙龈纤维肉瘤。我们采用大切缘根治性切除作为首选治疗方法,无需进行颈部清扫。经初步治疗后3年随访无复发及转移迹象。[J]孟加拉大学物理外科2022;40: 310 - 313
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引用次数: 0
Glomus Tumor of Finger Pulp - A Case Report 指髓血管球瘤1例
Pub Date : 2022-10-16 DOI: 10.3329/jbcps.v40i4.61896
Md. Moklesur Rahman, N. Akhter, A. Iqbal, S. Waheed, Akm Sharifur Rahman, Md Nur Alam
Glomus tumors are rare, vascular,benign, painfulneoplasm, originating from glomus bodies and comprise just 1% of tumors arising in the hand, with fewer than 10% in the volar pulp of digits. Hallmark symptoms of glomus tumors include hypersensitivity to cold, heightened pinprick sensitivity and paroxysmal pain. We report this case due to its rarity and it’s potentialto be included among the differential diagnosis if the lesion is painful. We report here a rare case of a 59-years male presenting with08-years history of pain in the palmer surface of distal phalanx of right little finger. The fingertip was incredibly sensitive to touchand the pain increased at night. He could not recollect any history of trauma. Palpation of the finger revealed tenderness with feeling of no lump. Magnetic resonance imaging(MRI) of the right little finger revealed a small altered signal intensity lesion measuring about 8.0x4.0mm at the ventral aspect of distal phalanx ofright little finger. After I/V contrast- moderate enhancement of the lesion is seen. An incision was made in the mid-axial plane. A circumscribed mass removed with careful &blunt dissection. It was a tan-yellow, soft tissue nodule of about 1- cm in diameter without stalk or adherences to joint capsule or bone. Histopathological examination revealed the mass as a glomus tumor. Symptoms improved on removal and the wound healed without complications. Glomus tumors in the volar digital pulp can be difficult to diagnose. Complete surgical excision of the tumor is the only effective treatment to achieve pain relief and low recurrence.We also emphasize the importance of keeping this tumor in mind among the possibilities of differential diagnosis of painful digital nodules.J Bangladesh Coll Phys Surg 2022; 40: 306-309
球囊瘤是一种罕见的血管性、良性、疼痛性肿瘤,起源于球囊体,仅占手部肿瘤的1%,少于10%发生在指掌髓。球囊瘤的标志性症状包括对寒冷过敏、针刺敏感性增高和阵发性疼痛。我们报告这个病例是因为它的罕见性,如果病变是疼痛的,它有可能被列入鉴别诊断。我们在此报告一个59岁男性的罕见病例,表现为右小指远端指骨帕面疼痛8年。指尖对触摸异常敏感,夜间疼痛加剧。他记不起任何创伤史。触诊手指触痛,无肿块感。右小指磁共振成像(MRI)示右小指远端指骨腹侧一小信号强度改变病灶,约为8.0 × 4.0mm。I/V对比后可见病变中度强化。在中轴平面上切开。用小心钝性解剖摘除的有边界的肿块。它是一个棕黄色的软组织结节,直径约1厘米,无柄或附着于关节囊或骨。组织病理学检查显示该肿块为血管球瘤。去除后症状改善,伤口愈合无并发症。掌侧指髓血管球瘤是一种难以诊断的肿瘤。完全手术切除肿瘤是缓解疼痛和降低复发的唯一有效治疗方法。我们也强调在鉴别诊断疼痛指结节的可能性中,将这种肿瘤牢记在心的重要性。[J]孟加拉大学物理外科2022;40: 306 - 309
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引用次数: 0
Impact of SARS-CoV-2 Infection during Pregnancy and Perinatal Outcome: Findings from Private Hospitals at Dhaka, Bangladesh 妊娠期间SARS-CoV-2感染和围产期结局的影响:来自孟加拉国达卡私立医院的调查结果
Pub Date : 2022-10-16 DOI: 10.3329/jbcps.v40i4.61889
S. Moni, Joysree Saha, Qumrun Nassa Ahmed, I. Jahan, Mosammad Alpana Jahan, Farhana Afroze Sheela, Mannan Ma, M. Shahidullah
Introduction: The pandemic novel corona virus (SARS-CoV- 2) infects pregnant women and affects pregnancy outcome. The perinatal outcome of COVID positive pregnancies attended at private hospitals during the last epidemic peak at Dhaka is unknown. The purpose of the study was to evaluate perinatal outcome among COVID positive and COVID negative pregnant women who delivered in the 2 study hospitals at Dhaka during the last epidemic wave.Methods: This retrospective study was conducted in 2 eminent private medical college& hospitals in Dhaka,namely Popular medical college &hospital (PMCH) and Greenlife medical college hospital (GLMC) over a period of 3 months from July 2021 to September 2021. COVID positive and COVID negative pregnant women who delivered in the study hospitals during the study period were included in this study. Outcome variables were COVID related maternal morbidity mortality, rate of caesarean delivery, stillbirth, preterm birth, low birth weight, neonatal COVID-19 positivity, neonatal death.Results: This study included 60 COVID positive and 60 COVID negative pregnant cases. COVID positive pregnant women delivered at earlier gestational age (weeks) than COVID negative cases(34.46±3.58 vs 36.50±3.20; p=0.001) Among COVID infected pregnancies,severe disease was observed in 15%; O2 support was needed in 68.3% and ICU admission required in 16.7% cases.The caesarean delivery rate ((93.3% vs 80%; p-.032) and preterm delivery rate (63.3% vs 35%; p-.002) were significantly higher among COVID positive cases. About 8.3% COVID affected pregnancies ended up with stillbirth.Maternal death rate due to COVID related complications was 5%.Proportion of low birth weight (LBW) was significantly more in infected pregnancies (65% vs 35%; p 0.001).No newborn from COVID positive mother was tested positive by RT-PCR at 24 hours of age.Conclusion: SARS-CoV-2 infection during pregnancy cancause moderate to severe disease requiring ICU admission and maternal death in 5% among COVID positive cases .It gives rise to more still birth, preterm birth, increasing number of LUCSand LBW. However maternal to neonatal transmission is not evident at 24-hour RT-PCR testing.J Bangladesh Coll Phys Surg 2022; 40: 270-278
大流行新型冠状病毒(SARS-CoV- 2)感染孕妇并影响妊娠结局。在达卡上一个疫情高峰期间,在私立医院就诊的COVID阳性孕妇的围产期结局尚不清楚。该研究的目的是评估上一波流行期间在达卡两家研究医院分娩的COVID阳性和COVID阴性孕妇的围产期结局。方法:回顾性研究于2021年7月至2021年9月在达卡两所著名私立医学院和医院,即Popular medical college &hospital (PMCH)和Greenlife medical college &hospital (GLMC)进行,为期3个月。在研究期间在研究医院分娩的COVID阳性和COVID阴性孕妇纳入本研究。结局变量为与COVID相关的孕产妇发病率死亡率、剖腹产率、死产、早产、低出生体重、新生儿COVID-19阳性、新生儿死亡。结果:本研究纳入了60例COVID阳性孕妇和60例COVID阴性孕妇。COVID阳性孕妇比COVID阴性孕妇早胎龄(周)(34.46±3.58 vs 36.50±3.20);p=0.001)在感染COVID的妊娠中,重症发生率为15%;需要氧气支持的占68.3%,需要住院的占16.7%。剖宫产率(93.3% vs 80%;P - 0.032)和早产率(63.3% vs 35%;p- 0.002)。大约8.3%的受COVID影响的怀孕最终以死产告终。COVID相关并发症导致的孕产妇死亡率为5%。感染妊娠中低出生体重(LBW)的比例明显更高(65%对35%;p 0.001)。新冠病毒阳性母亲的新生儿在24小时龄时未检测到RT-PCR阳性。结论:妊娠期感染SARS-CoV-2可导致中重度疾病,需入院ICU治疗,孕产妇死亡占COVID阳性病例的5%,可导致死产、早产、新生儿和低体重儿增加。然而,在24小时RT-PCR检测中,母体对新生儿的传播并不明显。[J]孟加拉大学物理外科2022;40: 270 - 278
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引用次数: 1
Assessment of Quality of Sexual Life in Male Patients with Psoriasis 男性银屑病患者性生活质量评价
Pub Date : 2022-10-16 DOI: 10.3329/jbcps.v40i4.61882
Azmiree Binte Aslam, R. Khan, Md Shayekh Abdullah, Md. Alauddin Khan
Introduction: Psoriasis is a global burden of disease characterized by the presence of well circumscribed erythematous papule & plaque of various size & shape, covered by silvery scales. It not only hampers the quality of life but also hampers the sexual function. Men who have psoriasis may be more likely to have sexual problems, such as sexual apathy, orgasmic dysfunction, erectile dysfunction (ED), etc. Stress tends to be a triggering or aggravating factor in psoriasis. In addition, the disease itself can generate emotional stress because of its lesions. It is thought that chronic inflammation.Results in metabolic diseases and proinflammatory cytokines give rise to the development of atherogenesis. Pelvic arterial atherosclerosis is another cause of sexual dysfunction. This study was designed to determine the impact of moderate to severe psoriasis on quality of life and sexual dysfunction in male patients.Methods: This case control study was conducted in Department of Dermatology and Venereology, Dhaka Medical College Hospital, among the 100 patients. Group- A was cases (male married patients age between 24 years and 60 years with history of moderate to severe psoriasis) and group-B were control (male married patients age between 24 years and 60 years without psoriasis). Then variables were analyzed and compared. Data was processed and analyzed with the help of computer program SPSS and Microsoft excel. Quantitative data expressed as mean and standard deviation and qualitative data as frequency and percentage. Comparison was done by tabulation and graphical presentation in the form of tables, pie chart, graphs, bar diagrams, histogram & charts etc.Results: It was found that majority of the patients i.e. 46% were between 34-43 years, mean age was found to 41.7±11.3 years. No significant difference in age and other demographic profile was observed between groups. Prevalence of IHD (8.0%), stroke (14.0%), dyslipidaemia (54.0%), neuropathy (26.0%) and PVD (8.0%) were higher in case or psoriatic patients. On evaluation of Dermatology Life Quality Index (DLQI), majority of patients (54%) score was 6-10, followed by 24.0% had score 2-5 and 22.0% of patients had score 11-20 or very large effect on patient’s life. Prevalence of erectile dysfunction was 36.0%, prevalence of orgasmic dysfunction was 24.0%. On multivariate analysis which was done by ordinal logistic regression procedure. The attributes found to be positively associated with sexual dysfunction severity in the multivariate model were patient’s age, disable status, sedentary work, duration of illness, etc.Conclusion: Erectile dysfunction and orgasmic dysfunction are common in psoriatic male patients. There is association with other comorbidities.J Bangladesh Coll Phys Surg 2022; 40: 233-228
银屑病是一种全球性的疾病负担,其特征是存在各种大小和形状的界限分明的红斑丘疹和斑块,被银色鳞片覆盖。它不仅影响生活质量,而且影响性功能。患有牛皮癣的男性可能更容易出现性问题,如性冷淡、性高潮功能障碍、勃起功能障碍(ED)等。压力往往是牛皮癣的触发或加重因素。此外,这种疾病本身也会因其病变而产生情绪压力。人们认为慢性炎症。结果代谢疾病和促炎细胞因子引起动脉粥样硬化的发展。盆腔动脉粥样硬化是性功能障碍的另一个原因。本研究旨在确定中度至重度牛皮癣对男性患者生活质量和性功能障碍的影响。方法:选取达卡医学院附属医院皮肤性病科收治的100例患者进行病例对照研究。A组为病例(男性已婚患者,年龄24 ~ 60岁,有中重度牛皮癣病史),b组为对照组(男性已婚患者,年龄24 ~ 60岁,无牛皮癣)。然后对变量进行分析比较。利用SPSS软件和excel软件对数据进行处理和分析。定量数据以平均值和标准差表示,定性数据以频率和百分比表示。采用表格、饼图、曲线图、条形图、直方图、图表等形式进行制表和图示比较。结果:患者年龄在34 ~ 43岁之间占46%,平均年龄为41.7±11.3岁。在年龄和其他人口统计学特征方面,两组间无显著差异。银屑病患者IHD(8.0%)、卒中(14.0%)、血脂异常(54.0%)、神经病变(26.0%)和PVD(8.0%)患病率较高。在皮肤科生活质量指数(DLQI)评价中,大多数患者(54%)得分为6-10分,其次为24.0%的患者得分为2-5分,22.0%的患者得分为11-20分或对患者生活影响很大。勃起功能障碍患病率为36.0%,性高潮障碍患病率为24.0%。运用有序逻辑回归程序进行多变量分析。在多变量模型中发现与性功能障碍严重程度正相关的属性有患者的年龄、残疾状态、久坐工作、疾病持续时间等。结论:银屑病男性患者普遍存在勃起功能障碍和性高潮障碍。与其他合并症有关联。[J]孟加拉大学物理外科2022;40: 233 - 228
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引用次数: 0
Quantification of T Cell Subsets in Bangladeshi COVID-19 Patients Creating Prospects towards Broader Research and Improved Patient Care 孟加拉国新冠肺炎患者T细胞亚群的量化为更广泛的研究和改善患者护理创造了前景
Pub Date : 2022-10-16 DOI: 10.3329/jbcps.v40i4.61876
F. Ahmed, S. Sultana
Abstract not availableJ Bangladesh Coll Phys Surg 2022; 40: 213-215
[j]孟加拉大学物理外科杂志,2022;40: 213 - 215
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引用次数: 0
Outcome of Venous Supercharged Pedicled Anterolateral Thigh Flap for Reconstruction of Soft Tissue Defect around the Knee Joint 静脉加压带蒂股前外侧皮瓣修复膝关节周围软组织缺损的疗效
Pub Date : 2022-10-16 DOI: 10.3329/jbcps.v40i4.61880
Khondokar Shohana Arju, Pradip Chandra Dash, Tanveer Ahmed, H. Reza, Gobinda Biswas, Md Noazesh Khan
Introduction: Soft tissue defects around the knee are common following motor vehicle accidents, burns especially electric burn, excision of malignancy etc. Reconstruction of soft tissue defect around the knee needs thin, pliable and tough skin. Recently distally based pedicled anterolateral thigh flap has been used for soft tissue reconstruction for its several advantages like long pedicle, sufficient amount of soft tissue and less donor site morbidity. But it has tendency towards venous congestion and this can be overcome with venous supercharging. This study was designed to evaluate the effectiveness of venous supercharging in reducing venous congestion in pedicled anterolateral thigh flap for reconstruction of soft tissue defect around the knee joint.Methods: This prospective observational study was carried out at Department of Plastic Surgery and Burn Unit, Dhaka Medical College Hospital and Sheikh Hasina National Institute of Burn and Plastic Surgery (SHNIBPS), Dhaka from August 2017 to June 2019. Twenty (20) patients who presented with defect around the knee were included in this study according to inclusion and exclusion criteria.Results: Maximum patients 5(25%)were day labour and wounds were created by MVA in most of the cases10(50%).Most common site was anterior aspect of knee joint 8(40%).The dimension of the wound size ranged from 5×3cm upto 7×14cm. Majority of the wounds ranged from 15×13cm to 17×14cm. The flap size ranged from 6×3.5cm upto 20×18cm. 18 (90%) flaps had no venous congestion, but 2(10%) cases had it. All flaps (20) survived well, 18 cases had acceptable scar and in 2 cases infection occurred. Regarding functional outcome of knee joints, 15 (75%) patients had full range of motion and 5(25%) patients had 5p -10p restriction in flexion of knee joints. Final outcome was found excellent in 16(80%) and satisfactory in 4(20%) cases.Conclusion: Venous supercharging in pedicled anterolateral thigh flap for soft tissue defect around the knee joint have shown to be effective in reducing venous congestion.J Bangladesh Coll Phys Surg 2022; 40: 233-239
简介:膝关节周围的软组织缺损常见于机动车事故、烧伤特别是电烧伤、恶性肿瘤切除等。膝关节周围软组织缺损的重建需要薄、柔韧、坚韧的皮肤。近年来,带蒂股前外侧皮瓣以其蒂长、软组织量大、供区并发症少等优点被广泛应用于软组织重建。但它有静脉充血的趋势,这可以通过静脉增压来克服。本研究旨在评估静脉增压在带蒂股前外侧皮瓣重建膝关节周围软组织缺损中减少静脉充血的有效性。方法:这项前瞻性观察性研究于2017年8月至2019年6月在达卡医学院医院整形外科和烧伤科以及达卡谢赫·哈西娜国家烧伤整形外科研究所(SHNIBPS)进行。根据纳入和排除标准,二十(20)名出现膝关节周围缺损的患者被纳入本研究。结果:最多5例(25%)患者为日间分娩,大多数病例10(50%)由MVA造成伤口。最常见的部位是膝关节前部8(40%)。伤口尺寸从5×3cm到7×14cm不等。伤口多在15×13cm~17×14cm之间。皮瓣大小从6×3.5cm到20×18cm不等。18例(90%)皮瓣无静脉淤血,2例(10%)有静脉淤血。所有皮瓣(20例)均存活良好,18例有可接受的瘢痕,2例发生感染。关于膝关节的功能结果,15名(75%)患者有全活动范围,5名(25%)患者膝关节屈曲有5p-10p的限制。16例(80%)最终结果良好,4例(20%)满意。结论:带蒂股前外侧皮瓣静脉增压治疗膝关节周围软组织缺损,可有效减少静脉充血。J Bangladesh Coll Phys Surg 2022;40:233-239
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引用次数: 0
Genital Tuberculosis Presenting as Primary Amenorrhoea 生殖器结核表现为原发性闭经
Pub Date : 2022-10-16 DOI: 10.3329/jbcps.v40i4.61895
H. Begum, M. Islam, Fatema Ashrafi
A 23-year-old married woman presented with primary amenorrhoea with well-developed 2ndary sex characteristics. She is chromosomally competent female (46xx) with average body built and had no problem in marital relationship. Clinical examinations and all relevant investigations including transvaginal ultrasound(TVS) showed uterus, adnexa normal size and volume. Progesterone challenge test was negative on 3 occasions. Laparoscopy showed distorted shape of fallopian tubes with beaded appearance. Biopsy from it and endometrial samplzings collected by aspiration showed granuloma with caseation necrosis, typical of tuberculosis (TB) though no AFB found on culture. PCRRFLP also positive for TB. So, primary amenorrhoea with unresponsive endometrium with underlying Genital Tuberculosis was clinical diagnosis. She received 9 months treatments of 4 drugs regimens of anti-TB.J Bangladesh Coll Phys Surg 2022; 40: 302-305
一位23岁的已婚妇女,以原发性闭经为主要表现,伴有第二性征。她是染色体胜任的女性(46xx),身材一般,婚姻关系没有问题。临床检查及所有相关检查包括经阴道超声(TVS)显示子宫、附件大小和体积正常。黄体酮激发试验阴性3次。腹腔镜显示输卵管形态扭曲,呈串珠状。活检和子宫内膜穿刺取样显示肉芽肿伴干酪样坏死,典型的结核(TB),但培养未发现AFB。PCRRFLP对结核也呈阳性。因此,原发性闭经伴子宫内膜无反应并伴有潜在生殖器结核是临床诊断。她接受了9个月的4种抗结核药物治疗方案。[J]孟加拉大学物理外科2022;40: 302 - 305
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Journal of Bangladesh College of Physicians & Surgeons
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