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Lost in translation: transferring knowledge from research to clinical practice 迷失在翻译中:将知识从研究转移到临床实践
J. Wallace
Using a new treatment is not an instantaneous act. There is a gap between research and practice and carefully evaluated evidence often fails to achieve widespread use. Various factors intercede along the pathway from knowledge generation to knowledge utilisation. These can hinder, or indeed facilitate, the use of research evidence in psychiatry. Knowledge translation is a discipline that attempts to identify and understand these barriers and facilitators to knowledge transfer. In this article, the terminology and key concepts of knowledge translation will be outlined, the evidence transfer pipeline described and obstacles and facilitators to uptake of evidence explored. The article also identifies sources of information on knowledge transfer. Innovative approaches designed to enhance the uptake of evidence from research, such as summaries, systematic reviews and targeted messaging, are also described.
使用一种新的治疗方法不是一蹴而就的。研究与实践之间存在差距,经过仔细评估的证据往往无法得到广泛应用。在从知识产生到知识利用的过程中,有各种各样的因素在起作用。这些可能会阻碍或促进精神病学研究证据的使用。知识翻译是一门试图识别和理解这些障碍和促进知识转移的学科。在本文中,将概述知识翻译的术语和关键概念,描述证据转移管道,并探讨证据吸收的障碍和促进因素。本文还指出了关于知识转移的信息来源。还介绍了旨在加强从研究中获取证据的创新方法,如摘要、系统评价和有针对性的信息传递。
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引用次数: 8
New diagnostic concepts in Alzheimer’s disease 阿尔茨海默病新诊断概念
A. Watkin, S. Sikdar, Biswadeep Majumdar, A. Richman
This article gives an overview of the profile of Alzheimer’s disease, its pathophysiology and recent developments in technology that enable better understanding of the mechanism of disease. The diagnostic criteria and role of biomarkers proposed are explained. The new subgroups described are outlined in table form for easy reference. Subtypes of mild cognitive impairment (MCI) are reviewed and the conversion of amnestic MCI to Alzheimer’s disease is considered. The implications and change to current clinical practice form the basis of the conclusion of the article.
本文概述了阿尔茨海默病的概况,其病理生理学和最近的技术发展,使人们更好地了解疾病的机制。介绍了生物标志物的诊断标准和作用。所描述的新子组以表格形式概述,以方便参考。回顾了轻度认知障碍(MCI)的亚型,并考虑了遗忘性MCI向阿尔茨海默病的转化。对当前临床实践的影响和变化构成了文章结论的基础。
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引用次数: 33
What civilian psychiatrists should know about military psychiatry 平民精神科医生应该知道多少军事精神病学的知识
M. Deahl, R. Siddiquee
Few of us have first-hand experience of military psychiatry. However, as a result of recent conflict and the imminent downsizing of the armed forces we will almost certainly be seeing increasing numbers of ex-servicemen in our clinics. This paper explains what civilian mental health professionals should know when dealing with service and ex-service men and women.
我们中很少有人有军事精神病学的第一手经验。然而,由于最近的冲突和武装部队即将缩减规模,我们几乎肯定会看到越来越多的退役军人来到我们的诊所。本文解释了平民心理健康专业人员在与现役和退役军人打交道时应该知道的事情。
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引用次数: 1
Supportive psychodynamic psychotherapy for psychosis 精神病的支持性心理动力学心理治疗
B. Rosenbaum, B. Martindale, A. Summers
The UK National Institute for Health and Care Excellence guidance suggests that psychodynamic principles may be used to understand the experiences of people with psychosis. In this article we consider the application of psychodynamic principles in psychotherapy for psychosis, focusing on one particular model: supportive psychodynamic psychotherapy (SPP). We describe this approach with a detailed fictitious case example and discuss how SPP has developed through significant modifications of classical psychoanalytic therapy and the evidence base for it. We consider its overlap with cognitive–behavioural therapy, its advantages and disadvantages, and the arguments for making SPP available as a treatment option in services for psychosis.
英国国家健康与护理卓越研究所的指导建议,精神动力学原理可以用来理解精神病患者的经历。在这篇文章中,我们考虑心理动力学原理在精神病心理治疗中的应用,重点是一个特殊的模式:支持性心理动力学心理治疗(SPP)。我们用一个详细的虚构案例来描述这种方法,并讨论SPP是如何通过对经典精神分析疗法的重大修改而发展起来的,以及它的证据基础。我们考虑了它与认知行为疗法的重叠,它的优点和缺点,以及将SPP作为精神病治疗选择的争论。
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引用次数: 11
Suicide prevention: are we doing enough? 预防自杀:我们做得够不够?
A. Cole-King, Victoria Parker, H. Williams, S. Platt
Healthcare professionals require an understanding of how the behaviour and characteristics of both patients and assessors can affect suicide risk identification and response. This article reviews the literature on how we currently assess suicide risk and considers the need for a paradigm shift in how healthcare professionals engage with and assess suicidal patients. It also reviews some of the evidence base for interventions to mitigate the risk of suicide and promotes pragmatic and compassionate interventions.
医疗保健专业人员需要了解患者和评估人员的行为和特征如何影响自杀风险的识别和反应。本文回顾了我们目前如何评估自杀风险的文献,并考虑了医疗保健专业人员如何参与和评估自杀患者的范式转变的必要性。它还回顾了一些证据基础的干预措施,以减轻自杀的风险,并促进务实和富有同情心的干预。
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引用次数: 17
Boredom among psychiatric in-patients: does it matter? 精神科住院病人的无聊感:重要吗?
R. Steele, P. Henderson, Frances Lennon, D. Swinden
Many psychiatric in-patients report boredom. Such complaints may appear trivial, but this literature review by a clinical librarian suggests that boredom is more complex than may initially appear and relates to wider areas of importance for in-patient psychiatric teams. Boredom may relate to the internal experience of meaning, which itself encompasses meaningful relationships and roles and a sense of control. Although meaningful therapeutic activities are vital, mental health professionals should focus on the internal as well as the external dimensions of boredom. Medications, particularly dopamine antagonist antipsychotics, may be a contributing factor. This article highlights the benefits of the clinical librarian role in synthesising research in mental health. Research can illuminate psychiatric practice in a more holistic way than purely by applying ‘scientific’ evidence in the practice of ‘biological’ psychiatry.
许多精神科住院病人表示厌烦。这样的抱怨可能看起来微不足道,但这篇由临床图书管理员撰写的文献综述表明,无聊比最初看起来要复杂得多,并且与住院精神科团队更广泛的重要领域有关。无聊可能与意义的内在体验有关,它本身包含有意义的关系、角色和控制感。虽然有意义的治疗活动是至关重要的,但心理健康专业人员应该关注无聊的内在和外在维度。药物治疗,特别是多巴胺拮抗剂抗精神病药物,可能是一个促成因素。这篇文章强调了临床图书馆员在心理健康综合研究中的作用。研究可以以一种更全面的方式来阐明精神病学实践,而不仅仅是在“生物”精神病学实践中应用“科学”证据。
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引用次数: 9
Hey kid, are you OK? A story of suicide survived 嘿,孩子,你还好吗?一个自杀的故事流传了下来
K. Hines, A. Cole-King, Margaret E. Blaustein
Kevin Hines gives a high-impact and deeply poignant account of his suicidal crisis, which culminated in an attempt to end his life, and an inspirational account of his recovery and return to mental well-being.
凯文·海恩斯(Kevin Hines)对他的自杀危机(最终以自杀告终)进行了深刻而深刻的描述,并对他的康复和精神健康进行了鼓舞人心的描述。
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引用次数: 4
To be or not to be: legal and ethical considerations in suicide prevention 生存还是毁灭:自杀预防中的法律和伦理考虑
Jaydip Sarkar
Making potentially critical clinical decisions in complex cases with the real risk of death by suicide is a most challenging job in psychiatry. Sadly, risk assessment and management of harm to self is a largely ignored area compared with risk of harm to others. The legal and ethical challenges are more nuanced, and contemporary training schemes and textbooks on psychiatry have not always done justice to this area, where front-line clinicians require probably most assistance. This article is an attempt to integrate the seemingly disparate threads from legal, ethical and clinical realms to assist decision-making, and it introduces a set of principles for managing these in clinical practice. It refers in particular to legislation in England and Wales, but the clinical and ethical issues discussed are universal.
在有自杀死亡风险的复杂病例中做出潜在的关键临床决定是精神病学中最具挑战性的工作。可悲的是,与伤害他人的风险相比,自我伤害的风险评估和管理在很大程度上是一个被忽视的领域。法律和道德方面的挑战更加微妙,当代精神病学培训计划和教科书并不总是公正地对待这一领域,而这一领域可能是一线临床医生最需要帮助的领域。本文试图整合法律、伦理和临床领域看似不相干的线索,以协助决策,并介绍了一套在临床实践中管理这些原则。它特别提到了英格兰和威尔士的立法,但所讨论的临床和伦理问题是普遍的。
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引用次数: 4
Rethinking placebo in psychiatry: how and why placebo effects occur † 重新思考精神病学中的安慰剂:安慰剂效应是如何以及为什么发生的
D. McQueen, Sarah Cohen, P. John-Smith, H. Rampes
This article outlines proximate (physical and mental) and ultimate mechanisms of placebo effects. Interpersonal processes contributing to placebo effects are reviewed and illustrated through research into the process of psychotherapy. Evolutionary theories of how and why the capacity for placebo effects might have evolved are described. The components of treatment and placebo effects are defined. It is concluded that maximising therapeutic placebo effects is effective and a valid clinical goal.
本文概述了安慰剂效应的近似(生理和心理)和最终机制。通过对心理治疗过程的研究,回顾和说明了人际过程对安慰剂效应的影响。描述了如何以及为什么安慰剂效应的能力可能已经进化的进化理论。定义了治疗和安慰剂效应的组成部分。结论是,最大限度地提高安慰剂治疗效果是有效的,也是一个有效的临床目标。
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引用次数: 12
Post-traumatic stress disorder: new directions in pharmacotherapy 创伤后应激障碍:药物治疗的新方向
B. Green
SUMMARY As many as 10% of the population experience post-traumatic stress disorder (PTSD) at some time in their lives. It often runs a severe, chronic and treatment-resistant course. This article reviews the evidence base for typically recommended treatments such as cognitive–behavioural therapy (CBT), eye movement desensitisation and reprocessing and selective serotonin reuptake inhibitors (SSRIs). It tabulates the major randomised controlled trials of SSRIs and trauma-focused CBT and reviews research on novel treatments such as ketamine, MDMA, quetiapine, propranolol and prazosin.
多达10%的人在一生中的某个时候经历过创伤后应激障碍(PTSD)。它通常是一个严重的、慢性的、难以治疗的过程。本文综述了典型推荐治疗的证据基础,如认知行为疗法(CBT)、眼动脱敏和再加工以及选择性血清素再摄取抑制剂(SSRIs)。它列出了SSRIs和创伤性CBT的主要随机对照试验,并回顾了氯胺酮、MDMA、喹硫平、心得安和哌唑嗪等新型治疗方法的研究。
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引用次数: 14
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Advances in psychiatric treatment : the Royal College of Psychiatrists' journal of continuing professional development
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