BioInorganic Reaction Mechanisms最新文献

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Kinetics and Mechanism of the Substitution Reactions of Triphenyltin(IV)[2-(2,6- dichlorophenyl)aminophenyl acetate] with Iodine 三苯基锡(IV)[2-(2,6-二氯苯基)乙酸氨基苯基]与碘取代反应的动力学与机理

BioInorganic Reaction Mechanisms

Pub Date : 2006-01-01 DOI: 10.1515/IRM.2006.6.1.49

Saqib Ali, S. Ahmad, M. Altaf, S. Shahzadi, A. Badshah

引用次数: 0

Kinetic Study of the Complexation of Bulky TMUSolvated Manganese(II), Iron(II), Cobalt(II), Nickel(II), Copper(II), Zinc(II), and Cadmium(II) Ions in Neat TMU (1,1,3,3-Tetramethylurea) Solvent 大块TMUSolvated锰(II)、铁(II)、钴(II)、镍(II)、铜(II)、锌(II)和镉(II)离子在纯TMU(1,1,3,3-四甲基脲)溶剂中的络合动力学研究

BioInorganic Reaction Mechanisms

Pub Date : 2006-01-01 DOI: 10.1515/IRM.2006.6.2.151

H. Tsuji, Y. Inada, S. Funahashi

引用次数: 0

Kinetic and Mechanistic Studies of Substitution on [(H2O)(tap)2RuORu(tap)2(H2O)]2+ Ion with Uridine in Aqueous Medium 尿苷取代[(H2O)(tap)2RuORu(tap)2(H2O)]2+离子的动力学和机理研究

BioInorganic Reaction Mechanisms

Pub Date : 2006-01-01 DOI: 10.1515/IRM.2006.6.1.9

Hriday Chattopadhyay, A. K. Ghosh

*Corresponding author: e-mail: alakghosh2002@yahoo.co.in Platinum complexes of ruthenium, rhodium, iridium and palladium have been reported to have considerable antibacterial power [1,2]. Ruthenium complexes are an order of magnitude less toxic than cis-platin. Studies demonstrate that a number of ruthenium compounds serve as bacterial mutagens and so indicate that at least some ruthenium complexes are capable of damaging genetic material. Screening studies on a series of ruthenium complexes show that many of them do exhibit antitumor [3-6], antiherpes [7], anti-HIV [8], antiamebic [9], anticancer [10], antileucomic [11] and antifungal activity [12,13]. Ruthenium-arene organometallic compounds are postulated to interact with DNA targets, although protein interactions have also been shown. These organometallic species are more stable than inorganic metal compounds, which facilitate pharmacokinetic studies, thereby increasing the Inorganic Reaction Mechanisims, Vol. 6, pp. 9-17 © 2006 Old City Publishing, Inc. Reprints available directly from the publisher Published by license under the OCP Science imprint, Photocopying permitted by license only a member of the Old City Publishing Group.

*通讯作者:e-mail: alakghosh2002@yahoo.co.in钌、铑、铱和钯的铂配合物已被报道具有相当的抗菌能力[1,2]。钌配合物的毒性比顺铂小一个数量级。研究表明，许多钌化合物可以作为细菌诱变剂，因此表明至少一些钌复合物能够破坏遗传物质。对一系列钌配合物的筛选研究表明，许多钌配合物确实具有抗肿瘤[3-6]、抗疱疹[7]、抗hiv[8]、抗阿米巴[9]、抗癌[10]、抗白血病[11]和抗真菌活性[12,13]。钌-芳烃有机金属化合物被假定与DNA目标相互作用，尽管蛋白质相互作用也已被证明。这些有机金属化合物比无机金属化合物更稳定，有利于药代动力学研究，从而增加了无机反应机理，第6卷，第9-17页©2006 Old City Publishing, Inc.。可直接从出版商处获得重印，在OCP科学印记下通过许可出版，仅允许旧城出版集团成员的许可复印。

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引用次数: 8

Mechanistic Insight from a Volume Profile for Electron Transfer Between Promethazine and Hexaaquairon(III) 异丙嗪与六aquairon之间电子转移的体积分布机制(III)

BioInorganic Reaction Mechanisms

Pub Date : 2006-01-01 DOI: 10.1515/IRM.2006.6.1.1

J. Wiśniewska, R. van Eldik

Promethazine (dimethyl-(2-phenothiazin-10-ylpropyl)-amine) is one of a series of Nalkylphenothiazines that modify the physiological action of neurotransmission receptors. They are therefore used as medicine in a variety of pharmacological therapies related to a reduction of the neurotransmission effects.1 Other interesting features of the phenothiazine class of drugs include their ability to undergo one electron-transfer reactions and to form charge-transfer complexes with various Inorganic Reaction Mechanisims, Vol. 6, pp. 1-8 © 2006 Old City Publishing, Inc. Reprints available directly from the publisher Published by license under the OCP Science imprint, Photocopying permitted by license only a member of the Old City Publishing Group.

异丙嗪(二甲基-(2-吩噻嗪-10-基丙基)胺)是一系列能改变神经传递受体生理作用的萘基吩噻嗪类药物之一。因此，它们被用作与减少神经传递效应有关的各种药理学疗法的药物吩噻嗪类药物的其他有趣特征包括它们能够进行一次电子转移反应，并形成各种无机反应机制的电荷转移复合物，第6卷，第1-8页©2006 Old City Publishing, Inc.。可直接从出版商处获得重印，在OCP科学印记下通过许可出版，仅允许旧城出版集团成员的许可复印。

引用次数: 4

Kinetic, Mechanistic and Spectral Investigation of Oxidative Degradation and Deamination of Atenolol by Cerium(IV) in Aqueous Perchloric acid Medium 高氯酸水溶液中铈(IV)氧化降解阿替洛尔的动力学、机理及光谱研究

BioInorganic Reaction Mechanisms

Pub Date : 2006-01-01 DOI: 10.1515/IRM.2006.6.1.59

M. B. Bellakki, R. Mahesh, S. Nandibewoor

Cerium(IV) has been used as an oxidising agent and an analytical reagent, especially in acid media [1]. Kinetic studies on the oxidation of different substrates using Ce(IV) as an oxidant in perchloric acid medium have been reported [2]. In sulphuric acid medium, Ce(IV) forms [3] several sulphate complexes, but their role has not received much attention so far. Thus the reaction rate increases with increase in acid concentration and this effect has not been understood. 4-(2-Hydroxy-3-isopropylaminopropoxy)phenylacetamide, commercially known as atenolol (ATN), a β-adrenoreceptor blocking agent, is used as an antihypertensive drug [4]. It is also used for antiangina treatment to relieve symptoms and improve tolerance, as an anti-arrhythmic to help regulate heartbeat, and in management of alcohol withdrawal, Inorganic Reaction Mechanisims, Vol. 6, pp. 59-70 © 2006 Old City Publishing, Inc. Reprints available directly from the publisher Published by license under the OCP Science imprint, Photocopying permitted by license only a member of the Old City Publishing Group.

铈(IV)已被用作氧化剂和分析试剂，特别是在酸性介质中[1]。已有报道以Ce(IV)作为氧化剂在高氯酸介质中氧化不同底物的动力学研究[2]。在硫酸介质中，Ce(IV)可形成[3]几种硫酸盐配合物，但其作用至今未受到重视。因此，反应速率随酸浓度的增加而增加，这种影响尚未被理解。4-(2-羟基-3-异丙基氨基丙氧基)苯乙酰胺，商业上称为阿替洛尔(ATN)，是一种β-肾上腺素受体阻滞剂，被用作降压药物[4]。它也用于抗心绞痛治疗，以缓解症状和提高耐受性，作为抗心律失常，帮助调节心跳，并用于戒酒管理，无机反应机制，第6卷，第59-70页©2006老城出版公司。可直接从出版商处获得重印，在OCP科学印记下通过许可出版，仅允许旧城出版集团成员的许可复印。

引用次数: 1

Kinetics and Mechanism of Oxidation of a Ternary Complex Involving Dipicolinatochromium(III) and Proline by N-bromsuccinimide n -溴琥珀酰亚胺氧化二吡啶铬(III)和脯氨酸三元配合物的动力学和机理

BioInorganic Reaction Mechanisms

Pub Date : 2006-01-01 DOI: 10.1515/IRM.2006.6.2.119

Eman S. H. Khaled

引用次数: 1

Kinetics of Interaction of the [Pd2Cl2(tppz)]2+ Cation with Guanine in Aqueous DMSO, and Solvatochromic Properties of the Complex in Aqueous DMSO Mixtures 水溶液DMSO中[Pd2Cl2(tppz)]2+阳离子与鸟嘌呤相互作用动力学及配合物在水溶液DMSO混合物中的溶剂致变色性质

BioInorganic Reaction Mechanisms

Pub Date : 2006-01-01 DOI: 10.1515/IRM.2006.6.2.83

Alena M. Corcoran, R. Haines

The binucleating ligand, 2,3,5,6-tetrakis(2pyridyl)pyrazine, (tppz) (Structure I), has been known for more than forty years [1], and has been used to produce homoand heterobimetallic complexes of osmium/ruthenium [2] and ruthenium/iridium [3]. The photoand electrochemical properties of these complexes, and those of osmium/osmium have been reported [4]. The formation of the iron(II) complexes of tppz were reported long ago [1], and we have reported a kinetic study of nucleophilic substitution at the [Fe(tppz)2] centre, together with the kinetics of oxidation of [Fe(tppz)2] and [Fe(tppz)(CN)3] [5]. Inorganic Reaction Mechanisims, Vol. 6, pp. 83-89 © 2006 Old City Publishing, Inc. Reprints available directly from the publisher Published by license under the OCP Science imprint, Photocopying permitted by license only a member of the Old City Publishing Group.

双核配体2,3,5,6-四akis(2pyridyl)pyrazine (tppz) (Structure I)已被发现四十多年[1]，并被用于制备锇/钌[2]和钌/铱[3]的同质和杂双金属配合物。这些配合物的光电性质和电化学性质，以及锇/锇配合物的光电性质已被报道[4]。tppz的铁(II)配合物的形成很早以前就有报道[1]，我们也报道了[Fe(tppz)2]中心的亲核取代动力学研究，以及[Fe(tppz)2]和[Fe(tppz)(CN)3]的氧化动力学[5]。无机反应机理，第6卷，第83-89页©2006老城出版股份有限公司可直接从出版商处获得重印，在OCP科学印记下通过许可出版，仅允许旧城出版集团成员的许可复印。

引用次数: 0

Competing Coordination and Oxygen Atom Transfer in a Reaction Between Triarylphosphines and a Chromium Hydroperoxo Complex 三芳基膦与氢过氧铬配合物反应中的竞争配位和氧原子转移

BioInorganic Reaction Mechanisms

Pub Date : 2005-10-01 DOI: 10.1515/IRM.2005.5.4.245

Oleg Pestovsky, A. Bakac

There is a remarkable resemblance in the chemistry and intermediates involved in the autoxidation of a macrocyclic Cr(II) complex LCr(H2O)2 (L1 = 1,4,8,11-tetraazacyclotetradecane, or cyclam) and the activation of molecular oxygen by cytochrome P450 enzymes [1,2]. For every major step in the P450 chemistry there is a corresponding step in the chemistry of L1Cr complex, including the hydroperoxo to high-valent oxo conversion of eq 1. The kinetics of this transformation have been studied earlier [2,3].

大环Cr(II)络合物LCr(H2O)2 (L1 = 1,4,8,11-四氮杂环十四烷，或cyclam)的自氧化和细胞色素P450酶对分子氧的激活在化学和中间体上具有显著的相似性[1,2]。对于P450化学中的每一个主要步骤，在L1Cr络合物的化学反应中都有相应的步骤，包括式1中氢过氧到高价氧的转化。这种转化的动力学已经在早期进行了研究[2,3]。

引用次数: 1

Reaction Kinetics and Mechanism of Formation of [MnW6O24]8- by Hypochlorous Acid Oxidation of Mn(II)aq in the Presence of Tungstate 钨酸盐存在下次氯酸氧化Mn(II)aq生成[MnW6O24]8-的反应动力学及机理

BioInorganic Reaction Mechanisms

Pub Date : 2005-01-01 DOI: 10.1515/IRM.2005.5.3.181

A. Nolan, J. A. Irwin, R. Burns, G. Lawrance

Oxidation of Mn(II) by HOCl in weakly acidic solution, in the presence of tungstate, results in the formation of the soluble heteropolyoxotungstate [MnW6O24]. The kinetics of formation of this species was studied from 15-35°C over the pH range 4.9-5.4 and found to exhibit solution autocatalytic behaviour. The oxidation kinetics was found to follow an expanded rate expression consisting of two terms:

在弱酸性溶液中，在钨酸盐存在的情况下，用HOCl氧化Mn(II)，形成可溶的钨酸杂多氧[MnW6O24]。在15-35°C、pH值4.9-5.4范围内研究了该物质的形成动力学，发现其表现出溶液自催化行为。发现氧化动力学遵循由两项组成的扩展速率表达式:

引用次数: 0

The Kinetics and Mechanism of the Oxidation of Inorganic Oxysulfur Compounds by Potassium Ferrate Part II - Tetrathionate Ions 高铁酸钾氧化无机含氧硫化合物的动力学与机理(ⅱ)-四硫酸盐离子

BioInorganic Reaction Mechanisms

Pub Date : 2005-01-01 DOI: 10.1515/IRM.2005.5.4.265

J. F. Read, S. Bewick, S. Oikle, Catherine Schaubel, S. N. Taylor, Annie Thériault, K. Watson

引用次数: 8

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