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Systematic Review: Effects of the Kampo Formula Yokukan-San-Ka-Chimpi-Hange on Behavioral and Psychological Symptoms of Dementia 系统评价:汉方“yokukan - sanka - chimpii - hange”对痴呆行为和心理症状的影响
Pub Date : 2017-11-10 DOI: 10.4172/2327-5162.1000254
M. Baba, S. Yakubo, E. Fukuda, Yukiko Ueda, Tomohiro Hattori, E. Shiba, M. Soma, Y. Arashima, T. Namiki
Introduction: Randomized usual-case controlled studies on Japanese dementia patients with behavioral and psychological symptoms were conducted to examine the effects of Kampo medicine Yokukan-San (YKS) on the behavioral and psychological symptoms of dementia (BPSD). These studies showed that YKS is effective in treating BPSD. Yokukan-San-Ka-Chimpi-Hange is a Kampo medicine made by adding dried citrus peel and pinellia tuber to YKS. In Japan, we usually administer Yokukan-San-Ka-Chimpi-Hange as Kracie Yokukan-San-Ka-Chimpi-Hange extract granules (KB-83), produced by Kracie Pharma, Ltd. (Tokyo, Japan). Methods: We investigated 3 trials carried out on the use of KB-83 for the treatment of severe dementia in elderly. Results: KB-83 showed no change in core symptoms after administration in cases of dementia, but significant improvements in BPSD were reported. KB-83 was particularly effective in treating aggressive symptoms such as restlessness or abusive language. Conclusion: In the treatment of dementia, we think that the administration of KB-83 is effective in mitigating the BPSD, and that further studies are need to investigate the effects of EK-83.
引言:对有行为和心理症状的日本痴呆症患者进行随机常规病例对照研究,以检验Kampo medicine Yokukan San(YKS)对痴呆症行为和心理特征(BPSD)的影响。这些研究表明YKS治疗BPSD是有效的。Yokukan San Ka Chimpi Hange是一种贡布药,通过在YKS中加入干柑橘皮和菠萝块茎制成。在日本,我们通常以Kracie Yokukan-San-Ka-Chimpi-Hange提取物颗粒(KB-83)的形式给药,该颗粒由Kracie Pharma,有限公司生产。方法:我们研究了KB-83治疗老年严重痴呆的3项试验。结果:KB-83在痴呆患者给药后核心症状没有变化,但BPSD有显著改善。KB-83在治疗烦躁不安或辱骂性语言等攻击性症状方面尤其有效。结论:在痴呆症的治疗中,我们认为给予KB-83可以有效地减轻BPSD,需要进一步研究EK-83的作用。
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引用次数: 0
Complementary and Alternative Medicines (Cam) Use among Cancer Patients: An Overview and the Decision Making 补充和替代药物(Cam)在癌症患者中的使用:综述和决策
Pub Date : 2017-10-28 DOI: 10.4172/2327-5162.1000253
M. Farooqui
Caner is a leading cause of death worldwide which requires a multidisciplinary treatment approach. Safety and efficacy of many of the modern therapies have been well established but still use of complementary and alternative medicines (CAM) are on rise among cancer patients. CAM decision making process is complex which is affected by many social and disease related variables. Prevalence based studies regarding CAM use reported a wide range of variation in percentage use of CAM among cancer patients which could be due to the way different studies defined CAM in their studies. Understanding CAM use decision making is crucial as it is highly individualized and revolves around several issues which can benefit patients and their care givers in treatment success.
癌症是世界范围内死亡的主要原因,需要多学科治疗方法。许多现代疗法的安全性和有效性已经得到了很好的证实,但在癌症患者中,补充和替代药物(CAM)的使用仍在增加。CAM决策过程复杂,受许多社会和疾病相关变量的影响。关于辅助治疗使用的基于流行率的研究报告了癌症患者中辅助治疗使用百分比的很大差异,这可能是由于不同研究在其研究中定义辅助治疗的方式。了解辅助替代疗法的使用决策是至关重要的,因为它是高度个性化的,围绕着几个问题,这些问题可以使患者和他们的护理人员在治疗成功中受益。
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引用次数: 1
The Effect of Yishen Jiangzhuo Granules on Serum IFGF23 and CFGF23 in Patients with Chronic Kidney Disease 3-5 Stage 益肾降浊颗粒对慢性肾病3-5期患者血清IFGF23和CFGF23的影响
Pub Date : 2017-10-20 DOI: 10.4172/2327-5162.1000249
Yi Wang, Zhongyan Liu, L. Cai, Ting Wang, Xiaoying Chen, Jing Zheng, Juxia Wang
Aim: The objective is to investigate the changes of serum IFGF23 and CFGF23 levels in patients with chronic kidney disease of 3-5 stage before and after treatment by Yishen Jiangzhuo Granules and its clinical significance. Methods: A subset of samples (n=76) from a cohort of patients with CKD of renal function between stage three and five. (Stage 3: n=37; stage 4: n=30; stage 5: n=9). The patients were treated in hospital or in clinic between October 2013 and April 2015 at the nephrology department of Fujian Provincial People's Hospital. Additionally, a total of 30 healthy volunteers were selected in this hospital during the same period as the normal control group. IFGF23, CFGF23 were detected by enzyme-linked immunosorbent assay (ELISA). Calcium (Ca), phosphorus (P), urea nitrogen (BUN), serum creatinine (Scr) was assessed by BECKMAN-C800 automatic biochemical analyzer. Urine creatinine was determined by Reversed Phase High Performance Liquid Chromatography. The endogenous creatinine clearance rate (Ccr) was calculated according to the simplified MDRD formula. Result: The expression levels of serum IFGF23 and CFGF23 did not change significantly before and after drug treatment. But the serum IFGF23 and CFGF23 expression level has been significantly increased in the CKD3 stage, while serum phosphorus levels has not yet increased. Compared with normal group, the expression level of serum IFGF23 and CFGF23 was significantly higher than that of the normal group before and after treatment. Both of them showed a tendency to increase gradually with the decrease of renal function, and the degree of increase of serum IFGF23 expression level was significantly higher than that of CFGF23. Scr and P levels were decreased in CKD 3-5 stage after treatment (P<0.05). In CKD 4-5 stage, after treatment, the serum calcium level was higher than that before treatment (P<0.05). In CKD 3-5 stage, after treatment, the Ccr was higher than that before treatment (P<0.05). Conclusion: IFGF23 increases rapidly with the decrease of Ccr and CFGF23 increases slowly with the decrease of Ccr. In the short term, Yishenjiangzhuo Granules cannot improve serum IFGF23 and CFGF23 levels in CKD 3-5 stage in patients, but it improves the renal function and the metabolism of calcium and phosphorus, and reduces the level of serum creatinine.
目的:探讨益肾降浊颗粒治疗3-5期慢性肾脏病患者血清IFGF23、CFGF23水平的变化及其临床意义。方法:从3期至5期肾功能CKD患者队列中选取样本子集(n=76)。(第三阶段:n=37;第四阶段:n=30;阶段5:n=9)。患者于2013年10月至2015年4月在福建省人民医院肾内科住院或门诊治疗。另外,在该院同期选取30名健康志愿者作为正常对照组。采用酶联免疫吸附法(ELISA)检测IFGF23、CFGF23。采用BECKMAN-C800全自动生化分析仪测定血清钙(Ca)、磷(P)、尿素氮(BUN)、肌酐(Scr)。采用反相高效液相色谱法测定尿肌酐。根据简化的MDRD公式计算内源性肌酐清除率(Ccr)。结果:药物治疗前后血清IFGF23、CFGF23表达水平无明显变化。但血清IFGF23和CFGF23表达水平在CKD3期显著升高,而血清磷水平尚未升高。与正常组比较,治疗前后血清IFGF23、CFGF23表达水平均显著高于正常组。随着肾功能的降低,两者均有逐渐升高的趋势,且血清IFGF23表达水平的升高程度明显高于CFGF23。治疗后CKD 3 ~ 5期Scr、P水平明显降低(P<0.05)。在CKD 4-5期,治疗后血清钙水平高于治疗前(P<0.05)。CKD 3-5期治疗后Ccr高于治疗前(P<0.05)。结论:IFGF23随Ccr的降低而快速升高,CFGF23随Ccr的降低而缓慢升高。益肾降浊颗粒短期内不能改善CKD 3-5期患者血清IFGF23和CFGF23水平,但能改善肾功能和钙磷代谢,降低血清肌酐水平。
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引用次数: 0
Holosynthesis: the new radical joy approach 全息合成:新的激进的快乐方法
Pub Date : 2017-10-09 DOI: 10.4172/2327-5162-C1-028
T. E. Pressman
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引用次数: 0
Influence of Postural Training of Diaphragm on Functional Lung Capacity 横膈膜体位训练对肺活量的影响
Pub Date : 2017-10-06 DOI: 10.4172/2327-5162.1000247
D. Gurn, J. Hudak, Šárka Tomková
Breathing is one of the basic life functions. High demands are placed on the respiratory system when increased value of power for example in sport. The main inspiratory muscle is the diaphragm, which performs this function in addition to other functions, mainly postural and sphincter. The aim of this study was to assess the effect on functional capacity of the lung after postural therapy. Trial involved 35 male elite athletes, 25 of which formed the experimental group and 10 was control group. Input and output measurements were identical and methodically divided into two main areas. Postural tests reported in the literature by prof. Kolar and spirometric test. The tests were carried out under constant conditions, and in the same time. The experimental group received postural training lasting six weeks. Comparing the results after completing postural training, we observed differences in postural execution like in spirometry tests in favor of the experimental group. Based on the results of our studies we suggest that postural training of diaphragm have a positive effect on the functional capacity of the lungs. Changes were not statistically significant at all endpoints. This may be caused by tested of elite athletes compared with the possible outcome of the general population. Individuality subjects and their psychosocial conditions during testing could also influence the outcome in a positive or negative direction.
呼吸是基本的生命功能之一。当力量值增加时,例如在运动中,对呼吸系统提出了很高的要求。主要的吸气肌是横膈膜,它除了执行其他功能外,还执行这个功能,主要是姿势和括约肌。本研究的目的是评估体位治疗后对肺功能的影响。试验纳入35名男性优秀运动员,其中试验组25人,对照组10人。投入和产出测量是相同的,并有条不紊地分为两个主要领域。Kolar教授的体位测试和肺活量测定。这些试验是在恒定条件下、同一时间内进行的。实验组接受为期6周的姿势训练。比较完成姿势训练后的结果,我们观察到实验组在姿势执行方面的差异,如肺活量测定测试。根据我们的研究结果,我们认为横膈膜的姿势训练对肺的功能能力有积极的影响。变化在所有终点均无统计学意义。这可能是由精英运动员的测试与一般人群的可能结果相比较引起的。个性受试者及其在测试期间的社会心理状况也可能对结果产生积极或消极的影响。
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引用次数: 2
Ionic Detoxification Reduces Obesity and Fatty Liver in Rats Fed a High- Fat Diet 离子解毒可减少高脂肪饮食大鼠的肥胖和脂肪肝
Pub Date : 2017-09-14 DOI: 10.4172/2327-5162.1000246
H. Yao
Background: Ionic detoxification (ID) or ionic water bath treatment is a simple alternative method to improve health but lacks scientific evidence. It is hypothesized that regular ID treatment can increase the excretion of toxic molecules from the body and improve metabolic disorders including obesity. Methods: To investigate the effect of ID treatment on high-fat diet-induced obesity and fatty liver, male Wistar rats were fed a low-fat control diet, a high-fat (HF) diet, or a HF diet with ID treatment (3 times/week) for 11 weeks. Triglyceride contents and fatty acid metabolic genes in perirenal adipose tissue and liver were determined. Results: Rats fed the HF diet had significantly higher body weight, liver weight, and adipose tissue (perirenal and epididymal) weight than did animals fed the low-fat diet. ID treatment significantly reduced body weight and perirenal adipose tissue weight induced by the HF diet. In addition, ID treatment reduced hepatic cholesterol and triglyceride contents. In liver, ID treatment reduced fatty acid synthesis (acetyl-CoA carboxylase and fatty acid synthase mRNA) more significantly than fatty acid oxidation (carnitine palmitoyl-transferase 1 and acyl CoA oxidase mRNA). In perirenal adipose tissue, ID treatment increased the lipolysis rate and reduced the triglyceride level. However, ID treatment had no significant effects on lipogenesis gene expression or adipose size in perirenal adipose tissue. Conclusions: The results of this study suggest that regular ID treatment may have beneficial effects on reducing obesity and fatty liver.
背景:离子排毒(ID)或离子水浴治疗是一种简单的改善健康的替代方法,但缺乏科学证据。据推测,定期ID治疗可以增加体内有毒分子的排泄,改善包括肥胖在内的代谢紊乱。方法:为了研究ID治疗对高脂饮食诱导的肥胖和脂肪肝的影响,雄性Wistar大鼠被喂食低脂对照饮食、高脂(HF)饮食或HF饮食加ID治疗(3次/周),持续11周。测定肾周脂肪组织和肝脏中甘油三酯含量和脂肪酸代谢基因。结果:喂食HF饮食的大鼠的体重、肝脏重量和脂肪组织(肾周和附睾)重量显著高于喂食低脂饮食的动物。ID治疗显著降低了HF饮食诱导的体重和肾周脂肪组织重量。此外,ID治疗降低了肝脏胆固醇和甘油三酯含量。在肝脏中,ID处理比脂肪酸氧化(肉碱棕榈酰转移酶1和酰基辅酶A氧化酶mRNA)更显著地减少了脂肪酸合成(乙酰辅酶A羧化酶和脂肪酸合成酶mRNA)。在肾周脂肪组织中,ID治疗增加了脂解率,降低了甘油三酯水平。然而,ID治疗对肾周脂肪组织中的脂肪生成基因表达或脂肪大小没有显著影响。结论:本研究的结果表明,定期ID治疗可能对减少肥胖和脂肪肝有有益效果。
{"title":"Ionic Detoxification Reduces Obesity and Fatty Liver in Rats Fed a High- Fat Diet","authors":"H. Yao","doi":"10.4172/2327-5162.1000246","DOIUrl":"https://doi.org/10.4172/2327-5162.1000246","url":null,"abstract":"Background: Ionic detoxification (ID) or ionic water bath treatment is a simple alternative method to improve health but lacks scientific evidence. It is hypothesized that regular ID treatment can increase the excretion of toxic molecules from the body and improve metabolic disorders including obesity. \u0000Methods: To investigate the effect of ID treatment on high-fat diet-induced obesity and fatty liver, male Wistar rats were fed a low-fat control diet, a high-fat (HF) diet, or a HF diet with ID treatment (3 times/week) for 11 weeks. Triglyceride contents and fatty acid metabolic genes in perirenal adipose tissue and liver were determined. \u0000Results: Rats fed the HF diet had significantly higher body weight, liver weight, and adipose tissue (perirenal and epididymal) weight than did animals fed the low-fat diet. ID treatment significantly reduced body weight and perirenal adipose tissue weight induced by the HF diet. In addition, ID treatment reduced hepatic cholesterol and triglyceride contents. In liver, ID treatment reduced fatty acid synthesis (acetyl-CoA carboxylase and fatty acid synthase mRNA) more significantly than fatty acid oxidation (carnitine palmitoyl-transferase 1 and acyl CoA oxidase mRNA). In perirenal adipose tissue, ID treatment increased the lipolysis rate and reduced the triglyceride level. However, ID treatment had no significant effects on lipogenesis gene expression or adipose size in perirenal adipose tissue. \u0000Conclusions: The results of this study suggest that regular ID treatment may have beneficial effects on reducing obesity and fatty liver.","PeriodicalId":90094,"journal":{"name":"Alternative & integrative medicine","volume":"6 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2327-5162.1000246","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43678561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Natural Remedies Lower Fibrinogen Levels in the Prevention ofAtherosclerosis 天然药物降低纤维蛋白原水平预防动脉粥样硬化
Pub Date : 2017-09-06 DOI: 10.4172/2327-5162.1000245
A. Narayan
Cardiovascular Disease (CVD), which includes heart attacks, stroke, and other cardiovascular diseases, are the number one cause of death in the United States. Data gathered from certain lab tests utilized as part of an early detection and prevention strategy can be used to gauge the efficacy of preventative measures in an effort to halt or slow the progress of the CVD. Acute phase reactants are proteins that increase or decrease in the presence of inflammatory stimuli. The most common acute phase reactant tests are Erythrocyte Sedimentation Rate (ESR), CReactive Protein (CRP), Fibrinogen, and Ferritin. of these four tests the most common tests currently used in conventional medicine are ESR and CRP. Fibrinogen, which originates in the liver, is a glycoprotein in vertebrates that helps in the formation of blood clots. Fibrinogen levels rise in the following conditions: Inflammation, tissue damage/trauma, infection, cancer, acute coronary syndrome, strokes, and inflammatory conditions. Fibrinogen tests are underutilized in conventional medicine. They are often used after a cardiovascular incident has occurred or if symptoms are severe enough to warrant a test. There is sufficient evidence which shows that fibrinogen levels slowly begin to rise long before a heart attack or stroke and may even be reflective of the severity of subclinical atherosclerotic conditions. Traditional Chinese Medicine (TCM) and other preventative natural medical systems have treatments which reduce or normalize Fibrinogen levels, thereby, preventing the progression of symptoms that can lead to more serious cardiovascular occurrences in the future. This article will review published studies that confirm natural remedies effectively lower fibrinogen levels.
心血管疾病(CVD),包括心脏病发作、中风和其他心血管疾病,是美国的头号死亡原因。作为早期发现和预防战略的一部分,从某些实验室测试中收集的数据可用于衡量预防措施的有效性,以阻止或减缓心血管疾病的进展。急性期反应物是在炎症刺激下增加或减少的蛋白质。最常见的急性期反应物试验是红细胞沉降率(ESR)、活性蛋白(CRP)、纤维蛋白原和铁蛋白。在这四种测试中,目前在常规医学中最常用的测试是ESR和CRP。纤维蛋白原起源于肝脏,是脊椎动物体内的一种糖蛋白,有助于形成血凝块。纤维蛋白原水平在以下情况下升高:炎症、组织损伤/创伤、感染、癌症、急性冠状动脉综合征、中风和炎症。纤维蛋白原测试在传统医学中未得到充分利用。它们通常在心血管事件发生后或症状严重到需要进行检查时使用。有充分的证据表明,纤维蛋白原水平在心脏病发作或中风之前就开始缓慢上升,甚至可能反映亚临床动脉粥样硬化状况的严重程度。传统中医和其他预防性的自然医疗系统有降低或使纤维蛋白原水平正常化的治疗方法,从而防止可能导致未来更严重的心血管事件的症状进展。本文将回顾已发表的证实自然疗法有效降低纤维蛋白原水平的研究。
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引用次数: 0
Acupuncture: Workshop on how and why it works 针灸:研讨会如何和为什么它的工作
Pub Date : 2017-08-22 DOI: 10.4172/2327-5162-C1-026
R. Jaffe
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引用次数: 0
Integration of acupuncture with modern medicine 针灸与现代医学的结合
Pub Date : 2017-08-22 DOI: 10.4172/2327-5162-C1-025
Jingduan Yang
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引用次数: 0
Exploratory Compatibility Regularity of Chinese Medicinal Prescription in Treating Osteoarthritis 探讨中药方剂治疗骨关节炎的配伍规律
Pub Date : 2017-07-27 DOI: 10.4172/2327-5162.1000244
Zhou Qiao, L. Jian, Xin Ling, Song Qian, Guo Jin-chen, Huang Dan
Background: Traditional Chinese medicine (TCM) is increasingly widely used as a complementary approach for the treatment of osteoarthritis. In this paper, we examined the implicit prescription patterns behind the Chinese medicinal formulae by using association rules mining and clustering analysis, so as to explore the compatibility regularity of Chinese medicinal prescription in the treatment or control of osteoarthritis. Methods: This study was based on a participant survey conducted in First Affiliated Hospital of Anhui University of Chinese Medicine. The Chinese medicinal prescriptions of inpatients with osteoarthritis were from June 2012 to June 2016. TCM was listed according to the selected medicinal formulae and the added information was organized to establish a database. The association rules and clustering are conducted on SPSS Modeler 14.2. An initial statistical analysis was carried out to categorize the herbs according to their medicinal types, dosage, natures, flavors, channel tropism, and functions. Based on the categorization, the frequencies of occurrences were computed. At the same time, the relationship between TCM and immune and inflammatory markers was analyzed. Results: The main features from the formulae data are: (1) Warm or cold herbs in the Five Properties category are the most frequently prescribed in the 3609 medicinal formulae. Sweet or bitter herbs in the Five Flavors category in which affinity to the Spleen meridian also are the most frequently prescribed in the 3609 medicinal formulae. (2) Herbs with blood-activating and stasis-resolving, tonifying and replenishing medicinal, water-disinhibiting damppercolating, heat-clearing and detoxicating or expelling wind-damp functions that are frequently prescribed; (3) Association rule analysis extracted three frequently used pairs of herbs, which are Red flower and Tao Ren, Pu Gong Ying and Bai Hua She She Cao, Fu Ling and Ze Xie. (4) Association rule between TCM and Immunoinflammation Index showed that Du Huo and Chen Pi was associated with increased super oxide dismutase enzyme. Mai Ya and Dan Shen was associated with decreased high-sensitivity C-reactive protein, erythrocyte sedimentation rate, complement C3, complement C4, and Ig(A). Mai Ya and Fu Ling were associated with decreased IgM. Conclusions: The results indicate that there is a close relationship between osteoarthritis and spleen dysfunctions. These prescriptions focus on herbs that replenishing qi and fortifying the spleen and blood-activating and stasis-resolving. It can also dry dampness to fortify the spleen and clear heat and detoxicating. Meanwhile, he use of tonifying and replenishing herbs and spleen-strengthening herbs also forms a basic pattern of the prescriptions.
背景:中医药作为骨关节炎的一种辅助治疗方法,得到了越来越广泛的应用。本文采用关联规则挖掘和聚类分析的方法,对中药配方背后的隐含处方模式进行了检验,以探讨中药配方在骨关节炎治疗或控制中的配伍规律。方法:本研究以安徽中医药大学附属第一医院的参与者调查为基础。骨关节炎住院患者的中药处方为2012年6月至2016年6月。根据所选的药物配方列出中药,并组织添加的信息建立数据库。关联规则和聚类是在SPSS Modeler 14.2上进行的。根据药材的种类、用量、性质、味性、归经性和作用,对其进行了初步的统计分析。在分类的基础上,计算了发生频率。同时分析了中医药与免疫和炎症标志物的关系。结果:3609个方剂中,温性或寒性中草药的用药频率最高。在3609个药物配方中,与脾经有亲和力的五味类中的甜或苦草药也是最常见的处方。(2) 常用的活血化瘀、补虚补药、去水润肠、清热解毒或祛风湿的中草药;(3) 关联规则分析提取了红花与桃仁、蒲公英与白花舍草、茯苓与泽泻三对常用药材。(4) 中医药与免疫炎症指数的相关性研究表明,杜活、陈皮与超氧化物歧化酶升高有关。麦芽和丹参与高敏C反应蛋白、红细胞沉降率、补体C3、补体C4和Ig(A)降低有关。麦芽和茯苓与IgM降低有关。结论:骨关节炎与脾功能异常有密切关系。这些方剂以益气健脾、活血化瘀为主。还可以燥湿健脾,清热解毒。同时,他所用的补虚益气、健脾中药也形成了方剂的基本格局。
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引用次数: 0
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Alternative & integrative medicine
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