Pub Date : 2017-01-01DOI: 10.4172/2327-5162.1000250
R. Gelabert
Introduction and objectives: Generalized anxiety disorder (GAD) is mainly observed in the primary care setting and may reach a prevalence of 5%. This retrospective study was conducted with the aim of assessing the results obtained using a therapeutic method based on pluralistic homeopathy. Material and Methods: An observational study of a cohort of 220 patients treated by a pluralistic homeopathic physician was performed. A total of 460 medical records were reviewed, among which 220 patients who met DSMIV-TR criteria for the diagnosis of GAD were selected. In relation to homeopathic remedies, remedy of temperament was prescribed in all cases. A complementary remedy, a remedy of autonomic regulation, causal remedy, constitution remedy and remedy of terrain or diathesis was prescribed when necessary. Criteria for grouping patients according to response to treatment were defined. On the basis of this response, levels of cure or lack of response were grouped. A specific database was designed for the purpose of the study. Results: The mean age of patients was 38 years. Women accounted for 78% of the cases. Associated general pathologic conditions were found in only 16% of patients. The duration of symptoms exceeded 12 months in 45% of the cases. At presentation, 31% of patients were taken conventional treatment (anxiolytics and/or antidepressants). The remedy of temperament was prescribed to all 220 cases. Starting of improvement was already observed at the first control visit in 73% of cases (158 patients) after 30 days of the baseline visit. In 157 of the 220 cases (71%), patients considered to be cured due to resolution of all symptoms. In 56.4% of cases (n=124), the length of follow-up was shorter than 2 years, and in 38.2% of cases (n=84) the follow-up ranged between 2 to 6 years. Nine cases (4%) have been followed between 6 and 10 years, and in 3 cases the follow-up was longer than 10 years. Cure achieved by means of homeopathic treatment was significantly associated with younger age, shorter duration of symptoms and absence of conventional pharmacologic treatment prior to consultation with the homeopathy. Conclusions: Data of this retrospective review shows that the applied homeopathic treatment may be effective in the management of patients with GAD. The scope of treatment may include both somatic manifestations of anxiety and deepest vital discomfort affecting the subject.
{"title":"Clinical Study of the Effectiveness of Pluralist Homeopathy in Generalized Anxiety Disorder","authors":"R. Gelabert","doi":"10.4172/2327-5162.1000250","DOIUrl":"https://doi.org/10.4172/2327-5162.1000250","url":null,"abstract":"Introduction and objectives: Generalized anxiety disorder (GAD) is mainly observed in the primary care setting and may reach a prevalence of 5%. This retrospective study was conducted with the aim of assessing the results obtained using a therapeutic method based on pluralistic homeopathy. Material and Methods: An observational study of a cohort of 220 patients treated by a pluralistic homeopathic physician was performed. A total of 460 medical records were reviewed, among which 220 patients who met DSMIV-TR criteria for the diagnosis of GAD were selected. In relation to homeopathic remedies, remedy of temperament was prescribed in all cases. A complementary remedy, a remedy of autonomic regulation, causal remedy, constitution remedy and remedy of terrain or diathesis was prescribed when necessary. Criteria for grouping patients according to response to treatment were defined. On the basis of this response, levels of cure or lack of response were grouped. A specific database was designed for the purpose of the study. Results: The mean age of patients was 38 years. Women accounted for 78% of the cases. Associated general pathologic conditions were found in only 16% of patients. The duration of symptoms exceeded 12 months in 45% of the cases. At presentation, 31% of patients were taken conventional treatment (anxiolytics and/or antidepressants). The remedy of temperament was prescribed to all 220 cases. Starting of improvement was already observed at the first control visit in 73% of cases (158 patients) after 30 days of the baseline visit. In 157 of the 220 cases (71%), patients considered to be cured due to resolution of all symptoms. In 56.4% of cases (n=124), the length of follow-up was shorter than 2 years, and in 38.2% of cases (n=84) the follow-up ranged between 2 to 6 years. Nine cases (4%) have been followed between 6 and 10 years, and in 3 cases the follow-up was longer than 10 years. Cure achieved by means of homeopathic treatment was significantly associated with younger age, shorter duration of symptoms and absence of conventional pharmacologic treatment prior to consultation with the homeopathy. Conclusions: Data of this retrospective review shows that the applied homeopathic treatment may be effective in the management of patients with GAD. The scope of treatment may include both somatic manifestations of anxiety and deepest vital discomfort affecting the subject.","PeriodicalId":90094,"journal":{"name":"Alternative & integrative medicine","volume":"6 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70258668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.4172/2327-5162.1000248
Dias, Paula, Pedro Lus, Olvia Rodrigues Pereira, S. Joao
Background: Currently, complementary and alternative medicine emerge as important therapies in the prevention and treatment of various health problems. In view of this, the present study aims to evaluate the efficacy of essential oils in reducing stress and anxiety levels in aromatherapy users, at a clinic of Braganca, Portugal. Methods: A study was performed with 36 individuals divided in two distinct groups: “aroma group” and “control group”. Individuals of "aroma group" were treated with a mixture of essential oils of Lavandula angustifolia Mill and Matricaria recutita L. applied with Effleurage massage while the individuals of "control group" received only Effleurage massage. Stress and anxiety levels of all individuals participating in the study were evaluated before and after the treatment. Additionally, the chemical composition of the essential oils was evaluated by GC and GC-MS. Results: In the aromatherapy assay, the “aroma group” showed a significant decrease of 12% and 30%, in stress and anxiety levels, respectively, in the “control group” this decrease was lower (3.3% and 2.6% for stress and anxiety levels, respectively).
{"title":"Aromatherapy in the Control of Stress and Anxiety","authors":"Dias, Paula, Pedro Lus, Olvia Rodrigues Pereira, S. Joao","doi":"10.4172/2327-5162.1000248","DOIUrl":"https://doi.org/10.4172/2327-5162.1000248","url":null,"abstract":"Background: Currently, complementary and alternative medicine emerge as important therapies in the prevention and treatment of various health problems. In view of this, the present study aims to evaluate the efficacy of essential oils in reducing stress and anxiety levels in aromatherapy users, at a clinic of Braganca, Portugal. Methods: A study was performed with 36 individuals divided in two distinct groups: “aroma group” and “control group”. Individuals of \"aroma group\" were treated with a mixture of essential oils of Lavandula angustifolia Mill and Matricaria recutita L. applied with Effleurage massage while the individuals of \"control group\" received only Effleurage massage. Stress and anxiety levels of all individuals participating in the study were evaluated before and after the treatment. Additionally, the chemical composition of the essential oils was evaluated by GC and GC-MS. Results: In the aromatherapy assay, the “aroma group” showed a significant decrease of 12% and 30%, in stress and anxiety levels, respectively, in the “control group” this decrease was lower (3.3% and 2.6% for stress and anxiety levels, respectively).","PeriodicalId":90094,"journal":{"name":"Alternative & integrative medicine","volume":"6 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2327-5162.1000248","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70258617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.4172/2327-5162.1000252
Lorenzo Freti, V. Condemi, M. Mazza, M. Nicola, L. Janiri, A. Antonietti, M. Gestro, U. Solimene
Background: In the recent decades, the relationship between psycho-physical disorders and weather conditions has taken on an increased scientific solidity. Furthermore, it is known to every clinician that healthcare practice has an important role in the management of psycho-physical disorders of patients affected by multiple sclerosis. Given that meteorosensitivity is related to the psycho-physical feebleness, this study is an attempt to clarify if treatments in a non-acute care rehabilitation centre can reduce the meteorosensitivity in patients with multiple sclerosis. Methods: In the spring 2014, 42 patients with MS, at Fondazione Don Gnocchi Santa Maria Nascente Centre (Milan, Italy), were observed by two evaluations (initial and final). The initial evaluation was the administration of METEO-Q, a questionnaire able to quantify the meteorosensitivity degree of the subjects, and Beck Depression Inventory-II, mainly. For each patient, passed one month, the final evaluation was carried out with the same modalities. Results: A statistically significant difference was found between initial and final meteorosensitivity degree (P=0.01), with better scores in final evaluations for most of the subjects. The correlation between Beck Depression Inventory-II and meteorosensitivity degree resulted significant and positive (R=0.377; P=0.001) and it confirms the link between psycho-physical feebleness and meteorosensitivity. Finally, no significant correlation emerged between initial meteorosensitivity degree and body mass index (R=0.187; P=0.236). Conclusions: This study confirms the possibility of improving meteorosensitivity, probably by rehabilitation too. Future studies could clarify the effects of health care practice on meteorosensitivity.
背景:近几十年来，心理生理障碍和天气状况之间的关系在科学上得到了越来越多的证实。此外，每个临床医生都知道，医疗保健实践在多发性硬化症患者的心理生理障碍管理中起着重要作用。鉴于气象敏感性与心理-生理虚弱有关，本研究试图澄清在非急性护理康复中心的治疗是否可以降低多发性硬化症患者的气象敏感性。方法:2014年春季，意大利米兰圣玛丽亚新生中心(Fondazione Don Gnocchi Santa Maria Nascente Centre)对42例MS患者进行初步和最终评估。初步评价主要是使用METEO-Q(一份能够量化受试者气象敏感性程度的问卷)和Beck抑郁症量表- ii的管理情况。对于每个患者，经过一个月后，以相同的方式进行最终评估。结果:初始气象敏感性与最终气象敏感性差异有统计学意义(P=0.01)，多数受试者最终评价得分较高。贝克抑郁量表- ii与气象敏感性呈显著正相关(R=0.377;P=0.001)，它证实了心理-生理虚弱与气象敏感性之间的联系。最后，初始气象敏感性与体重指数无显著相关(R=0.187;P = 0.236)。结论:这项研究证实了改善气象敏感性的可能性，也可能是通过恢复。未来的研究可以阐明卫生保健实践对气象敏感性的影响。
{"title":"Meteorosensitivity in a Group of Patients Affected by Multiple Sclerosisand Hospitalized in a Rehabilitation Facility: An Observational Study","authors":"Lorenzo Freti, V. Condemi, M. Mazza, M. Nicola, L. Janiri, A. Antonietti, M. Gestro, U. Solimene","doi":"10.4172/2327-5162.1000252","DOIUrl":"https://doi.org/10.4172/2327-5162.1000252","url":null,"abstract":"Background: In the recent decades, the relationship between psycho-physical disorders and weather conditions has taken on an increased scientific solidity. Furthermore, it is known to every clinician that healthcare practice has an important role in the management of psycho-physical disorders of patients affected by multiple sclerosis. Given that meteorosensitivity is related to the psycho-physical feebleness, this study is an attempt to clarify if treatments in a non-acute care rehabilitation centre can reduce the meteorosensitivity in patients with multiple sclerosis. Methods: In the spring 2014, 42 patients with MS, at Fondazione Don Gnocchi Santa Maria Nascente Centre (Milan, Italy), were observed by two evaluations (initial and final). The initial evaluation was the administration of METEO-Q, a questionnaire able to quantify the meteorosensitivity degree of the subjects, and Beck Depression Inventory-II, mainly. For each patient, passed one month, the final evaluation was carried out with the same modalities. Results: A statistically significant difference was found between initial and final meteorosensitivity degree (P=0.01), with better scores in final evaluations for most of the subjects. The correlation between Beck Depression Inventory-II and meteorosensitivity degree resulted significant and positive (R=0.377; P=0.001) and it confirms the link between psycho-physical feebleness and meteorosensitivity. Finally, no significant correlation emerged between initial meteorosensitivity degree and body mass index (R=0.187; P=0.236). Conclusions: This study confirms the possibility of improving meteorosensitivity, probably by rehabilitation too. Future studies could clarify the effects of health care practice on meteorosensitivity.","PeriodicalId":90094,"journal":{"name":"Alternative & integrative medicine","volume":"1 2 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2327-5162.1000252","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70258737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.4172/2327-5162.1000E121
Nozomi Donoyama
{"title":"Alternative and Integrative Medicine in Japan","authors":"Nozomi Donoyama","doi":"10.4172/2327-5162.1000E121","DOIUrl":"https://doi.org/10.4172/2327-5162.1000E121","url":null,"abstract":"","PeriodicalId":90094,"journal":{"name":"Alternative & integrative medicine","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2327-5162.1000E121","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70259350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-12-05DOI: 10.4172/2327-5162.1000226
Hyunyoung Ko, Sammy Le, Sang Dol Kim
Objectives: To assess the evidence for the effectiveness of yoga in the management of menstrual pain and the symptoms associated with dysmenorrhea. Methods: A search was conducted using CINAHL, the Cochrane library, Embase, PsycINFO, PubMed, and KoreaMed electronic databases to identify randomized controlled trials (RCTs) reported effects of yogic intervention on dysmenorrhea published in any language between January 1966 and October 2014. Quality assessment was conducted using the Cochrane risk of bias tool. Results: Two potential trials were identified of which two were included in the review. Quality critical appraisal had low or moderate risk of bias. The available data could only be included as a narrative description. A significant difference was observed between experimental and control groups in pain intensity and pain duration (p<0.05) and thyroid-stimulating hormone (p<0.002), follicle-stimulating hormone (p<0.02), luteinizing hormone (p<0.001), and prolactin (p<0.02) were decreased significantly in the experimental group, compared with the control group. Conclusions: There is evidence from two RCTs that yoga interventions may be favorable effective for dysmenorrhea. However the findings should be interpreted with caution due to the number of small RCTs and quality limitation partly. Therefore further high quality RCTs are required to investigate the hypothesis that yoga alleviates menstrual pain and the symptoms associated with dysmenorrhea, to confirm and further comprehend the effects of standardized yoga programs in dysmenorrhea.
{"title":"Effects of Yoga on Dysmenorrhea: A Systematic Review of Randomized Controlled Trials","authors":"Hyunyoung Ko, Sammy Le, Sang Dol Kim","doi":"10.4172/2327-5162.1000226","DOIUrl":"https://doi.org/10.4172/2327-5162.1000226","url":null,"abstract":"Objectives: To assess the evidence for the effectiveness of yoga in the management of menstrual pain and the symptoms associated with dysmenorrhea. Methods: A search was conducted using CINAHL, the Cochrane library, Embase, PsycINFO, PubMed, and KoreaMed electronic databases to identify randomized controlled trials (RCTs) reported effects of yogic intervention on dysmenorrhea published in any language between January 1966 and October 2014. Quality assessment was conducted using the Cochrane risk of bias tool. Results: Two potential trials were identified of which two were included in the review. Quality critical appraisal had low or moderate risk of bias. The available data could only be included as a narrative description. A significant difference was observed between experimental and control groups in pain intensity and pain duration (p<0.05) and thyroid-stimulating hormone (p<0.002), follicle-stimulating hormone (p<0.02), luteinizing hormone (p<0.001), and prolactin (p<0.02) were decreased significantly in the experimental group, compared with the control group. Conclusions: There is evidence from two RCTs that yoga interventions may be favorable effective for dysmenorrhea. However the findings should be interpreted with caution due to the number of small RCTs and quality limitation partly. Therefore further high quality RCTs are required to investigate the hypothesis that yoga alleviates menstrual pain and the symptoms associated with dysmenorrhea, to confirm and further comprehend the effects of standardized yoga programs in dysmenorrhea.","PeriodicalId":90094,"journal":{"name":"Alternative & integrative medicine","volume":"5 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2327-5162.1000226","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70258603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-29DOI: 10.4172/2327-5162.C1.020
P. Chumark, Srichan Phornchirasilps
{"title":"Effect of aqueous extract of Moringa Oleifera lam leaves on LDL receptor mRNA level of HepG2 cells in comparison to atorvastatin","authors":"P. Chumark, Srichan Phornchirasilps","doi":"10.4172/2327-5162.C1.020","DOIUrl":"https://doi.org/10.4172/2327-5162.C1.020","url":null,"abstract":"","PeriodicalId":90094,"journal":{"name":"Alternative & integrative medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70259996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-29DOI: 10.4172/2327-5162.C1.021
Prakash Kulkarni
{"title":"Significance of the vedic rituals in controlling and recovering diseases","authors":"Prakash Kulkarni","doi":"10.4172/2327-5162.C1.021","DOIUrl":"https://doi.org/10.4172/2327-5162.C1.021","url":null,"abstract":"","PeriodicalId":90094,"journal":{"name":"Alternative & integrative medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70260057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-21DOI: 10.4172/2327-5162.1000225
M. Nomoto
Background: Drugs with various mechanisms of action such as antimicrobial agents, adapalene, and benzoyl peroxide are used to treat acne worldwide. In Japan, Kampo medicines have also traditionally been used for acne, including the medicine Jumihaidokuto (JHT). The mechanisms of action of Kampo medicines such as JHT have not been fully clarified, but it has been pointed out that oxidative stress is involved in the development of acne. Therefore, the author focused on the antioxidative effect of JHT and examined its relationship with acne improvement. Methods: JHT (9 g/day) was administered for 3 weeks to 53 patients with acne, followed by measuring the diacron-reactive oxygen metabolites (d-ROMs) value as an indicator of oxidative stress, the biological antioxidant potential (BAP) value as an indicator of antioxidative potency, and the numbers of inflammatory and non-inflammatory skin rashes occurring before and after JHT administration. After the administration of JHT, the following results were observed. Results: 1) The d-ROMs values of subjects who had a high baseline d-ROMs value were significantly reduced and the BAP values of those who had a low baseline BAP value were significantly increased; 2) there were significant reductions in the numbers of inflammatory and non-inflammatory skin rashes; 3) there was a significant correlation between the d-ROMs value and the number of non-inflammatory skin rashes; 4) the d-ROMs values of patients who rated their acne as “improved” by questionnaire were significantly reduced. Conclusion: The above results suggest that an antioxidative effect is one of the mechanisms by which JHT contributes to acne improvement.
{"title":"A Study on the Mechanisms of Action of Jumihaidokuto for Patients withAcne: The Relationship between the Antioxidative Effect of Jumihaidokutoand Acne Improvement","authors":"M. Nomoto","doi":"10.4172/2327-5162.1000225","DOIUrl":"https://doi.org/10.4172/2327-5162.1000225","url":null,"abstract":"Background: Drugs with various mechanisms of action such as antimicrobial agents, adapalene, and benzoyl \u0000 peroxide are used to treat acne worldwide. In Japan, Kampo medicines have also traditionally been used for acne, \u0000 including the medicine Jumihaidokuto (JHT). The mechanisms of action of Kampo medicines such as JHT have not \u0000 been fully clarified, but it has been pointed out that oxidative stress is involved in the development of acne. Therefore, \u0000 the author focused on the antioxidative effect of JHT and examined its relationship with acne improvement. \u0000Methods: JHT (9 g/day) was administered for 3 weeks to 53 patients with acne, followed by measuring the \u0000 diacron-reactive oxygen metabolites (d-ROMs) value as an indicator of oxidative stress, the biological antioxidant potential (BAP) value as an indicator of antioxidative potency, and the numbers of inflammatory and non-inflammatory \u0000 skin rashes occurring before and after JHT administration. After the administration of JHT, the following results were \u0000 observed. \u0000Results: 1) The d-ROMs values of subjects who had a high baseline d-ROMs value were significantly reduced \u0000 and the BAP values of those who had a low baseline BAP value were significantly increased; 2) there were significant \u0000 reductions in the numbers of inflammatory and non-inflammatory skin rashes; 3) there was a significant correlation \u0000 between the d-ROMs value and the number of non-inflammatory skin rashes; 4) the d-ROMs values of patients who \u0000 rated their acne as “improved” by questionnaire were significantly reduced. \u0000Conclusion: The above results suggest that an antioxidative effect is one of the mechanisms by which JHT \u0000 contributes to acne improvement.","PeriodicalId":90094,"journal":{"name":"Alternative & integrative medicine","volume":"2016 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2016-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2327-5162.1000225","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70259065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-10-31DOI: 10.4172/2327-5162.1000224
Ilaria Giangr, M. Dinu, G. Pagliai, F. Sofi, Aless, R. Casini
Background and Aim: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, affecting up to one-third of the population in industrialized countries. Silymarin and S-Adenosyl-L-Methionine (SAMe) have therapeutic potential for treatment of liver disease. The aim of the present pilot study was to evaluate the possible effect of a supplementation with Silymarin and SAMe in NAFLD patients. Methods: Fifteen NAFLD patients (mean age: 46.3 ± 15 years) confirmed by ultra-sonographic findings were subjected to a 12-month oral supplementation with Silymarin and SAMe. Anthropometric measurements, biochemical parameters, liver function and hepatic fat content were assessed at baseline, at 6 months and at the end of treatment. Results: After a 12-months’ oral supplementation a significant improvement (p<0.05) in several biochemical parameters such as total cholesterol (mean reduction: -8.67 mg/dL), insulin (-1.34 U/L) and HOMA-IR (-1.35) was observed. Similarly, serum levels of alanine aminotransferase (ALT) and alkaline phosphatase (ALP) significantly decreased by 13% (-3.87 U/L and -10.4 U/L respectively), with a small but significant amelioration in the risk profile. Finally, the ultrasonography examination revealed an improvement in liver echo-texture and a regression of the degree of hepatic steatosis, associated with a 22% increase of the Doppler Perfusion Index (DPI), which corresponds to better liver hemodynamic. Conclusion: Our findings suggest that a prolonged Silymarin and SAMe supplementation could be used as an adjunctive therapy to improve metabolic risk profile and hepatic steatosis in patients with NAFLD. Further research is needed to confirm these preliminary results.
{"title":"Efficacy of Oral Supplementation with Silymarin and S-Adenosyl-L-Methioninein Patients with Non Alcoholic Fatty Liver Disease - A Pilot Study","authors":"Ilaria Giangr, M. Dinu, G. Pagliai, F. Sofi, Aless, R. Casini","doi":"10.4172/2327-5162.1000224","DOIUrl":"https://doi.org/10.4172/2327-5162.1000224","url":null,"abstract":"Background and Aim: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, affecting up to one-third of the population in industrialized countries. Silymarin and S-Adenosyl-L-Methionine (SAMe) have therapeutic potential for treatment of liver disease. The aim of the present pilot study was to evaluate the possible effect of a supplementation with Silymarin and SAMe in NAFLD patients. Methods: Fifteen NAFLD patients (mean age: 46.3 ± 15 years) confirmed by ultra-sonographic findings were subjected to a 12-month oral supplementation with Silymarin and SAMe. Anthropometric measurements, biochemical parameters, liver function and hepatic fat content were assessed at baseline, at 6 months and at the end of treatment. Results: After a 12-months’ oral supplementation a significant improvement (p<0.05) in several biochemical parameters such as total cholesterol (mean reduction: -8.67 mg/dL), insulin (-1.34 U/L) and HOMA-IR (-1.35) was observed. Similarly, serum levels of alanine aminotransferase (ALT) and alkaline phosphatase (ALP) significantly decreased by 13% (-3.87 U/L and -10.4 U/L respectively), with a small but significant amelioration in the risk profile. Finally, the ultrasonography examination revealed an improvement in liver echo-texture and a regression of the degree of hepatic steatosis, associated with a 22% increase of the Doppler Perfusion Index (DPI), which corresponds to better liver hemodynamic. Conclusion: Our findings suggest that a prolonged Silymarin and SAMe supplementation could be used as an adjunctive therapy to improve metabolic risk profile and hepatic steatosis in patients with NAFLD. Further research is needed to confirm these preliminary results.","PeriodicalId":90094,"journal":{"name":"Alternative & integrative medicine","volume":"5 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2327-5162.1000224","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70259030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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