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Association between maternal overprotection and premenstrual disorder: a machine learning based exploratory study.
IF 2.3 4区 医学 Q2 PSYCHIATRY Pub Date : 2025-02-24 DOI: 10.1186/s13030-025-00326-y
Kaori Tsuyuki, Miho Egawa, Takuma Ohsuga, Akihiko Ueda, Kazuki Shimada, Tsukasa Ueno, Kazuko Hiyoshi, Keita Ueda, Masaki Mandai

Background: Premenstrual disorder (PMD), which includes premenstrual syndrome and premenstrual dysphoric disorder, has a complex pathogenesis and may be closely related to emotional cognition and memory. However, the mechanisms underlying these associations remain unclear. Therefore, this study used machine learning to explore the roles of various factors that are not typically considered risk-factors for PMD.

Methods: A predictive model for PMD was constructed using a dataset of questionnaire responses and heartrate variability data collected from 60 participants during their follicular and luteal phases. Based on the Japanese version of the Premenstrual Symptom Screening Tool, the binary objective variable (PMD status) was defined as "PMD" for moderate-to-severe premenstrual syndrome and premenstrual dysphoric disorder and other conditions as "non-PMD." The contribution of each feature to the predictive model was assessed using the Shapley Additive exPlanations (SHAP) model-interpretation framework.

Results: Of the 58 participants (providing 117 data points), 17 (34 data points) were in the PMD group and 41 (83 data points) were in the non-PMD group. The area under the receiver operating characteristic curve was 0.90 (95% confidence interval: 0.82-0.98). Among the top 20 features with the highest SHAP values, six were associated with maternal bonding. Four of the six mother-related characteristics were associated with overprotection.

Conclusions: Based on these findings, parental bonding experiences, including maternal overprotection, may be associated with the presence of PMD.

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引用次数: 0
The impact of polycystic ovary syndrome on attention: an empirical investigation.
IF 2.3 4区 医学 Q2 PSYCHIATRY Pub Date : 2025-02-14 DOI: 10.1186/s13030-024-00320-w
Maitreyi Redkar, Azizuddin Khan

Background: Polycystic Ovary Syndrome (PCOS) is an endocrinal dysfunction characterized by androgen excess, irregular or absent menstruation, and polycystic ovarian morphology. While extensive research is conducted on the biochemical and medical ramifications of PCOS. However, there is not much research on cognitive mechanisms, especially attention. Attention is the fundamental cognitive ability that influences other cognitive and psychological phenomena. Therefore, the present study attempts to investigate the effect of PCOS on attention.

Methods: Flanker's task examining focussed attention and Posner's cueing task measuring divided attention was administered to 173 female participants, of which 101 constituted the PCOS group and the remaining were control. The Analysis of Variance was used to analyze the data.

Results: These findings demonstrated that the PCOS group took longer in focused attention, 557.21 milliseconds (SD = 169.70), compared to the reaction time of 462.88 milliseconds (SD = 120.80) in divided attention. Concerning accuracy, the PCOS group made more errors in the focused attention task at 0.98 (SD = 0.41), while for the divided attention task, it was 0.99 (SD = 0.27).

Conclusions: Women with PCOS showed more error and slower reaction time in focused attention.

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引用次数: 0
Development of computer adaptive tests to assess the psychological status of individuals with an eating disorder or type 2 diabetes.
IF 2.3 4区 医学 Q2 PSYCHIATRY Pub Date : 2025-02-14 DOI: 10.1186/s13030-025-00325-z
Takeshi Horie, Ken Kurisu, Shuji Inada, Kenshi Kawahara, Yutaka Matsuyama, Hiroe Kikuchi, Yoshiharu Yamamoto, Toshimasa Yamauchi, Kazuhiro Yoshiuchi

Background: Individuals with type 2 diabetes and eating disorders must change their eating behaviors, which are often influenced by psychological factors like depression and anxiety. To efficiently assess daily psychological status, the present study aimed to develop computerized adaptive tests (CAT) based on item response theory (IRT).

Methods: Individuals with depression, anxiety disorders, eating disorders, type 2 diabetes, and healthy persons participated in the study. Participants completed six questionnaires, including momentary and most recent one-week depression, anxiety, and positive affect. We selected items meeting the IRT assumptions, applied a graded response model, and conducted CAT simulations.

Results: Across all six questionnaires, the CAT simulations used a smaller number of items and exhibited substantial Pearson's correlation coefficients exceeding 0.95 between simulated and full item-set mood status estimates. These estimated mood scores demonstrated satisfactory concurrent validity with the Hospital Anxiety and Depression Scale and sufficient discriminant validity between the clinical group and healthy controls.

Conclusion: These findings suggest that these scales offer efficient measurement of the mood status of individuals with an eating disorder or type 2 diabetes.

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引用次数: 0
Association of high complement and low immunoglobulins with the clinical symptoms of patients with fibromyalgia. 高补体和低免疫球蛋白与纤维肌痛患者临床症状的关系。
IF 2.3 4区 医学 Q2 PSYCHIATRY Pub Date : 2025-01-21 DOI: 10.1186/s13030-024-00321-9
Satoshi Izuno, Masako Hosoi, Kozo Anno, Takahiro A Kato, Nobuyuki Sudo, Kazufumi Yoshihara

Background: Fibromyalgia (FM) is a disease characterized by chronic widespread pain concomitant with various symptoms such as fatigue and anxiety. Although chronic inflammation has been implicated in the immunological abnormalities of FM, there are few human studies on complement and immunoglobulins. In this study, we investigated the immunological characteristics of FM patients and the association between their clinical symptoms and immunological indices, including complement and immunoglobulins.

Methods: 1) The serum 50% hemolytic complement activity (CH50), C3, C4, IgG, IgM, and hsCRP of 36 FM patients and 30 healthy sex- and age-matched controls (HC) were measured and compared. 2) Data from the Brief Pain Inventory (pain intention and pain interference subscales), the visual analog scale (VAS) (low back pain, knee pain, and fatigue), the State-Trait Anxiety Inventory and the Center for Epidemiologic Studies Depression Scale (anxiety and depression), and CH50, IgG, and hsCRP as immunological indices were acquired for 41 FM patients. Correlation analysis was done of the clinical symptom and immunological indices.

Results: 1) The FM group had significantly higher CH50 and lower IgG and IgM than the HC group after adjusting for body mass index (BMI). 2) Correlation analysis of immunological indices and clinical symptoms showed a positive, partial correlation between CH50 and fatigue and trait anxiety after adjusting for sex, age, and BMI.

Conclusions: FM patients had higher CH50 and lower immunoglobulin levels than HCs. CH50 was also associated with the fatigue and trait anxiety of FM patients. Further studies are needed to determine whether changes in these immunological indices can be used as biomarkers and/or therapeutic targets for FM.

背景:纤维肌痛(FM)是一种以慢性广泛性疼痛为特征并伴有疲劳和焦虑等多种症状的疾病。虽然慢性炎症与FM的免疫异常有关,但很少有关于补体和免疫球蛋白的人体研究。在这项研究中,我们研究了FM患者的免疫学特征以及他们的临床症状与免疫指标(包括补体和免疫球蛋白)的关系。方法:1)测定36例FM患者和30例性别、年龄匹配的健康对照者血清50%溶血补体活性(CH50)、C3、C4、IgG、IgM和hsCRP。2)采集41例FM患者的简短疼痛量表(疼痛意向和疼痛干扰亚量表)、视觉模拟量表(VAS)(腰痛、膝关节疼痛和疲劳)、状态-特质焦虑量表和流行病学研究中心抑郁量表(焦虑和抑郁),以及免疫指标CH50、IgG和hsCRP。对临床症状与免疫学指标进行相关性分析。结果:1)经体重指数(BMI)调整后,FM组CH50显著高于HC组,IgG和IgM显著低于HC组。2)免疫指标与临床症状的相关分析显示,调整性别、年龄、BMI后,CH50与疲劳、特质焦虑呈正偏相关。结论:FM患者的CH50水平高于hc患者,免疫球蛋白水平低于hc患者。CH50也与FM患者的疲劳和特质焦虑有关。需要进一步的研究来确定这些免疫指标的变化是否可以作为FM的生物标志物和/或治疗靶点。
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引用次数: 0
Association of preconception premenstrual disorders with perinatal depression: an analysis of the perinatal clinical database of a single Japanese institution. 孕前经前紊乱与围产期抑郁的关联:对日本某机构围产期临床数据库的分析。
IF 2.3 4区 医学 Q2 PSYCHIATRY Pub Date : 2024-12-23 DOI: 10.1186/s13030-024-00323-7
Takuma Ohsuga, Miho Egawa, Kaori Tsuyuki, Akihiko Ueda, Maya Komatsu, Yoshitsugu Chigusa, Haruta Mogami, Masaki Mandai

Background: Recent studies have identified premenstrual disorders (PMDs) as a risk factor for postpartum depression. However, routine screening for preconception PMDs is not yet common in Japan. This study investigated the association between preconception PMDs and perinatal depression in a single tertiary care setting.

Methods: We analyzed data from pregnant women who gave birth at Kyoto University Hospital between April 2020 and October 2023. The Premenstrual Symptoms Screening Tool was administered at the first postconception visit to retrospectively assess PMD status before the current pregnancy. The Edinburgh Postnatal Depression Scale (EPDS) was administered during pregnancy and one month postpartum as a prospective measure of perinatal depression. EPDS cutoff values were set at 12/13 during pregnancy and 8/9 at one month postpartum.

Results: Of the 781 women analyzed, 53 had preconception PMD. Univariate and multivariate logistic regression analyses revealed that preconception PMD was associated with an EPDS score of ≥ 13 during pregnancy, with a crude odds ratio (OR) of 5.78 (95% confidence interval [CI]: 2.70-11.75) and an adjusted OR of 3.71 (95% CI: 1.54-8.35). For an EPDS score of ≥ 9 at 1 month postpartum, the crude OR was 3.36 (95% CI: 1.79-6.12) and the adjusted OR was 2.16 (95% CI: 1.04-4.35).

Conclusions: Our findings indicate that preconception PMDs are a significant risk factor for both depression during pregnancy and postpartum depression. These results support the implementation of preconception PMD screening during antenatal checkups as a preventive measure and to identify women in need of early mental health care.

背景:最近的研究已经确定经前障碍(PMDs)是产后抑郁症的一个危险因素。然而,对孕前经前综合症的常规筛查在日本还不普遍。本研究调查了在单一三级保健设置孕前经前综合症和围产期抑郁症之间的关系。方法:我们分析了2020年4月至2023年10月在京都大学医院分娩的孕妇的数据。经前症状筛查工具在第一次受孕后访问时使用,以回顾性评估当前妊娠前的经前抑郁状态。爱丁堡产后抑郁量表(EPDS)在怀孕期间和产后一个月进行,作为围产期抑郁的前瞻性测量。EPDS临界值为妊娠期12/13,产后1个月为8/9。结果:在分析的781名女性中,53名患有孕前经前综合症。单因素和多因素logistic回归分析显示,孕前PMD与妊娠期EPDS评分≥13相关,粗比值比(OR)为5.78(95%可信区间[CI]: 2.70-11.75),校正比值比(OR)为3.71 (95% CI: 1.54-8.35)。产后1个月EPDS评分≥9时,粗OR为3.36 (95% CI: 1.79-6.12),调整OR为2.16 (95% CI: 1.04-4.35)。结论:我们的研究结果表明,孕前经前综合症是怀孕期间抑郁和产后抑郁的重要危险因素。这些结果支持在产前检查期间进行孕前PMD筛查,作为一项预防措施,并确定需要早期心理保健的妇女。
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引用次数: 0
Psychogenic fever and neurodevelopmental disorders among Japanese children. 日本儿童的心因性发热和神经发育障碍。
IF 2.3 4区 医学 Q2 PSYCHIATRY Pub Date : 2024-12-18 DOI: 10.1186/s13030-024-00322-8
Ayumi Okada, Yoshie Shigeyasu, Chikako Fujii, Chie Tanaka, Mana Hanzawa, Akiko Sugihara, Makiko Horiuchi, Hirokazu Tsukahara

Background: Psychosocial stress can induce various physical symptoms, including fever, which is a commonly seen symptom in pediatric practice. In cases of unexplained fever, psychogenic fever should be considered as a potential cause. Children with neurodevelopmental disorders may be more vulnerable to stress and therefore more prone to developing somatic symptoms than their peers. This study aimed to elucidate the characteristics of children with psychogenic fever and comorbidity.

Methods: This study included 21 patients with psychogenic fever who visited the Department of Pediatric Psychosomatic Medicine, Okayama University Hospital. Information on age, sex, disease onset, final estimated diagnosis, comorbidities, treatment course, and outcome was obtained from the patients' medical records.

Results: Of the 21 patients included, 7 were boys and 14 were girls, and their median age was 13.0 (range: 8.6-14.6) years. A total of 19 patients had no attendance at school, and all patients showed signs of maladjustment in school. The comorbidities included orthostatic dysregulation (n = 4) and migraine (n = 3). Neurodevelopmental disorders were observed in nine patients, eight of whom were diagnosed after the initial visit. The mean treatment duration was 37.2 months. The outcomes were complete remission (n = 9), improvement (n = 4), discontinuation (n = 1), and referral to another physician (n = 7).

Conclusion: Various comorbidities were observed in the patients of this study with psychogenic fever, including the coexistence of neurodevelopmental disorders, such as autistic spectrum disorder. Children with neurodevelopmental disorders are prone to psychological stress resulting from difficulties in social adjustment. It is crucial to understand the developmental characteristics and environmental adaptation of patients to facilitate accurate diagnosis and treatment.

背景:心理社会压力可引起各种身体症状,包括发烧,这是儿科实践中常见的症状。在不明原因发热的病例中,应将心因性发热视为潜在病因。患有神经发育障碍的儿童可能更容易受到压力的影响,因此比同龄人更容易出现躯体症状。本研究旨在探讨儿童心因性发热及其合并症的特点。方法:本研究纳入了在冈山大学附属医院小儿心身内科就诊的21例心因性发热患者。从患者的医疗记录中获得年龄、性别、疾病发病、最终估计诊断、合并症、治疗过程和结果等信息。结果:21例患者中,男孩7例,女孩14例,中位年龄13.0岁(范围8.6 ~ 14.6)。共有19例患者没有上学,所有患者都表现出学校适应不良的迹象。合并症包括直立性失调(n = 4)和偏头痛(n = 3)。在9名患者中观察到神经发育障碍,其中8名在初次就诊后被诊断出来。平均治疗时间37.2个月。结果为完全缓解(n = 9)、改善(n = 4)、停药(n = 1)和转诊(n = 7)。结论:本研究中心因性发热患者存在多种合并症,包括神经发育障碍的共存,如自闭症谱系障碍。患有神经发育障碍的儿童容易因社会适应困难而产生心理压力。了解患者的发育特点和环境适应对准确诊断和治疗至关重要。
{"title":"Psychogenic fever and neurodevelopmental disorders among Japanese children.","authors":"Ayumi Okada, Yoshie Shigeyasu, Chikako Fujii, Chie Tanaka, Mana Hanzawa, Akiko Sugihara, Makiko Horiuchi, Hirokazu Tsukahara","doi":"10.1186/s13030-024-00322-8","DOIUrl":"10.1186/s13030-024-00322-8","url":null,"abstract":"<p><strong>Background: </strong>Psychosocial stress can induce various physical symptoms, including fever, which is a commonly seen symptom in pediatric practice. In cases of unexplained fever, psychogenic fever should be considered as a potential cause. Children with neurodevelopmental disorders may be more vulnerable to stress and therefore more prone to developing somatic symptoms than their peers. This study aimed to elucidate the characteristics of children with psychogenic fever and comorbidity.</p><p><strong>Methods: </strong>This study included 21 patients with psychogenic fever who visited the Department of Pediatric Psychosomatic Medicine, Okayama University Hospital. Information on age, sex, disease onset, final estimated diagnosis, comorbidities, treatment course, and outcome was obtained from the patients' medical records.</p><p><strong>Results: </strong>Of the 21 patients included, 7 were boys and 14 were girls, and their median age was 13.0 (range: 8.6-14.6) years. A total of 19 patients had no attendance at school, and all patients showed signs of maladjustment in school. The comorbidities included orthostatic dysregulation (n = 4) and migraine (n = 3). Neurodevelopmental disorders were observed in nine patients, eight of whom were diagnosed after the initial visit. The mean treatment duration was 37.2 months. The outcomes were complete remission (n = 9), improvement (n = 4), discontinuation (n = 1), and referral to another physician (n = 7).</p><p><strong>Conclusion: </strong>Various comorbidities were observed in the patients of this study with psychogenic fever, including the coexistence of neurodevelopmental disorders, such as autistic spectrum disorder. Children with neurodevelopmental disorders are prone to psychological stress resulting from difficulties in social adjustment. It is crucial to understand the developmental characteristics and environmental adaptation of patients to facilitate accurate diagnosis and treatment.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"18 1","pages":"23"},"PeriodicalIF":2.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Assessment of the renal function of patients with anorexia nervosa. 更正:神经性厌食症患者肾功能评估。
IF 2.3 4区 医学 Q2 PSYCHIATRY Pub Date : 2024-10-21 DOI: 10.1186/s13030-024-00319-3
Hiroyuki Miyahara, Yoshie Shigeyasu, Chikako Fujii, Chie Tanaka, Mana Hanzawa, Akiko Sugihara, Ayumi Okada, Hirokazu Tsukahara
{"title":"Correction: Assessment of the renal function of patients with anorexia nervosa.","authors":"Hiroyuki Miyahara, Yoshie Shigeyasu, Chikako Fujii, Chie Tanaka, Mana Hanzawa, Akiko Sugihara, Ayumi Okada, Hirokazu Tsukahara","doi":"10.1186/s13030-024-00319-3","DOIUrl":"10.1186/s13030-024-00319-3","url":null,"abstract":"","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"18 1","pages":"22"},"PeriodicalIF":2.3,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examining illness narratives in the context of the postoperative psychological state: A mixed-methods study of emotion-focused illness narrative. 在术后心理状态背景下研究疾病叙事:以情绪为中心的疾病叙事混合方法研究。
IF 2.3 4区 医学 Q2 PSYCHIATRY Pub Date : 2024-10-12 DOI: 10.1186/s13030-024-00318-4
Tünde Lévai, György Lázár, Erna Krajinovic, Iván Devosa, Melinda Látos
{"title":"Examining illness narratives in the context of the postoperative psychological state: A mixed-methods study of emotion-focused illness narrative.","authors":"Tünde Lévai, György Lázár, Erna Krajinovic, Iván Devosa, Melinda Látos","doi":"10.1186/s13030-024-00318-4","DOIUrl":"https://doi.org/10.1186/s13030-024-00318-4","url":null,"abstract":"","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"18 1","pages":"21"},"PeriodicalIF":2.3,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11470729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum TNFα and IL-17A levels may predict increased depressive symptoms: findings from the Shika Study cohort project in Japan. 血清 TNFα 和 IL-17A 水平可预测抑郁症状的加重:日本 Shika 研究队列项目的发现。
IF 2.3 4区 医学 Q2 PSYCHIATRY Pub Date : 2024-10-02 DOI: 10.1186/s13030-024-00317-5
Hirohito Tsuboi, Hiroyuki Sakakibara, Yuuki Minamida-Urata, Hiromasa Tsujiguchi, Akinori Hara, Keita Suzuki, Sakae Miyagi, Masaharu Nakamura, Chie Takazawa, Takayuki Kannon, Jiaye Zhao, Yukari Shimizu, Aki Shibata, Aya Ogawa, Fumihiko Suzuki, Yasuhiro Kambayashi, Tadashi Konoshita, Atsushi Tajima, Hiroyuki Nakamura

Background: Low-grade systemic inflammation may be a key player in the immune activation that has been reported for mental health deterioration. We hypothesised that elevated serum levels of inflammatory cytokines increase neuroinflammation and exacerbate depressive symptoms.

Methods: The participants were part of a cohort study for whom data was available for both 2015 and 2019. In 2015, blood samples were collected from 232 participants. Their depressive symptoms were assessed both 2015 and 2019 using the Centre for Epidemiologic Studies Depression Scale (CES-D) (n = 33). The multiplex immunoassay system (Luminex® 200) was used to measure the serum concentrations of IL-6, IL-10, IL-12, IL-17A and TNFα. Data were analysed using linear models with the level of significance considered to be p < 0.05.

Results: After controlling for age, BMI, smoking and alcohol consumption, in 2015 the serum concentrations of IL-17A and TNFα in 2015 were significantly positively associated with the CES-D scores of women (standardised β (B) = .027, p < 0.01 and B = 0.26, p < 0.01, respectively). The serum concentrations of IL-17A and TNFα of men were significantly positively associated with the CES-D scores of 2019 (B = 0.62, p = 0.02 and B = 0.59, p = 0.02, respectively).

Conclusions: In this cross-sectional study, we found a significant positive correlation between the depressive symptoms and serum TNFα and IL-17A levels of women. In addition, our longitudinal findings suggest the possibility that TNFα and IL-17A could elevate the depressive symptoms of men.

背景:低水平的全身性炎症可能是导致免疫激活的关键因素,有报道称免疫激活会导致精神健康恶化。我们假设,血清中炎症细胞因子水平的升高会加重神经炎症并加剧抑郁症状:参与者是一项队列研究的一部分,2015 年和 2019 年的数据均可获得。2015 年,研究人员采集了 232 名参与者的血液样本。在 2015 年和 2019 年均使用流行病学研究中心抑郁量表(CES-D)对他们的抑郁症状进行了评估(n = 33)。多重免疫测定系统(Luminex® 200)用于测量血清中IL-6、IL-10、IL-12、IL-17A和TNFα的浓度。采用线性模型对数据进行分析,显著性水平为 p 结果:在控制了年龄、体重指数、吸烟和饮酒量后,2015 年女性血清中 IL-17A 和 TNFα 的浓度与 CES-D 评分呈显著正相关(标准化 β (B) = .027,p 结论:IL-6、IL-10、IL-12、IL-17A 和 TNFα 的浓度与 CES-D 评分呈显著正相关(标准化 β (B) = .027,p):在这项横断面研究中,我们发现女性的抑郁症状与血清TNFα和IL-17A水平之间存在明显的正相关。此外,我们的纵向研究结果表明,TNFα和IL-17A可能会加重男性的抑郁症状。
{"title":"Serum TNFα and IL-17A levels may predict increased depressive symptoms: findings from the Shika Study cohort project in Japan.","authors":"Hirohito Tsuboi, Hiroyuki Sakakibara, Yuuki Minamida-Urata, Hiromasa Tsujiguchi, Akinori Hara, Keita Suzuki, Sakae Miyagi, Masaharu Nakamura, Chie Takazawa, Takayuki Kannon, Jiaye Zhao, Yukari Shimizu, Aki Shibata, Aya Ogawa, Fumihiko Suzuki, Yasuhiro Kambayashi, Tadashi Konoshita, Atsushi Tajima, Hiroyuki Nakamura","doi":"10.1186/s13030-024-00317-5","DOIUrl":"10.1186/s13030-024-00317-5","url":null,"abstract":"<p><strong>Background: </strong>Low-grade systemic inflammation may be a key player in the immune activation that has been reported for mental health deterioration. We hypothesised that elevated serum levels of inflammatory cytokines increase neuroinflammation and exacerbate depressive symptoms.</p><p><strong>Methods: </strong>The participants were part of a cohort study for whom data was available for both 2015 and 2019. In 2015, blood samples were collected from 232 participants. Their depressive symptoms were assessed both 2015 and 2019 using the Centre for Epidemiologic Studies Depression Scale (CES-D) (n = 33). The multiplex immunoassay system (Luminex® 200) was used to measure the serum concentrations of IL-6, IL-10, IL-12, IL-17A and TNFα. Data were analysed using linear models with the level of significance considered to be p < 0.05.</p><p><strong>Results: </strong>After controlling for age, BMI, smoking and alcohol consumption, in 2015 the serum concentrations of IL-17A and TNFα in 2015 were significantly positively associated with the CES-D scores of women (standardised β (B) = .027, p < 0.01 and B = 0.26, p < 0.01, respectively). The serum concentrations of IL-17A and TNFα of men were significantly positively associated with the CES-D scores of 2019 (B = 0.62, p = 0.02 and B = 0.59, p = 0.02, respectively).</p><p><strong>Conclusions: </strong>In this cross-sectional study, we found a significant positive correlation between the depressive symptoms and serum TNFα and IL-17A levels of women. In addition, our longitudinal findings suggest the possibility that TNFα and IL-17A could elevate the depressive symptoms of men.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"18 1","pages":"20"},"PeriodicalIF":2.3,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of the renal function of patients with anorexia nervosa. 评估神经性厌食症患者的肾功能。
IF 2.3 4区 医学 Q2 PSYCHIATRY Pub Date : 2024-09-29 DOI: 10.1186/s13030-024-00316-6
Hiroyuki Miyahara, Yoshie Shigeyasu, Chikako Fujii, Chie Tanaka, Mana Hanzawa, Akiko Sugihara, Ayumi Okada, Hirokazu Tsukahara

Background: A decreased glomerular filtration rate (GFR), estimated using creatinine (Cr- eGFR), is often found at the initial presentation of anorexia nervosa (AN). Its pathophysiology has been explained mainly by dehydration, and chronic hypokalemia is also thought to be a cause. However, because we have often experienced cases of AN with decreased Cr-eGFR without these conditions, we must consider different etiologies. The focus of this paper is on low free triiodothyronine (FT3) syndrome. We also discuss the utility of eGFR, estimated using cystatin-C (CysC-eGFR), for these patients.

Methods: The data of 39 patients diagnosed with AN between January 2005 and December 2023 was available for study. The characteristics of patients at the lowest and highest body mass index standard deviation score (BMI-SDS) were examined. Data on the parameters Cr-eGFR, CysC-eGFR, dehydration markers, potassium (K), and hormonal data and BMI-SDS were assessed during the treatment course to evaluate the correlations in these parameters. Blood hematocrit, uric acid (UA), blood urine nitrogen (BUN) level, and urine specific gravity were adopted as dehydration markers; FT3, free thyroxine, thyroid stimulating hormone, and insulin-like growth factor were adopted as hormonal data. Cr-eGFR and simultaneously evaluated dehydration markers, K, or hormonal data were extracted and correlations associated with the changes in BMI-SDS were examined. Furthermore, Cr-eGFR and simultaneously assessed CysC-eGFR were compared.

Results: When the BMI-SDS was at the lowest value, low-FT3 syndrome was shown. Severe hypokalemia was not found in our study. A linear relation was not found between Cr-eGFR and BMI-SDS. A statistically significant correlation was found between Cr-eGFR and FT3 (p = 0.0025). Among the dehydration markers, statistically significant correlations were found between Cr-eGFR and BUN or UA. The difference between Cr-eGFR and CysC-eGFR was prominent, and CysC-eGFR showed much higher values.

Conclusions: Our data indicates that low-FT3 syndrome and dehydration were related to the renal function of our patients with AN. Furthermore, our data suggest that caution is needed in the interpretation of kidney function evaluation when using CysC-eGFR in cases of AN.

背景:在神经性厌食症(AN)的初期症状中,通常会发现肾小球滤过率(GFR)下降,而肾小球滤过率是用肌酐(Cr- eGFR)来估算的。其病理生理学原因主要是脱水,慢性低钾血症也被认为是原因之一。然而,由于我们经常遇到的神经性厌食症患者在没有上述症状的情况下出现 Cr-eGFR 降低,因此我们必须考虑不同的病因。本文的重点是低游离三碘甲状腺原氨酸(FT3)综合征。我们还讨论了使用胱抑素-C(CysC-eGFR)估算的 eGFR 对这些患者的实用性:研究收集了 2005 年 1 月至 2023 年 12 月期间确诊的 39 例 AN 患者的数据。研究考察了体重指数标准差(BMI-SDS)最低和最高的患者的特征。在治疗过程中评估了Cr-eGFR、CysC-eGFR、脱水指标、钾(K)、激素数据和BMI-SDS等参数,以评估这些参数之间的相关性。脱水指标包括血细胞比容、尿酸(UA)、血尿氮(BUN)水平和尿比重;激素数据包括绒毛膜促性腺激素(FT3)、游离甲状腺素、促甲状腺激素和胰岛素样生长因子。提取 Cr-eGFR 和同时评估的脱水指标、K 或激素数据,并研究其与 BMI-SDS 变化的相关性。此外,还对 Cr-eGFR 和同时评估的 CysC-eGFR 进行了比较:结果:当 BMI-SDS 处于最低值时,出现低 FT3 综合征。我们的研究未发现严重的低钾血症。Cr-eGFR 与 BMI-SDS 之间未发现线性关系。Cr-eGFR 与 FT3 之间存在统计学意义上的相关性(p = 0.0025)。在脱水指标中,Cr-eGFR 与 BUN 或 UA 之间存在统计学意义上的显著相关性。Cr-eGFR与CysC-eGFR之间的差异非常明显,CysC-eGFR显示出更高的值:我们的数据表明,低 FT3 综合征和脱水与 AN 患者的肾功能有关。结论:我们的数据表明,低 FT3 综合征和脱水与 AN 患者的肾功能有关。此外,我们的数据还表明,在 AN 患者中使用 CysC-eGFR 进行肾功能评估时需要谨慎。
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引用次数: 0
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BioPsychoSocial Medicine
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