The author herein reports a hitherto undescribed entity of cutaneous primordial carcinoma with triple differentiation into basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and porocarcinoma (PC) in a 66-year-old man. The patient was treated by tumor excision with wide margins. Pathologically, the margins were negative for tumor cells. The patient is now healthy 1 year after the excision. The tumor measured 3 cm × 2 cm × 2 cm and arose from the epidermis. The percentage of the occupying area was 60% in BCC, 20% in SCC, and 20% in PC. Histologically, BCC was characterized by basalioma cells, melanin pigmentation, peripheral palisading, and cleft formation, SCC by ample acidophilic cytoplasm, individual keratinization and cancer pearls, and PC by poroma cells and tubular structures containing cuticles. Cystic changes in BCC and SCC, keratotic nature of BCC, and acatholytic features of SCC were also seen in places. There were gradual merges among the three components. Immunohistochemically, BCC component was characterized by strong and diffuse expression of KIT, PDGFRA and p63, weak expressions of cytokeratin (CK) AE1/3, CK CAM5.2, CK34BE12, and negative expressions of CK18, CK19, CEA and CA19-9. SCC component was characterized by strongly positive expressions of p63, CEA, CK34BE12, CK7 and CK8, and negative expressions of CK18, CK19, and CA19-9. PC was characterized by strongly positive expressions of KIT, PDGFRA, CK34BE12, CK7, CK8, CK18, CK19, CEA, S100 protein, CA19-9, MUC1, and negative expression of p63. The present case revealed that there are primary cutaneous keratinocytic primordial carcinomas with triple differentiations into BCC, SCC, and PC. The present case is the first example of such tumors. It is thought that KIT and PDFRA-positive stem cells or cancer stem cells in the BCC component give rise to the SCC and PC components in the present case.
{"title":"Primary cutaneous keratinocytic primordial carcinoma with triple differentiations into basal cell carcinoma, sqaumous cell carcinoma, and porocarcinoma","authors":"T. Terada","doi":"10.5430/crcp.v4n1p7","DOIUrl":"https://doi.org/10.5430/crcp.v4n1p7","url":null,"abstract":"The author herein reports a hitherto undescribed entity of cutaneous primordial carcinoma with triple differentiation into basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and porocarcinoma (PC) in a 66-year-old man. The patient was treated by tumor excision with wide margins. Pathologically, the margins were negative for tumor cells. The patient is now healthy 1 year after the excision. The tumor measured 3 cm × 2 cm × 2 cm and arose from the epidermis. The percentage of the occupying area was 60% in BCC, 20% in SCC, and 20% in PC. Histologically, BCC was characterized by basalioma cells, melanin pigmentation, peripheral palisading, and cleft formation, SCC by ample acidophilic cytoplasm, individual keratinization and cancer pearls, and PC by poroma cells and tubular structures containing cuticles. Cystic changes in BCC and SCC, keratotic nature of BCC, and acatholytic features of SCC were also seen in places. There were gradual merges among the three components. Immunohistochemically, BCC component was characterized by strong and diffuse expression of KIT, PDGFRA and p63, weak expressions of cytokeratin (CK) AE1/3, CK CAM5.2, CK34BE12, and negative expressions of CK18, CK19, CEA and CA19-9. SCC component was characterized by strongly positive expressions of p63, CEA, CK34BE12, CK7 and CK8, and negative expressions of CK18, CK19, and CA19-9. PC was characterized by strongly positive expressions of KIT, PDGFRA, CK34BE12, CK7, CK8, CK18, CK19, CEA, S100 protein, CA19-9, MUC1, and negative expression of p63. The present case revealed that there are primary cutaneous keratinocytic primordial carcinomas with triple differentiations into BCC, SCC, and PC. The present case is the first example of such tumors. It is thought that KIT and PDFRA-positive stem cells or cancer stem cells in the BCC component give rise to the SCC and PC components in the present case.","PeriodicalId":90463,"journal":{"name":"Case reports in clinical pathology","volume":"4 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2016-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/crcp.v4n1p7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71210894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Histiocytic sarcoma (HS) is a rare, non-Langerhan’s, malignant histiocytic neoplasm that occurs in lymph nodes and extranodal sites mainly the skin and intestine. Amidst the cases reported so far; majority of the cases previously diagnosed as HS have been Primary T cell lymphomas (PTCL). Cases primarily involving the extranodal sites are rare, with a confusing clinical picture and thus, are often misdiagnosed. Here we report a rare case of extranodal HS in a 54-year-old man, a previously treated case of gastrointestinal stromal tumor (GIST) of the stomach, who now presented with abdominal pain. On imaging, a growth was detected in the small bowel without accompanying lymphadenopathy.
{"title":"A histiocytic twist in a tale of GIST","authors":"A. Gangoli, K. Sharma, K. Chaudhary","doi":"10.5430/CRCP.V3N4P50","DOIUrl":"https://doi.org/10.5430/CRCP.V3N4P50","url":null,"abstract":"Histiocytic sarcoma (HS) is a rare, non-Langerhan’s, malignant histiocytic neoplasm that occurs in lymph nodes and extranodal sites mainly the skin and intestine. Amidst the cases reported so far; majority of the cases previously diagnosed as HS have been Primary T cell lymphomas (PTCL). Cases primarily involving the extranodal sites are rare, with a confusing clinical picture and thus, are often misdiagnosed. Here we report a rare case of extranodal HS in a 54-year-old man, a previously treated case of gastrointestinal stromal tumor (GIST) of the stomach, who now presented with abdominal pain. On imaging, a growth was detected in the small bowel without accompanying lymphadenopathy.","PeriodicalId":90463,"journal":{"name":"Case reports in clinical pathology","volume":"3 1","pages":"50"},"PeriodicalIF":0.0,"publicationDate":"2016-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/CRCP.V3N4P50","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71210160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This is an interesting case of a 53-year-old Caucasian male with a history of recurrent follicular lymphoma (FL) treated with chemotherapy. After 12 years, he developed lymphadenopathy and had an axillary lymph node biopsy which showed transformation to Diffuse Large B-cell lymphoma (DLBCL) with background FL. The patient was treated with chemotherapy and his course was complicated by cellulitis/abscess formation of the right thigh. Computerized Tomography scan showed a large necrotic nodal conglomerate within the right inguinal region measuring 7.8 cm × 5.1 cm and an excisional biopsy was performed. The lymph node architecture was effaced by sheets of large, atypical, pleomorphic cells with open/vesicular chromatin and scattered prominent nucleoli. Focal areas showed residual/recurrent FL, grade I-II. Immunohistochemical stains showed that the large neoplastic cells express CD4, CD68, CD163, BCL-6, lysozyme, CD45 and S-100. The morphologic and immunophenotypic findings are consistent with histiocytic sarcoma (HS). Fluorescence in-situ hybridization studies of the HS showed translocation t(14;18)(q32;q21), a gene rearrangement involving 3q27(BCL6), and gain of 14q32(IgH). The patient’s prior FL and DLBCL were shown to have the same translocation t(14;18)(q32;q21). The molecular findings show a common cell lineage between all three diagnoses confirming that FL can transform into DLBCL and transdifferentiate into HS.
这是一个有趣的病例，53岁的白人男性，有复发滤泡性淋巴瘤(FL)的病史，并接受化疗。12年后，他发展为淋巴结病，腋窝淋巴结活检显示为弥漫性大b细胞淋巴瘤(DLBCL)，伴背景性FL。患者接受化疗，其病程并发右大腿蜂窝组织炎/脓肿形成。计算机断层扫描显示右侧腹股沟区有一个7.8 cm × 5.1 cm的大坏死结节性砾岩，并行切除活检。淋巴结结构被大的、非典型的、多形性的细胞片所抹去，染色质呈开/泡状，核仁分散突出。病灶区域显示残留/复发性FL, I-II级。免疫组化染色显示大肿瘤细胞表达CD4、CD68、CD163、BCL-6、溶菌酶、CD45和S-100。形态学和免疫表型与组织细胞肉瘤(HS)一致。HS的荧光原位杂交研究显示易位t(14;18)(q32;q21)，涉及3q27(BCL6)的基因重排，以及14q32(IgH)的获得。患者先前的FL和DLBCL显示有相同的易位t(14;18)(q32;q21)。分子研究结果显示，这三种诊断之间具有共同的细胞谱系，证实FL可以转化为DLBCL并转分化为HS。
{"title":"A rare case of follicular lymphoma with transformation to diffuse large B-cell lymphoma and transdifferentiation to histiocytic sarcoma","authors":"A. Rjoop, S. Pandey, R. Levy","doi":"10.5430/CRCP.V3N4P45","DOIUrl":"https://doi.org/10.5430/CRCP.V3N4P45","url":null,"abstract":"This is an interesting case of a 53-year-old Caucasian male with a history of recurrent follicular lymphoma (FL) treated with chemotherapy. After 12 years, he developed lymphadenopathy and had an axillary lymph node biopsy which showed transformation to Diffuse Large B-cell lymphoma (DLBCL) with background FL. The patient was treated with chemotherapy and his course was complicated by cellulitis/abscess formation of the right thigh. Computerized Tomography scan showed a large necrotic nodal conglomerate within the right inguinal region measuring 7.8 cm × 5.1 cm and an excisional biopsy was performed. The lymph node architecture was effaced by sheets of large, atypical, pleomorphic cells with open/vesicular chromatin and scattered prominent nucleoli. Focal areas showed residual/recurrent FL, grade I-II. Immunohistochemical stains showed that the large neoplastic cells express CD4, CD68, CD163, BCL-6, lysozyme, CD45 and S-100. The morphologic and immunophenotypic findings are consistent with histiocytic sarcoma (HS). Fluorescence in-situ hybridization studies of the HS showed translocation t(14;18)(q32;q21), a gene rearrangement involving 3q27(BCL6), and gain of 14q32(IgH). The patient’s prior FL and DLBCL were shown to have the same translocation t(14;18)(q32;q21). The molecular findings show a common cell lineage between all three diagnoses confirming that FL can transform into DLBCL and transdifferentiate into HS.","PeriodicalId":90463,"journal":{"name":"Case reports in clinical pathology","volume":"3 1","pages":"45"},"PeriodicalIF":0.0,"publicationDate":"2016-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/CRCP.V3N4P45","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71210036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stephanie Van Aelst, T. Tousseyn, R. Sciot, M. Debiec-Rychter, X. Sagaert
We describe a challenging differential diagnosis of a poorly differentiated tumor arising in the abdominal cavity of a 76-year-old woman. After histological and immunohistochemical analysis the differential diagnosis between a plasmablastic lymphoma (PBL) and a dedifferentiated liposarcoma remained. Molecular testing was necessary to make a definite diagnosis of PBL. To the best of our knowledge, this is the first report in literature of PBL with MDM2 overexpression and amplification. Awareness of this finding could prove useful for appropriate patient management.
{"title":"A rare case of plasmablastic lymphoma with MDM2 overexpression and amplification","authors":"Stephanie Van Aelst, T. Tousseyn, R. Sciot, M. Debiec-Rychter, X. Sagaert","doi":"10.5430/CRCP.V3N4P41","DOIUrl":"https://doi.org/10.5430/CRCP.V3N4P41","url":null,"abstract":"We describe a challenging differential diagnosis of a poorly differentiated tumor arising in the abdominal cavity of a 76-year-old woman. After histological and immunohistochemical analysis the differential diagnosis between a plasmablastic lymphoma (PBL) and a dedifferentiated liposarcoma remained. Molecular testing was necessary to make a definite diagnosis of PBL. To the best of our knowledge, this is the first report in literature of PBL with MDM2 overexpression and amplification. Awareness of this finding could prove useful for appropriate patient management.","PeriodicalId":90463,"journal":{"name":"Case reports in clinical pathology","volume":"3 1","pages":"41"},"PeriodicalIF":0.0,"publicationDate":"2016-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/CRCP.V3N4P41","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71210014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: We aimed to underline the importance of the covert comorbidities like ileal intestinal polyps in pediatric abdominal operations for appendicitis. Case: A 10-year-old girl was referred to us from the emergency ward with the complaints of abdominal pain and vomiting. After detailed examination, we decided to conduct an abdominal exploration in suspicion of potential acute appendicitis. During the laparotomy, an acute simple appendicitis was found and appendectomy was performed. We further explored the abdomen to rule out a possible Meckel diverticulitis, during which an ileal intraluminal mass was palpated about 10 cm proximal to the intestinal ileocecal valve. We performed enterotomy and resected the polypoid mass completely. The histopathological reports were lymphoid hyperplasia for the appendicitis and intestinal hyperplastic polyp for the polypoid mass. Follow up of the patient after 6 months was eventless. Conclusions: Comorbidities like intestinal polyps should be part of the considerations during the abdominal explorations for acute appendicitis. Missing an ileal polyp may lead to a second operation.
{"title":"An ileal hyperplastic polyp comorbidity in the case of acute appendicitis","authors":"C. Irşi, Ş. Karaçay","doi":"10.5430/CRCP.V3N4P37","DOIUrl":"https://doi.org/10.5430/CRCP.V3N4P37","url":null,"abstract":"Introduction: We aimed to underline the importance of the covert comorbidities like ileal intestinal polyps in pediatric abdominal operations for appendicitis. Case: A 10-year-old girl was referred to us from the emergency ward with the complaints of abdominal pain and vomiting. After detailed examination, we decided to conduct an abdominal exploration in suspicion of potential acute appendicitis. During the laparotomy, an acute simple appendicitis was found and appendectomy was performed. We further explored the abdomen to rule out a possible Meckel diverticulitis, during which an ileal intraluminal mass was palpated about 10 cm proximal to the intestinal ileocecal valve. We performed enterotomy and resected the polypoid mass completely. The histopathological reports were lymphoid hyperplasia for the appendicitis and intestinal hyperplastic polyp for the polypoid mass. Follow up of the patient after 6 months was eventless. Conclusions: Comorbidities like intestinal polyps should be part of the considerations during the abdominal explorations for acute appendicitis. Missing an ileal polyp may lead to a second operation.","PeriodicalId":90463,"journal":{"name":"Case reports in clinical pathology","volume":"3 1","pages":"37"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/CRCP.V3N4P37","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71209931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Sokol, J. Rosenberg, Jeremy D. Clark, W. Nunery, H. B. Lee, C. Wertenbaker
A 49-year-old male with a history of sclerosing mediastinitis presented with complaints of bilateral (left greater than right) eye pain and redness for 3 weeks. Clinically, the patient demonstrated signs of bilateral dacryoadenitis and myositis. CT confirmed enlargement of both lacrimal glands and lateral rectus muscles. Due to the relationship between sclerosing mediastinitis and orbital inflammatory pseudotumor (OIP), the patient was treated with oral prednisone with a brisk response. OIP is common in ophthalmic practice and treating physicians should be aware of the associations with systemic disease processes.
{"title":"Bilateral orbital myositis and dacryoadenitis after sclerosing mediastinitis","authors":"J. Sokol, J. Rosenberg, Jeremy D. Clark, W. Nunery, H. B. Lee, C. Wertenbaker","doi":"10.5430/CRCP.V3N4P33","DOIUrl":"https://doi.org/10.5430/CRCP.V3N4P33","url":null,"abstract":"A 49-year-old male with a history of sclerosing mediastinitis presented with complaints of bilateral (left greater than right) eye pain and redness for 3 weeks. Clinically, the patient demonstrated signs of bilateral dacryoadenitis and myositis. CT confirmed enlargement of both lacrimal glands and lateral rectus muscles. Due to the relationship between sclerosing mediastinitis and orbital inflammatory pseudotumor (OIP), the patient was treated with oral prednisone with a brisk response. OIP is common in ophthalmic practice and treating physicians should be aware of the associations with systemic disease processes.","PeriodicalId":90463,"journal":{"name":"Case reports in clinical pathology","volume":"3 1","pages":"33"},"PeriodicalIF":0.0,"publicationDate":"2016-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/CRCP.V3N4P33","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71210334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Only 5 cases of follicular lymphoma (FL) have been reported in the prostate. A 68-year-old man presented with dysuria. Laboratory data did not indicate malignancy in the prostate with serums PSA of 4.6 ng/ml. Imaging techniques identified no tumors and lympho-adenopathy other than the prostatic enlargement. The patient was clinically diagnosed as prostatic hyperplasia, and trans-urethral resection of prostate (TURP) (65 g) was done. Histologically, the TURP-specimens showed severe nodular proliferation of atypical small lymphocytes consisting of small centrocytic lymphocytes and large centroblastic lymphocytes, the number of the latter being 2/HPF. Immunohistochemically, the tumor cells and nodular areas were positive for CD45, CD20, CD79a, bcl-2, bcl-6, and CD10. They were negative for pan-cytokeratin (AE1/3, CAM5.2), CD3, CD45RO, CD56, PSA, chromogranin-A, synaptophysin, NSE, CD138, CD15, CD30 and cyclin D1. No significant number of plasma cells were seen by immunohistochemistry for light chains and CD138. A pathological diagnosis of primary FL (grade 1) of the prostate was made. No tumors were identified by various imaging techniques, and the prostatic FL was diagnosed as primary. The patient underwent low-dose R-CHOP chemotherapy and focal radiation, probably resulting in complete remission. No recurrence has been found 5 months after the diagnosis.
{"title":"Primary follicular lymphoma of the prostate","authors":"T. Terada","doi":"10.5430/CRCP.V3N4P24","DOIUrl":"https://doi.org/10.5430/CRCP.V3N4P24","url":null,"abstract":"Only 5 cases of follicular lymphoma (FL) have been reported in the prostate. A 68-year-old man presented with dysuria. Laboratory data did not indicate malignancy in the prostate with serums PSA of 4.6 ng/ml. Imaging techniques identified no tumors and lympho-adenopathy other than the prostatic enlargement. The patient was clinically diagnosed as prostatic hyperplasia, and trans-urethral resection of prostate (TURP) (65 g) was done. Histologically, the TURP-specimens showed severe nodular proliferation of atypical small lymphocytes consisting of small centrocytic lymphocytes and large centroblastic lymphocytes, the number of the latter being 2/HPF. Immunohistochemically, the tumor cells and nodular areas were positive for CD45, CD20, CD79a, bcl-2, bcl-6, and CD10. They were negative for pan-cytokeratin (AE1/3, CAM5.2), CD3, CD45RO, CD56, PSA, chromogranin-A, synaptophysin, NSE, CD138, CD15, CD30 and cyclin D1. No significant number of plasma cells were seen by immunohistochemistry for light chains and CD138. A pathological diagnosis of primary FL (grade 1) of the prostate was made. No tumors were identified by various imaging techniques, and the prostatic FL was diagnosed as primary. The patient underwent low-dose R-CHOP chemotherapy and focal radiation, probably resulting in complete remission. No recurrence has been found 5 months after the diagnosis.","PeriodicalId":90463,"journal":{"name":"Case reports in clinical pathology","volume":"3 1","pages":"24"},"PeriodicalIF":0.0,"publicationDate":"2016-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/CRCP.V3N4P24","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71210192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leiomyosarcoma of spermatic cord is very rare. The patient is 65-year-old man who presented with a tumor in scrotum. Excision of tumor was performed and it showed a solid tumor measuring 4 cm × 3 cm × 3 cm in left spermatic cord. Histologically, it showed proliferation of hypercellular atypical spindle cells with hyperchromatic nuclei. The tumor cells were arranged with fascicles of cigar-shaped spindled cells with scant acidophilic cytoplasm. The tumor was not encapsulated, and mild invasive features into surrounding tissue were noted. The mitotic index was 17; 17 mitotic figures were seen in 10 high-power-fields. Atypical mitosis was also seen. Immunohistochemically, tumor cells were positive for vimentin, α-smooth muscle actin, h-caldesmon,desmin (focal), p53, and Ki-67 (labeling index = 34%). No other tumors were identified in the body, and the patient further treated with auxiliary local radiation and chemotherapy (cisplatin and doxorubicin). He is now healthy and free from tumors in the body 15 months after the operation.
精索平滑肌肉瘤非常罕见。患者为65岁男性，阴囊肿瘤。行肿瘤切除术，左侧精索见一个4 cm × 3 cm × 3 cm的实体瘤。组织学上表现为细胞核深染的非典型梭形细胞增生。肿瘤细胞呈雪茄状梭形细胞束状排列，胞质嗜酸性不足。肿瘤未被包裹，并有轻微侵入周围组织的特征。有丝分裂指数为17;10个高倍视场17个有丝分裂象。非典型有丝分裂也可见。免疫组化结果显示，肿瘤细胞vimentin、α-平滑肌肌动蛋白、h-caldesmon、desmin(局灶)、p53、Ki-67阳性(标记指数34%)。体内未发现其他肿瘤，患者进一步接受辅助局部放化疗(顺铂和阿霉素)。手术15个月后，他现在很健康，体内没有肿瘤。
{"title":"Leiomyosarcoma of the spermatic cord","authors":"T. Terada","doi":"10.5430/CRCP.V3N4P29","DOIUrl":"https://doi.org/10.5430/CRCP.V3N4P29","url":null,"abstract":"Leiomyosarcoma of spermatic cord is very rare. The patient is 65-year-old man who presented with a tumor in scrotum. Excision of tumor was performed and it showed a solid tumor measuring 4 cm × 3 cm × 3 cm in left spermatic cord. Histologically, it showed proliferation of hypercellular atypical spindle cells with hyperchromatic nuclei. The tumor cells were arranged with fascicles of cigar-shaped spindled cells with scant acidophilic cytoplasm. The tumor was not encapsulated, and mild invasive features into surrounding tissue were noted. The mitotic index was 17; 17 mitotic figures were seen in 10 high-power-fields. Atypical mitosis was also seen. Immunohistochemically, tumor cells were positive for vimentin, α-smooth muscle actin, h-caldesmon,desmin (focal), p53, and Ki-67 (labeling index = 34%). No other tumors were identified in the body, and the patient further treated with auxiliary local radiation and chemotherapy (cisplatin and doxorubicin). He is now healthy and free from tumors in the body 15 months after the operation.","PeriodicalId":90463,"journal":{"name":"Case reports in clinical pathology","volume":"3 1","pages":"29"},"PeriodicalIF":0.0,"publicationDate":"2016-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/CRCP.V3N4P29","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71210260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N N Shameem, A. Bece, M. Stockler, C. Sandroussi, G. Watson, G. Hruby
The most common sites of metastases from prostate cancer are the regional lymph nodes and bones followed by lung, liver, pleura and adrenals. We describe an unusual presentation of metastatic prostate cancer with omental metastases as the only site of disease. An otherwise well 72-year-old man was investigated for a rising prostate specific antigen (PSA) 12 months after curative-intent radiotherapy and androgen deprivation for high risk prostate cancer. CT scans showed omental caking with no evidence of bony or other metastases. Omental biopsy demonstrated adenocarcinoma of prostatic origin.
{"title":"A rare case of omental metastasis as first and singular site of failure from localized prostate cancer","authors":"N N Shameem, A. Bece, M. Stockler, C. Sandroussi, G. Watson, G. Hruby","doi":"10.5430/CRCP.V3N4P20","DOIUrl":"https://doi.org/10.5430/CRCP.V3N4P20","url":null,"abstract":"The most common sites of metastases from prostate cancer are the regional lymph nodes and bones followed by lung, liver, pleura and adrenals. We describe an unusual presentation of metastatic prostate cancer with omental metastases as the only site of disease. An otherwise well 72-year-old man was investigated for a rising prostate specific antigen (PSA) 12 months after curative-intent radiotherapy and androgen deprivation for high risk prostate cancer. CT scans showed omental caking with no evidence of bony or other metastases. Omental biopsy demonstrated adenocarcinoma of prostatic origin.","PeriodicalId":90463,"journal":{"name":"Case reports in clinical pathology","volume":"3 1","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2016-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71210107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The authors report a case of a 79-year-old, previously healthy, gentleman who presented with progressive proximal muscle weakness, petechial rash, weight loss, fatigue and diplopia. Neurologic exam demonstrated bilateral esotropia in the primary position and proximal muscle weakness in both upper and lower extremities bilaterally. Subsequent serum laboratory studies, cerebrospinal fluid analysis and neuroimaging failed to identify a unifying diagnosis. The patient was ultimately diagnosed with intravascular large B cell lymphoma (IVLBCL) via skin biopsy and subsequently underwent a single cycle of chemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) before dying from respiratory failure. This case highlights the importance of entertaining a broad differential diagnosis for non-anatomical distribution of central nervous system (CNS) findings, especially when prior investigations into a structural cause have been unrevealing.
{"title":"The answer is skin deep: A case of intravascular large B cell lymphoma presenting as progressive paresis and bilateral abducens nerve palsy","authors":"T. Patil, J. Mansoori, R. Murphy, S. Malkoski","doi":"10.5430/CRCP.V3N3P72","DOIUrl":"https://doi.org/10.5430/CRCP.V3N3P72","url":null,"abstract":"The authors report a case of a 79-year-old, previously healthy, gentleman who presented with progressive proximal muscle weakness, petechial rash, weight loss, fatigue and diplopia. Neurologic exam demonstrated bilateral esotropia in the primary position and proximal muscle weakness in both upper and lower extremities bilaterally. Subsequent serum laboratory studies, cerebrospinal fluid analysis and neuroimaging failed to identify a unifying diagnosis. The patient was ultimately diagnosed with intravascular large B cell lymphoma (IVLBCL) via skin biopsy and subsequently underwent a single cycle of chemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) before dying from respiratory failure. This case highlights the importance of entertaining a broad differential diagnosis for non-anatomical distribution of central nervous system (CNS) findings, especially when prior investigations into a structural cause have been unrevealing.","PeriodicalId":90463,"journal":{"name":"Case reports in clinical pathology","volume":"3 1","pages":"72"},"PeriodicalIF":0.0,"publicationDate":"2016-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/CRCP.V3N3P72","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71209623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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