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Apneic Oxygenation and High Flow 无氧氧合和高流量
Pub Date : 2018-12-31 DOI: 10.23937/2377-4630/1410081
Saracoglu Ayten, Pence Halime Hanim, Yılmaz Mehmet, Saracoglu Kemal Tolga
Prevention and minimizing serious complications during difficult airway management is an important goal for anesthesia providers. Using the high flow cannula oxygenation systems it is possible to improve the clinical outcomes, increase patient safety and reduce the rate of complications. A possible mechanism of this method can be explain by ‘Aventilatory Mass Flow’ which is a physilogical phenomenon. Several methods can be used to implement apneic oxygenation such as nasopharyngeal catheter, nasal cannula, face mask, Venturi mask, transtracheal endobronchial catheters, dual blade laryngoscopes and High Flow Nasal Cannula Oxygenation (HFNCO) systems. However each method has some restrictions. In this review we aim to focus on the important features of HFNCO systems including the indications, contraindications and possible complications.
预防和尽量减少气道困难管理期间的严重并发症是麻醉提供者的一个重要目标。使用高流量插管氧合系统可以改善临床结果,提高患者安全性并降低并发症发生率。这种方法的一个可能机制可以用“复仇质量流”来解释,这是一种物理现象。几种方法可用于实施呼吸暂停氧合,如鼻咽导管、鼻插管、面罩、文丘里面罩、经气管支气管内导管、双刀片喉镜和高流量鼻插管氧合(HFNCO)系统。然而,每种方法都有一些限制。在这篇综述中,我们的目的是关注HFNCO系统的重要特征,包括适应症、禁忌症和可能的并发症。
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引用次数: 4
A Rare Case of an Adult Congenital Diaphragmatic Hernia becoming Symptomatic after an Elective Procedure 一例罕见的成人先天性膈疝在择期手术后出现症状
Pub Date : 2018-12-31 DOI: 10.23937/2377-4630/1410078
V. Stylianos, Y DolinskiSylvia
Citation: Voulgarelis S, Dolinski SY (2018) A Rare Case of an Adult Congenital Diaphragmatic Hernia becoming Symptomatic after an Elective Procedure. Int J Anesthetic Anesthesiol 5:078. doi.org/10.23937/23774630/1410078 Accepted: November 01, 2018: Published: November 03, 2018 Copyright: © 2018 Voulgarelis S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
引文:Voulgarelis S,Dolinski SY(2018)一例罕见的成人先天性膈疝在选择性手术后出现症状。《国际麻醉学杂志》5:078。doi.org/10.23937/23774630/1410078接受时间:2018年11月1日:发布时间:2018月3日版权所有:©2018 Voulgarelis S等人。这是一篇根据知识共享署名许可证条款分发的开放获取文章,该许可证允许在任何媒体中不受限制地使用、分发和复制,前提是原始作者和来源可信。
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引用次数: 3
Lumbar Sympathetic Block for Bilateral Post-Prostatectomy Lower Extremity Pain in the Femoral Nerve Distribution 腰交感神经阻滞治疗双侧前列腺切除术后股神经分布的下肢疼痛
Pub Date : 2018-12-31 DOI: 10.23937/2377-4630/1410070
F. Fadi, Kalaydjian Antranig, C. Yuen, S. Pascal, A. Martín
Objective: Lower extremities nerves damage is a known complication of prostatectomies. Lumbar sympathetic block is a well-established treatment for sympathetically-mediated lower extremity pain. We report a case of bilateral lower extremity pain in a femoral distribution that developed after a robotic assisted prostatectomy and resolved after a lumbar sympathetic block. Case Report: A 69-year-old male patient presented with bilateral thigh pain one month after an uneventful robotic-assisted laparoscopic prostatectomy in the femoral nerve distribution. CT scan was unremarkable save for expected postsurgical changes. The patient failed conservative treatment. Considering a possible sympathetically-mediated pain, we performed a right lumbar sympathetic block that improved his pain. Conclusions: A lumbar sympathetic block can be used a salvage therapy when conservative management fails. Materials and Methods Patient informed consent was obtained for submission of the case report.
目的:下肢神经损伤是前列腺切除术的常见并发症。腰交感神经阻滞是一种公认的治疗交感神经介导的下肢疼痛的方法。我们报告了一例股骨分布的双侧下肢疼痛,该疼痛在机器人辅助前列腺切除术后发生,并在腰交感神经阻滞后缓解。病例报告:一名69岁男性患者在顺利进行机器人辅助腹腔镜前列腺切除术一个月后,股神经分布出现双侧大腿疼痛。除了预期的术后变化外,CT扫描并不显著。该病人未经保守治疗。考虑到可能是交感神经介导的疼痛,我们进行了右腰部交感神经阻滞,改善了他的疼痛。结论:当保守治疗失败时,腰交感神经阻滞可作为抢救性治疗。材料和方法提交病例报告需征得患者知情同意书。
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引用次数: 0
An Accidental Arterial Puncture and Anticoagulation after Internal Jugular Vein Catheterization Resulting in Massive Hematoma and Airway Compromise 颈内静脉置管后意外动脉穿刺和抗凝导致大量血肿和气道损伤
Pub Date : 2018-12-31 DOI: 10.23937/2377-4630/1410069
R. Kurt, H. Till, P. Tobias, H. Alkadhi, R SpahnDonat
Central Venous Catheterization is a common procedure in daily clinical practice. The internal jugular, subclavian and the femoral veins are the most frequently catheterized central veins. Pneumothorax, hematothorax, arterial puncture, hematoma, nerve lesions, damage to the left thoracic duct, and air embolism are among the main mechanical complications. Nowadays, there are two techniques in daily clinical use: the traditional technique and the ultrasound guided technique. The traditional technique relies on the use of anatomical landmarks, but the failure rate is higheven in experienced hands. Furthermore, several different complications range from mechanical problems (5-19% of cases) to infections and thrombotic events (2-26%). There is compelling evidence that ultrasound-guided CVC insertion via the internal jugular veins is associated with higher success rates and fewer mechanical complications compared with the traditional techniques based on external anatomical landmarks. We report a clinical case of 76-years-old female patient requiring urgent placement of a central venous catheter and unrecognized arterial puncture and subsequent heparin overdose with nearly fatal outcome. eral venous access, administration of parenteral nutrition, vascular access in patients whose peripheral veins are difficult to catheterize, and procedures that require access to large-caliber vessels [1]. The central vessels that are most frequently catheterized are the internal jugular, subclavian, and femoral veins. The traditional CVC insertion technique relies on the use of anatomical landmarks rather than ultrasound guidance. But even in experienced hands, the traditional technique is associated with a high failure rate and several complications ranging from mechanical problems (5-19% of cases) to infections and thrombotic events (2-26%) [1-4]. Pneumothorax, hematothorax, arterial puncture, hematoma, nerve lesions, damage to the left thoracic duct, and air embolism are among the main mechanical complications [5]. The incidence of complications increase 6-fold after the third insertion attempt [1]. Other risk factors that are known to increase the incidence of complications are an inexperienced operator, the presence of anatomical variants as well as co-existing medical conditions such as clotting disorders, pulmonary emphysema, hypovolemia, or difficulties related to conditions under which the procedure is performed (i.e. an emergency) [5]. CASe RePoRT
中心静脉置管是临床上常见的一种方法。颈内静脉、锁骨下静脉和股静脉是最常见的导管中心静脉。胸腔积液、血胸、动脉穿刺、血肿、神经损伤、左胸导管损伤和空气栓塞是主要的机械并发症。目前,临床上常用的技术有两种:传统技术和超声引导技术。传统的技术依赖于解剖标志的使用,但即使在经验丰富的手上,失败率也很高。此外,几种不同的并发症包括机械问题(5-19%的病例)、感染和血栓事件(2-26%)。有令人信服的证据表明,与基于外部解剖标志的传统技术相比,超声引导下经颈内静脉插入CVC具有更高的成功率和更少的机械并发症。我们报告了一例76岁女性患者的临床病例,该患者需要紧急放置中心静脉导管,并进行未经识别的动脉穿刺,随后肝素过量,结果几乎致命。外静脉通路、给予肠外营养、外周静脉难以插管的患者的血管通路,以及需要进入大口径血管的手术[1]。最常插入导管的中心血管是颈内静脉、锁骨下静脉和股静脉。传统的CVC插入技术依赖于解剖标志的使用,而不是超声引导。但即使在经验丰富的手上,传统技术也会导致高失败率和多种并发症,从机械问题(5-19%的病例)到感染和血栓事件(2-26%)[1-4]。胸腔积液、血胸、动脉穿刺、血肿、神经损伤、左胸导管损伤和空气栓塞是主要的机械并发症[5]。第三次插入后并发症的发生率增加了6倍[1]。已知会增加并发症发生率的其他风险因素包括缺乏经验的操作员、解剖变异的存在以及共存的医疗状况,如凝血障碍、肺气肿、低血容量或与手术条件相关的困难(即紧急情况)[5]。现金RePoRT
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引用次数: 1
Dexmedetomidine Infusion an Effective Intra-Operative Medication for Patients Undergoing Laparoscopic Cholecystectomy 右美托咪定输注是腹腔镜胆囊切除术患者术中有效的药物
Pub Date : 2018-12-31 DOI: 10.23937/2377-4630/1410083
Jan Summaira, A. Tawheed, R. Saima
Background: Laparoscopic surgeries involves creation of pneumo-peritoneum with insufflation of gas usually CO2 thereby increasing intra-abdominal pressure. The Intra-abdominal pressure above 10 mmHg causes adverse hemodynamic changes. Various agents have been used to attenuate these adverse effects. Dexmedetomidine alpha-2 agonist has sedative, sympatholytic, analgesic and anxiolytic properties and used in laparoscopic cholecystectomies for attenuation of adverse hemodynamic changes and to maintain hemodynamic stability. Material and methods: 60 patients of ASA 1-2 undergoing elective laparoscopic cholecystectomy were randomly allotted to two groups. Each group consists of 30 patients. Group 1 patients received dexmedetomidine infusion @0.2 microgram/kg/hour and group 2 patients received normal saline @0.2 microgram/kg/hour after intubation. The medication was stopped at the end of peritoneal deflation. Intraoperative hemodynamic stability was assessed by monitoring heart rate and Mean arterial pressure. Results: In Dexmedetomidine group, the haemodynamic response was significantly attenuated. Conclusion: Dexmedetomidine infusion in the dose of 0.2 μg/kg/hour effectively attenuates haemodynamic stress response to pneumo-peritoneum during laparoscopic surgery.
背景:腹腔镜手术包括通过注入气体(通常是CO2)来产生气腹,从而增加腹内压力。超过10mmHg的腹腔内压力会引起不利的血液动力学变化。已经使用了各种药剂来减轻这些不良影响。右美托咪定α-2激动剂具有镇静、解交感神经、镇痛和抗焦虑的特性,用于腹腔镜胆囊切除术,以减轻不良的血液动力学变化并保持血液动力学稳定性。材料与方法:将60例ASA 1~2型择期腹腔镜胆囊切除术患者随机分为两组。每组30名患者。第1组患者在插管后接受右美托咪定0.2微克/kg/小时输注,第2组患者在0.2微克/kg/h输注生理盐水。腹膜放气结束时停止用药。通过监测心率和平均动脉压来评估术中血液动力学的稳定性。结果:右美托咪定组的血液动力学反应明显减弱。结论:剂量为0.2μg/kg/h的右美托咪定可有效减轻腹腔镜手术中气腹引起的血液动力学应激反应。
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引用次数: 1
Interdisciplinary Anesthesia Tray Revision Project: Reducing the Opportunity for Human Error 跨学科麻醉托盘修订项目:减少人为错误的机会
Pub Date : 2018-06-30 DOI: 10.23937/2377-4630/1410067
Kl Smith, C. Sharp, E. Smith, M. Currie, K. Hall, T. Vu, M. Lee, R. L. Cooper
Background: Medication errors cause an estimated 100,000 to 400,000 patient deaths in the United States annually (IOM). Previous reviews on this alarming statistic consistently identify human error as the most common etiology. The potential for medication errors is especially high risk in the operating suite, where the provider simultaneously selects, doses and verifies medications to be administered to patients. Additionally, a lack of standardization and error reduction strategies in this setting creates the environment for medication administration errors, prompting multiple recommendations for interventions to minimize human error. Methods: This project took place in three phases. In the Evaluation phase, evidence-based literature on anesthesia medication safety practices were evaluated, and high-risk/ look-alike, sound-alike medications on anesthesia medication trays were identified. In the Standardization phase, the interdisciplinary team developed strategies to organize the medication trays to improve safety. These standardized strategies were executed throughout the anesthesia mediation trays in the final Implementation phase. Results: A total of eight-three changes were made to the anesthesia medication trays. Sixty medications were removed, with an average of ten removals per tray. High risk medications were replaced with unit-of-use or ready-to-use syringes when possible, with an average of four replacements per tray. The greatest number of medication tray changes was in the trauma operating suite with a total of twenty-eight. Conclusions: Numerous opportunities were identified to decrease the potential for human error by standardizing anesthesia medication trays with a focus on optimizing medication safety. Organization and standardization of anesthesia medication trays is an economical strategy to decrease opportunity for human error in the operating suite that requires minimal capital outlay. Although previous studies have recommended strategies and technologies to improve medication safety in the operating suites; these interventions have yet to be implemented. Our unique study demonstrates successful intervention implementation.
背景:在美国,每年估计有10万到40万患者因用药错误而死亡(IOM)。先前对这一令人震惊的统计数据的评论一致认为,人为错误是最常见的病因。在手术室中,药物错误的潜在风险尤其高,因为提供者同时选择、剂量和验证要给患者的药物。此外,在这种情况下,缺乏标准化和减少错误的策略创造了药物管理错误的环境,促使多种干预措施的建议,以尽量减少人为错误。方法:本研究分三个阶段进行。在评估阶段,对麻醉用药安全实践的循证文献进行评估,并确定麻醉用药托盘上的高风险/相似、相似药物。在标准化阶段,跨学科团队制定了组织药物托盘以提高安全性的策略。在最后实施阶段,这些标准化策略在整个麻醉调解托盘中执行。结果:共更换麻醉药盘83次。取出60种药物,平均每托盘取出10种。在可能的情况下,将高风险药物替换为使用单位注射器或即用型注射器,平均每个托盘更换四次。更换药物托盘次数最多的是创伤手术室,共28次。结论:通过标准化麻醉药物托盘,重点是优化用药安全,确定了许多机会来减少人为错误的可能性。麻醉药物托盘的组织和标准化是一种经济的策略,可以减少手术室中人为错误的机会,这需要最小的资本支出。虽然以前的研究已经推荐了改善手术室用药安全的策略和技术;这些干预措施尚未得到实施。我们独特的研究证明了干预措施的成功实施。
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引用次数: 3
Sevoflurane but not Propofol Induces Immunomodulatory Effects in Patients Undergoing Aortic Valve Replacement and Cardiopulmonary Bypass 七氟醚而非异丙酚诱导主动脉瓣置换术和体外循环患者的免疫调节作用
Pub Date : 2018-06-30 DOI: 10.23937/2377-4630/1410068
Veiras Sonia, G. R. Rodríguez, S. Tomás, R. Javier, Baluja Aurora, A. Julian
Background: Volatile anaesthetics, most of all sevoflurane, have been described as providers of myocardial preconditioning, but few articles are focused on immunomodulatory effects of these agents. We aimed to study the effects of different anaesthetic procotols with sevoflurane and propofol on immunomodulation in patients undergoing cardiopulmonary bypass (CBP). Methods: Twenty-five patients scheduled for aortic valve replacement undergoing CBP were studied and divided in three groups depending on anaesthetic protocol: sevoflurane for induction, maintenance and CBP period (group 1); propofol for induction, maintenance and CBP period (group 2); propofol for induction and CBP period and sevoflurane for maintenance before and after CBP (group 3). Blood samples were obtained at baseline, immediately after sternal closure, 24 hours, 72 hours and 7 days after surgery. TLR2 and TLR4 expression were measured in monocytes and lymphocytes, and serum levels of tumoral necrosis factor α (TNFα), Cystatin C, Reactive C Protein (PCR), Propeptide Brain Natriuretic Protein (Pro-BNP) and Interleukin (IL) 6, IL-2R and IL-8 were analyzed. Conclusions: Compared with propofol, sevoflurane anaesthesia was associated to lower expression of TLR2 in monocytes and lower serum levels of inflammatory mediators.
背景:挥发性麻醉剂,主要是七氟醚,被描述为心肌预处理的提供者,但很少有文章关注这些药物的免疫调节作用。我们的目的是研究七氟醚和异丙酚不同麻醉方案对体外循环(CBP)患者免疫调节的影响。方法:选取25例主动脉瓣置换术行CBP的患者为研究对象,根据麻醉方案分为三组:七氟醚用于诱导、维持和CBP周期(1组);异丙酚用于诱导、维持和CBP期间(组2);异丙酚用于诱导和CBP期间,七氟醚用于CBP前后的维持(组3)。分别于基线、关闭胸骨后立即、术后24小时、72小时和7天采集血样。检测TLR2和TLR4在单核细胞和淋巴细胞中的表达,分析血清肿瘤坏死因子α (TNFα)、胱抑素C、反应C蛋白(PCR)、前肽脑利钠蛋白(Pro-BNP)和白细胞介素(IL) 6、IL- 2r、IL-8的水平。结论:与异丙酚相比,七氟醚麻醉可降低单核细胞中TLR2的表达,降低血清炎症介质水平。
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引用次数: 0
Acute Pain Management in a Child: A Case Report of 46-Days of Popliteal Sciatic Nerve Catheter 儿童急性疼痛的处理:46天腘窝坐骨神经导管1例报告
Pub Date : 2018-06-30 DOI: 10.23937/2377-4630/1410063
Laurent Hertz, C. Sola, P. D. L. Arena, C. Dadure
Background: The use of perineural catheter for more than 72 hours is rare in perioperative practice, but was especially reported for chronic pain, oncologic related pain or palliative care. The main concern remains the risk of neurological or infectious complication. No guideline clearly specifies the maximum duration of perineural catheter maintenance and the safety of long-term catheters is discussed. Case report: We described the case of an 11-year-old boy who suffered a serious injury on his foot. An ultrasound guided sciatic nerve block was performed, with placement of a non-tunneled perineural catheter. The catheter could be used for 46 days with an excellent efficiency both for analgesia (continuous infusion) and anesthesia (additional bolus for surgical procedure). No infectious or neurological related complication to regional anesthesia was notified. Conclusion: This case demonstrates all the benefits that can be expected by long-term perineural catheter, even if it should be managed with great caution and after careful assessment of the risk-benefit balance. number of days before removal of the catheter with an increased risk after 3 days of catheter maintenance [2]. But only few transient and no major neurologic complications were reported [2]. In pediatric, PNBC are often used for postoperative analgesia after orthopedic or general surgery and are typically removed after only 2-3 days. Long term used of PNBC have yet been described for control of chronic pain, oncologic related pain or palliative care in young adults and children [3-5]. We present the case of a child who required the use of a PNBC over a long period of 46 days for perioperative pain management. The child and his family consented to the anonymous publication of this case. Description of the Case An 11-years-old boy, weighting 38 kg, without medical or surgical history, was admitted to our unit after a motor vehicle-pedestrian trauma. The child presented a faciocranial trauma with an initial loss of consciousness but a Glasgow score of 14 at the arrival of medical assistance. A fracture of the right horizontal branch of the mandibular corpus was diagnosed and treated by surgical osteosynthesis. Moreover, there was a severe injury with a large soft tissue defect extending from the internal malleolus to the second phalangeal of the right hallux and musculotendinous and osseous exposure. No vascular compromise was noted and the limited initial neurological exam was not able to objectify significant nerve injury or deficit. The patient complained of diffuse pain. However, shocked by the accident, it was not possible to assess the level of his pain. It was decided to treat him by sedation-analgesia with ketamine. Surgical CASe RePoRt
背景:围手术期使用神经导管超过72小时的情况很少见,但在慢性疼痛、肿瘤相关疼痛或姑息治疗中尤其有报道。主要关注的仍然是神经系统或感染性并发症的风险。没有明确规定会阴导管维护的最长持续时间的指南,也没有讨论长期导管的安全性。病例报告:我们描述了一个11岁男孩的案例,他的脚受了重伤。在超声引导下进行坐骨神经阻滞,并放置非隧道式神经导管。该导管可使用46天,在镇痛(持续输注)和麻醉(外科手术的额外推注)方面都具有良好的效率。未报告区域麻醉的感染性或神经系统相关并发症。结论:该病例证明了长期神经导管可以预期的所有益处,即使应该非常谨慎地进行管理,并在仔细评估风险-收益平衡后进行管理。移除导管前的天数,导管维护3天后风险增加[2]。但仅报告了少数短暂性神经系统并发症,且无重大神经系统并发症[2]。在儿科,PNBC通常用于骨科或普通外科手术后的术后镇痛,通常仅在2-3天后取出。PNBC的长期使用尚未被描述用于控制年轻成人和儿童的慢性疼痛、肿瘤相关疼痛或姑息治疗[3-5]。我们介绍了一个需要在46天的长时间内使用PNBC进行围手术期疼痛管理的儿童的案例。孩子和他的家人同意匿名公布这一案件。病例描述一名11岁男孩,体重38公斤,无病史或手术史,因机动车行人受伤入院。这名儿童出现了面颅创伤,最初失去意识,但在医疗救助到达时,格拉斯哥评分为14。诊断和治疗了一例下颌骨右侧水平支骨折。此外,还有一个严重的损伤,从内踝延伸到右拇第二指骨的大的软组织缺损,以及肌肉腱和骨暴露。没有发现血管损伤,有限的初步神经检查无法客观化显著的神经损伤或缺损。病人抱怨弥漫性疼痛。然而,由于对事故感到震惊,无法评估他的疼痛程度。决定用氯胺酮进行镇静镇痛治疗。外科病例RePoRt
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引用次数: 1
Transient Unilateral Lower Limb Palsy after Open Surgery Thoraco-Abdominal Aorta Repair 胸腹主动脉修补术后短暂性单侧下肢麻痹
Pub Date : 2018-06-30 DOI: 10.23937/2377-4630/1410066
Corazzi Francesco, Brusa Stefania, G. Enrico, Civilini Efrem, Poletto Luca, R. Ferdinando
Paraplegia is one of the most devastating complication after Thoraco-abdominal Aorta (TAA) repair both in open surgery and in endovascular procedure, caused by critical obstruction to blood perfusion of the Spinal Cord. Spinal Cord Ischemia (SCI) may be due to hemodynamic impairment and/or to segmental artery occlusion during aortic clamping [1,2]. We report a case of chronically dissected Thoraco-abdominal Aortic Aneurysm (TAAA) which showed unilateral transient neurological impairment of the left lower limb, postoperatively.
截瘫是胸腹主动脉(TAA)修复术后最具破坏性的并发症之一,无论是在开放手术还是血管内手术中,都是由脊髓血液灌注的严重阻塞引起的。脊髓缺血(SCI)可能是由于血液动力学损伤和/或主动脉夹闭过程中的节段性动脉闭塞[1,2]。我们报告了一例慢性剖切的胸腹主动脉瘤(TAAA),术后表现为单侧短暂性左下肢神经损伤。
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引用次数: 0
Analyzing Volatile Anesthetic Consumption by Auditing Fresh Gas Flow: An Observational Study at an Academic Hospital. 通过审计新鲜气体流量分析挥发性麻醉剂的消耗:一项学术医院的观察研究。
Pub Date : 2018-01-01 Epub Date: 2018-04-26 DOI: 10.23937/2377-4630/1410064
Luis Tollinche, KaySee Tan, Austin Han, Leslie Ojea, Cindy Yeoh

Background: In a climate of cost containment, it is critical to analyze and optimize all perioperative variable costs. Fresh gas flow is one important variable that determines utilization of inhalational agents and can be tightly controlled by the anesthesia provider. Manufacturers of inhalational agents have recommendations for minimum gas flow for their respective agents. Any gas flow above these recommendations is considered misuse and leads to unnecessary expense. The purpose of this study was to characterize and quantify the excess use of inhalational agents by analyzing fresh gas flow rates for long duration cases.

Methods: Over a span of three months, operating room records were analyzed for all procedures lasting greater than 4 hours. End tidal inhalation agent percentage for Sevoflurane and Isoflurane and fresh gas flows were analyzed. 303 unique patients with at least 4 hours of anesthesia time were included. Analysis excluded the first and last 30 minutes of all anesthetics to account for need for higher gas flows during induction/emergence of anesthesia. 152 patients received sevoflurane alone. 33 patients received isoflurane alone. 107 patients received both isoflurane and sevoflurane and were included in sevoflurane group given the higher gas flow needs of sevoflurane. 11 patients received neither agent and were excluded from analysis. We proceed with n = 292 unique patients. (259 in Sevo, 33 in iso) We used the two-sided one sample t-test setting 2 ml/min as the null for sevo and 1 ml/min as the null for iso; we ran analysis using a nonparametric test that didn't require the fresh gas flow to be normally distributed - the two-sided one-sample Wilcoxon rank-sum test: p value = < 0.0001.

Results: The results of our study revealed a sevoflurane (n = 259) mean fresh gas flow (L/min) 2.55 (95% CI, 2.45-2.66) - significantly different from null of 2 ml/min (p < 0.0001). Isoflurane (n = 33) mean fresh gas flows (L/min) 2.33 (95% CI, 2.00-2.66) - significantly different from null of 1 l/min (p < 0.0001).

Conclusion: Manufacturer recommendation for sevoflurane is to maintain gas flows 1-2 l/min and Isoflurane at above 1 l/min. Given these recommendations, the anesthesia providers delivered fresh gas flows at least 28% higher than necessary for sevoflurane and at least 130% greater than necessary for isoflurane anesthetics that lasted greater than 4 hours. This is an area where cost reduction can be readily achieved. Future plans to realize a reduction in inhalational agent utilization include education of the benefits of fresh gas flow and instituting a low fresh gas flow policy.

背景:在成本控制的环境下,分析和优化所有围手术期可变成本是至关重要的。新鲜气体流量是决定吸入性药物使用的一个重要变量,可以由麻醉提供者严格控制。吸入剂的制造商对各自药剂的最小气体流量有建议。任何超过这些建议的气体流量都被认为是误用,并导致不必要的费用。本研究的目的是通过分析长期病例的新鲜气体流速来表征和量化吸入性药物的过量使用。方法:对3个月来所有手术时间超过4小时的手术室记录进行分析。末端潮汐吸入剂对七氟醚和异氟醚的吸收率及新鲜气体流量进行了分析。303例患者麻醉时间至少为4小时。分析排除了所有麻醉药的最初和最后30分钟,以解释麻醉诱导/出现期间需要更高的气体流量。152例患者单独使用七氟醚。33例患者单独使用异氟醚。107例患者同时使用异氟醚和七氟醚,由于七氟醚的气体流量需求较高,被纳入七氟醚组。11例患者未接受任何药物治疗,并被排除在分析之外。我们继续研究n = 292例独特的患者。(259在Sevo中,33在iso中)我们使用双侧单样本t检验设置2ml /min为零,1ml /min为零。我们使用不要求新鲜气体流量为正态分布的非参数检验进行分析,即双侧单样本Wilcoxon秩和检验:p值= < 0.0001。结果:我们的研究结果显示,七氟醚(n = 259)的平均新鲜气体流量(L/min)为2.55 (95% CI, 2.45-2.66),与零值2 ml/min有显著差异(p < 0.0001)。异氟烷(n = 33)平均新鲜气体流量(L/min) 2.33 (95% CI, 2.00-2.66) -与零值1 L/min显著不同(p < 0.0001)。结论:七氟醚的推荐气量为1-2 l/min,异氟醚的推荐气量为1 l/min以上。考虑到这些建议,麻醉提供者提供的新鲜气体流量比持续时间超过4小时的七氟醚麻醉至少高28%,比异氟醚麻醉至少高130%。这是一个很容易实现成本降低的领域。未来实现减少吸入剂使用的计划包括教育新鲜气体流量的好处和制定低新鲜气体流量政策。
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引用次数: 7
期刊
International journal of anesthetics and anesthesiology
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