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International journal of cancer research最新文献

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Inhibitory Effect of Lentils, Green Split and Yellow Peas (Sprouted and Non-sprouted) on Azoxymethane-induced Aberrant Crypt Foci in Fisher 344 Male Rats 小扁豆、绿裂豆和黄豆(发芽和未发芽)对偶氮甲烷诱导的Fisher 344雄性大鼠异常隐窝灶的抑制作用
International journal of cancer research
Pub Date : 2014-01-01 DOI: 10.3923/IJCR.2014.27.36
K. Busambwa, R. L. Miller-Ceb, L. Aboagye, L. Dalrymple, J. Boateng, L. Shackelfor, L. Walker, M. Verghese
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引用次数: 5
Effect of Catha edulis on the Activities of Enzyme Markers of Carcinogenicity in Chemically-induced Hepatocellular Carcinoma in Rabbits 毛竹对兔化学诱导肝细胞癌致癌性酶标志物活性的影响
International journal of cancer research
Pub Date : 2014-01-01 DOI: 10.3923/IJCR.2014.1.13
Haider Al-Mamary, Amina El-Shaiban, M. Al-Habori, A. Al-Meeri, A. Al-zubairi, M. Al-Mamary
{"title":"Effect of Catha edulis on the Activities of Enzyme Markers of Carcinogenicity in Chemically-induced Hepatocellular Carcinoma in Rabbits","authors":"Haider Al-Mamary, Amina El-Shaiban, M. Al-Habori, A. Al-Meeri, A. Al-zubairi, M. Al-Mamary","doi":"10.3923/IJCR.2014.1.13","DOIUrl":"https://doi.org/10.3923/IJCR.2014.1.13","url":null,"abstract":"","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"51 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74738221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Role of Serum Osteopontin Level as a Diagnostic Biomarker for Early Hepatocellular Carcinoma 血清骨桥蛋白水平在早期肝细胞癌诊断中的作用
International journal of cancer research
Pub Date : 2014-01-01 DOI: 10.3923/IJCR.2014.37.45
M. Abdelhami, E. DohaEl-Sayed, N. Omar
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引用次数: 6
Significance of Immunohistochemical Expression of Fascin and Caveolin-1 in Non Small Cell Lung Cancer 非小细胞肺癌中fastin和Caveolin-1免疫组化表达的意义
International journal of cancer research
Pub Date : 2014-01-01 DOI: 10.3923/IJCR.2014.14.26
N. Osman, S. Hini, S. E. Elwany, Mohamed A. Ibrahie
{"title":"Significance of Immunohistochemical Expression of Fascin and Caveolin-1 in Non Small Cell Lung Cancer","authors":"N. Osman, S. Hini, S. E. Elwany, Mohamed A. Ibrahie","doi":"10.3923/IJCR.2014.14.26","DOIUrl":"https://doi.org/10.3923/IJCR.2014.14.26","url":null,"abstract":"","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"74 1","pages":"14-26"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80609918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Apoptotic Effect of Wortmannolone on Cancer Cells through Potent ROS Induction. 沃曼诺酮通过活性氧诱导癌细胞凋亡的作用。
International journal of cancer research
Pub Date : 2013-11-01
Ulyana Muñoz Acuña, Nighat Fatima, Safia Ahmed, Leng Chee Chang, Esperanza J Carcache de Blanco

Nuclear factor κappa-B inhibitors isolated from natural sources that induce apoptosis are promising new agents with anticancer properties. Wortmannin and wortmannolone were isolated from endophytic fungus (Penicillum polonicum) and showed NF-κB inhibitory effects with inhibitory concentration (IC50) of 0.47 μM and 2.06 μM for wortmannin and wortmannolone, respectively. The activity was compared with rocaglamide (IC50=0.075 μM). The mechanism through which wortmannin and wortmannolone exhibited an attenuating effect on the NF-κB pathway was further evaluated in this study. Wortmannolone showed significant reactive oxygen species (ROS) inducing effects in HeLa cervical cells. The ROS inducing effect was concentration dependent, and the ROS generating activity was comparable with daunomycin, a potent chemotherapeutic agent. The findings suggested that the elevated formation of ROS was partially involved in the induction of apoptosis in treated cells. Potent cytotoxic and apoptotic effects were also displayed in MDA-MB-231 hormone independent breast cancer cells when treated with wortmannolone (IC50=3.79 nM). Thus, wortmannolone, a furanosteroid from an endophytic fungus, is a promising agent for further drug development.

从天然来源分离的核因子κappa-B抑制剂具有诱导细胞凋亡的作用，是一种很有前景的新型抗癌药物。Wortmannin和wortmannolone从内生真菌青霉菌(penicium polonicum)中分离得到，对NF-κB具有抑制作用，抑制浓度(IC50)分别为0.47 μM和2.06 μM。与rocaglamide进行活性比较(IC50=0.075 μM)。本研究进一步探讨了wortmannin和wortmannolone对NF-κB通路的衰减作用机制。沃特曼诺酮对HeLa宫颈细胞有明显的活性氧诱导作用。活性氧诱导作用具有浓度依赖性，活性氧生成活性与强效化疗药物道诺霉素相当。结果提示，ROS的形成升高部分参与了处理细胞凋亡的诱导。沃曼诺酮对MDA-MB-231不依赖激素的乳腺癌细胞也显示出强大的细胞毒和凋亡作用(IC50=3.79 nM)。因此，从内生真菌中提取的呋喃甾体wortmannolone是一种有前途的药物开发剂。
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引用次数: 0
Proliferative Inhibition and Apoptotic Mechanism on Human Non-small-cell Lung Cancer (A549 Cells) of a Novel Cucurbitacin from Wilbrandia ebracteata Cogn 新型葫芦素对人非小细胞肺癌(A549细胞)的增殖抑制及凋亡机制研究
International journal of cancer research
Pub Date : 2013-02-01 DOI: 10.3923/IJCR.2013.54.68
I. T. Silva, M. R. Teixeira, K. L. Lang, T. R. Guimarães, S. E. Dudek, F. Durán, S. Ludwig, M. Caro, E. Schenkel, C. Simões
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引用次数: 5
The p.Pro47Ser Polymorphism of TP53: A Systematic Review TP53的p.Pro47Ser多态性:一个系统综述
International journal of cancer research
Pub Date : 2013-01-01 DOI: 10.3923/IJCR.2013.1.8
N. Chandel, A. Chauhan, K. Guleria
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引用次数: 2
Cytoprotective Effect and Antioxidant Properties of Silymarin on Cisplatin Induced Hepatotoxicity in Rats: A Biochemical and Histochemical Study 水飞蓟素对顺铂致大鼠肝毒性的细胞保护作用和抗氧化作用:生化和组织化学研究
International journal of cancer research
Pub Date : 2013-01-01 DOI: 10.3923/IJCR.2013.9.23
N. S. Abouzeinab
{"title":"Cytoprotective Effect and Antioxidant Properties of Silymarin on Cisplatin Induced Hepatotoxicity in Rats: A Biochemical and Histochemical Study","authors":"N. S. Abouzeinab","doi":"10.3923/IJCR.2013.9.23","DOIUrl":"https://doi.org/10.3923/IJCR.2013.9.23","url":null,"abstract":"","PeriodicalId":90856,"journal":{"name":"International journal of cancer research","volume":"45 1","pages":"9-23"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87009216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Goyazensolide Induces Apoptosis in Cancer Cells in vitro and in vivo. 戈雅唑内酯诱导体外和体内癌细胞凋亡
International journal of cancer research
Pub Date : 2013-01-01 DOI: 10.3923/ijcr.2013.36.53
Ulyana Muñoz Acuña, Qi Shen, Yulin Ren, Daniel D Lantvit, Jennifer A Wittwer, A Douglas Kinghorn, Steven M Swanson, Esperanza J Carcache de Blanco

As part of the screening program for anticancer agents from natural sources, the sesquiterpene lactone goyazensolide (GZL) was identified as a potent NF-κB inhibitor. The hollow-fiber assay was used to evaluate the anti-tumor efficacy of GZL in vivo. The mechanistic effects of GZL were evaluated in the HT-29 colonic cell line to reveal the pathway through which GZL exerts its effects. NF-κB subunits p65 and p50 were inhibited, and the upstream mediator IκB kinase (IKKβ) was downregulated in a dose-dependent manner. Apoptosis was mediated by caspase-3, and cell cycle arrest was detected in G1-phase. Consequently, 96% of the cell population was in sub G1-phase after treatment with GZL (10 μM).The antitumor effect of GZL was observed at a dose of 12.5 mg/kg. Cell adhesion was affected as a result of NF-κB inhibition. GZL appears to selectively target the transcription factor NF-κB. In summary, GZL sensitizes HT-29 colon cancer cells to apoptosis and cell death in a dose-dependent manner both in vivo and in vitro, through NF-κB inhibition (IC50 = 3.8 μM). Thus, it is a new potent lead compound for further development into a new effective chemotherapeutic agent.

作为天然抗癌剂筛选计划的一部分，倍半萜内酯戈雅唑内酯（GZL）被鉴定为一种有效的 NF-κB 抑制剂。研究人员利用空心纤维试验评估了 GZL 在体内的抗肿瘤功效。在HT-29结肠细胞系中评估了GZL的机理效应，以揭示GZL发挥效应的途径。NF-κB亚基p65和p50受到抑制，上游介质IκB激酶（IKKβ）以剂量依赖的方式下调。细胞凋亡由 Caspase-3 介导，细胞周期停滞在 G1 期。因此，经GZL（10 μM）处理后，96%的细胞处于亚G1期。NF-κB受到抑制后，细胞粘附性受到影响。GZL似乎选择性地靶向转录因子NF-κB。总之，GZL通过抑制NF-κB（IC50 = 3.8 μM），以剂量依赖的方式在体内和体外使HT-29结肠癌细胞凋亡和细胞死亡。因此，它是一种新的强效先导化合物，可进一步开发成新的有效化疗药物。
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引用次数: 0
Cortactin and EGFR Proteins Expression in Egyptian Patients with Non-small Cell Lung Carcinoma 埃及非小细胞肺癌患者表皮凝集素和EGFR蛋白的表达
International journal of cancer research
Pub Date : 2013-01-01 DOI: 10.3923/IJCR.2013.24.35
A. I. Fawzy, M. Gayyed, N. Tawfik
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引用次数: 1
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