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Neuromyelitis Optica in Behçet's Disease Successfully Treated with Radiographic MRI Regression: Case Report 影像学MRI回归治疗Behçet病视神经脊髓炎1例
Pub Date : 2017-08-31 DOI: 10.4172/2167-7921.1000250
B. Elnady, T. Elkhouly, M. Alshaar, Hawazen Alqahtani, M. Algethami, Abdulmajeed Algethami
Behcet's disease (BD) is a multisystem vasculitis of unknown origin that involves the parenchymal central nervous system (neuro-BD) in less than 10 percent of patients affecting both brain and spinal cord. We reported a rare case of 21-year-old male patient with NBD-myelitis in the form of neuromyelitis optica (NMO) which treated successfully with cyclophosphamide, with marvelous MRI radiographic regression as no disease activity was detected and the patient reported no adverse event, after six cyclophosphamide cycles, cervical MRI marked regression. This case may be an example for decision making and management in such rare cases.
白塞病(BD)是一种起源不明的多系统血管炎,在不到10%的同时影响大脑和脊髓的患者中涉及实质中枢神经系统(neuro-BD)。我们报告了一例罕见的21岁男性NBD脊髓炎患者,其表现为视神经脊髓炎(NMO),用环磷酰胺成功治疗,由于没有检测到疾病活动,患者报告没有不良事件,在六个环磷酰胺周期后,颈部MRI显着消退。这种情况可能是这种罕见情况下决策和管理的一个例子。
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引用次数: 1
Iatrogenic Resorption of a Mandibular Condyle Following 3rd Molar Wisdom Tooth Surgery 第三磨牙智齿术后下颌髁的医源性吸收
Pub Date : 2017-08-24 DOI: 10.4172/2167-7921.1000247
E. RussellVickers
Unilateral osteoarthritis of the mandibular condyle is typically associated with trauma to the temporomandibular joint from sports activities, falls and criminal assaults. In this unusual case the complete destruction of the condyle occurred after a long difficult extraction of a 3rd molar wisdom tooth in a young adult. Downward and lateral pressure from a dental forceps extraction that was applied anterior to the angle of the mandible, combined with the masseter muscle acting as the fulcrum resulted in rapid and complete resorption of the condyle. Clinical signs showed a marked deviation of the maxillary-mandibular incisal midline and formation of an open bite malocclusion on the unaffected side. There was a restricted oral opening, difficulty in chewing food and the patient was psychologically depressed. Acute pain management was achieved with a soft diet, heat applications and non-steroidal antiinflammatory drugs. Long term pain management strategies included an explanation of current surgical techniques of temporalis muscle flap advancement and joint prosthesis, and the future potential of the ‘stem cell in bioscaffold’ approach for joint regeneration in this young patient.
单侧髁突骨关节炎通常与运动、跌倒和犯罪袭击对颞下颌关节的创伤有关。在这种不寻常的情况下,年轻人在长时间艰难地拔除第三磨牙智齿后,髁突发生了完全破坏。下颌角前方的牙钳拔除产生的向下和侧向压力,加上咬肌作为支点,导致髁状突快速完全吸收。临床症状显示上下颌切迹中线明显偏离,未受影响一侧形成开放性咬合错牙合。口腔开放受限,咀嚼食物困难,患者心理抑郁。通过软性饮食、热敷和非甾体抗炎药实现了急性疼痛管理。长期疼痛管理策略包括解释目前颞肌瓣推进和关节假体的手术技术,以及“生物支架中的干细胞”方法在这名年轻患者关节再生方面的未来潜力。
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引用次数: 1
Implementation of Safety Standards in Saudi Arabian Scientific Laboratories: An Empirical Study 沙特阿拉伯科学实验室安全标准的实施:实证研究
Pub Date : 2017-08-24 DOI: 10.4172/2167-7921.1000249
Khaled M Alsubiaee, Mohammad S Alshahrani, Alnashmi B Alazmi, Rifca A Alsadoon
Background: Implementing safety procedures and precautions minimize the risk of exposure to toxic chemicals and costs of a consequence of a hazardous work environment. Therefore, the aim of this study is to measure the perception of safety standards implementation at different laboratories at the Kingdom of Saudi Arabia. Methods: A cross-sectional study use questionnaire consists of 25 questions. A total of 73 employees, researchers, and students participate in questionnaires distributed in Riyadh, Dammam and Abha cities on 2016, May 10th to June 5th. Results: The majority of participants is male, living in Riyadh, married and has an education higher than secondary school. The age of participants is 28 ± 5 years. Conclusion: The study shows variations in the implementation of security measures and standards at laboratories in three different cities in Saudi Arabia. The Large-scale longitudinal study is recommended for next research.
背景:实施安全程序和预防措施可将接触有毒化学品的风险和危险工作环境造成的成本降至最低。因此,本研究的目的是衡量沙特阿拉伯王国不同实验室对安全标准实施的看法。方法:横断面研究使用问卷由25个问题组成。2016年5月10日至6月5日,共有73名员工、研究人员和学生参加了在利雅得、达曼和阿布哈市分发的问卷调查。结果:大多数参与者是男性,居住在利雅得,已婚,受教育程度高于中学。参与者的年龄为28±5岁。结论:该研究显示,沙特阿拉伯三个不同城市的实验室在实施安全措施和标准方面存在差异。下一步研究建议采用大规模纵向研究。
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引用次数: 3
Are Brachiocephalic Atherosclerotic Plaques to be considered as Predictors of Myocardial Infarction in Rheumatoid Arthritis Patients 类风湿性关节炎患者的臂头动脉粥样硬化斑块是否可作为心肌梗死的预测因素
Pub Date : 2017-08-24 DOI: 10.4172/2167-7921.1000248
E. S. Stumberga, G. Krūmiņa, H. Mikažāne, S. Seņkāne, Liana Ziediana
Introduction: Carotid ultrasound based on assessment of intima media thickness (IMT) and presence of plaques has been considered to be a cheap and efficient way to measure clinical atherosclerosis. Both carotid IMT and carotid plaques have been proved to be good predictors of CV (cardiovascular) events of rheumatic patients, offering additional value to the traditional risk scores in the prediction of CVD (cardiovascular disease). The objective of the study was to determine whether atherosclerotic brachiocephalic plaques, traditional CV risk factors as well as RA (rheumatoid arthritis) disease activity have an effect on the risk of myocardial infarction in RA patients with comparable disease duration. Methods: A case control study was performed within the prospective cohort of 92 RA patients, out of them were female 81%, aged 40-84. In cases there were 20 patients who had developed their first myocardial infarction (MI) after the diagnosis of RA. The case and control groups were matched by sex and disease duration. RA activity and severity were determined by DAS28 scores and HAQ questionnaires, ultrasonography of synovitis. Information about traditional (BMI, smoking history, diabetes mellitus, primary arterial hypertension) and disease-specific risk factors was thoroughly gathered. AIP (atherogenic index of plasma (log10 TG/HDLC) was calculated. Brachiocephalic artery hemodynamic parameters, IMT and plaques were assessed using the high resolution B mode and Doppler–mode ultrasound. Results: Patients with MI (myocardial infarction) were older in comparison to control RA patients, mostly females (85%). The case and control groups were matched by disease duration and gender. One of the classic risk factors for 95% of patients with MI had been suffering from arterial hypertension (HTN). The odds ratio for MI patients with HTN was 12 (95% CI 1.5 to 95.4). Seropositivity, erosions and synovitis of small joints, joint replacement surgery was similar for case and control groups. Seropositivity was found in 95% of the case group. Despite that, RF (rheumatoid factor) was more presented in case group. High RA disease activity (DAS 28 above 5.1) was observed among 55% of patients with MI (p=0.007). The odds ratio for MI patients with a high disease activity (DAS 28>5.1) was 3.95 (95% CI 1.40 to 11.13). About 50% of cases were smokers. Smoking status, BMI, diabetes, atherogenix index did not differ between cases and controls. IMT (intima media thickness) dx et sin were age dependent, correlated with hemodinamicaly non-significant atherosclerotic plaques. Furthermore, atherosclerotic lesions were not more pronounced in RA patients with versus without CVD. Non-hemodinamicaly significant atherosclerotic plaques and IMT sin were associated with hypertensive disease. Conclusion: In our case-control study, MI was observed in older individuals RF positive, being positively associated with systolic arterial hypertension. Increased risk to MI was found in patients
引言:基于内膜-中膜厚度(IMT)和斑块存在评估的颈动脉超声被认为是测量临床动脉粥样硬化的一种廉价有效的方法。颈动脉IMT和颈动脉斑块已被证明是风湿病患者心血管事件的良好预测指标,为传统风险评分预测心血管疾病提供了额外的价值。本研究的目的是确定动脉粥样硬化性头臂斑块、传统CV风险因素以及RA(类风湿性关节炎)疾病活动是否对疾病持续时间相似的RA患者的心肌梗死风险有影响。方法:在92名RA患者的前瞻性队列中进行病例对照研究,其中81%为女性,年龄40-84岁。在病例中,有20名患者在诊断为RA后出现了第一次心肌梗死(MI)。病例组和对照组根据性别和疾病持续时间进行匹配。通过DAS28评分和HAQ问卷、滑膜炎超声检查来确定RA活动性和严重程度。全面收集有关传统(BMI、吸烟史、糖尿病、原发性动脉高压)和疾病特异性危险因素的信息。计算AIP(血浆动脉粥样硬化指数(log10TG/HDLC)。使用高分辨率B模式和多普勒模式超声评估腕头动脉血流动力学参数、IMT和斑块。结果:与对照RA患者相比,MI(心肌梗死)患者年龄较大,大多为女性(85%)。病例组和对照组根据疾病持续时间和性别进行匹配。95%的MI患者的典型危险因素之一是患有动脉高压(HTN)。MI患者合并HTN的比值比为12(95%CI 1.5至95.4)。病例组和对照组的血清阳性、小关节侵蚀和滑膜炎、关节置换手术相似。95%的病例组血清阳性。尽管如此,RF(类风湿因子)在病例组中的表现更多。在55%的MI患者中观察到高RA疾病活动性(DAS 28高于5.1)(p=0.007)。具有高疾病活动性的MI患者的比值比(DAS 28>5.1)为3.95(95%CI 1.40至11.13)。大约50%的病例是吸烟者。吸烟状况、BMI、糖尿病、动脉粥样硬化指数在病例和对照组之间没有差异。IMT(内膜-中膜厚度)dx和sin是年龄依赖性的,与血液学上不显著的动脉粥样硬化斑块相关。此外,有心血管疾病的RA患者与没有心血管疾病的患者相比,动脉粥样硬化病变并不更明显。非血液学显著的动脉粥样硬化斑块和IMT-sin与高血压疾病相关。结论:在我们的病例对照研究中,在RF阳性的老年人中观察到MI,与收缩性动脉高压呈正相关。在DAS 28高于5.1的高疾病活动性患者中发现MI风险增加。
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引用次数: 0
Consent for Treatment in the UK - 2017 Update 英国治疗同意书-2017年更新
Pub Date : 2017-07-20 DOI: 10.4172/2167-7921.1000E116
P. Lee, A. Davies, Bethan Whiting, S. Masud
Catering for all educational levels, ethnicities and ages with medical consent has always been difficult. There is a general consensus in the literature that there is a need for a review of treatment consent to ensure patient comprehension and satisfaction. In recent years, the medical profession has found an increase in the cost of litigation. Marino et al. [1] highlighted that in Italy Trauma and Orthopaedics is the “most sued” specialty and Kadakia et al. [2] showed that patients actually have very little understanding when questioned about their own trauma. The study found that less than half of the patients knew what bone they had fractured and less than 20% knew their recovery time. This suggests the need for a reform in how patients are given information to ensure higher comprehension and satisfaction in surgical procedures. The General Medical Council [3], in “Good Medical Practice” 2013, detailed that exchange of information is key to good decision making and so how are patients expected to make informed decisions when they do not know the information? A recent supreme court judgement has altered the legal landscape in the consent process in the UK. The outcome of the Montgomery v Lanarkshire Health Board legal battle has become a landmark Scottish case and has had a profound effect on the British legal system as the judgment disseminated from the highest British court.
在征得医疗同意的情况下满足所有教育水平、种族和年龄的需求一直很困难。文献中普遍认为,有必要对治疗同意书进行审查,以确保患者的理解和满意度。近年来,医学界发现诉讼费用有所增加。Marino等人[1]强调,在意大利,创伤和骨科是“最受起诉”的专业,Kadakia等人[2]表明,当被问及自己的创伤时,患者实际上几乎没有理解。研究发现,不到一半的患者知道自己骨折了什么骨头,不到20%的患者知道他们的恢复时间。这表明有必要改革向患者提供信息的方式,以确保在外科手术中获得更高的理解力和满意度。美国医学总会[3]在2013年的“良好医疗规范”中详细说明了信息交流是良好决策的关键,因此,当患者不知道信息时,他们如何做出明智的决策?最高法院最近的一项判决改变了英国同意程序的法律格局。蒙哥马利诉拉纳克郡卫生委员会的法律诉讼结果已成为苏格兰一个具有里程碑意义的案件,并随着英国最高法院的判决的传播,对英国法律体系产生了深远影响。
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引用次数: 1
High Body Mass Index and its Effect on Total Knee Replacement 高体重指数及其在全膝关节置换术中的作用
Pub Date : 2017-07-14 DOI: 10.4172/2167-7921.1000245
A. Sobti, J. Sudhakar
Osteoarthritis (OA) is the leading cause of disability and knee OA alone affects over 250 million people worldwide [1]. Joint arthroplasty for knee is one of the most common elective and cost effective surgical intervention for end stage lower-limb arthritis [1]. The National Joint Registry (NJR) indicates that by the year 2030 the demand for total knee replacement (TKR) will be nearly 3.5 million cases. The current cost burden to the National Health Service (NHS) is enormous and its estimated to rise in excess of £7000 per case [2]. This will have a huge bearing on the already cash crushed health care system.
骨关节炎(OA)是导致残疾的主要原因,仅膝关节OA就影响了全球超过2.5亿人。膝关节置换术是治疗终末期下肢关节炎最常见且最具成本效益的手术干预方法之一。国家联合登记处(NJR)指出,到2030年,全膝关节置换术(TKR)的需求将接近350万例。目前,英国国家医疗服务体系(NHS)的成本负担非常沉重,据估计,每年每例病例的成本将超过7000英镑。这将对已经被现金压垮的医疗保健系统产生巨大影响。
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引用次数: 3
Steroids and Osteoarthritis 类固醇和骨关节炎
Pub Date : 2017-07-07 DOI: 10.4172/2167-7921.1000E115
C. Perkins, Bethan Whiting, P. Lee
Corticosteroids are used in the treatment of arthritis. Despite the differences in the aetiology of rheumatoid and osteoarthritis; joint pain, stiffness, swelling and deformity remain features of both conditions. These factors contribute to the disability of both conditions and impact patients’ quality of life [1]. Current management is focused on reducing joint pain and inflammation, whilst improving or maintaining joint function [2] Although not recommended as the first line treatment in rheumatoid or osteoarthritis, steroids have been used selectively in the management of these symptoms. Corticosteroids are used in combination with other treatments and in various preparations. Other injectable substances are available and is explained by Golding et al in this issue. For the purpose of this editorial we will focus on the use of injected corticosteroids.
皮质类固醇用于治疗关节炎。尽管类风湿和骨关节炎的病因不同;关节疼痛、僵硬、肿胀和畸形仍然是这两种情况的特征。这些因素导致两种情况的残疾,并影响患者的生活质量。目前的治疗重点是减轻关节疼痛和炎症,同时改善或维持关节功能[2]虽然不推荐作为类风湿或骨关节炎的一线治疗,但类固醇已被选择性地用于治疗这些症状。皮质类固醇与其他治疗方法和各种制剂联合使用。其他可注射的物质是可用的,并解释了Golding等人在这个问题。出于这篇社论的目的,我们将重点关注注射皮质类固醇的使用。
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引用次数: 4
Details of a Tendon–Sparing Posterior Approach in Hemiarthroplasty in the Treatment of Displaced Intracapsular Neck of Femur Fracture 保留腱的后入路在半关节成形术中治疗股骨颈囊内移位骨折的细节
Pub Date : 2017-06-20 DOI: 10.4172/2167-7921.1000243
P. Lee, J. Charity, J. Timperley
This paper details a tendon–sparing surgical technique allowing hemiarthroplasty through a posterior approach in all cases whilst preserving the Quadriceps coxa. The SPAIRE (Sparing Piriformis and Internus, Repair Externus) technique, described by Hanly et al. for routine use in total hip replacement, theoretically offers the functional benefits of the posterior approach with reduced risk of dislocation. It may also facilitate early mobilisation after hip fracture surgery with potential reduction in medical complications and mortality. In this study, we report our initial experience using the same SPAIRE technique for hemiarthroplasty to treat all patients with displaced intracapsular neck of femur fractures, irrespective of skeletal dimension and BMI. Our results suggest that the SPAIRE technique is feasible and safe to be used in all cases requiring hemiarthroplasty. Further research should be encouraged to investigate the role of the SPAIRE technique in fractured neck of femur surgery.
本文详细介绍了一种保留肌腱的手术技术,该技术允许在所有情况下通过后部入路进行半关节成形术,同时保留股四头肌-髋关节。Hanly等人描述的用于全髋关节置换术的SPAIRE(Sparing Piriformis and Internus,Repair Externus)技术在理论上提供了后入路的功能优势,降低了脱位风险。它还可以促进髋部骨折手术后的早期动员,从而潜在地降低医疗并发症和死亡率。在这项研究中,我们报告了我们使用相同的SPAIRE技术进行半关节成形术治疗所有股骨颈囊内移位骨折患者的初步经验,无论骨骼尺寸和BMI如何。我们的研究结果表明,SPAIRE技术在所有需要半关节成形术的病例中都是可行和安全的。应鼓励进一步研究SPAIRE技术在股骨颈骨折手术中的作用。
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引用次数: 0
Intra-articular Injections for Management of Knee Osteoarthritis 关节内注射治疗膝骨关节炎
Pub Date : 2017-05-20 DOI: 10.4172/2167-7921.1000242
D. Golding, James P. Brock, Bethan Whiting, P. Lee
Knee pain is an increasingly common presentation to general practitioners worldwide which is thought to be related to the obesity epidemic, an ageing population and increasingly sedentary lifestyles in more developed nations. Degenerative osteoarthritis (OA) accounts for the majority of presentations in older age groups and this has traditionally been treated with analgesia, lifestyle modifications and adjuncts such as physiotherapy, braces and insoles. All these therapies aim to delay the need of total knee replacement (TKR), which is often the end-point for severe knee OA. However, TKR is associated with poor levels of patient satisfaction, low functional outcomes and has recently been shown to have low levels of cost-effectiveness except in patients with severe disabling OA. Increasingly doctors are turning to intra-articular injections which can provide temporary pain relief such as corticosteroids, hyaluronic acid and platelet rich plasma. This article aims to review the current options for intraarticular injections, comment on their efficacy and suggest areas for future development.
膝关节疼痛在全世界的全科医生中越来越常见,这被认为与肥胖流行、人口老龄化和发达国家越来越久坐的生活方式有关。退行性骨关节炎(OA)在老年人群中占大多数,传统上通过镇痛、改变生活方式和辅助治疗(如物理治疗、牙套和鞋垫)来治疗。所有这些疗法的目的是延迟全膝关节置换术(TKR)的需要,这通常是严重膝关节OA的终点。然而,TKR与患者满意度低、功能预后低有关,最近的研究表明,除了严重致残性OA患者外,TKR的成本效益水平较低。越来越多的医生转向关节内注射,如皮质类固醇、透明质酸和富含血小板的血浆,这可以暂时缓解疼痛。本文旨在回顾目前关节内注射的选择,评论其疗效,并提出未来发展的领域。
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引用次数: 3
Rheumatoid Arthritis and Osteoporosis: A Case Study 类风湿关节炎和骨质疏松:一个案例研究
Pub Date : 2017-05-05 DOI: 10.4172/2167-7921.1000240
P. Raghavan
Metadichol® is a Nano emulsion of long-chain alcohols called as Policosanol and is present in foods such as rice, sugar cane, wheat, and peanuts. Metadichol® acts on Nuclear Vitamin D receptors (VDR) that are present in cells throughout the body to stimulate the immune system and inhibit a variety of disease processes, resulting from inflammation to infection [1]. We present a case study of a patient with Rheumatoid arthritis with the high levels of RF antibodies, CRP and ESR levels, and low bone mineral density leading to osteoporosis. The case report shows how Metadichol® by its actions on the VDR has affected key biomarkers and mitigated the disease conditions without any side effects. Also, his bone density improved dramatically. Metadichol® is safe because it consists of natural components of conventional foods and has no known adverse side effects. Its constituents are present in many foods that we consume every day. Metadichol® has the potential to serve as a novel, safe solution to help patients with RA and other autoimmune diseases that confront the world today.
Metadichol®是一种长链醇的纳米乳液,被称为多酚醇,存在于大米、甘蔗、小麦和花生等食品中。Metadichol®作用于存在于全身细胞中的核维生素D受体(VDR),以刺激免疫系统并抑制从炎症到感染[1]的各种疾病过程。我们报告一例类风湿关节炎患者,RF抗体、CRP和ESR水平高,骨密度低导致骨质疏松症。该病例报告显示了Metadichol®如何通过其对VDR的作用影响关键生物标志物并减轻疾病状况而没有任何副作用。此外,他的骨密度也显著提高。Metadichol®是安全的,因为它由传统食品的天然成分组成,没有已知的不良副作用。它的成分存在于我们每天食用的许多食物中。Metadichol®有潜力作为一种新的、安全的解决方案,帮助当今世界面临RA和其他自身免疫性疾病的患者。
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引用次数: 7
期刊
Journal of arthritis
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