Pub Date : 2016-07-18DOI: 10.4172/2167-7921.1000211
F. Liu, Han Xie, Weiguo Liang, Dongping Ye, Yicun Yao
Purpose: There are few studies compares surgery with proximal femoral nail antirotation (PFNA) in lateral decubitus with that in supine position about their advantages and disadvantages for patients with intertrochanteric femoral fractures. Previous studies reported conflicting findings. This meta-analysis was to compare the efficacy and safety of surgery with PFNA in different surgical positions. Methods: Relevant randomized controlled trials comparing surgery with PFNA in lateral decubitus with surgery in supine position for intertrochanteric fractures patients were included into this meta-analysis. Inclusion criteria of this meta-analysis were: randomized controlled trials comparing lateral decubitus with supine position for surgery for intertrochanteric fractures and reporting at least one of the main outcomes, including blood loss, operating time, hospital stay, and length of incision, Harris values and union time. Results: Six randomized controlled trials were finally included into this meta-analysis. Pooled results showed that there were less blood loss, less operation time, smaller incision and higher Harris values score in lateral decubitus group. Sensitivity analysis by sequential omission of individual studies showed the significance of weighted mean difference was robust, which suggested this outcome was credible. Conclusions: Surgery with PFNA in lateral decubitus can benefit intertrochanteric fractures patients with less blood loss, less operation time, shorter incision and high Harris values scores compared with surgery in supine position according to our research.
{"title":"A Meta-analysis Comparing Lateral Decubitus with Supine Position for Surgery for Intertrochanteric Fractures","authors":"F. Liu, Han Xie, Weiguo Liang, Dongping Ye, Yicun Yao","doi":"10.4172/2167-7921.1000211","DOIUrl":"https://doi.org/10.4172/2167-7921.1000211","url":null,"abstract":"Purpose: There are few studies compares surgery with proximal femoral nail antirotation (PFNA) in lateral decubitus with that in supine position about their advantages and disadvantages for patients with intertrochanteric femoral fractures. Previous studies reported conflicting findings. This meta-analysis was to compare the efficacy and safety of surgery with PFNA in different surgical positions. \u0000Methods: Relevant randomized controlled trials comparing surgery with PFNA in lateral decubitus with surgery in supine position for intertrochanteric fractures patients were included into this meta-analysis. Inclusion criteria of this meta-analysis were: randomized controlled trials comparing lateral decubitus with supine position for surgery for intertrochanteric fractures and reporting at least one of the main outcomes, including blood loss, operating time, hospital stay, and length of incision, Harris values and union time. \u0000Results: Six randomized controlled trials were finally included into this meta-analysis. Pooled results showed that there were less blood loss, less operation time, smaller incision and higher Harris values score in lateral decubitus group. Sensitivity analysis by sequential omission of individual studies showed the significance of weighted mean difference was robust, which suggested this outcome was credible. \u0000Conclusions: Surgery with PFNA in lateral decubitus can benefit intertrochanteric fractures patients with less blood loss, less operation time, shorter incision and high Harris values scores compared with surgery in supine position according to our research.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"5 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2016-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7921.1000211","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70834590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-07-11DOI: 10.4172/2167-7921.1000209
Ying Gao, X. Liu, Lanling Zhang, T. Xia, Dong-Bao Zhao
Academic productions by Chinese scholars have grown to the second place worldwide since 2009. However, little was known about Chinese academic contributions and influences on rheumatic diseases. In order to present a panorama of this field, a bibliometric analysis was performed based on data from two databases from 1987 to 2015. China has kept the third place in rheumatic diseases’ publications since 2013. Nevertheless, most of these articles came with low impact factors and infrequent citations. Multidisciplinary teams led by orthopedists and rheumatologists were being built. Most popular journals mainly focused on rheumatology, while journals about Chinese medicine were unpopular. Though on right tracks, to study rheumatic diseases well in China, efforts from all aspects are needed.
{"title":"Brief Report on Academic Productions on Rheumatic Diseases in China","authors":"Ying Gao, X. Liu, Lanling Zhang, T. Xia, Dong-Bao Zhao","doi":"10.4172/2167-7921.1000209","DOIUrl":"https://doi.org/10.4172/2167-7921.1000209","url":null,"abstract":"Academic productions by Chinese scholars have grown to the second place worldwide since 2009. However, little was known about Chinese academic contributions and influences on rheumatic diseases. In order to present a panorama of this field, a bibliometric analysis was performed based on data from two databases from 1987 to 2015. China has kept the third place in rheumatic diseases’ publications since 2013. Nevertheless, most of these articles came with low impact factors and infrequent citations. Multidisciplinary teams led by orthopedists and rheumatologists were being built. Most popular journals mainly focused on rheumatology, while journals about Chinese medicine were unpopular. Though on right tracks, to study rheumatic diseases well in China, efforts from all aspects are needed.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"2016 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2016-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70834550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-07-09DOI: 10.4172/2167-7921.1000207
P. Lee, James P. Brock, C. Woodford, A. Robertson
We report the clinical and radiological outcomes of acromioclavicular (AC) joint reconstructive surgery using Arthrex Dog Bone Button FibertapeConstruct. 33 Patients were identified between April 2013 and April 2015 who had undergone AC joint repair using the Dog Bone double Endobutton for Rockwood Grade III-V injuries. Radiological follow up was made by measuring coracoclavicular distance (CCD). Patients were clinically evaluated using DASH (Disabilities of Arm, Shoulder and Hand) and ASES (American Shoulder and Elbow Surgeons) scores. Radiologically there was a mean CCD reduction of 7.1 mm (n=26) and mean post-operative CCD of 13.1 (Normal range 11-13 mm) Clinically, the mean post-operative ASES was 89.4 (n=22) (Best score 100). A mean reduction of 50.5 was reported from pre to post-operative DASH scores, with a mean post-operative score of 12.5 (n=18) (Best score 0). One dislocation (due to a fall in the post-operative period) and one infection were reported. Arthroscopic stabilisation of AC joint using Arthrex Dog Bone Fibertape construct is minimally invasive and shows good anatomic restoration of the joint. Early clinical results are promising but more numbers and longer term follow up are needed.
我们报告使用Arthrex Dog Bone Button FibertapeConstruct进行肩锁关节重建手术的临床和影像学结果。在2013年4月至2015年4月期间，33例患者因Rockwood III-V级损伤，使用Dog Bone双Endobutton进行AC关节修复。通过测量喙锁骨距离(CCD)进行影像学随访。采用DASH(手臂、肩膀和手的残疾)和ASES(美国肩肘外科医生)评分对患者进行临床评估。影像学上平均CCD缩小7.1 mm (n=26)，术后平均CCD缩小13.1 mm(正常范围11-13 mm)。临床上，术后平均asa为89.4 (n=22)(最高评分为100)。术后DASH评分平均降低50.5分，术后平均评分12.5分(n=18)(最佳评分0分)。报告1例脱位(由于术后跌倒)和1例感染。关节镜下使用Arthrex Dog Bone Fibertape结构固定AC关节是微创的，并且显示了良好的关节解剖恢复。早期临床结果令人鼓舞，但需要更多的数据和更长期的随访。
{"title":"A Radiological and Clinical Evaluation of Acromioclavicular Joint Reconstruction Using Dog Bone Double Endobutton Technique","authors":"P. Lee, James P. Brock, C. Woodford, A. Robertson","doi":"10.4172/2167-7921.1000207","DOIUrl":"https://doi.org/10.4172/2167-7921.1000207","url":null,"abstract":"We report the clinical and radiological outcomes of acromioclavicular (AC) joint reconstructive surgery using Arthrex Dog Bone Button FibertapeConstruct. 33 Patients were identified between April 2013 and April 2015 who had undergone AC joint repair using the Dog Bone double Endobutton for Rockwood Grade III-V injuries. Radiological follow up was made by measuring coracoclavicular distance (CCD). Patients were clinically evaluated using DASH (Disabilities of Arm, Shoulder and Hand) and ASES (American Shoulder and Elbow Surgeons) scores. Radiologically there was a mean CCD reduction of 7.1 mm (n=26) and mean post-operative CCD of 13.1 (Normal range 11-13 mm) Clinically, the mean post-operative ASES was 89.4 (n=22) (Best score 100). A mean reduction of 50.5 was reported from pre to post-operative DASH scores, with a mean post-operative score of 12.5 (n=18) (Best score 0). One dislocation (due to a fall in the post-operative period) and one infection were reported. Arthroscopic stabilisation of AC joint using Arthrex Dog Bone Fibertape construct is minimally invasive and shows good anatomic restoration of the joint. Early clinical results are promising but more numbers and longer term follow up are needed.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"52 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2016-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7921.1000207","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70834802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-07-09DOI: 10.4172/2167-7921.1000208
Jacques P. Brown, J. Gosselin
Although effective treatment and good adherence to their DMARDs, some patients with rheumatoid arthritis experience transient worsening in severity of disease for which the causes remain unknown. Here the authors comment the potential contribution of Epstein-Barr virus infection in rheumatoid arthritis and the relationship between such infection and the Toll-like receptor system in the exacerbation of the inflammatory response.
{"title":"Does Epstein-Barr Virus Infection Contribute to Disease Flares in Rheumatoid Arthritis?","authors":"Jacques P. Brown, J. Gosselin","doi":"10.4172/2167-7921.1000208","DOIUrl":"https://doi.org/10.4172/2167-7921.1000208","url":null,"abstract":"Although effective treatment and good adherence to their DMARDs, some patients with rheumatoid arthritis experience transient worsening in severity of disease for which the causes remain unknown. Here the authors comment the potential contribution of Epstein-Barr virus infection in rheumatoid arthritis and the relationship between such infection and the Toll-like receptor system in the exacerbation of the inflammatory response.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"13 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70834976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-07-05DOI: 10.4172/2167-7921.1000206
Vivek Kumar, J. Prakash, Varsha Gupta, M. Y. Khan
Joint destruction in rheumatoid arthritis (RA) is due to tissue injury in the area caused by inflammatory reactions, release of MMPs and free radicals produced by neutrophils and macrophages. The control of free radical production may have therapeutic roles thus the study was done to check the status of lipid peroxidation product malondialdehyde (MDA) and a few antioxidant enzymes in RA patients. 45 RA patients and 40 controls were selected. Controls were asymptomatic and RA patients were selected according to ACR criteria. RA patients had significantly high MDA, SOD and ALP and reduced activity of catalase and GR as compared to controls. SOD showed positive correlation with ALP. GR was positively related with MDA, SOD and ALP. The study shows that MDA is involved in the pathogenesis of RA. The system is trying to quench free radicals by high SOD activity. Higher production of H2O2 or some other mechanism is responsible for inhibition of catalase and GR. However system is trying to reduce the damage by neutralizing superoxide anion. Therapeutic intervention of the oxidative stress may be considered for effective control of inflammation in RA patients.
{"title":"Antioxidant Enzymes in Rheumatoid Arthritis","authors":"Vivek Kumar, J. Prakash, Varsha Gupta, M. Y. Khan","doi":"10.4172/2167-7921.1000206","DOIUrl":"https://doi.org/10.4172/2167-7921.1000206","url":null,"abstract":"Joint destruction in rheumatoid arthritis (RA) is due to tissue injury in the area caused by inflammatory reactions, release of MMPs and free radicals produced by neutrophils and macrophages. The control of free radical production may have therapeutic roles thus the study was done to check the status of lipid peroxidation product malondialdehyde (MDA) and a few antioxidant enzymes in RA patients. 45 RA patients and 40 controls were selected. Controls were asymptomatic and RA patients were selected according to ACR criteria. RA patients had significantly high MDA, SOD and ALP and reduced activity of catalase and GR as compared to controls. SOD showed positive correlation with ALP. GR was positively related with MDA, SOD and ALP. The study shows that MDA is involved in the pathogenesis of RA. The system is trying to quench free radicals by high SOD activity. Higher production of H2O2 or some other mechanism is responsible for inhibition of catalase and GR. However system is trying to reduce the damage by neutralizing superoxide anion. Therapeutic intervention of the oxidative stress may be considered for effective control of inflammation in RA patients.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"2016 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7921.1000206","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70834743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-30DOI: 10.4172/2167-7921.1000E112
Wang Lin, C. Chou
Knee osteoarthritis (KOA) is an intractable and devastating consequence of degeneration that results in tremendous impact on daily activities. Painful disabling KOA occurs in more than 10% of people who are over 55 years old. Those who are severely disabled account for up to 25% of aging people and KOA is a major cause of total knee replacement [1-3]. Current osteoarthritis therapies largely rely on rest, weight loss, bracing and assistive devices, physical modalities, therapeutic exercises, and pharmacological interventions [4] which are unsatisfactory for the majority of severe disabled patients, who are left with ambulation deficit despite vigorous treatment intervention. Although numerous patients can be treated with surgery, some of them are not good candidates due to multiple co-morbidities. For these reasons, intra-articular (IA) treatments that reduce chronic joint pain and improve function is the long-term effective and safe alternative options. In a number of recent studies, pain intensity and functional performance resulted from osteoarthritis has been improved after IA injection of botulinum toxin type A (BoNT-A).
{"title":"Therapeutic Effects of Intra-articular Botulinum Toxin Type A in Knee Osteoarthritis","authors":"Wang Lin, C. Chou","doi":"10.4172/2167-7921.1000E112","DOIUrl":"https://doi.org/10.4172/2167-7921.1000E112","url":null,"abstract":"Knee osteoarthritis (KOA) is an intractable and devastating consequence of degeneration that results in tremendous impact on daily activities. Painful disabling KOA occurs in more than 10% of people who are over 55 years old. Those who are severely disabled account for up to 25% of aging people and KOA is a major cause of total knee replacement [1-3]. Current osteoarthritis therapies largely rely on rest, weight loss, bracing and assistive devices, physical modalities, therapeutic exercises, and pharmacological interventions [4] which are unsatisfactory for the majority of severe disabled patients, who are left with ambulation deficit despite vigorous treatment intervention. Although numerous patients can be treated with surgery, some of them are not good candidates due to multiple co-morbidities. For these reasons, intra-articular (IA) treatments that reduce chronic joint pain and improve function is the long-term effective and safe alternative options. In a number of recent studies, pain intensity and functional performance resulted from osteoarthritis has been improved after IA injection of botulinum toxin type A (BoNT-A).","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"5 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7921.1000E112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70837186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-30DOI: 10.4172/2167-7921.1000E111
P. Lee, James P. Brock
The two articles in this month’s press of e Journal of Arthritis, one by Ekinci et al. titled ‘A New Treatment Option in Osteoarthritis: Prolotherapy Injections’ and the other by Senatorov et al. titled ‘Clinical Outcome of Hylan G-F 20 Injections in Shoulder and Hip Osteoarthritis: A Retrospective Review’ raise several important points surrounding the topic of intra-articular injections [1,2]. Firstly that there is a paucity of high quality literature in the eld that o en leads to inconclusive or misrepresented conclusions on drug e cacy in established treatments [1,2]. e articles also highlight the heterogeneity in injection procedure, site, concentration, preparation and outcome measurements [1,2]. is editorial will, therefore, provide a concise review on some of the current injection therapies and suggest possible improvements to methodological structure to inspire readers strive for high quality data. Further, through an example of a possible novel therapy, Actovegin, this editorial will hopefully challenge readers’ way of thinking to consider the reapplication of established drugs; posing the question can you teach an old drug new tricks?
{"title":"Intra-articular Injections for Osteoarthritis: From Bench to Bedside, can we Teach Old Drugs New Tricks?","authors":"P. Lee, James P. Brock","doi":"10.4172/2167-7921.1000E111","DOIUrl":"https://doi.org/10.4172/2167-7921.1000E111","url":null,"abstract":"The two articles in this month’s press of e Journal of Arthritis, one by Ekinci et al. titled ‘A New Treatment Option in Osteoarthritis: Prolotherapy Injections’ and the other by Senatorov et al. titled ‘Clinical Outcome of Hylan G-F 20 Injections in Shoulder and Hip Osteoarthritis: A Retrospective Review’ raise several important points surrounding the topic of intra-articular injections [1,2]. Firstly that there is a paucity of high quality literature in the eld that o en leads to inconclusive or misrepresented conclusions on drug e cacy in established treatments [1,2]. e articles also highlight the heterogeneity in injection procedure, site, concentration, preparation and outcome measurements [1,2]. is editorial will, therefore, provide a concise review on some of the current injection therapies and suggest possible improvements to methodological structure to inspire readers strive for high quality data. Further, through an example of a possible novel therapy, Actovegin, this editorial will hopefully challenge readers’ way of thinking to consider the reapplication of established drugs; posing the question can you teach an old drug new tricks?","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"2016 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7921.1000E111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70837117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-17DOI: 10.4172/2167-7921.1000204
S. Gul, P. Lee, A. Davies
Anterior knee pain and patellofemoral instability have a multi-factorial aetiology and are therefore difficult to treat. A variety of surgical treatment options have been proposed for such patients. Tibial tubercle transfer is one such option and has been described using different surgical techniques. There is however a paucity of literature regarding the procedure itself and its clinical outcomes. Purpose: This study describes the clinical efficacy and outcome of a Tibial Tubercle Transfer (TTT). Study Design: Case series. Methods: 86 consecutive patients who underwent TTT for anterior knee pain and/or patellofemoral instability were studied prospectively. All patients received the same rehabilitation protocol postoperatively. Clinical outcome was measured using the Kujala knee score pre-operatively and at follow-up. Patients were also asked to rate their satisfaction with the procedure. Mean duration of follow up was 1.7 years (6 months to 3 years). Results: 94% of patients were satisfied with their decision to undergo the operation at the latest follow up. The mean Kujala score pre-operatively was 46 points with a Standard deviation (SD) of 14.35. At 6 months the mean Kujala score had improved to 70 points with a standard deviation of 20.25. Patients with patella-femoral instability alone showed greater improvement of Kujala scores compared to patients with anterior knee pain alone or pain plus instability. Conclusion: Our experience suggests that tibial tubercle transfer provides a safe and effective surgical treatment option for patients with anterior knee pain and patellofemoral instability. Patients with patellofemoral instability preoperatively derived the most benefit.
{"title":"Clinical Outcomes of Tibial Tubercle Transfer for Anterior Knee Pain and Patello-femoral Instability","authors":"S. Gul, P. Lee, A. Davies","doi":"10.4172/2167-7921.1000204","DOIUrl":"https://doi.org/10.4172/2167-7921.1000204","url":null,"abstract":"Anterior knee pain and patellofemoral instability have a multi-factorial aetiology and are therefore difficult to treat. A variety of surgical treatment options have been proposed for such patients. Tibial tubercle transfer is one such option and has been described using different surgical techniques. There is however a paucity of literature regarding the procedure itself and its clinical outcomes. Purpose: This study describes the clinical efficacy and outcome of a Tibial Tubercle Transfer (TTT). Study Design: Case series. Methods: 86 consecutive patients who underwent TTT for anterior knee pain and/or patellofemoral instability were studied prospectively. All patients received the same rehabilitation protocol postoperatively. Clinical outcome was measured using the Kujala knee score pre-operatively and at follow-up. Patients were also asked to rate their satisfaction with the procedure. Mean duration of follow up was 1.7 years (6 months to 3 years). Results: 94% of patients were satisfied with their decision to undergo the operation at the latest follow up. The mean Kujala score pre-operatively was 46 points with a Standard deviation (SD) of 14.35. At 6 months the mean Kujala score had improved to 70 points with a standard deviation of 20.25. Patients with patella-femoral instability alone showed greater improvement of Kujala scores compared to patients with anterior knee pain alone or pain plus instability. Conclusion: Our experience suggests that tibial tubercle transfer provides a safe and effective surgical treatment option for patients with anterior knee pain and patellofemoral instability. Patients with patellofemoral instability preoperatively derived the most benefit.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"22 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70834903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-15DOI: 10.4172/2167-7921.1000203
P. Lee, P. Alderman, P. Roberts
The tribological behaviour of the bearing surface in hip arthroplasty is greatly influenced by its surface roughness. During cemented hip arthroplasty, bone cement may contaminate the bearing surface. Hence, the aim of this study was to investigate the effect of cement polymerization on a highly cross-linked polyethylene(HCLP) bearing surface as any process influences the surface roughness of the bearing surface can have potential long term effect on the wear rate. Three new HCLP liners were used. A map of the surface topography of each liner was obtained using a white light interferometric microscope at five different locations in accordance with the standard BSEN ISO 4288:1998. Bone cement was then applied to the bearing surface and allowed to polymerise, then removed and irrigated with saline. The surface roughness measurement procedure was repeated again for all samples. The Ra results showed a 21% increase in mean surface roughness after cement contamination (p=0.01). The average Ra value pre-contamination was 190 nm while post-contamination was 230 nm. There were also changes in the surface topography observed with 3D surface mapping. Our study indicates that bone cement contamination of the HCLP surface can significantly increase its surface roughness and alter its surface topography. Surgeons should be aware of this potentially serious effect on the bearing and be vigilant to avoid bone cement contamination during arthroplasty surgery.
髋关节置换术中承载表面的摩擦学性能受其表面粗糙度的影响很大。在骨水泥髋关节置换术中，骨水泥可能会污染承载面。因此，本研究的目的是研究水泥聚合对高交联聚乙烯(HCLP)轴承表面的影响，因为任何影响轴承表面粗糙度的工艺都可能对磨损率产生潜在的长期影响。使用了三个新的HCLP衬管。根据BSEN ISO 4288:1998标准，使用白光干涉显微镜在五个不同的位置获得每个衬垫的表面地形图。然后将骨水泥涂在支座表面并使其聚合，然后取出并用生理盐水冲洗。对所有样品再次重复表面粗糙度测量程序。Ra结果显示，水泥污染后平均表面粗糙度增加21% (p=0.01)。污染前平均Ra值为190 nm，污染后平均Ra值为230 nm。通过三维表面映射观察到的表面形貌也发生了变化。我们的研究表明骨水泥污染HCLP表面会显著增加其表面粗糙度并改变其表面形貌。外科医生应该意识到这对轴承的潜在严重影响，并在关节置换术中警惕避免骨水泥污染。
{"title":"Polymerizing Bone Cement can Roughen a Polyethylene Bearing Surface on Total Hip Replacement A Surface Analysis","authors":"P. Lee, P. Alderman, P. Roberts","doi":"10.4172/2167-7921.1000203","DOIUrl":"https://doi.org/10.4172/2167-7921.1000203","url":null,"abstract":"The tribological behaviour of the bearing surface in hip arthroplasty is greatly influenced by its surface roughness. During cemented hip arthroplasty, bone cement may contaminate the bearing surface. Hence, the aim of this study was to investigate the effect of cement polymerization on a highly cross-linked polyethylene(HCLP) bearing surface as any process influences the surface roughness of the bearing surface can have potential long term effect on the wear rate. Three new HCLP liners were used. A map of the surface topography of each liner was obtained using a white light interferometric microscope at five different locations in accordance with the standard BSEN ISO 4288:1998. Bone cement was then applied to the bearing surface and allowed to polymerise, then removed and irrigated with saline. The surface roughness measurement procedure was repeated again for all samples. The Ra results showed a 21% increase in mean surface roughness after cement contamination (p=0.01). The average Ra value pre-contamination was 190 nm while post-contamination was 230 nm. There were also changes in the surface topography observed with 3D surface mapping. Our study indicates that bone cement contamination of the HCLP surface can significantly increase its surface roughness and alter its surface topography. Surgeons should be aware of this potentially serious effect on the bearing and be vigilant to avoid bone cement contamination during arthroplasty surgery.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"2016 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70834071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-11DOI: 10.4172/2167-7921.1000201
R. Vasko, S. Blaschke, J. Streich, G. Müller, P. Korsten, H. Dihazi
Background: To identify differentially regulated serum proteins, we compared proteome profiles of sera from patients with rheumatoid arthritis (RA) and healthy controls using proteomics. Methods: Sera were collected from 43 patients with RA and 48 healthy volunteers. The samples were cleared of the most abundant major proteins by immunoaffinity chromatography. Serum protein profiles between the two groups were compared by two-dimensional differential gel electrophoresis (2D-DIGE) and differentially regulated proteins were studied using mass spectrometry. Results: We identified 26 differentially expressed serum proteins between patients with RA and healthy controls. A quantitatively significant change of protein levels was defined as at least 1.5-fold upregulation or 0.6-fold downregulation respectively. Using these criteria, patients with RA exhibited significantly higher levels of leucine-rich alpha-2-glycoprotein (p<0.01), apolipoprotein A-IV (p<0.001), clusterin (p<0.001), haptoglobin (p<0.001), Ig alpha-1 chain C region (p<0.05), retinol-binding protein 4 (p<0.001), serum amyloid A (p<0.01) and alpha-1-antichymotrypsin (p<0.01). The levels of serotransferrin were significantly decreased in RA patients (p<0.01). Conclusion: We identified eight proteins with significantly increased and one protein with significantly decreased serum levels in RA patients compared to healthy controls. Several of these proteins may be implicated in the pathogenesis of RA and may have potential in diagnostics and activity assessment of RA.
背景:为了鉴定不同调节的血清蛋白，我们使用蛋白质组学比较了类风湿关节炎(RA)患者和健康对照者血清的蛋白质组谱。方法:采集43例RA患者血清和48例健康志愿者血清。用免疫亲和层析法清除样品中最丰富的主要蛋白。采用二维差异凝胶电泳(2D-DIGE)比较两组血清蛋白谱，采用质谱法研究差异调节蛋白。结果:我们在RA患者和健康对照组之间鉴定了26种差异表达的血清蛋白。蛋白水平的定量显著变化分别定义为至少1.5倍上调或0.6倍下调。根据这些标准，RA患者的富含亮氨酸的α -2糖蛋白(p<0.01)、载脂蛋白A- iv (p<0.001)、聚簇蛋白(p<0.001)、触珠蛋白(p<0.001)、Ig α -1链C区(p<0.05)、视黄醇结合蛋白4 (p<0.001)、血清淀粉样蛋白A (p<0.01)和α -1抗凝乳胰蛋白酶(p<0.01)水平均显著升高。RA患者血清转铁蛋白水平明显降低(p<0.01)。结论:我们发现与健康对照相比，RA患者血清中8种蛋白水平显著升高，1种蛋白水平显著降低。其中一些蛋白可能与RA的发病机制有关，并可能在RA的诊断和活性评估中具有潜力。
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