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Clinical, laboratory, and MRI features differentiating tuberculous and pyogenic spondylodiscitis: a propensity score-matched analysis. 鉴别结核性和化脓性脊柱炎的临床、实验室和MRI特征:倾向评分匹配分析。
IF 2.8 3区 医学 Q2 RESPIRATORY SYSTEM Pub Date : 2026-02-05 DOI: 10.1186/s12890-026-04148-8
Dilek Bulut, Saffet Öztürk, Aslı Haykır Solay, Fatma Şanlı, Ayşe Nur Soykuvvet Ayhan, Semanur Kuzi, Tülay Ünver Ulusoy, İrfan Şencan, Gönül Çiçek Şentürk
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引用次数: 0
Efficacy and cost-effectiveness of VATS versus chest tube drainage in first-episode primary spontaneous pneumothorax with blebs: a propensity score-matched retrospective study. VATS与胸管引流对首发原发性自发性气胸伴水泡的疗效和成本效益:一项倾向评分匹配的回顾性研究
IF 2.8 3区 医学 Q2 RESPIRATORY SYSTEM Pub Date : 2026-02-05 DOI: 10.1186/s12890-026-04155-9
Qingcai Lin

Background: Optimal management for first-episode primary spontaneous pneumothorax (PSP) with pulmonary blebs remains uncertain, balancing recurrence prevention against procedural costs. This study compared video-assisted thoracoscopic surgery (VATS) and chest tube drainage in terms of recurrence prevention and cost-effectiveness, incorporating sensitivity analyses to evaluate robustness across variable assumptions.

Methods: In a retrospective cohort (2010-2020), 245 first-episode PSP patients with computed tomography (CT)-confirmed blebs were included. Propensity score matching (1:1, caliper = 0.02) balanced baseline characteristics (age, bleb size, etc.), generating 33 matched pairs. Primary outcomes were recurrence rate and incremental cost-effectiveness ratio (ICER).

Results: VATS reduced 5-year recurrence rates from 48.5% to 12.1% (P = 0.004; absolute risk reduction [ARR] = 36.4%, number needed to treat [NNT] = 2.75) and improved recurrence-free interval (hazard ratio [HR] = 0.166, P < 0.001). The base-case ICER was ¥160,300 per quality-adjusted life-year (QALY) gained (¥48,937 per recurrence avoided), with 99.14% probability of cost-effectiveness at China's World Health Organization (WHO)-recommended willingness-to-pay (WTP) threshold (¥287,247 / QALY). Sensitivity analyses confirmed robustness: ICER remained favorable at ¥156,338 / QALY when pneumothorax utility dropped to 0.5; a 20% cost increase yielded ¥192,200 / QALY. Discount rate variations (3%: ¥159,800 / QALY; 6%: ¥138,029 / QALY) maintained > 98.4% cost-effectiveness probability.

Conclusions: VATS reduces recurrence by 83.4% in first-episode PSP with blebs and demonstrates robust cost-effectiveness. Early surgical intervention should be considered for patients with blebs across diverse resource settings.

背景:首发原发性自发性气胸伴肺泡的最佳治疗方法仍不确定,如何平衡预防复发和手术成本。本研究比较了视频辅助胸腔镜手术(VATS)和胸管引流在预防复发和成本效益方面的差异,并结合敏感性分析来评估不同假设下的稳健性。方法:在一项回顾性队列研究(2010-2020)中,纳入了245例首发PSP患者,这些患者均有计算机断层扫描(CT)证实的水泡。倾向评分匹配(1:1,卡尺= 0.02)平衡基线特征(年龄,气泡大小等),产生33对匹配。主要结局为复发率和增量成本-效果比(ICER)。结果:VATS将5年复发率从48.5%降低至12.1% (P = 0.004;绝对风险降低率[ARR] = 36.4%,所需治疗次数[NNT] = 2.75),改善无复发间隔(风险比[HR] = 0.166, P = 98.4%成本-效果概率)。结论:VATS可使首发PSP伴水泡患者的复发率降低83.4%,并具有良好的成本效益。对于不同资源环境下的水泡患者,应考虑早期手术干预。
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引用次数: 0
Evaluation of multimodal large language models for pneumothorax assessment in real-world clinical scenarios. 评价多模态大语言模型在真实临床场景中评估气胸。
IF 2.8 3区 医学 Q2 RESPIRATORY SYSTEM Pub Date : 2026-02-05 DOI: 10.1186/s12890-026-04151-z
Kadir Baturhan Ciflik, Busra Ozdemir Ciflik
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引用次数: 0
Bronchoscopic closure of intubation-related bronchopleural fistulas using combined argon plasma coagulation and fibrin glue: a case series. 支气管镜下氩气等离子凝血和纤维蛋白胶联合治疗插管相关支气管胸膜瘘:一个病例系列。
IF 2.8 3区 医学 Q2 RESPIRATORY SYSTEM Pub Date : 2026-02-04 DOI: 10.1186/s12890-026-04147-9
Siavash Kooranifar, Ata Jafrasteh, Taghi Riahi, Vahan Moradians, Banafshe Darvishi Teli, Tayeb Ramim
{"title":"Bronchoscopic closure of intubation-related bronchopleural fistulas using combined argon plasma coagulation and fibrin glue: a case series.","authors":"Siavash Kooranifar, Ata Jafrasteh, Taghi Riahi, Vahan Moradians, Banafshe Darvishi Teli, Tayeb Ramim","doi":"10.1186/s12890-026-04147-9","DOIUrl":"https://doi.org/10.1186/s12890-026-04147-9","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond symptoms: uncovering type 2 inflammation and small airway dysfunction in Treatment-Naïve asthma. 症状之外:发现Treatment-Naïve哮喘的2型炎症和小气道功能障碍
IF 2.8 3区 医学 Q2 RESPIRATORY SYSTEM Pub Date : 2026-02-02 DOI: 10.1186/s12890-026-04116-2
Yutaka Nakano, Rika Nakano, Takuya Yukawa, Akihiro Arita
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引用次数: 0
Demographic, clinical, and immunological features in combined immunodeficiency patients: a comparative analysis of those with and without pulmonary manifestations - a multicenter study from Iran. 合并免疫缺陷患者的人口学、临床和免疫学特征:一项来自伊朗的多中心研究:有和没有肺部表现的患者的比较分析
IF 2.8 3区 医学 Q2 RESPIRATORY SYSTEM Pub Date : 2026-01-31 DOI: 10.1186/s12890-026-04115-3
Ghamartaj Khanbabaee, Matin Pourghasem, Mahnaz Jamee, Seyed Ahmad Tabatabaii, Mitra Khalili, Samin Sharafian, Mehrnaz Mesdaghi, Mahnaz Sadeghi-Shabestari, Armin Shirvani, Saeid Sadr, Arefeh Zahmatkesh, Samaneh Delavari, Narges Eslami, Nazanin Farahbakhsh, Mahboubeh Mansouri, Ebrahim Tabiei, Seyedeh Zalfa Modarresi, Abdolhamid Taghizadeh Behbahani, Golnaz Eslamian, Mazdak Fallahi, Javad Enayat, Shahrzad Fallah, Mahsa Pourghasem, Asghar Aghamohammadi, Zahra Chavoshzadeh

Background: Combined immunodeficiency (CID) involves profound defects in B and T lymphocyte development and function. This study examined clinical and immunological phenotypes of CID patients with and without pulmonary manifestations.

Methods: This retrospective multicenter study included 53 CID patients diagnosed between 2009 and 2022 with available thoracic computed tomography scans. Patients were categorized based on pulmonary manifestations presence. Demographic, clinical, and laboratory characteristics were compared using conservative statistical thresholds (P < 0.01). All laboratory parameters were interpreted using age-adjusted pediatric reference ranges.

Results: Among 53 patients (56.6% male), 43 had pulmonary abnormalities on HRCT. Common clinical features included skin lesions (43.4%), failure to thrive (34%), and autoimmunity (32.1%). HRCT revealed pneumonia (28.3%), bronchiectasis (18.9%), interstitial lung disease with BOOP-like pattern (3.8%), and other findings. Using age-adjusted pediatric reference ranges, profound immunological defects were confirmed: absolute lymphocyte count below the 5th percentile in 92% (49/53), CD3 + T cells below the 5th percentile in 94% (47/50 tested), CD4 + T cells below the 5th percentile in 96% (51/53), CD19 + B cells below the 5th percentile in 94% (50/53), and hypogammaglobulinaemia (IgG below the 5th percentile) in 98% (52/53). Patients with abnormal HRCT had significantly lower CD4 + T-cell counts (178 vs. 498 cells/µL; P = 0.008) and CD19 + B-cell counts (42 vs. 189 cells/µL; P = 0.009). Bronchoscopy identified Aspergillus fumigatus, Streptococcus pneumoniae, and multidrug-resistantAcinetobacter baumannii. Deceased patients showed significantly lower baseline platelets (183,000 vs. 266,000 cells/µL; P = 0.009), IgG (380 vs. 720 mg/dL; P = 0.007), and IgE (0.8 vs. 12 IU/mL; P = 0.008).

Conclusion: Pulmonary manifestations affect 81.1% of Iranian CID patients. Low baseline platelets, IgG, and IgE constitute a robust prognostic triad for mortality (P = 0.009, P = 0.007, P = 0.008 respectively). Application of age-adjusted reference ranges revealed profound immunological defects. Systematic HRCT surveillance using low-dose protocols and distinguishing infectious sequelae from immune-mediated lung disease guides targeted management in resource-limited settings.

背景:联合免疫缺陷(CID)涉及B和T淋巴细胞发育和功能的严重缺陷。本研究检查了有和没有肺部表现的CID患者的临床和免疫表型。方法:这项回顾性多中心研究纳入了2009年至2022年间诊断为CID的53例患者,并进行了可用的胸部计算机断层扫描。根据肺部表现对患者进行分类。采用保守统计学阈值比较人口学、临床和实验室特征(P)。结果:53例患者(56.6%为男性)中,43例HRCT表现为肺部异常。常见的临床特征包括皮肤病变(43.4%)、生长失败(34%)和自身免疫(32.1%)。HRCT显示肺炎(28.3%)、支气管扩张(18.9%)、boop样肺间质性疾病(3.8%)及其他表现。使用儿童年龄校正参考范围,证实了严重的免疫缺陷:92%(49/53)的绝对淋巴细胞计数低于第5百分位数,94%(47/50)的CD3 + T细胞低于第5百分位数,96%(51/53)的CD4 + T细胞低于第5百分位数,94%(50/53)的CD19 + B细胞低于第5百分位数,98%(52/53)的低γ -球蛋白血症(IgG低于第5百分位数)。HRCT异常患者CD4 + t细胞计数(178比498细胞/µL, P = 0.008)和CD19 + b细胞计数(42比189细胞/µL, P = 0.009)显著降低。支气管镜检查发现了烟曲霉、肺炎链球菌和耐多药鲍曼不动杆菌。死亡患者的基线血小板(183,000 vs. 266,000细胞/ μ L, P = 0.009)、IgG (380 vs. 720 mg/dL, P = 0.007)和IgE (0.8 vs. 12 IU/mL, P = 0.008)均显著降低。结论:81.1%的伊朗CID患者有肺部表现。低基线血小板、IgG和IgE构成了死亡率的可靠预后三因素(P = 0.009, P = 0.007, P = 0.008)。年龄调整参考值范围的应用揭示了深刻的免疫缺陷。在资源有限的情况下,采用低剂量方案进行系统的HRCT监测,并将传染性后遗症与免疫介导的肺部疾病区分开来,可指导有针对性的管理。
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引用次数: 0
Understanding emotional and practical challenges of initiating oxygen therapy in pulmonary fibrosis: insights from a patient-centered survey. 了解在肺纤维化中启动氧疗的情绪和实际挑战:来自以患者为中心的调查的见解。
IF 2.8 3区 医学 Q2 RESPIRATORY SYSTEM Pub Date : 2026-01-31 DOI: 10.1186/s12890-026-04143-z
Marjolein Drent, Lian Trapman, Miranda Hennevelt-Leenen, Jan C Grutters, Anne-Marie Russell
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引用次数: 0
Isoniazid-induced alopecia in isoniazid-monoresistant pulmonary tuberculosis. 异烟肼单耐药肺结核患者异烟肼致脱发。
IF 2.8 3区 医学 Q2 RESPIRATORY SYSTEM Pub Date : 2026-01-31 DOI: 10.1186/s12890-026-04150-0
Emine Afşin, Şeref Özkara, Fatma Ceren Gökdemir
{"title":"Isoniazid-induced alopecia in isoniazid-monoresistant pulmonary tuberculosis.","authors":"Emine Afşin, Şeref Özkara, Fatma Ceren Gökdemir","doi":"10.1186/s12890-026-04150-0","DOIUrl":"https://doi.org/10.1186/s12890-026-04150-0","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146091950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mobile phone auscultation to delineate pneumonia from other respiratory conditions and controls: a prospective cohort study. 手机听诊与其他呼吸系统疾病和对照:一项前瞻性队列研究。
IF 2.8 3区 医学 Q2 RESPIRATORY SYSTEM Pub Date : 2026-01-30 DOI: 10.1186/s12890-026-04135-z
Martin Huecker, Ryan Close, Jonathan Mattingly, Haely Studebaker, Craig Zeigler, Daniel O'Brien, Jeremy Thomas
{"title":"Mobile phone auscultation to delineate pneumonia from other respiratory conditions and controls: a prospective cohort study.","authors":"Martin Huecker, Ryan Close, Jonathan Mattingly, Haely Studebaker, Craig Zeigler, Daniel O'Brien, Jeremy Thomas","doi":"10.1186/s12890-026-04135-z","DOIUrl":"https://doi.org/10.1186/s12890-026-04135-z","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elevated MMP2 expression in fibrotic interstitial lung disease: a potential biomarker for assessment of disease severity. 纤维化间质性肺疾病中MMP2表达升高:评估疾病严重程度的潜在生物标志物
IF 2.8 3区 医学 Q2 RESPIRATORY SYSTEM Pub Date : 2026-01-29 DOI: 10.1186/s12890-026-04139-9
Yiying Huang, Tianbai Niu, Jiawen Yang, Yining Liu, Zehu Chen, Kongqiu Wang, Xiaobin Zheng, Xuegang Li, Jing Liu
{"title":"Elevated MMP2 expression in fibrotic interstitial lung disease: a potential biomarker for assessment of disease severity.","authors":"Yiying Huang, Tianbai Niu, Jiawen Yang, Yining Liu, Zehu Chen, Kongqiu Wang, Xiaobin Zheng, Xuegang Li, Jing Liu","doi":"10.1186/s12890-026-04139-9","DOIUrl":"https://doi.org/10.1186/s12890-026-04139-9","url":null,"abstract":"","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
BMC Pulmonary Medicine
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