Nasim Zarrin, Marzieh Beigom Khezri, Raheleh Safaei, M. Oladi
Background: Several supplementary approaches have been used to increase the patient’s comfort during phacoemulsification under topical anesthesia. Objective: This study aimed to compare the effects of lidocaine/paracetamol (LP) and midazolam/fentanyl (MF) administration on pain intensity and hemodynamic changes in patients undergoing cataract surgery using phacoemulsification. Methods: This study was designed and implemented as a pilot randomized double-blinded clinical trial. A total number of 80 patients with cataracts scheduled for phacoemulsification were randomly assigned to two groups (40 subjects in each group) to receive lidocaine at a dose of 1.5 mg/kg and then infused with 1 g of paracetamol in 100 cc of normal saline (LP group) or midazolam 0.2 mg/kg and fentanyl 1.5 µg/kg (MF group). Hemodynamic parameters and sedation scores were measured before, 5, and 15 minutes after surgery, and then during recovery. Furthermore, pain (VAS), patient-surgeon satisfaction, propofol, and opioid consumption were all assessed. Findings: The sedation scores during recovery in the LP group were significantly lower (P= 0.04) than those in the MF group. Respiratory depression was also significantly lower (P<0.001) in the LP group compared to that infused by MF. According to other findings, no significant difference was observed between both study groups. Conclusion: The use of lidocaine-paracetamol as a supplementary approach for patients undergoing cataract surgery under topical anesthesia can cause better sedation scores with lower respiratory depression compared to the use of midazolam-fentanyl.
背景:在表面麻醉下进行超声乳化术时，一些辅助方法被用来增加患者的舒适度。目的:比较利多卡因/扑热息痛(LP)和咪达唑仑/芬太尼(MF)对白内障超声乳化术患者疼痛强度和血流动力学变化的影响。方法:本研究采用随机双盲临床试验设计和实施。选择80例拟行超声乳化术的白内障患者，随机分为两组(每组40例)，先给予1.5 mg/kg剂量的利多卡因，然后在100 cc生理盐水中灌注扑热息痛1 g (LP组)或咪达唑仑0.2 mg/kg +芬太尼1.5µg/kg (MF组)。在术前、术后5分钟和15分钟以及恢复期间分别测量血流动力学参数和镇静评分。此外，疼痛(VAS)、患者-外科医生满意度、异丙酚和阿片类药物消耗均被评估。结果:LP组恢复时镇静评分显著低于MF组(P= 0.04)。LP组呼吸抑制明显低于MF组(P<0.001)。根据其他研究结果，两个研究组之间没有观察到显著差异。结论:与咪达唑仑-芬太尼相比，利多卡因-扑热息痛作为表面麻醉下白内障手术患者的辅助用药可获得更好的镇静评分，同时伴有下呼吸抑制。
{"title":"Comparing the Effects of Lidocaine/Paracetamol and Midazolam/Fentanyl as a Premedication on Pain Intensity and Hemodynamic Changes in Patients Undergoing Cataract Surgery With Topical Anesthesia: A Randomized Double-blinded Pilot Study","authors":"Nasim Zarrin, Marzieh Beigom Khezri, Raheleh Safaei, M. Oladi","doi":"10.32598/jid.26.2.5","DOIUrl":"https://doi.org/10.32598/jid.26.2.5","url":null,"abstract":"Background: Several supplementary approaches have been used to increase the patient’s comfort during phacoemulsification under topical anesthesia. Objective: This study aimed to compare the effects of lidocaine/paracetamol (LP) and midazolam/fentanyl (MF) administration on pain intensity and hemodynamic changes in patients undergoing cataract surgery using phacoemulsification. Methods: This study was designed and implemented as a pilot randomized double-blinded clinical trial. A total number of 80 patients with cataracts scheduled for phacoemulsification were randomly assigned to two groups (40 subjects in each group) to receive lidocaine at a dose of 1.5 mg/kg and then infused with 1 g of paracetamol in 100 cc of normal saline (LP group) or midazolam 0.2 mg/kg and fentanyl 1.5 µg/kg (MF group). Hemodynamic parameters and sedation scores were measured before, 5, and 15 minutes after surgery, and then during recovery. Furthermore, pain (VAS), patient-surgeon satisfaction, propofol, and opioid consumption were all assessed. Findings: The sedation scores during recovery in the LP group were significantly lower (P= 0.04) than those in the MF group. Respiratory depression was also significantly lower (P<0.001) in the LP group compared to that infused by MF. According to other findings, no significant difference was observed between both study groups. Conclusion: The use of lidocaine-paracetamol as a supplementary approach for patients undergoing cataract surgery under topical anesthesia can cause better sedation scores with lower respiratory depression compared to the use of midazolam-fentanyl.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78694863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Health risks from asbestos exposures have been evaluated, considering past professional histories when exposures at workplaces were higher than today. A linear no-threshold (LNT) model has been applied, although its relevance is unproven. Fibers are often found in the lungs and pleura of deceased people. Fiber findings do not prove that a disease is caused by asbestos. It is reasonable to assume that a targeted search for mesothelioma and other asbestos-related conditions in asbestos workers resulted in an increased detection rate. Histological and immunohistochemical characteristics of malignant mesothelioma partly overlap with other cancers, which may contribute to the overdiagnosis in exposed populations. The etiology and differential diagnosis of malignant pleural mesothelioma as well as differences in carcinogenicity between different asbestos types are briefly discussed here. In the author’s opinion, current regulations applied in some countries are excessive and should be reconsidered based on independent research. The most promising way to obtain reliable information would be through lifelong bioassays. It can be reasonably assumed that the non-use of asbestos-containing brakes, fireproofing, insulation, etc. increases the harm caused by fires, traffic accidents, and armed conflicts.
{"title":"Asbestos-related Lung Diseases: A Brief Update","authors":"S. Jargin","doi":"10.32598/jid.26.2.2","DOIUrl":"https://doi.org/10.32598/jid.26.2.2","url":null,"abstract":"Health risks from asbestos exposures have been evaluated, considering past professional histories when exposures at workplaces were higher than today. A linear no-threshold (LNT) model has been applied, although its relevance is unproven. Fibers are often found in the lungs and pleura of deceased people. Fiber findings do not prove that a disease is caused by asbestos. It is reasonable to assume that a targeted search for mesothelioma and other asbestos-related conditions in asbestos workers resulted in an increased detection rate. Histological and immunohistochemical characteristics of malignant mesothelioma partly overlap with other cancers, which may contribute to the overdiagnosis in exposed populations. The etiology and differential diagnosis of malignant pleural mesothelioma as well as differences in carcinogenicity between different asbestos types are briefly discussed here. In the author’s opinion, current regulations applied in some countries are excessive and should be reconsidered based on independent research. The most promising way to obtain reliable information would be through lifelong bioassays. It can be reasonably assumed that the non-use of asbestos-containing brakes, fireproofing, insulation, etc. increases the harm caused by fires, traffic accidents, and armed conflicts.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77237309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Sheikhi, Z. Hosseinkhani, Ramesh Hoseinzadeh Khezri, Zohre Froozanfar, F. Khodamoradi
Background: Health promotion among health workers requires appropriate evidence of relevant determinants. Objective: This study was conducted to investigate the relationship between mental health and its measured covariates with self-rated health (SRH) among health workers during the COVID-19 pandemic in northwest Iran. Methods: In this cross-sectional study, we recruited 569 health workers from three educational hospitals of Qazvin University of Medical Sciences, Iran. From July 1 to September 5 (2020), participants were asked to provide demographic and clinical information and to complete the symptom checklist 90 (SCL-90) questionnaire. The relationship between suboptimal SRH with each of the SCL-90 domains and measured covariates were analyzed using logistic regression models. Findings: The Mean±SD age of participants was 34.73(7.95) years. A total of 148 health workers (26%) reported their suboptimal SRH, which was higher in women (odds ratio [OR]: 1.98; 95% confidence interval [CI]: 1.21, 3.24), as well as among participants without physical activity (OR: 2.14; 95% CI: 1.35, 3.39). Depression (OR: 2.13; 95% CI: 1.64, 2.77) and anxiety (OR: 3.76; 95% CI: 2.78, 5.09) showed significantly higher odds of suboptimal SRH. Also, other SCL-90 domains indicated a positive association with suboptimal SRH during the COVID-19 pandemic. Conclusion: Mental health, gender, and physical activity were significant variables related to SRH. The current findings suggest that we should pay attention to mental health problems and other important covariates during the COVID-19 epidemic. Hence, policymakers should consider this issue in health promotion programs for health workers.
{"title":"Investigating Self-rated Health Among Health Workers During COVID-19 Pandemic in Northwest Iran","authors":"M. Sheikhi, Z. Hosseinkhani, Ramesh Hoseinzadeh Khezri, Zohre Froozanfar, F. Khodamoradi","doi":"10.32598/jid.26.2.6","DOIUrl":"https://doi.org/10.32598/jid.26.2.6","url":null,"abstract":"Background: Health promotion among health workers requires appropriate evidence of relevant determinants. Objective: This study was conducted to investigate the relationship between mental health and its measured covariates with self-rated health (SRH) among health workers during the COVID-19 pandemic in northwest Iran. Methods: In this cross-sectional study, we recruited 569 health workers from three educational hospitals of Qazvin University of Medical Sciences, Iran. From July 1 to September 5 (2020), participants were asked to provide demographic and clinical information and to complete the symptom checklist 90 (SCL-90) questionnaire. The relationship between suboptimal SRH with each of the SCL-90 domains and measured covariates were analyzed using logistic regression models. Findings: The Mean±SD age of participants was 34.73(7.95) years. A total of 148 health workers (26%) reported their suboptimal SRH, which was higher in women (odds ratio [OR]: 1.98; 95% confidence interval [CI]: 1.21, 3.24), as well as among participants without physical activity (OR: 2.14; 95% CI: 1.35, 3.39). Depression (OR: 2.13; 95% CI: 1.64, 2.77) and anxiety (OR: 3.76; 95% CI: 2.78, 5.09) showed significantly higher odds of suboptimal SRH. Also, other SCL-90 domains indicated a positive association with suboptimal SRH during the COVID-19 pandemic. Conclusion: Mental health, gender, and physical activity were significant variables related to SRH. The current findings suggest that we should pay attention to mental health problems and other important covariates during the COVID-19 epidemic. Hence, policymakers should consider this issue in health promotion programs for health workers.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73323672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rozita Behadori, S. Dodangeh, Seyedeh Azam Nabavi, A. Allami
Background: Statins may be protective against viral infection and have been suggested for the treatment of coronavirus disease 2019 (COVID-19). Objective: In this study, we aimed to evaluate the effect of atorvastatin on COVID-19 patients. Methods: Our study is a randomized double-blind controlled clinical trial that constitutes a population of COVID-19 patients admitted to Bu-Ali Sina Hospital in Qazvin, Iran, from May to August 2021. For the intervention and control groups, in addition to the national standard treatment, atorvastatin 40 mg tablet and placebo were daily administered for 7 days, respectively. A questionnaire including demographic characteristics, history of underlying diseases, vital signs, laboratory and imaging results, and outcome (alive, died) was completed on the first, third, and fifth days of hospitalization. Finally, the obtained data were analyzed by SPSS software, version 25. Findings: One hundred five patients with COVID-19 (62 females and 43 males, mean age 69 years) were studied. On days 3 and 5 after the intervention, no significant difference was observed between the groups in terms of vital signs, laboratory findings, hospitalization time, and need for intensive care unit hospitalization. However, 5.7% of patients in the atorvastatin group and 0% of patients in the control group died (P=0.243). Among the studied variables, C-reactive protein (P=0.227 vs P=0.002), blood urea nitrogen (P=0.055 vs P<0.001), and creatinine (P=0.598 vs P=0.013) decreased significantly in the statin group (no control group during days 0-5). Conclusion: There was no evidence about the harm and benefits of statin treatment during COVID-19 hospitalization.
背景:他汀类药物可能对病毒感染有保护作用，已被建议用于治疗冠状病毒病2019 (COVID-19)。目的:本研究旨在评价阿托伐他汀对COVID-19患者的疗效。方法:本研究是一项随机双盲对照临床试验，纳入了2021年5月至8月在伊朗加兹温市Bu-Ali Sina医院住院的COVID-19患者。干预组和对照组在国家标准治疗的基础上，每日分别给予阿托伐他汀片40mg和安慰剂，连续7天。在住院第1天、第3天和第5天完成一份调查问卷，包括人口统计学特征、基础疾病史、生命体征、实验室和影像学结果以及结果(存活、死亡)。最后，用SPSS软件25版对所得数据进行分析。结果:共纳入新冠肺炎患者105例，其中女性62例，男性43例，平均年龄69岁。干预后第3、5天，两组患者生命体征、实验室检查结果、住院时间、重症监护病房住院次数均无显著差异。而阿托伐他汀组和对照组分别有5.7%和0%的患者死亡(P=0.243)。在研究的变量中，c反应蛋白(P=0.227 vs P=0.002)、血尿素氮(P=0.055 vs P<0.001)和肌酐(P=0.598 vs P=0.013)在他汀类药物组(0-5天无对照组)显著降低。结论:在COVID-19住院期间，没有证据表明他汀类药物治疗的利弊。
{"title":"Effect of Statin Treatment on COVID-19 Patients’ Outcomes: A Randomized Double-blind Controlled Clinical Trial","authors":"Rozita Behadori, S. Dodangeh, Seyedeh Azam Nabavi, A. Allami","doi":"10.32598/jid.26.2.8","DOIUrl":"https://doi.org/10.32598/jid.26.2.8","url":null,"abstract":"Background: Statins may be protective against viral infection and have been suggested for the treatment of coronavirus disease 2019 (COVID-19). Objective: In this study, we aimed to evaluate the effect of atorvastatin on COVID-19 patients. Methods: Our study is a randomized double-blind controlled clinical trial that constitutes a population of COVID-19 patients admitted to Bu-Ali Sina Hospital in Qazvin, Iran, from May to August 2021. For the intervention and control groups, in addition to the national standard treatment, atorvastatin 40 mg tablet and placebo were daily administered for 7 days, respectively. A questionnaire including demographic characteristics, history of underlying diseases, vital signs, laboratory and imaging results, and outcome (alive, died) was completed on the first, third, and fifth days of hospitalization. Finally, the obtained data were analyzed by SPSS software, version 25. Findings: One hundred five patients with COVID-19 (62 females and 43 males, mean age 69 years) were studied. On days 3 and 5 after the intervention, no significant difference was observed between the groups in terms of vital signs, laboratory findings, hospitalization time, and need for intensive care unit hospitalization. However, 5.7% of patients in the atorvastatin group and 0% of patients in the control group died (P=0.243). Among the studied variables, C-reactive protein (P=0.227 vs P=0.002), blood urea nitrogen (P=0.055 vs P<0.001), and creatinine (P=0.598 vs P=0.013) decreased significantly in the statin group (no control group during days 0-5). Conclusion: There was no evidence about the harm and benefits of statin treatment during COVID-19 hospitalization.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84333607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Hashemipour, Sabereh Afshar, Somaieh Kiani, Pouria Shahsavari, Milad Badri, Arefeh Ghobadi, Mohammad Reza Hadizadeh Khairkhahan
Background: Adverse effects of high parathormone hormone (PTH) in critical illness have been described in some studies. Objective: The relationship between high PTH levels with mortality in hospitalized patients with COVID-19 was evaluated in the present study. Methods: A total of 123 patients were included in the study. The patients were evaluated in phase 1 (on admission) and phase 2 (days 4-6 of hospitalization). The patients were categorized into four groups based on the PTH status in both phases: normal PTH1/normal PTH2 (group 1), high PTH1/normal PTH2 (group 2), high PTH1/high PTH2 (group 3), and normal PTH1/high PTH2 (group 4). The multiple logistic regression analysis was performed to examine the independent association of late hyperparathyroidism with mortality. After excluding ineligible participants, 115 patients in phase 1 and 96 patients in phase 2 (days 4-6 of hospitalization) were evaluated. Findings: The level of phase 2 PTH in non-survivors was significantly higher than in survivors (57.5±40.9 pg/mL vs. 27.6±16.2 pg/mL, P=0.001). The mortality rate was significantly higher in high-PTH groups in phase 2 compared to normal-PTH groups in this phase (50% and 42.9% in groups 3 and 4 vs. 6.6% and 18.2% in PTH groups 1 and 2, respectively, P=0.007). Late hyperparathyroidism was associated with 11.4 times higher mortality risk (95% CI: 2.3-56.1, P=0.003). Conclusion: Late hyperparathyroidism remained a significant predictor of mortality after adjusting for the main PTH secretion modulators and disease severity. Late hyperparathyroidism is an independent and strong risk factor for mortality in COVID-19. Further studies are necessary to clarify the mechanisms involved.
{"title":"The Impact of Late Secondary Hyperparathyroidism on Mortality in COVID-19 Patients: A Longitudinal Study","authors":"S. Hashemipour, Sabereh Afshar, Somaieh Kiani, Pouria Shahsavari, Milad Badri, Arefeh Ghobadi, Mohammad Reza Hadizadeh Khairkhahan","doi":"10.32598/jid.26.2.3","DOIUrl":"https://doi.org/10.32598/jid.26.2.3","url":null,"abstract":"Background: Adverse effects of high parathormone hormone (PTH) in critical illness have been described in some studies. Objective: The relationship between high PTH levels with mortality in hospitalized patients with COVID-19 was evaluated in the present study. Methods: A total of 123 patients were included in the study. The patients were evaluated in phase 1 (on admission) and phase 2 (days 4-6 of hospitalization). The patients were categorized into four groups based on the PTH status in both phases: normal PTH1/normal PTH2 (group 1), high PTH1/normal PTH2 (group 2), high PTH1/high PTH2 (group 3), and normal PTH1/high PTH2 (group 4). The multiple logistic regression analysis was performed to examine the independent association of late hyperparathyroidism with mortality. After excluding ineligible participants, 115 patients in phase 1 and 96 patients in phase 2 (days 4-6 of hospitalization) were evaluated. Findings: The level of phase 2 PTH in non-survivors was significantly higher than in survivors (57.5±40.9 pg/mL vs. 27.6±16.2 pg/mL, P=0.001). The mortality rate was significantly higher in high-PTH groups in phase 2 compared to normal-PTH groups in this phase (50% and 42.9% in groups 3 and 4 vs. 6.6% and 18.2% in PTH groups 1 and 2, respectively, P=0.007). Late hyperparathyroidism was associated with 11.4 times higher mortality risk (95% CI: 2.3-56.1, P=0.003). Conclusion: Late hyperparathyroidism remained a significant predictor of mortality after adjusting for the main PTH secretion modulators and disease severity. Late hyperparathyroidism is an independent and strong risk factor for mortality in COVID-19. Further studies are necessary to clarify the mechanisms involved.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87245344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Hossain Esmaeili, Hashem Haghdost-Yazdi, M. Sofiabadi, Hasan Azhdari-Zarmehri, Ali Tishuri
Background: The lateral hypothalamus (LH), which produces orexin, is vital for body solution homeostasis. Lateral hypothalamus (LH) lesion causes adipsia and its stimulation increases water intake. Objective: This study aimed to investigate the effect of an intracerebroventricular (ICV) injection of orexin-A (OXA) on water-drinking behavior in water-deprived rats. Metods: A total of 32 male Wistar rats (220–250 g) were used and divided into 4 groups, control (no injection), vehicle (Normal saline, 5 µL), OXA (30 µg/rat), SB-334867 (OXA receptor selective antagonist, 30 µg/rat). After the microinjection of drugs or vehicles in the right lateral ventricle, each rat was placed individually into the metabolic cage and the amount of water intake, the delay time for the first water intake, and the referral number for water intake were recorded for 4 h. Findings: This study showed that ICV administration of OXA increased both water intake and the referral number for water intake in water-deprived animals (P<0.05). On the other hand, ICV administration of SB-334867 decreased water intake compared to vehicle and control groups. Conclusion: It can be concluded that OXA has a regulatory role in water drinking behavior in water-depriving states.
{"title":"The Role of Orexin-A in Water Intake in Water-deprived Rats","authors":"Mohammad Hossain Esmaeili, Hashem Haghdost-Yazdi, M. Sofiabadi, Hasan Azhdari-Zarmehri, Ali Tishuri","doi":"10.32598/jid.26.2.4","DOIUrl":"https://doi.org/10.32598/jid.26.2.4","url":null,"abstract":"Background: The lateral hypothalamus (LH), which produces orexin, is vital for body solution homeostasis. Lateral hypothalamus (LH) lesion causes adipsia and its stimulation increases water intake. Objective: This study aimed to investigate the effect of an intracerebroventricular (ICV) injection of orexin-A (OXA) on water-drinking behavior in water-deprived rats. Metods: A total of 32 male Wistar rats (220–250 g) were used and divided into 4 groups, control (no injection), vehicle (Normal saline, 5 µL), OXA (30 µg/rat), SB-334867 (OXA receptor selective antagonist, 30 µg/rat). After the microinjection of drugs or vehicles in the right lateral ventricle, each rat was placed individually into the metabolic cage and the amount of water intake, the delay time for the first water intake, and the referral number for water intake were recorded for 4 h. Findings: This study showed that ICV administration of OXA increased both water intake and the referral number for water intake in water-deprived animals (P<0.05). On the other hand, ICV administration of SB-334867 decreased water intake compared to vehicle and control groups. Conclusion: It can be concluded that OXA has a regulatory role in water drinking behavior in water-depriving states.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88693545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Fish tapeworms of the genus Diphyllobothrium are pseudophyllidean cestodes transmitted through the consumption of raw or inadequately cooked fish. Objective: The current systematic review and meta-analysis aim to estimate the global prevalence of Diphyllobothrium in dogs and cats based on published literature. Methods: Multiple English databases (PubMed, Scopus, ProQuest, Web of Science, and Google Scholar) were explored for relevant papers published until December 2021. Findings: Among the 37 studies that were included, 32 documented Diphyllobothrium infection in dogs and five in cats. The pooled prevalence (95% confidence interval) was 0.060% (0.030%-0.100%). The analysis based on country showed that the highest pooled prevalence in dogs and cats was observed in Bangladesh (0.250%, 0.149%-0.366%) and Indonesia (0.254%, 0.182%-0.333%), respectively. Based on the continent, Africa (0.109%, 0.017%-0.264%) and Asia (0.060%, 0%-0.345%) were the most common regions for infection in dogs and cats, respectively. Among different diagnostic methods, the highest pooled prevalence was related to molecular (0.661%, 0.573%-0.743%) and parasitological techniques (0.041%, 0%-0.217%) for dogs and cats’ studies, respectively. Conclusion: The findings show the importance of establishing a prevention and control measure focused on improving regular deworming and enhancing awareness of parasitic zoonotic diseases to minimize the transmission risk.
背景:双叶绦虫属的鱼绦虫是通过食用生的或未充分煮熟的鱼传播的假茶树绦虫。目的:本系统综述和荟萃分析旨在根据已发表的文献估计双扇门菌在狗和猫中的全球患病率。方法:检索PubMed、Scopus、ProQuest、Web of Science、Google Scholar等多个英文数据库，检索截至2021年12月发表的相关论文。研究结果:在纳入的37项研究中，32项记录了狗的双门螺杆菌感染，5项记录了猫的双门螺杆菌感染。合并患病率(95%置信区间)为0.060%(0.030% ~ 0.100%)。基于国家的分析显示，孟加拉国(0.250%，0.149%-0.366%)和印度尼西亚(0.254%，0.182%-0.333%)的猫狗总患病率最高。从各大洲来看，非洲(0.109%，0.017%-0.264%)和亚洲(0.060%，0%-0.345%)分别是狗和猫感染最常见的地区。在不同的诊断方法中，狗和猫的总患病率最高的分别是分子技术(0.661%，0.573 ~ 0.743%)和寄生虫技术(0.041%，0% ~ 0.217%)。结论:建立以定期驱虫和提高对人畜共患寄生虫病的认识为重点的预防和控制措施对降低传播风险具有重要意义。
{"title":"The Global Prevalence of Diphyllobothrium in Dogs, and Cats: A Systematic Review and Meta-analysis","authors":"Aida Vafae Eslahi, Meysam Olfatifar, Fatemeh Barikbin, Leila Zaki, Milad Badri","doi":"10.32598/jid.26.1.1","DOIUrl":"https://doi.org/10.32598/jid.26.1.1","url":null,"abstract":"Background: Fish tapeworms of the genus Diphyllobothrium are pseudophyllidean cestodes transmitted through the consumption of raw or inadequately cooked fish. Objective: The current systematic review and meta-analysis aim to estimate the global prevalence of Diphyllobothrium in dogs and cats based on published literature. Methods: Multiple English databases (PubMed, Scopus, ProQuest, Web of Science, and Google Scholar) were explored for relevant papers published until December 2021. Findings: Among the 37 studies that were included, 32 documented Diphyllobothrium infection in dogs and five in cats. The pooled prevalence (95% confidence interval) was 0.060% (0.030%-0.100%). The analysis based on country showed that the highest pooled prevalence in dogs and cats was observed in Bangladesh (0.250%, 0.149%-0.366%) and Indonesia (0.254%, 0.182%-0.333%), respectively. Based on the continent, Africa (0.109%, 0.017%-0.264%) and Asia (0.060%, 0%-0.345%) were the most common regions for infection in dogs and cats, respectively. Among different diagnostic methods, the highest pooled prevalence was related to molecular (0.661%, 0.573%-0.743%) and parasitological techniques (0.041%, 0%-0.217%) for dogs and cats’ studies, respectively. Conclusion: The findings show the importance of establishing a prevention and control measure focused on improving regular deworming and enhancing awareness of parasitic zoonotic diseases to minimize the transmission risk.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77136802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robabeh Faghany Baladehi, A. Bazmani, Mahin Ahangar Oskouee, Abolfazl Jafari-Sales, T. Pirzadeh, Behrouz Shokouhi, Mohammad Yousef Memar, Hossein Bannazadeh Baghi
Background: Prostate cancer (PCa), as the fifth leading cause of death, is the second most common cancer diagnosis in men worldwide. Human papillomavirus (HPV) can potentially contribute to PCa development and chronic inflammation. HPV infection leads to malignant and benign lesions in the genital areas of men and women. The data on the role of HPV in PCa development is contradictory. Objective: This study aims to investigate the frequency of HPV in PCa samples in hospitals in Tabriz City, Iran. Methods: This study was conducted in a cross-sectional descriptive manner. Paraffin tissue blocks including 50 patients with primary prostate adenocarcinoma and 50 patients with benign prostatic hyperplasia (BPH) were selected from Tabriz hospitals. All samples were examined for the presence of HPV16/18 by the polymerase chain reaction (PCR) method. Findings: 3 out of 50 PCa patients are infected with HPV18. None of the benign and malignant prostate samples are infected with HPV 16. Therefore, in our study, no connection exists between HPV and PCa. The Mean±SD age of HPV positive samples was 61.33±11.50 years. Conclusion: The result of this research does not support the role of HPV in the development of PCa. Therefore, additional studies are necessary to clarify the possible role of HPV in prostate carcinogenesis.
{"title":"Frequency of Human Papilloma Virus 16/18 Patients With Prostate Cancer by Polymerase Chain Reaction Method in Hospitals of Tabriz City, Iran","authors":"Robabeh Faghany Baladehi, A. Bazmani, Mahin Ahangar Oskouee, Abolfazl Jafari-Sales, T. Pirzadeh, Behrouz Shokouhi, Mohammad Yousef Memar, Hossein Bannazadeh Baghi","doi":"10.32598/jid.26.1.2","DOIUrl":"https://doi.org/10.32598/jid.26.1.2","url":null,"abstract":"Background: Prostate cancer (PCa), as the fifth leading cause of death, is the second most common cancer diagnosis in men worldwide. Human papillomavirus (HPV) can potentially contribute to PCa development and chronic inflammation. HPV infection leads to malignant and benign lesions in the genital areas of men and women. The data on the role of HPV in PCa development is contradictory. Objective: This study aims to investigate the frequency of HPV in PCa samples in hospitals in Tabriz City, Iran. Methods: This study was conducted in a cross-sectional descriptive manner. Paraffin tissue blocks including 50 patients with primary prostate adenocarcinoma and 50 patients with benign prostatic hyperplasia (BPH) were selected from Tabriz hospitals. All samples were examined for the presence of HPV16/18 by the polymerase chain reaction (PCR) method. Findings: 3 out of 50 PCa patients are infected with HPV18. None of the benign and malignant prostate samples are infected with HPV 16. Therefore, in our study, no connection exists between HPV and PCa. The Mean±SD age of HPV positive samples was 61.33±11.50 years. Conclusion: The result of this research does not support the role of HPV in the development of PCa. Therefore, additional studies are necessary to clarify the possible role of HPV in prostate carcinogenesis.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":"157 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79955182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Sadabadi, M. Shahi, Sousan Darroudi, Azam Rastgar Moghadam, Sahar Heidari-Bakavoli, Asma Porsa, Sara Saffar Soflaei, H. Esmaeili, M. Mouhebati, Ghodratollah Salehi Sangani, G. Ferns, Bibi Razieh Hoseini Farash, M. Ghayour-Mobarhan
Background: Heat shock protein 27 (HSP27) is found in several cell types of adults, such as cardiomyocytes, and endothelial cells. It is expressed in response to different cellular stress conditions. HSP27 decreases the levels of reactive oxygen species (ROS) and dyslipidemia is closely associated with increased endothelial production of reactive oxygen species (ROS). Objective: Higher serum HSP27 antigen and anti-HSP27 antibodies have been reported in patients with unstable angina and myocardial infarction Methods: This population-based case-control study was conducted in 2018. We investigated serum anti-HSP27 antibody titers in all participants with dyslipidemia from the Mashhad stroke and heart atherosclerotic disorder (MASHAD) study (n=8141) and those who were healthy in terms of dyslipidemia (n=1637) using an in-house enzyme-linked immune sorbent assay (ELISA) in individuals with dyslipidemia. Findings: Anti-HSP27 titers were significantly lower in individuals with dyslipidemia compared to people without dyslipidemia (P=0.036). Conclusion: Our results revealed that the anti-HSP27 antibody titer was lower in the participants with dyslipidemia than in the negative group. However, there may be a confounding effect of drug therapy. In a subgroup of dyslipidemic subjects, we observed lower anti-HSP27 antibody titers in patients treated with some drugs (statins or corticosteroids, non-steroidal anti-inflammatory drugs [NSAIDs], or anti-diabetic and anti-hypertensive) compared to subjects untreated with these drugs.
{"title":"Serum Anti-heat Shock Protein 27 Antibody Titers in Patients With Dyslipidemia: A Population-based Case-control Study","authors":"F. Sadabadi, M. Shahi, Sousan Darroudi, Azam Rastgar Moghadam, Sahar Heidari-Bakavoli, Asma Porsa, Sara Saffar Soflaei, H. Esmaeili, M. Mouhebati, Ghodratollah Salehi Sangani, G. Ferns, Bibi Razieh Hoseini Farash, M. Ghayour-Mobarhan","doi":"10.32598/jid.26.1.7","DOIUrl":"https://doi.org/10.32598/jid.26.1.7","url":null,"abstract":"Background: Heat shock protein 27 (HSP27) is found in several cell types of adults, such as cardiomyocytes, and endothelial cells. It is expressed in response to different cellular stress conditions. HSP27 decreases the levels of reactive oxygen species (ROS) and dyslipidemia is closely associated with increased endothelial production of reactive oxygen species (ROS). Objective: Higher serum HSP27 antigen and anti-HSP27 antibodies have been reported in patients with unstable angina and myocardial infarction Methods: This population-based case-control study was conducted in 2018. We investigated serum anti-HSP27 antibody titers in all participants with dyslipidemia from the Mashhad stroke and heart atherosclerotic disorder (MASHAD) study (n=8141) and those who were healthy in terms of dyslipidemia (n=1637) using an in-house enzyme-linked immune sorbent assay (ELISA) in individuals with dyslipidemia. Findings: Anti-HSP27 titers were significantly lower in individuals with dyslipidemia compared to people without dyslipidemia (P=0.036). Conclusion: Our results revealed that the anti-HSP27 antibody titer was lower in the participants with dyslipidemia than in the negative group. However, there may be a confounding effect of drug therapy. In a subgroup of dyslipidemic subjects, we observed lower anti-HSP27 antibody titers in patients treated with some drugs (statins or corticosteroids, non-steroidal anti-inflammatory drugs [NSAIDs], or anti-diabetic and anti-hypertensive) compared to subjects untreated with these drugs.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73365857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Forouharmehr, N. Shams, N. Nazifi, A. Jaydari, Ehsan Rashidian
Background: The heparin-binding hemagglutinin (HBHA) protein belonging to Mycobacterium tuberculosis is known as a molecular adjuvant. Objective: Hence, the expression of this protein in the prokaryotic system is essential. Methods: To predict an appropriate signal peptide for the expression of the HBHA protein, 50 signal peptides were selected from the signal peptide database. Then, the crucial parameters of signal peptides, including the probability of signal peptide, different regions of signal peptides, physicochemical features, sorting of signal peptides, and sub-cellular location were completely investigated by reliable tools. After the best-predicted signal peptide was identified, it was linked to the HBHA protein, and its secondary structure, tertiary structure, and in silico cloning in pET21a (+) was assessed. Findings: The results of different evaluations confirmed that only 13 signal peptides passed all features, including clearance of N, H, and C regions, D-score >0.7, instability index >40, and periplasmic localization. Finally, based on D-scores, among these 13 signal peptides, the asr (acid shock RNA) peptide with D-score=90 was selected as the best-predicted signal peptide to apply. Moreover, the results showed that the secondary structure of the adjuvant linked to asr peptide contained 88.18% alpha helix and 9.5% random coil. Also, the results of in silico cloning showed that the nucleotide sequences of the adjuvant linked to the asr peptide were successfully cloned between BamHI and XhoI enzymes in the multiple cloning site of pET21a (+). Conclusion: The results of this study confirmed that the asr peptide can be used as an appropriate signal peptide for the expression of the HBHA protein in the prokaryotic system.
{"title":"Prediction of an Efficient Signal Peptide for Optimized Expression of Mycobacterium Tuberculosis Heparin-binding Hemagglutinin Gene in Periplasmic Compartment of Escherichia Coli: A Bioinformatics Investigation","authors":"A. Forouharmehr, N. Shams, N. Nazifi, A. Jaydari, Ehsan Rashidian","doi":"10.32598/jid.26.1.4","DOIUrl":"https://doi.org/10.32598/jid.26.1.4","url":null,"abstract":"Background: The heparin-binding hemagglutinin (HBHA) protein belonging to Mycobacterium tuberculosis is known as a molecular adjuvant. Objective: Hence, the expression of this protein in the prokaryotic system is essential. Methods: To predict an appropriate signal peptide for the expression of the HBHA protein, 50 signal peptides were selected from the signal peptide database. Then, the crucial parameters of signal peptides, including the probability of signal peptide, different regions of signal peptides, physicochemical features, sorting of signal peptides, and sub-cellular location were completely investigated by reliable tools. After the best-predicted signal peptide was identified, it was linked to the HBHA protein, and its secondary structure, tertiary structure, and in silico cloning in pET21a (+) was assessed. Findings: The results of different evaluations confirmed that only 13 signal peptides passed all features, including clearance of N, H, and C regions, D-score >0.7, instability index >40, and periplasmic localization. Finally, based on D-scores, among these 13 signal peptides, the asr (acid shock RNA) peptide with D-score=90 was selected as the best-predicted signal peptide to apply. Moreover, the results showed that the secondary structure of the adjuvant linked to asr peptide contained 88.18% alpha helix and 9.5% random coil. Also, the results of in silico cloning showed that the nucleotide sequences of the adjuvant linked to the asr peptide were successfully cloned between BamHI and XhoI enzymes in the multiple cloning site of pET21a (+). Conclusion: The results of this study confirmed that the asr peptide can be used as an appropriate signal peptide for the expression of the HBHA protein in the prokaryotic system.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86724069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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