Sepas Haji Sobhani, M. M. Daei, S. Dodangeh, Majid Hajikarimi, Navid Mohammadi
Background: Metabolic syndrome (MetS) comprises a group of conditions that happen together and increase the risk of heart disorders. MetS has known characteristic diagnostic criteria and is diagnosed through physical examination and blood tests. This syndrome is extremely prevalent in patients with acute myocardial infarction. We aimed to determine the prevalence of MetS and its relationship with myocardial infarction and response to treatment in patients suffering from acute myocardial infarction under fibrinolytic treatment. Methods: In this cross-sectional study, 145 patients with acute ST-elevation myocardial infarction (STEMI) were enrolled. They were referred to Bu-Ali Sina Hospital in Qazvin, Iran, between January 2018 and January 2019 and were candidates for thrombolytic therapy. The patients were divided into two groups with and without MetS according to the NCEP ATP III definition (the National Cholesterol Education Program-Adult Treatment Panel III). In each group, the ST resolution of more than 50% in electrocardiogram was evaluated 90 minutes after thrombolytic administration. In addition, angiographic information and left ventricular ejection fraction (LVEF) were compared between the two groups. Results: Overall, the prevalence of MetS was 57.2% in the study population. After treatment, ST-segment resolution of more than 50%, the number of involved coronary vessels, the thrombolysis in myocardial infarction flow grade, mean LVEF, and type of myocardial infarction were similar in both study groups. Conclusion: Our study indicates that MetS does not affect the response rate to thrombolytic treatment.
背景:代谢综合征(MetS)包括一组共同发生并增加心脏疾病风险的疾病。MetS有已知的特征性诊断标准，通过身体检查和血液检查来诊断。这种综合征在急性心肌梗死患者中极为普遍。我们的目的是确定急性心肌梗死患者在纤溶治疗下MetS的患病率及其与心肌梗死的关系和对治疗的反应。方法:在这项横断面研究中，纳入145例急性st段抬高型心肌梗死(STEMI)患者。在2018年1月至2019年1月期间，他们被转介到伊朗加兹温的Bu-Ali Sina医院，并成为溶栓治疗的候选人。根据NCEP ATP III(国家胆固醇教育计划-成人治疗小组III)的定义，将患者分为有和没有MetS的两组。在每组中，在溶栓给药后90分钟评估心电图ST分辨率超过50%。并比较两组血管造影信息及左室射血分数(LVEF)。结果:总体而言，研究人群中MetS的患病率为57.2%。治疗后，两组患者st段溶解率均大于50%，冠脉受累数、心肌梗死溶栓程度、血流等级、平均LVEF、心肌梗死类型相似。结论:我们的研究表明MetS不影响溶栓治疗的应答率。
{"title":"Impact of Metabolic Syndrome in Patients With Acute Myocardial Infarction After Thrombolytic Therapy","authors":"Sepas Haji Sobhani, M. M. Daei, S. Dodangeh, Majid Hajikarimi, Navid Mohammadi","doi":"10.32598/jid.25.4.3","DOIUrl":"https://doi.org/10.32598/jid.25.4.3","url":null,"abstract":"Background: Metabolic syndrome (MetS) comprises a group of conditions that happen together and increase the risk of heart disorders. MetS has known characteristic diagnostic criteria and is diagnosed through physical examination and blood tests. This syndrome is extremely prevalent in patients with acute myocardial infarction. We aimed to determine the prevalence of MetS and its relationship with myocardial infarction and response to treatment in patients suffering from acute myocardial infarction under fibrinolytic treatment. Methods: In this cross-sectional study, 145 patients with acute ST-elevation myocardial infarction (STEMI) were enrolled. They were referred to Bu-Ali Sina Hospital in Qazvin, Iran, between January 2018 and January 2019 and were candidates for thrombolytic therapy. The patients were divided into two groups with and without MetS according to the NCEP ATP III definition (the National Cholesterol Education Program-Adult Treatment Panel III). In each group, the ST resolution of more than 50% in electrocardiogram was evaluated 90 minutes after thrombolytic administration. In addition, angiographic information and left ventricular ejection fraction (LVEF) were compared between the two groups. Results: Overall, the prevalence of MetS was 57.2% in the study population. After treatment, ST-segment resolution of more than 50%, the number of involved coronary vessels, the thrombolysis in myocardial infarction flow grade, mean LVEF, and type of myocardial infarction were similar in both study groups. Conclusion: Our study indicates that MetS does not affect the response rate to thrombolytic treatment.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76680334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Ghorbani, Maryam Qeraati, Khdijeh Esmaelzadeh, Monirosadat Mirzadeh, Nafiseh Rastgoo, M. Zohal
Background: The initial reports of an outbreak of SARS-CoV-2 pneumonia suggest that COVID-19 is a severe disease. Objective: We aimed to investigate the clinical parameters and mortality of patients with SARS-CoV-2 pneumonia admitted to the intensive care unit (ICU) of Velayat Hospital in Qazvin, Iran. Methods: In this single-centered, cross-sectional, and retrospective study, we enrolled all adult patients with COVID-19 admitted to the intensive care unit (ICU) of Velayat Hospital from March 20 to April 30, 2020. Sociodemographic data, laboratory values, and disease outcomes of the patients were collected. Then, the obtained data were compared between survivors and non-survivors. Results: Of 1100 patients with SARS-CoV-2 pneumonia, 74 adult patients were included in this study. The Mean±SD age of the 52 patients was 60.1±16.46 years. All patients had underlying diseases. The Mean±SD time from admission to discharge from the ICU was 12.39±6.48 days. The logistic regression test indicated that the amount of blood urea nitrogen (BUN) during hospitalization in the ICU was associated with increased mortality risk (OR=1.081, 95% CI=1.024-1.141; P=0.005). Moreover, the same test showed that platelet count (OR: 0.991, 95% CI: 0.985-0.997; P=0.002) and hemoglobin concentration (OR: 0.691, 95% CI: 0.502-0.951; P=0.023) were associated with a decreased mortality risk in ICU patients; this means that patients with higher hemoglobin concentration and platelet counts had a lower mortality risk in ICU. Conclusion: The mortality rate of patients with SARS-CoV-2 pneumonia is high. The BUN level was a predictor of mortality in patients with COVID-19. Therefore, it is recommended that BUN be measured during initial referral, and based on that, timely and appropriate corrective actions be conducted.
{"title":"Clinical Parameters and Mortality in COVID-19 Patients Admitted to an Intensive Care Unit (ICU) in Qazvin City","authors":"A. Ghorbani, Maryam Qeraati, Khdijeh Esmaelzadeh, Monirosadat Mirzadeh, Nafiseh Rastgoo, M. Zohal","doi":"10.32598/jid.25.4.6","DOIUrl":"https://doi.org/10.32598/jid.25.4.6","url":null,"abstract":"Background: The initial reports of an outbreak of SARS-CoV-2 pneumonia suggest that COVID-19 is a severe disease. Objective: We aimed to investigate the clinical parameters and mortality of patients with SARS-CoV-2 pneumonia admitted to the intensive care unit (ICU) of Velayat Hospital in Qazvin, Iran. Methods: In this single-centered, cross-sectional, and retrospective study, we enrolled all adult patients with COVID-19 admitted to the intensive care unit (ICU) of Velayat Hospital from March 20 to April 30, 2020. Sociodemographic data, laboratory values, and disease outcomes of the patients were collected. Then, the obtained data were compared between survivors and non-survivors. Results: Of 1100 patients with SARS-CoV-2 pneumonia, 74 adult patients were included in this study. The Mean±SD age of the 52 patients was 60.1±16.46 years. All patients had underlying diseases. The Mean±SD time from admission to discharge from the ICU was 12.39±6.48 days. The logistic regression test indicated that the amount of blood urea nitrogen (BUN) during hospitalization in the ICU was associated with increased mortality risk (OR=1.081, 95% CI=1.024-1.141; P=0.005). Moreover, the same test showed that platelet count (OR: 0.991, 95% CI: 0.985-0.997; P=0.002) and hemoglobin concentration (OR: 0.691, 95% CI: 0.502-0.951; P=0.023) were associated with a decreased mortality risk in ICU patients; this means that patients with higher hemoglobin concentration and platelet counts had a lower mortality risk in ICU. Conclusion: The mortality rate of patients with SARS-CoV-2 pneumonia is high. The BUN level was a predictor of mortality in patients with COVID-19. Therefore, it is recommended that BUN be measured during initial referral, and based on that, timely and appropriate corrective actions be conducted.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73090786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Physicians’ knowledge and comments are important in the uptake of human papillomavirus (HPV) screening among women. We aimed to evaluate the knowledge of senior medical students on HPV as future physicians of Iran. Methods: A cross-sectional study was performed between March 2021 and May 2021. All final-year medical students of Tabriz University of Medical Sciences were invited to complete an online standardized questionnaire through a mobile app. The Independent samples t test was performed for data analysis in SPSS software version 16. Results: In the present study, 215 female medical students and 128 male ones participated, with an average age of 23.14 (SD=1.21) years. Most of the students (85.67%) were single. The average knowledge score of the students was 9.25 (SD=6.21), demonstrating their low level of knowledge of HPV. Furthermore, no significant score differences were observed between students regarding their gender and marital status. Conclusion: Regarding the low scores of final-year medical students’ knowledge of HPV, educational programs should be directed to HPV to improve medical students’ knowledge about this virus and its related diseases.
{"title":"Knowledge About Human Papilloma Virus Among Medical Students of Tabriz University of Medical Sciences","authors":"M. Baradaran-Binazir","doi":"10.32598/jid.25.4.8","DOIUrl":"https://doi.org/10.32598/jid.25.4.8","url":null,"abstract":"Background: Physicians’ knowledge and comments are important in the uptake of human papillomavirus (HPV) screening among women. We aimed to evaluate the knowledge of senior medical students on HPV as future physicians of Iran. Methods: A cross-sectional study was performed between March 2021 and May 2021. All final-year medical students of Tabriz University of Medical Sciences were invited to complete an online standardized questionnaire through a mobile app. The Independent samples t test was performed for data analysis in SPSS software version 16. Results: In the present study, 215 female medical students and 128 male ones participated, with an average age of 23.14 (SD=1.21) years. Most of the students (85.67%) were single. The average knowledge score of the students was 9.25 (SD=6.21), demonstrating their low level of knowledge of HPV. Furthermore, no significant score differences were observed between students regarding their gender and marital status. Conclusion: Regarding the low scores of final-year medical students’ knowledge of HPV, educational programs should be directed to HPV to improve medical students’ knowledge about this virus and its related diseases.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72546645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Mirabedini, H. Pakniat, M. Mahdavi, S. A. Razavi, Ali Emami, Ali Sarbazi Golezari
Background: Preeclampsia is one of the common disorders in pregnancy. It is characterized by hypertension and proteinuria in the second half of pregnancy. It is also one of the three main causes of death in pregnant women. Objective: This study investigated the risk factors of preeclampsia in women referred to Kowsar Hospital in Qazvin Province, Iran. Methods: In this case-control study, after reviewing 7855 cases of pregnant women referred to Kowsar Hospital in 2016, 171 hospitalized patients with severe preeclampsia were put in the case group, and 171 patients with delivery problems were in the control group. Then, we compared the collected data about risk factors, such as a history of preeclampsia, hypertension, smoking, diabetes mellitus, infertility, twin, and body mass index, in both groups. Results: The Mean±SD age of the pregnant women with preeclampsia was 31.19±6.42 years with an interquartile interval of 26-35 years. History of preeclampsia (P=0.02), hypertension (P=0.001), and body mass index (P=0.001) were significantly higher in the preeclampsia group than in the control group. Also, there was no significant relationship between a history of diabetes mellitus, infertility, or twin with preeclampsia (P<0.05). Conclusion: This study showed that the risk factors of a history of preeclampsia, hypertension, and body mass index significantly differed between the case and control groups.
{"title":"Preeclampsia and Its Associated Risk Factors: A Case-control Study in Qazvin Province","authors":"M. Mirabedini, H. Pakniat, M. Mahdavi, S. A. Razavi, Ali Emami, Ali Sarbazi Golezari","doi":"10.32598/jid.25.4.5","DOIUrl":"https://doi.org/10.32598/jid.25.4.5","url":null,"abstract":"Background: Preeclampsia is one of the common disorders in pregnancy. It is characterized by hypertension and proteinuria in the second half of pregnancy. It is also one of the three main causes of death in pregnant women. Objective: This study investigated the risk factors of preeclampsia in women referred to Kowsar Hospital in Qazvin Province, Iran. Methods: In this case-control study, after reviewing 7855 cases of pregnant women referred to Kowsar Hospital in 2016, 171 hospitalized patients with severe preeclampsia were put in the case group, and 171 patients with delivery problems were in the control group. Then, we compared the collected data about risk factors, such as a history of preeclampsia, hypertension, smoking, diabetes mellitus, infertility, twin, and body mass index, in both groups. Results: The Mean±SD age of the pregnant women with preeclampsia was 31.19±6.42 years with an interquartile interval of 26-35 years. History of preeclampsia (P=0.02), hypertension (P=0.001), and body mass index (P=0.001) were significantly higher in the preeclampsia group than in the control group. Also, there was no significant relationship between a history of diabetes mellitus, infertility, or twin with preeclampsia (P<0.05). Conclusion: This study showed that the risk factors of a history of preeclampsia, hypertension, and body mass index significantly differed between the case and control groups.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82420194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The COVID-18 pandemic severely affected people older than 65 years, especially those with age-related comorbidities, causing a disproportionate death burden in this age group. The reasons for this difference from other respiratory virus pandemics have been attributed to the aging-induced changes in the immune system, and their effects on the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. In this brief review, I summarize some of the recent findings throwing light on the relationship between aging, immunity, and the severity of COVID-19.
{"title":"Aging and Immunity in COVID-19","authors":"R. Paganelli","doi":"10.32598/jid.26.3.2","DOIUrl":"https://doi.org/10.32598/jid.26.3.2","url":null,"abstract":"The COVID-18 pandemic severely affected people older than 65 years, especially those with age-related comorbidities, causing a disproportionate death burden in this age group. The reasons for this difference from other respiratory virus pandemics have been attributed to the aging-induced changes in the immune system, and their effects on the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. In this brief review, I summarize some of the recent findings throwing light on the relationship between aging, immunity, and the severity of COVID-19.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80250191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Salimeh Nezamivand-Chegini, P. Abedi, Azam Honarmandpour, F. Namjouyan, Masoumeh Yaralizadeh, S. Ghanbari
Background: No evidence exists for the lowest effective dose of magnesium on menstrual pain. Objective: To determine and compare the effects of two different doses of magnesium on pain intensity and menstrual blood loss in students with primary dysmenorrhea. Methods: Sixty dysmenorrhea patients were randomly assigned to one of two therapeutic groups and one placebo group (receiving one tablet a day of 300 or 150 mg magnesium sulphate or placebo from the 15th cycle day until no pain existed on the following cycle). Visual analogue scale (VAS) and Hjgham collected data for two cycles before and two cycles after the intervention. The data were analyzed using one-way ANOVA and ANCOVA tests. Findings: No significant difference was observed between the groups in terms of baseline characteristics. Both intervention groups outperformed the placebo group in terms of pain intensity (adjusted differences of -2.9, 95% confidence intervals of -3.3 to -2.4 and -1.9, -2.4 to -1.5, respectively) and menstrual bleeding (-20.0, -26.0 to -14.0, and -13.0, -19.0 to -7.0, respectively), as well as the secondary outcome, i.e. rest duration and ibuprofen consumption. In terms of pain alleviation and menstrual bleeding, participants in the 300 mg magnesium group outperformed those in the 150 mg magnesium group. No significant difference was observed between intervention groups regarding secondary outcomes. Conclusion: Both magnesium levels are useful in alleviating pain and reducing menstrual bleeding, although 300 mg of magnesium was more effective.
{"title":"The Effect of Magnesium Sulfate on Pain Intensity and Menstrual Blood Loss in Students With Primary Dysmenorrhea: A Randomized Controlled Trial","authors":"Salimeh Nezamivand-Chegini, P. Abedi, Azam Honarmandpour, F. Namjouyan, Masoumeh Yaralizadeh, S. Ghanbari","doi":"10.32598/jid.26.3.3","DOIUrl":"https://doi.org/10.32598/jid.26.3.3","url":null,"abstract":"Background: No evidence exists for the lowest effective dose of magnesium on menstrual pain. Objective: To determine and compare the effects of two different doses of magnesium on pain intensity and menstrual blood loss in students with primary dysmenorrhea. Methods: Sixty dysmenorrhea patients were randomly assigned to one of two therapeutic groups and one placebo group (receiving one tablet a day of 300 or 150 mg magnesium sulphate or placebo from the 15th cycle day until no pain existed on the following cycle). Visual analogue scale (VAS) and Hjgham collected data for two cycles before and two cycles after the intervention. The data were analyzed using one-way ANOVA and ANCOVA tests. Findings: No significant difference was observed between the groups in terms of baseline characteristics. Both intervention groups outperformed the placebo group in terms of pain intensity (adjusted differences of -2.9, 95% confidence intervals of -3.3 to -2.4 and -1.9, -2.4 to -1.5, respectively) and menstrual bleeding (-20.0, -26.0 to -14.0, and -13.0, -19.0 to -7.0, respectively), as well as the secondary outcome, i.e. rest duration and ibuprofen consumption. In terms of pain alleviation and menstrual bleeding, participants in the 300 mg magnesium group outperformed those in the 150 mg magnesium group. No significant difference was observed between intervention groups regarding secondary outcomes. Conclusion: Both magnesium levels are useful in alleviating pain and reducing menstrual bleeding, although 300 mg of magnesium was more effective.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78661537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Majid Eterafi, Shima Makaremi, Hamidreza Shaker, N. Fouladi, Vahid Khaze Shahgoli, F. Jeddi, E. Safarzadeh
Background: Coronavirus disease-2019 (COVID-19), an infectious disease, has been known as a worldwide pandemic involving many countries, including Iran. Meantime, the analyses of clinical and demographic features of the fourth surge in COVID-19 patients provide a better overview of disease management and mortality reduction. Objective: This study aimed to identify the effective clinical and demographic hallmarks of the fourth wave of COVID-19 in Ardabil Province, Iran. Methods: We carried out a population-based analytical cross-sectional study using clinical and demographic characteristics of COVID-19 from February 2021 to May 2021 among confirmed COVID-19 patients who were admitted to the hospital during the fourth surge. Predictors of intensive care unit (ICU) admission and death were evaluated by controlling for intervening variables. Findings: We evaluated 500 patients, of whom 54.5% were men, and 45.5% were women. Among them, 35.1% of patients had hypertension as the main comorbidity, followed by diabetes (21.4%), cardiovascular disease (8.4 %), renal diseases (2.4%), and others. The findings indicated that increasing age has increased mortality among patients with COVID-19. Moreover, our results showed that among the analyzed items, age, sex, and cerebral vascular accident (CVA) were indicated as predictors of ICU admission. Conclusion: This evaluation demonstrated that old age and comorbidities are two major risk factors for reducing the probability of recovery and increasing admission to the ICU. Therefore, elderly individuals with at least one co-morbidity are at higher risk of becoming infected.
{"title":"Demographic, Clinical, and Paraclinical Characteristics of the Fourth Surge of the COVID-19 Pandemic in Ardabil Province, Iran","authors":"Majid Eterafi, Shima Makaremi, Hamidreza Shaker, N. Fouladi, Vahid Khaze Shahgoli, F. Jeddi, E. Safarzadeh","doi":"10.32598/jid.26.3.5","DOIUrl":"https://doi.org/10.32598/jid.26.3.5","url":null,"abstract":"Background: Coronavirus disease-2019 (COVID-19), an infectious disease, has been known as a worldwide pandemic involving many countries, including Iran. Meantime, the analyses of clinical and demographic features of the fourth surge in COVID-19 patients provide a better overview of disease management and mortality reduction. Objective: This study aimed to identify the effective clinical and demographic hallmarks of the fourth wave of COVID-19 in Ardabil Province, Iran. Methods: We carried out a population-based analytical cross-sectional study using clinical and demographic characteristics of COVID-19 from February 2021 to May 2021 among confirmed COVID-19 patients who were admitted to the hospital during the fourth surge. Predictors of intensive care unit (ICU) admission and death were evaluated by controlling for intervening variables. Findings: We evaluated 500 patients, of whom 54.5% were men, and 45.5% were women. Among them, 35.1% of patients had hypertension as the main comorbidity, followed by diabetes (21.4%), cardiovascular disease (8.4 %), renal diseases (2.4%), and others. The findings indicated that increasing age has increased mortality among patients with COVID-19. Moreover, our results showed that among the analyzed items, age, sex, and cerebral vascular accident (CVA) were indicated as predictors of ICU admission. Conclusion: This evaluation demonstrated that old age and comorbidities are two major risk factors for reducing the probability of recovery and increasing admission to the ICU. Therefore, elderly individuals with at least one co-morbidity are at higher risk of becoming infected.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80999559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Influenza is a respiratory infection that causes a wide range of symptoms, from mild symptoms to a significantly impaired disease. Objective: This study aims to examine demographic characteristics, clinical features, and underlying medical conditions in children and adults hospitalized with laboratory-confirmed influenza. Methods: This was a retrospective comparative study on 333 adults and 102 children hospitalized with symptoms of acute respiratory tract infection and seasonal influenza confirmed by reverse transcription polymerase chain reaction (RT-PCR) in three university hospitals, in Qazvin City, Iran, during two influenza seasons (March 2017 and February 2019). Findings: Most clinical manifestations of influenza were similar among adults. A significant difference was observed among the two groups in terms of 1) a greater proportion of male patients in children (66.7%) and female patients in adults (58.6%); 2) adults were more exposed to risk factors than children (median 1 vs. 0); 3) a greater proportion of children presenting influenza-related encephalopathy (38.2% vs. 26.7%) and upper respiratory signs compared to adults; 4) a greater proportion of adults presenting lower respiratory signs and symptoms compared to children. The most common underlying conditions were asthma and diabetes mellitus (DM) in adults and diabetes mellitus (DM) and cancer in children. The duration of hospitalization had a significant relationship with the number of risk factors (r=0.219, P<0.001). Conclusion: In summary, influenza-related encephalopathy and upper respiratory signs are more prevalent in children, and in contrast, adults are more likely to have underlying medical conditions than children with seasonal influenza.
背景:流感是一种呼吸道感染，可引起多种症状，从轻微症状到严重受损的疾病。目的:本研究旨在研究实验室确诊流感住院儿童和成人的人口统计学特征、临床特征和潜在医疗条件。方法:对2017年3月和2019年2月两个流感季节(伊朗加兹温市三所大学医院经逆转录聚合酶链反应(RT-PCR)确诊的急性呼吸道感染和季节性流感症状住院的333名成人和102名儿童进行回顾性比较研究。结果:成人流感的临床表现基本相似。两组间差异有统计学意义:(1)儿童男性患者占66.7%，成人女性患者占58.6%;2)成人对危险因素的暴露程度高于儿童(中位数为1比0);3)与成人相比，出现流感相关脑病(38.2% vs. 26.7%)和上呼吸道体征的儿童比例更高;4)与儿童相比，出现下呼吸道体征和症状的成年人比例更高。最常见的潜在疾病是成人哮喘和糖尿病(DM)，儿童糖尿病(DM)和癌症。住院时间与危险因素数有显著相关(r=0.219, P<0.001)。结论:总之，流感相关脑病和上呼吸道体征在儿童中更为普遍，相反，成人比季节性流感儿童更可能有潜在的医疗条件。
{"title":"Clinical Characteristics and Underlying Medical Conditions Among Hospitalized Children and Adult Patients With Seasonal Influenza","authors":"Gholamreza Ghoreishi, B. Bijani, A. Allami","doi":"10.32598/jid.26.3.4","DOIUrl":"https://doi.org/10.32598/jid.26.3.4","url":null,"abstract":"Background: Influenza is a respiratory infection that causes a wide range of symptoms, from mild symptoms to a significantly impaired disease. Objective: This study aims to examine demographic characteristics, clinical features, and underlying medical conditions in children and adults hospitalized with laboratory-confirmed influenza. Methods: This was a retrospective comparative study on 333 adults and 102 children hospitalized with symptoms of acute respiratory tract infection and seasonal influenza confirmed by reverse transcription polymerase chain reaction (RT-PCR) in three university hospitals, in Qazvin City, Iran, during two influenza seasons (March 2017 and February 2019). Findings: Most clinical manifestations of influenza were similar among adults. A significant difference was observed among the two groups in terms of 1) a greater proportion of male patients in children (66.7%) and female patients in adults (58.6%); 2) adults were more exposed to risk factors than children (median 1 vs. 0); 3) a greater proportion of children presenting influenza-related encephalopathy (38.2% vs. 26.7%) and upper respiratory signs compared to adults; 4) a greater proportion of adults presenting lower respiratory signs and symptoms compared to children. The most common underlying conditions were asthma and diabetes mellitus (DM) in adults and diabetes mellitus (DM) and cancer in children. The duration of hospitalization had a significant relationship with the number of risk factors (r=0.219, P<0.001). Conclusion: In summary, influenza-related encephalopathy and upper respiratory signs are more prevalent in children, and in contrast, adults are more likely to have underlying medical conditions than children with seasonal influenza.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85343383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Yekefallah, A. Ahmadi, R. Kalhor, S. Soltani, P. Namdar, S. Mohammadi
Background: The demand for home care services has increased not only due to the increase in the elderly population but also due to consumer preference and technological advances that allow for the provision of sophisticated home care. Home healthcare services aim to help people improve their performance, live a more independent life, improve their well-being, and help them stay at home, and avoid hospitalization. Objective: This study was conducted to compare the quality of life (QoL) of COVID-19 patients under home care at a hospital in Qazvin City, Iran. Methods: his study was a cohort study. The samples included two groups of patients, hospitalized patients due to COVID-19 and patients with COVID-19 who received medical and nursing care at home. Patients were matched for age, underlying disease, and severity of the COVID-19 disease. In this study, a 3-month follow-up on changes in QoL compared to before hospitalization and receiving care at home was performed using a QoL questionnaire (SF-12). Findings: The mean score of QoL in the home care group was 32.36±2.15 and in the hospitalized group, it was 29.70±2.94, which shows a statistically significant difference, and the quality of home care patients reported to be higher than hospitalized patients (P<0.001, t=7.20) Conclusion: Receiving hospital care at home increases the QoL for patients with COVID-19. This finding can be generalized during different epidemics, and home care can be an excellent alternative to hospitalization for some patients.
{"title":"Comparison of the Quality of Life of COVID-19 Patients Cared for at Home and in the Hospital","authors":"L. Yekefallah, A. Ahmadi, R. Kalhor, S. Soltani, P. Namdar, S. Mohammadi","doi":"10.32598/jid.26.3.6","DOIUrl":"https://doi.org/10.32598/jid.26.3.6","url":null,"abstract":"Background: The demand for home care services has increased not only due to the increase in the elderly population but also due to consumer preference and technological advances that allow for the provision of sophisticated home care. Home healthcare services aim to help people improve their performance, live a more independent life, improve their well-being, and help them stay at home, and avoid hospitalization. Objective: This study was conducted to compare the quality of life (QoL) of COVID-19 patients under home care at a hospital in Qazvin City, Iran. Methods: his study was a cohort study. The samples included two groups of patients, hospitalized patients due to COVID-19 and patients with COVID-19 who received medical and nursing care at home. Patients were matched for age, underlying disease, and severity of the COVID-19 disease. In this study, a 3-month follow-up on changes in QoL compared to before hospitalization and receiving care at home was performed using a QoL questionnaire (SF-12). Findings: The mean score of QoL in the home care group was 32.36±2.15 and in the hospitalized group, it was 29.70±2.94, which shows a statistically significant difference, and the quality of home care patients reported to be higher than hospitalized patients (P<0.001, t=7.20) Conclusion: Receiving hospital care at home increases the QoL for patients with COVID-19. This finding can be generalized during different epidemics, and home care can be an excellent alternative to hospitalization for some patients.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76083152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Koushan, Ahmad Yari Khosroushahi, M. H. Geranmayeh, S. Hashemipour, Mahnaz Ghadimi Yari, H. K. Haghighian
Background: Hypothyroidism has been associated with complications such as increased inflammation, and oxidative stress. Objective: This pilot study was created to assess the impact of Illicium verum (I. verum) on serum levels of thyroid hormones as well as depression, anxiety, and stress in hypothyroidism patients given the detrimental effects of oxidative stress on thyroid function and considering the antioxidant properties of I. verum. Methods: In this double-blind clinical research with a placebo group, which was performed as a pilot, 20 hypothyroid individuals were recruited. Participants were randomly allocated to a capsule containing 1.5 g of I. verum (per day) (n=10) or a placebo (n=10) for 8 weeks. Thyroid hormones, including free triiodothyronine (FT3), free thyroxine (FT4), triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) were measured at the beginning and end of the study. Furthermore, depression and stress were assessed using the Depression Anxiety Stress Scales-21 (DASS-21) survey. Quantitative analysis was performed using SPSS software, version 20. Findings: No discernible difference was observed between the blood thyroid hormone levels at the baseline. TSH levels in the intervention group decreased significantly at the end of the study, while FT3, FT4, T3, and T4 levels increased significantly (P<0.05). Compared to the study’s initial findings, the intervention group experienced considerably lower mean changes in terms of depression, anxiety, and stress scores. (P<0.05). Conclusion: The I. verum supplement can be helpful as a dietary supplement with antioxidant properties in patients with hypothyroidism. This herbal supplement can increase the effectiveness of medication in patients with hypothyroidism.
背景:甲状腺功能减退与炎症增加和氧化应激等并发症有关。目的:考虑到氧化应激对甲状腺功能的不利影响，并考虑到八头草的抗氧化特性，本初步研究旨在评估八头草(I. verum)对甲状腺功能低下患者血清甲状腺激素水平以及抑郁、焦虑和应激的影响。方法:本双盲临床研究以安慰剂组为先导，招募20例甲状腺功能低下患者。参与者被随机分配到含有1.5 g verum(每天)的胶囊(n=10)或安慰剂(n=10)，持续8周。在研究开始和结束时测量甲状腺激素，包括游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、三碘甲状腺原氨酸(T3)、甲状腺素(T4)和促甲状腺激素(TSH)。此外，使用抑郁焦虑压力量表-21 (DASS-21)调查评估抑郁和压力。采用SPSS软件20进行定量分析。结果:基线时血液甲状腺激素水平无明显差异。干预组在研究结束时TSH水平显著降低，FT3、FT4、T3、T4水平显著升高(P<0.05)。与研究的初始结果相比，干预组在抑郁、焦虑和压力得分方面的平均变化要低得多。(P < 0.05)。结论:枳实可作为抗氧化性膳食补充剂用于甲状腺功能减退患者。这种草药补充剂可以增加甲状腺功能减退患者的药物治疗效果。
{"title":"The Effect of an Aqueous Extract of Illicium verum on Serum Levels of Thyroid Hormones and Depression, Anxiety, and Stress in Patients With Hypothyroidism","authors":"Y. Koushan, Ahmad Yari Khosroushahi, M. H. Geranmayeh, S. Hashemipour, Mahnaz Ghadimi Yari, H. K. Haghighian","doi":"10.32598/jid.26.3.1","DOIUrl":"https://doi.org/10.32598/jid.26.3.1","url":null,"abstract":"Background: Hypothyroidism has been associated with complications such as increased inflammation, and oxidative stress. Objective: This pilot study was created to assess the impact of Illicium verum (I. verum) on serum levels of thyroid hormones as well as depression, anxiety, and stress in hypothyroidism patients given the detrimental effects of oxidative stress on thyroid function and considering the antioxidant properties of I. verum. Methods: In this double-blind clinical research with a placebo group, which was performed as a pilot, 20 hypothyroid individuals were recruited. Participants were randomly allocated to a capsule containing 1.5 g of I. verum (per day) (n=10) or a placebo (n=10) for 8 weeks. Thyroid hormones, including free triiodothyronine (FT3), free thyroxine (FT4), triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) were measured at the beginning and end of the study. Furthermore, depression and stress were assessed using the Depression Anxiety Stress Scales-21 (DASS-21) survey. Quantitative analysis was performed using SPSS software, version 20. Findings: No discernible difference was observed between the blood thyroid hormone levels at the baseline. TSH levels in the intervention group decreased significantly at the end of the study, while FT3, FT4, T3, and T4 levels increased significantly (P<0.05). Compared to the study’s initial findings, the intervention group experienced considerably lower mean changes in terms of depression, anxiety, and stress scores. (P<0.05). Conclusion: The I. verum supplement can be helpful as a dietary supplement with antioxidant properties in patients with hypothyroidism. This herbal supplement can increase the effectiveness of medication in patients with hypothyroidism.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89294700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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