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C1-C2 Joint Distraction and Fusion: A Robust Surgical Technique for Atlantoaxial Dislocation with Basilar Invagination C1-C2 关节牵引和融合:治疗寰枢关节脱位伴基底动脉内陷的稳健手术技术
Pub Date : 2024-01-08 DOI: 10.17756/jnen.2024-111
Tejesh Shavi, Sathwik Shetty, Bopanna Kumar, Praveen Ganigi, Khurram Khan
Background: Atlantoaxial dislocation (AAD) and Basilar invagination (BI) are complex craniospinal alignment pathologies with significant clinical morbidity at presentation and a potential for life threatening complications. To realign the craniospinal complex optimally various strategies have been employed over the years ranging from, transoral odontoidectomy to sublaminar wire fixation and in situ screw fixation with significant morbidity and sub-optimal outcomes. This study focuses on our experience with the current treatment strategy of C1-C2 joint distraction and fusion, in managing this complex pathology. Purpose: To study the clinical and
背景:寰枢椎脱位(AAD)和基底内陷(BI)是复杂的颅椎对位病症,临床发病率高,并可能出现危及生命的并发症。为了以最佳方式重新对位颅椎复合体,多年来采用了多种策略,包括经口蝶骨切除术、椎板下钢丝固定术和原位螺钉固定术等,但都有显著的发病率和不理想的治疗效果。本研究的重点是介绍我们在治疗这种复杂病症时,采用 C1-C2 关节牵引和融合术这一现行治疗策略的经验。目的:研究临床和
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引用次数: 0
Intravascular Proliferation: A Case Report of Intravascular Large B Cell Lymphoma Arising within a Glioblastoma, IDH Wild Type 血管内增殖:胶质母细胞瘤中出现的血管内大 B 细胞淋巴瘤(IDH 野生型)病例报告
Pub Date : 2023-11-11 DOI: 10.17756/jnen.2023-109
Jennifer Pfeiffer, William Oliver Humphrey, Alissa Ashley Thomas, John Charles DeWitt
A synchronous multiple primary tumors is a second tumor that occurs within two months of identification of the first primary cancer. Collision tumors is the definition given to two synchronous tumors in the same organ whereby distinct borders between the two primary tumors are maintained. The occurrence of collision tumors is a very rare phenomenon. Here, we describe a case of an 82-year-old woman who presented with approximately one month’s duration of neurologic deficits. Magnetic resonance imaging (MRI) revealed a left parietal lobe lesion which was radiographically concerning for a high-grade glioma. Following surgical resection microscopic examination of the mass revealed high-grade glioma with synchronous malignant lymphoma involving tumor vasculature, consistent with a collision of glioblastoma, IDH-wildtype, and intravascular large B cell lymphoma. To our knowledge, this represents the first reported case of a collision tumor involving these two entities.
同步多发性原发肿瘤是指在第一个原发肿瘤发生后两个月内发生的第二个肿瘤。碰撞肿瘤是指在同一器官中发生的两个同步肿瘤,两个原发肿瘤之间保持明显的边界。碰撞肿瘤是一种非常罕见的现象。在此,我们描述了一例 82 岁女性的病例,她出现神经功能缺损约一个月。磁共振成像(MRI)显示其左顶叶病变,放射学检查显示为高级别胶质瘤。手术切除后,对肿块进行显微镜检查,发现高级别胶质瘤伴有累及肿瘤血管的同步恶性淋巴瘤,这与胶质母细胞瘤、IDH-野生型和血管内大B细胞淋巴瘤的碰撞一致。据我们所知,这是首例报道的涉及这两种实体的碰撞性肿瘤。
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引用次数: 0
Report on the 8th Neurological Disorders Summit (NDS-2023) 第八届神经系统疾病峰会报告(NDS-2023)
Pub Date : 2023-01-01 DOI: 10.17756/jnen.2023-108
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引用次数: 0
Proceedings of the 8th Neurological Disorders Summit (NDS-2023) 第八届神经系统疾病高峰会议论文集(NDS-2023)
Pub Date : 2023-01-01 DOI: 10.17756/jnen.2023-suppl1
L. Ju, Jiepei Zhu, T. Morey, N. Gravenstein, C. Seubert, T. Vasilopoulos, A. Martynyuk, Chisato Kinoshita, K. Aoyama, T. Nakaki, E. Spinazzi, Mychael Delgardo, Andrés Pascual-Leones, Colby T Joncas, G. Mandigo, S. Lavine, J. Grinband, E. Sander, I. Khaliulin, Maryam Kartawy, H. Amal, Juliana Condoleo, Hu Wang, C. K. Bullen, Xiaoli Rong, Hao Fang, Senthilkumar S. Karuppagounder, Yongxing Gao, T. Dawson, V. Dawson, Jin-chong Xu, Jong-Hyun Son, Amanda K. Gerenza, Gabrielle M. Bingener, J. Bonkowsky, Kharon Grimmet, L. Gangwani, LouAnne E. Boyd, S. Upreti, Madhumita P. Ghosh, M. Podda, Saviana Antonella, Barbati, Chiara D'Amelio, Ida Nifo Sarrapocchiello, S. Fusco, Claudio Grassi, Matea Drlje, Sara Trnski, Andrija Štajduhar, Mihaela Bobić-Rasonja, Davide di Cenco, Eugene Kim, Eilidh MacNicol, K. Ilić, D. Cash, S. Škokić, N. Milošević, M. Youdim, Ofira Einstein Presenter, A. Katz, T. Ben-Hur, R. Howell, M. Lloyd-Puryear, Rabea Iris Pantelatos, K. Moen, A. Vik, T. Skandsen, René Daniel, S. Efrati, A. Hadanny, S
Introduction: Preexisting neurodegenerative diseases, perioperative stress, and inflammation play an essential role in accelerated neurocognitive decline after general anesthesia (GA) and surgery, termed perioperative neurocognitive disorder (PND). PND is an important public health problem potentially affecting millions of patients. Because neurodegenerative diseases pre-vail and worsen with age, PND is most readily detectable and studied in the aging population. Traumatic brain injury (TBI), with >50 million cases/year, is a dominant cause of disability in young adults. Similar to PND, the pathophysiology of TBI involves lasting dysregulation of stress response systems, neuroinflammation, and cognitive decline. Patients with a history of TBI may also require GA/surgery or sedation to treat conditions unrelated to TBI, or injuries sustained at the time of TBI. Here we tested whether the effects of GA/surgery, TBI, and subsequent repeated exposure to the general anesthetic sevoflurane (SEVO) interact to induce neurological and neuroendocrine abnormalities in the exposed young adult male rats (an animal model of PND) and/or in their future offspring (intergenerational PND). Methods: All animal procedures were approved by IACUC. Sprague-Dawley
先前存在的神经退行性疾病,围手术期应激和炎症在全麻(GA)和手术后加速神经认知衰退中起重要作用,称为围手术期神经认知障碍(PND)。PND是一个重要的公共卫生问题,可能影响数百万患者。由于神经退行性疾病随着年龄的增长而发生和恶化,PND在老年人群中最容易被发现和研究。外伤性脑损伤(TBI)是导致年轻人残疾的主要原因,每年约有5000万例。与PND相似,创伤性脑损伤的病理生理包括持续的应激反应系统失调、神经炎症和认知能力下降。有TBI病史的患者也可能需要GA/手术或镇静来治疗与TBI无关的疾病,或TBI时持续的损伤。在这里,我们测试了GA/手术、TBI和随后反复暴露于全身麻醉剂七氟醚(SEVO)的影响是否会在暴露的年轻成年雄性大鼠(PND的动物模型)和/或它们未来的后代(代际PND)中引起神经和神经内分泌异常。方法:所有动物实验均经IACUC批准。Sprague-Dawley
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引用次数: 0
Amyotrophic Lateral Sclerosis: Therapeutic Progress in Neurology Practice 肌萎缩性侧索硬化症:神经病学实践的治疗进展
Pub Date : 2023-01-01 DOI: 10.17756/jnen.2023-100
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引用次数: 0
An Individualized Intervention, Based on the Feldenkrais Method, for Multiple Sclerosis Symptoms: The Neuroplasticity Scale Assessment 基于Feldenkrais方法的个体化干预多发性硬化症症状:神经可塑性量表评估
Pub Date : 2023-01-01 DOI: 10.17756/jnen.2023-102
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引用次数: 0
Hypovitaminosis D in Painful Peripheral Neuropathy 疼痛性周围神经病变的维生素D缺乏症
Pub Date : 2023-01-01 DOI: 10.17756/jnen.2023-107
Jin Jun Luo, Nae J. Dun
Vitamin D is an essential vitamin necessary for maintaining proper bone structure by regulating calcium-phosphorus metabolism in the body. Vitamin D, as a hormone, also has effects on the nervous system. Peripheral neuropathy (PN) comprises a group of disorders involving the peripheral nervous system, which includes sensory, motor, and autonomic nerves. PN manifests as various symptoms, such as pain, numbness, and muscle weakness, alone or in combination. PN is caused by a wide variety of etiologies. Accumulating evidence from clinical and laboratory studies shows that hypovitaminosis-D may be a potentially independent risk factor for painful PN. Administering vitamin D to patients with hypovitaminosis-D alleviates their neuropathic symptoms. In this article, we review up-to-date clinical observations on hypovitaminosis-D
维生素D是一种必需的维生素,通过调节体内钙磷代谢来维持正常的骨骼结构。维生素D作为一种激素,对神经系统也有影响。周围神经病变(PN)包括一组涉及周围神经系统的疾病,包括感觉神经、运动神经和自主神经。PN表现为各种症状,如疼痛、麻木和肌肉无力,单独或合并。PN是由多种病因引起的。来自临床和实验室研究的越来越多的证据表明,维生素d缺乏症可能是疼痛性PN的潜在独立危险因素。维生素D缺乏症患者服用维生素D可减轻其神经病变症状。在本文中,我们回顾最新的临床观察维生素d缺乏症
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引用次数: 0
If Light Could Help: The Use of Transcranial Photobiomodulation in Parkinson’s Disease. A Controlled Clinical Study 如果光可以帮助:经颅光生物调节在帕金森病中的应用。对照临床研究
Pub Date : 2023-01-01 DOI: 10.17756/jnen.2023-105
Federica Peci, R. Pica, S. Peci, Cerebro Company
Objective: The aim of this study is to investigate whether a 4-week phys-iotherapeutic rehabilitation combined with transcranial photobiomodulation (tPBM) treatment is more effective than the only motor rehabilitation and if the improvement persists at 1-month follow-up. Methods: We investigated 40 Parkinson’s disease (PD) patients, divided into two different groups: a control group that underwent only physiotherapeutic rehabilitation and the experimental one that underwent physiotherapeutic rehabilitation combined with PBM treatment. Outcome measures were UPDRS Part I, Part II and Part III. Patients were evaluated at admission, at the end of 4-week treatment and at 1 month follow up. Results: All outcome measures improved for each group, but significantly improved at the end of treatment for the experimental group not only related to motor symptoms but also to everyday struggle. Conclusion: Our results demonstrate that the combination of PBM treat-ment with physiotherapeutic rehabilitation was effective in improving motor symptoms in PD patients and the improvement in balance, gait and tremor were partially maintained after 1 month.
目的:本研究旨在探讨为期4周的物理治疗康复联合经颅光生物调节(tPBM)治疗是否比单独的运动康复更有效,以及在1个月的随访中是否持续改善。方法:选取40例帕金森病(PD)患者为研究对象,将其分为单纯物理康复治疗组和物理康复联合PBM治疗组。结局指标为UPDRS第一部分、第二部分和第三部分。在入院时、4周治疗结束时和1个月随访时对患者进行评估。结果:各组的各项指标均有改善,但实验组在治疗结束时不仅在运动症状方面有显著改善,而且在日常挣扎方面也有显著改善。结论:我们的研究结果表明,PBM联合物理治疗康复对改善PD患者的运动症状是有效的,并且在1个月后,平衡、步态和震颤的改善得以部分维持。
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引用次数: 0
Primitive Reflex Integration and Reading Achievement in the Classroom 原始反射整合与课堂阅读成绩
Pub Date : 2023-01-01 DOI: 10.17756/jnen.2023-103
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引用次数: 0
Disease Modification Therapy with Anti-Soluble Aβ Protofibril Antibody for Alzheimer Disease 抗可溶性Aβ原纤维抗体治疗阿尔茨海默病
Pub Date : 2023-01-01 DOI: 10.17756/jnen.2023-101
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Journal of neurology and experimental neuroscience
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