Dhananjay Gupta, R. Pradeep, A. Mehta, M. Javali, P. T. Acharya, Srinivasa Rangasetty
Results and conclusion: Despite being a century old disease, the nomenclature and diagnostic criteria have undergone constant modifications. The most common symptoms are headache, visual disturbances and tinnitus. Treatment strategies include weight reduction, lifestyle modification, Acetazolamide, analgesics for headache, topiramate and surgical procedures like shunt diversion or optic nerve sheath fenestration.
{"title":"Idiopathic Intracranial Hypertension: A Review of Nomenclature, Diagnostic Criteria and Management Strategies","authors":"Dhananjay Gupta, R. Pradeep, A. Mehta, M. Javali, P. T. Acharya, Srinivasa Rangasetty","doi":"10.17756/jnen.2020-071","DOIUrl":"https://doi.org/10.17756/jnen.2020-071","url":null,"abstract":"Results and conclusion: Despite being a century old disease, the nomenclature and diagnostic criteria have undergone constant modifications. The most common symptoms are headache, visual disturbances and tinnitus. Treatment strategies include weight reduction, lifestyle modification, Acetazolamide, analgesics for headache, topiramate and surgical procedures like shunt diversion or optic nerve sheath fenestration.","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67649503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Sarcoidosis is a rare idiopathic systemic inflammatory disorder characterized by the formation of the non-caseating granulomas. Neurological complications involve approximately 5% of the patients with systemic sarcoidosis. Most literatures on neurosarcoidosis are anecdotal case reports. Studies of a series of cases of neurosarcoidosis are sparse. In this report, we studied clinical, laboratory and neuroimaging findings in patients with sarcoidosis involving the central nervous system (CNS). Methods: Clinical charts were retrospectively reviewed for the past 10 years to identify patients with a clinically conformed diagnosis of sarcoidosis, which was proven by a previously biopsied histological evaluation. Subjects with neurological presentation and clinically diagnosed neurosarcoidosis were collected. Subjects with identifiable etiologies causing a CNS structural lesion and/or dysfunction other than sarcoidosis, incomplete data, or sarcoidosis without nervous system complications were excluded. The collected data of clinical, laboratory and neuroimaging findings were analyzed. Results: Twenty-nine patients (age: 51.7 ± 9.0 years, range: 36 - 77, female / male = 21 / 8) were studied. Common clinical presentations were seizures (34.5%); Bell’s palsy (17.2%) with facial hypoesthesia (13.8%); limb weakness (13.8%) and/or numbness (6.9%); abducens nerve paresis (6.9%); hydrocephalus (6.9%), nystagmus (3.4%), and optical neuritis (3.4%). MRI showed abnormalities in discrete areas in the brain and spinal cord involving the parenchyma in different anatomic locations, leptomeninges and cranial nerves. Abnormal laboratory findings showed elevated ACE level in plasma and cerebrospinal fluid, impaired liver functions with reduced level of triglycerides, and elevated protein with decreased glucose and mild lymphocytosis in cerebrospinal fluid. Conclusion: Diagnosis of neurosarcoidosis remains a clinical challenge. Seizures were most frequently seen at presentation in patients with sarcoidosis involving the CNS. Laboratory studies of impaired liver function with reduced triglycerides, and CSF elevated levels of ACE and protein with decreased glucose and mild lymphocytosis may aid in differentiating neurosarcoidosis from other CNS inflammatory demyelinating disorders.
{"title":"Clinical, Laboratory and Neuroimaging Findings in Patients with Sarcoidosis Involving the CNS: Study of 29 Cases","authors":"A. Mehta, J. Luo","doi":"10.17756/jnen.2020-065","DOIUrl":"https://doi.org/10.17756/jnen.2020-065","url":null,"abstract":"Introduction: Sarcoidosis is a rare idiopathic systemic inflammatory disorder characterized by the formation of the non-caseating granulomas. Neurological complications involve approximately 5% of the patients with systemic sarcoidosis. Most literatures on neurosarcoidosis are anecdotal case reports. Studies of a series of cases of neurosarcoidosis are sparse. In this report, we studied clinical, laboratory and neuroimaging findings in patients with sarcoidosis involving the central nervous system (CNS). Methods: Clinical charts were retrospectively reviewed for the past 10 years to identify patients with a clinically conformed diagnosis of sarcoidosis, which was proven by a previously biopsied histological evaluation. Subjects with neurological presentation and clinically diagnosed neurosarcoidosis were collected. Subjects with identifiable etiologies causing a CNS structural lesion and/or dysfunction other than sarcoidosis, incomplete data, or sarcoidosis without nervous system complications were excluded. The collected data of clinical, laboratory and neuroimaging findings were analyzed. Results: Twenty-nine patients (age: 51.7 ± 9.0 years, range: 36 - 77, female / male = 21 / 8) were studied. Common clinical presentations were seizures (34.5%); Bell’s palsy (17.2%) with facial hypoesthesia (13.8%); limb weakness (13.8%) and/or numbness (6.9%); abducens nerve paresis (6.9%); hydrocephalus (6.9%), nystagmus (3.4%), and optical neuritis (3.4%). MRI showed abnormalities in discrete areas in the brain and spinal cord involving the parenchyma in different anatomic locations, leptomeninges and cranial nerves. Abnormal laboratory findings showed elevated ACE level in plasma and cerebrospinal fluid, impaired liver functions with reduced level of triglycerides, and elevated protein with decreased glucose and mild lymphocytosis in cerebrospinal fluid. Conclusion: Diagnosis of neurosarcoidosis remains a clinical challenge. Seizures were most frequently seen at presentation in patients with sarcoidosis involving the CNS. Laboratory studies of impaired liver function with reduced triglycerides, and CSF elevated levels of ACE and protein with decreased glucose and mild lymphocytosis may aid in differentiating neurosarcoidosis from other CNS inflammatory demyelinating disorders.","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67648808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.17756/jnen.2020-suppl2
{"title":"Global Virtual Conference on Alzheimer’s Disease and Dementia (GVCAD-2020)","authors":"","doi":"10.17756/jnen.2020-suppl2","DOIUrl":"https://doi.org/10.17756/jnen.2020-suppl2","url":null,"abstract":"","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67649870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.17756/jnen.2020-suppl1
{"title":"Online Meeting on Parkinson’s Disease (OMPD-2020)","authors":"","doi":"10.17756/jnen.2020-suppl1","DOIUrl":"https://doi.org/10.17756/jnen.2020-suppl1","url":null,"abstract":"","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67649752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adam B O'Connell, B. Sinnott, Timothy R. Kuchel, S. Perumal, Cara K Fraser, Kim M Hemsley, A. Jennifer Morton
{"title":"Neurological Examination of Sheep (Ovis aries) with Unilateral and Bilateral Quinolinic Acid Lesions of the Striatum Assessed by Magnetic Resonance Imaging","authors":"Adam B O'Connell, B. Sinnott, Timothy R. Kuchel, S. Perumal, Cara K Fraser, Kim M Hemsley, A. Jennifer Morton","doi":"10.17756/jnen.2019-054","DOIUrl":"https://doi.org/10.17756/jnen.2019-054","url":null,"abstract":"","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42285353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W. Bahnasy, O. Ragab, Abdelmoneim Ahmed Nagy Eissa
Findings: This study reported a case of 65-year-old male patient with paraneoplastic NMOSD. The patient presented with quadriparesis due to acute cervical long segment myelitis not responsive to pulse steroid therapy; 18 months later he developed acute bilateral diminution of visual acuity due to bilateral optic neuritis with no response to either pulse steroid therapy or IVIG. Serological serum tests revealed that the patient was AQP–4–IgG positive, but after 22 months of the initial presentation, the patient showed widespread metastasis in bone and liver secondary to bronchogenic carcinoma.
{"title":"Neuromyelitis Optica as a Paraneoplastic Manifestation of Bronchogenic Carcinoma: A Case Report","authors":"W. Bahnasy, O. Ragab, Abdelmoneim Ahmed Nagy Eissa","doi":"10.17756/jnen.2019-058","DOIUrl":"https://doi.org/10.17756/jnen.2019-058","url":null,"abstract":"Findings: This study reported a case of 65-year-old male patient with paraneoplastic NMOSD. The patient presented with quadriparesis due to acute cervical long segment myelitis not responsive to pulse steroid therapy; 18 months later he developed acute bilateral diminution of visual acuity due to bilateral optic neuritis with no response to either pulse steroid therapy or IVIG. Serological serum tests revealed that the patient was AQP–4–IgG positive, but after 22 months of the initial presentation, the patient showed widespread metastasis in bone and liver secondary to bronchogenic carcinoma.","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67648389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alzheimer’s Disease, is a Cure Possible?","authors":"B. Kakulas","doi":"10.17756/jnen.2019-050","DOIUrl":"https://doi.org/10.17756/jnen.2019-050","url":null,"abstract":"","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67648248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Published by United Scientific Group The 3rd Chinese American Neurological Association (CANA) Annual Meeting with CME credentials was successfully held in Houston, Texas on November 3, 2018. This CME meeting was combined with, and a part of, the Joint Annual Meeting of Alliance of North American Chinese Physicians (ANACP), CANA, and American Association of Chinese Rehabilitation Physicians (AACRP).
{"title":"The Third Chinese American Neurological Association Annual Meeting","authors":"Kevin Xie, J. Luo","doi":"10.17756/JNEN.2019-046","DOIUrl":"https://doi.org/10.17756/JNEN.2019-046","url":null,"abstract":"Published by United Scientific Group The 3rd Chinese American Neurological Association (CANA) Annual Meeting with CME credentials was successfully held in Houston, Texas on November 3, 2018. This CME meeting was combined with, and a part of, the Joint Annual Meeting of Alliance of North American Chinese Physicians (ANACP), CANA, and American Association of Chinese Rehabilitation Physicians (AACRP).","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67648489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Idiopathic Focal Cerebritis Mimicking a Neoplasm","authors":"","doi":"10.17756/jnen.2019-062","DOIUrl":"https://doi.org/10.17756/jnen.2019-062","url":null,"abstract":"","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67648912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
5th Neurological Disorders Summit (NDS-2019) was held at Four Points by Sheraton, Los Angeles, CA, USA from July 18-20, 2019, organized by United Scientific Group, a nonprofit organization. This three-day conference had gathered 114 participants from 31 countries; had 64 oral presentations and 38 poster presentations on a wide variety of topics on Neurological Disorders and the related fields. Here are the highlights of some topics in the Summit.
{"title":"Report on the 5th Neurological Disorders Summit (NDS-2019)","authors":"J. Luo","doi":"10.17756/jnen.2019-055","DOIUrl":"https://doi.org/10.17756/jnen.2019-055","url":null,"abstract":"5th Neurological Disorders Summit (NDS-2019) was held at Four Points by Sheraton, Los Angeles, CA, USA from July 18-20, 2019, organized by United Scientific Group, a nonprofit organization. This three-day conference had gathered 114 participants from 31 countries; had 64 oral presentations and 38 poster presentations on a wide variety of topics on Neurological Disorders and the related fields. Here are the highlights of some topics in the Summit.","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67648255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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