{"title":"A Characterization of Epileptiform Activity Associated with TAU Seeding and Amyloid Pathology in the APPKM670/671NL.PS1/L166P and APP-KI Animal Models","authors":"","doi":"10.17756/jnen.2022-096","DOIUrl":"https://doi.org/10.17756/jnen.2022-096","url":null,"abstract":"","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67650639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Antoniades, Athanasiou Alkinoos, Sarlis Panagiotis, Polyzoidis Stavros, Keramidiotis Iraklis, Patsalas Ioannis, Magras Ioannis
1Residents of First Department of Neurosurgery, AHEPA University General Hospital, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece 2Consultants of First Department of Neurosurgery, AHEPA University General Hospital, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece 3Professors of Neurosurgery of First Department of Neurosurgery, AHEPA University General Hospital, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece
{"title":"Implications of Vertebral Artery Blunt Injury to Cervical Spine Trauma Treatment: Short Narrative Review of the Literature Based on Four Cases","authors":"E. Antoniades, Athanasiou Alkinoos, Sarlis Panagiotis, Polyzoidis Stavros, Keramidiotis Iraklis, Patsalas Ioannis, Magras Ioannis","doi":"10.17756/jnen.2021-089","DOIUrl":"https://doi.org/10.17756/jnen.2021-089","url":null,"abstract":"1Residents of First Department of Neurosurgery, AHEPA University General Hospital, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece 2Consultants of First Department of Neurosurgery, AHEPA University General Hospital, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece 3Professors of Neurosurgery of First Department of Neurosurgery, AHEPA University General Hospital, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67650224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Jazebi, Ch Evans, Hima S Kadaru, Divya Kompella, M. Raji, F. Fang, M. Pappolla, Shao-Jun Tang, J. Chung, B. Hammock, Xiang Fang
HIV-sensory neuropathy (HIV-SN) is a debilitating complication in HIV patients with or without anti-retroviral treatment (ART). Common symptoms of HIV-SN include pain, decreased sensation, paresthesias, and dysesthesias in a symmetric stocking-glove distribution. While HIV-1 protein such as gp120 is implicated in HIV-SN (e.g. impaired large-diameter fiber), ART itself was recently shown to contribute to HIV-SN in HIV patients and impair thin fiber. Multiple host mechanisms may play roles during the pathogenesis of HIV-SN, including neuron-glia interactions in the spinal dorsal horn (SDH), inflammation, mitochondrial dysfunction and endoplasmic reticulum stress. Concurrent infections, such as tuberculosis, also carry a higher likelihood of HIV-SN as well as environmental or genetic predisposition. Pro-inflammatory cytokines such as IL-1, IL2 receptor-alpha, and tumor necrosis factor (TNF) along with abnormal lactate levels have been identified as potential players within the complex pathophysiology of this condition. In this paper, we review the pathophysiology of HIV neuropathy, focusing on the various treatment options available or under investigation. Although several treatment options are available e.g., the capsaicin patch and spinal cord stimulation, symptomatic control of HIV-SN are often challenging. Alternative approaches such as self-hypnosis, resistance exercise, cannabinoids, and acupuncture have all shown promising results, but need further investigation.
{"title":"HIV-related Neuropathy: Pathophysiology, Treatment and Challenges.","authors":"N. Jazebi, Ch Evans, Hima S Kadaru, Divya Kompella, M. Raji, F. Fang, M. Pappolla, Shao-Jun Tang, J. Chung, B. Hammock, Xiang Fang","doi":"10.17756/JNEN.2021-082","DOIUrl":"https://doi.org/10.17756/JNEN.2021-082","url":null,"abstract":"HIV-sensory neuropathy (HIV-SN) is a debilitating complication in HIV patients with or without anti-retroviral treatment (ART). Common symptoms of HIV-SN include pain, decreased sensation, paresthesias, and dysesthesias in a symmetric stocking-glove distribution. While HIV-1 protein such as gp120 is implicated in HIV-SN (e.g. impaired large-diameter fiber), ART itself was recently shown to contribute to HIV-SN in HIV patients and impair thin fiber. Multiple host mechanisms may play roles during the pathogenesis of HIV-SN, including neuron-glia interactions in the spinal dorsal horn (SDH), inflammation, mitochondrial dysfunction and endoplasmic reticulum stress. Concurrent infections, such as tuberculosis, also carry a higher likelihood of HIV-SN as well as environmental or genetic predisposition. Pro-inflammatory cytokines such as IL-1, IL2 receptor-alpha, and tumor necrosis factor (TNF) along with abnormal lactate levels have been identified as potential players within the complex pathophysiology of this condition. In this paper, we review the pathophysiology of HIV neuropathy, focusing on the various treatment options available or under investigation. Although several treatment options are available e.g., the capsaicin patch and spinal cord stimulation, symptomatic control of HIV-SN are often challenging. Alternative approaches such as self-hypnosis, resistance exercise, cannabinoids, and acupuncture have all shown promising results, but need further investigation.","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"7 1 1","pages":"15-24"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67649961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.17756/jnen.2021-suppl1
{"title":"Proceedings of the 6th Neurological Disorders Summit (NDS-2021)","authors":"","doi":"10.17756/jnen.2021-suppl1","DOIUrl":"https://doi.org/10.17756/jnen.2021-suppl1","url":null,"abstract":"","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67650145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Several genetic makers have been identified as predisposing factors in the aetiology of motor neuron disease, MND /ALS. Chief among these are mutations in the SOD1 gene but many other aberration of the genome have been implicated mainly in the form of structural variants (SVs). Comparison is made between sporadic MND/ALS and a similar degenerative disorder endemic on the island of Guam known to be caused by Cycad toxicity. The long incubation period of both conditions points to a complex time-dependent pathogenesis.
{"title":"Perspectives in Motor Neuron Disease and Amyotrophic Lateral Sclerosis","authors":"B. Kakulas","doi":"10.17756/jnen.2021-088","DOIUrl":"https://doi.org/10.17756/jnen.2021-088","url":null,"abstract":"Several genetic makers have been identified as predisposing factors in the aetiology of motor neuron disease, MND /ALS. Chief among these are mutations in the SOD1 gene but many other aberration of the genome have been implicated mainly in the form of structural variants (SVs). Comparison is made between sporadic MND/ALS and a similar degenerative disorder endemic on the island of Guam known to be caused by Cycad toxicity. The long incubation period of both conditions points to a complex time-dependent pathogenesis.","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67650119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The 6th Chinese American Neurological Association Annual Meeting","authors":"","doi":"10.17756/jnen.2021-090","DOIUrl":"https://doi.org/10.17756/jnen.2021-090","url":null,"abstract":"","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67650497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. George, Neena Baby, Neethu Thambi, Sapna Joy, S. Radhakrishnan, V. V. Thomas, P. Prasad
1Department of Neurology, Renai Medicity Multi Superspeciality Hospital, Kochi , Kerala, India 2Department of Pulmonology, Renai Medicity Multi Super-speciality Hospital, Kochi, Kerala, India 3Department of Microbiology, Renai Medicity Multi Super-speciality Hospital, Kochi, Kerala, India 4Department of Radiology, Renai Medicity Multi Super-speciality Hospital, Kochi, Kerala, India 5Department of ENT, Renai Medicity Multi Super-speciality Hospital, Kochi, Kerala, India
{"title":"A Rare Case of Rhino Orbito Cerebral Mucor Mycosis Associated with COVID 19 Infection","authors":"M. George, Neena Baby, Neethu Thambi, Sapna Joy, S. Radhakrishnan, V. V. Thomas, P. Prasad","doi":"10.17756/jnen.2021-085","DOIUrl":"https://doi.org/10.17756/jnen.2021-085","url":null,"abstract":"1Department of Neurology, Renai Medicity Multi Superspeciality Hospital, Kochi , Kerala, India 2Department of Pulmonology, Renai Medicity Multi Super-speciality Hospital, Kochi, Kerala, India 3Department of Microbiology, Renai Medicity Multi Super-speciality Hospital, Kochi, Kerala, India 4Department of Radiology, Renai Medicity Multi Super-speciality Hospital, Kochi, Kerala, India 5Department of ENT, Renai Medicity Multi Super-speciality Hospital, Kochi, Kerala, India","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67649847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rafaela Ianisky, T. Wrubleski, J. Tafarel, V. L. Dias, M. Cristina, Figueroa Magalhães
Background: Cerebral Venous Thrombosis is an underdiagnosed form of stroke. Its presentation as association of headache with visual symptoms is unusual in literature, particularly in patients without predisposing factors; so, the diagnosis is often delayed, especially by the non-neurologists. The case is discussed in the light of diagnostic challenge and how an understanding of the basic sciences can explain its clinical presentation.
{"title":"Cerebral Venous Thrombosis – A Diagnostic Challenge","authors":"Rafaela Ianisky, T. Wrubleski, J. Tafarel, V. L. Dias, M. Cristina, Figueroa Magalhães","doi":"10.17756/jnen.2021-087","DOIUrl":"https://doi.org/10.17756/jnen.2021-087","url":null,"abstract":"Background: Cerebral Venous Thrombosis is an underdiagnosed form of stroke. Its presentation as association of headache with visual symptoms is unusual in literature, particularly in patients without predisposing factors; so, the diagnosis is often delayed, especially by the non-neurologists. The case is discussed in the light of diagnostic challenge and how an understanding of the basic sciences can explain its clinical presentation.","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67650536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Report on the Sixth Neurological Disorders Summit (NDS-2021)","authors":"","doi":"10.17756/jnen.2021-086","DOIUrl":"https://doi.org/10.17756/jnen.2021-086","url":null,"abstract":"","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67650466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The 5th Chinese American Neurological Association Annual Meeting","authors":"Jin Jun Luo, Qing Ni","doi":"10.17756/jnen.2020-078","DOIUrl":"https://doi.org/10.17756/jnen.2020-078","url":null,"abstract":"","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67649268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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