Hemoglobin has been reported to be a biological Fenton reagent, as a consequence of oxidations believed to be produced by hydroxyl radicals. These hydroxyl radicals were thought to be generated from the reaction of hemoglobin with hydrogen peroxide. However, the oxidations that were observed were in fact due to the generation of a strongly oxidizing iron (IV) ferryl species, and not due to hydroxyl radicals. (First online: March 1, 2022)
{"title":"Hemoglobin Is Not a Biological Fenton Reagent","authors":"P. Penketh","doi":"10.20455/ros.2022.c.801","DOIUrl":"https://doi.org/10.20455/ros.2022.c.801","url":null,"abstract":"Hemoglobin has been reported to be a biological Fenton reagent, as a consequence of oxidations believed to be produced by hydroxyl radicals. These hydroxyl radicals were thought to be generated from the reaction of hemoglobin with hydrogen peroxide. However, the oxidations that were observed were in fact due to the generation of a strongly oxidizing iron (IV) ferryl species, and not due to hydroxyl radicals.\u0000(First online: March 1, 2022)","PeriodicalId":91793,"journal":{"name":"Reactive oxygen species (Apex, N.C.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49361406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The 5-year survival rates for ovarian cancer are 93%, 75%, and 30% for localized, regional, and distant tumors, respectively. These vast differences in survival rates underscore the need to identify novel therapeutic targets that are effective at different stages of tumor progression to better treat all patients diagnosed with this deadly disease. Manganese superoxide dismutase (SOD2) is a mitochondrial antioxidant enzyme responsible for eliminating superoxide and preventing oxidative damage to the mitochondria. Recent studies have implicated changes in SOD2 expression levels in multiple cancers, including breast, colorectal, prostate, and head and neck. While studies have begun to unravel the role of SOD2 in ovarian cancer, no one has looked at the specific role SOD2 plays in distinct stages of tumor progression of ovarian cancer. Here, we report SOD2 deficiency (accomplished through utilizing shRNA techniques) results in increased invasive and migratory ability of SKOV3 cells, a commonly used ovarian adenocarcinoma cell line. In contrast, SOD2-deficient SKOV3 cells display abrogated anchorage-independent growth in soft agar. These studies in SKOV3 cells indicate that SOD2 expression hampers invasion and migration critical for early tumor initiation but helps maintain anchorage-independent growth necessary for ovarian cancer metastases. In aggregate, SOD2 plays a context-dependent role in ovarian cancer progression and its utility as a therapeutic target for later-stage anchorage-independent ovarian cancer cells should be further explored. (First online: March 1, 2022)
{"title":"The Role of SOD2 in Migration and Anchorage-Independent Growth of SKOV3 Ovarian Cancer Cells","authors":"S. Gilligan, M. O’Shea, Calli A. Davison-Versagli","doi":"10.20455/ros.2022.r.801","DOIUrl":"https://doi.org/10.20455/ros.2022.r.801","url":null,"abstract":"The 5-year survival rates for ovarian cancer are 93%, 75%, and 30% for localized, regional, and distant tumors, respectively. These vast differences in survival rates underscore the need to identify novel therapeutic targets that are effective at different stages of tumor progression to better treat all patients diagnosed with this deadly disease. Manganese superoxide dismutase (SOD2) is a mitochondrial antioxidant enzyme responsible for eliminating superoxide and preventing oxidative damage to the mitochondria. Recent studies have implicated changes in SOD2 expression levels in multiple cancers, including breast, colorectal, prostate, and head and neck. While studies have begun to unravel the role of SOD2 in ovarian cancer, no one has looked at the specific role SOD2 plays in distinct stages of tumor progression of ovarian cancer. Here, we report SOD2 deficiency (accomplished through utilizing shRNA techniques) results in increased invasive and migratory ability of SKOV3 cells, a commonly used ovarian adenocarcinoma cell line. In contrast, SOD2-deficient SKOV3 cells display abrogated anchorage-independent growth in soft agar. These studies in SKOV3 cells indicate that SOD2 expression hampers invasion and migration critical for early tumor initiation but helps maintain anchorage-independent growth necessary for ovarian cancer metastases. In aggregate, SOD2 plays a context-dependent role in ovarian cancer progression and its utility as a therapeutic target for later-stage anchorage-independent ovarian cancer cells should be further explored.\u0000(First online: March 1, 2022)","PeriodicalId":91793,"journal":{"name":"Reactive oxygen species (Apex, N.C.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45183655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abhijit Sarkar, Swarnendu Basak, Sumit Ghosh, Sushweta Mahalanobish, P. Sil
The mortality rate due to malaria has increased tremendously in the last decade. Even though the causative agent of this disease is known, the preventive measures are not potent enough to control the spread of this disease. Malarial infection involves a strong interrelationship between oxidative stress and pathogenesis. This review addresses the various oxidative stress-related mechanisms associated with vector defense, host immunity, plasmodial pathogenesis, and corresponding therapeutic strategies. The mechanisms involving host and vector defense show both similarity and contradiction to the processes involving plasmodial pathogenesis under different circumstances. Therefore, corresponding ameliorative peculiarities are observed in the therapeutic mechanisms adopted by the anti-malarial drugs. The malarial parasite augments oxidative stress to weaken the host and exerts antioxidant effects against host defense mechanisms. However, the anti-malarial drugs induce oxidative insult to reduce parasitic load and exert antioxidant effects against parasite infection-induced oxidative stress in host. Thus, the anti-malarial drugs exhibit antioxidant activity in hosts and/or pro-oxidant activity in parasites.
{"title":"Insights into the Relation between Oxidative Stress and Malaria: A Mechanistic and Therapeutic Approach","authors":"Abhijit Sarkar, Swarnendu Basak, Sumit Ghosh, Sushweta Mahalanobish, P. Sil","doi":"10.20455/ros.2021.m.805","DOIUrl":"https://doi.org/10.20455/ros.2021.m.805","url":null,"abstract":"The mortality rate due to malaria has increased tremendously in the last decade. Even though the causative agent of this disease is known, the preventive measures are not potent enough to control the spread of this disease. Malarial infection involves a strong interrelationship between oxidative stress and pathogenesis. This review addresses the various oxidative stress-related mechanisms associated with vector defense, host immunity, plasmodial pathogenesis, and corresponding therapeutic strategies. The mechanisms involving host and vector defense show both similarity and contradiction to the processes involving plasmodial pathogenesis under different circumstances. Therefore, corresponding ameliorative peculiarities are observed in the therapeutic mechanisms adopted by the anti-malarial drugs. The malarial parasite augments oxidative stress to weaken the host and exerts antioxidant effects against host defense mechanisms. However, the anti-malarial drugs induce oxidative insult to reduce parasitic load and exert antioxidant effects against parasite infection-induced oxidative stress in host. Thus, the anti-malarial drugs exhibit antioxidant activity in hosts and/or pro-oxidant activity in parasites.","PeriodicalId":91793,"journal":{"name":"Reactive oxygen species (Apex, N.C.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46880773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This Education & Resources web page lists major clinical studies on antioxidant-based modalities or related entities in disease intervention and health promotion, which were published in highly influential journals during 2020. It should be noted that this is not intended to be a complete list, but is rather to focus on rigorously designed and well conducted high-profile randomized controlled trials (RCTs) whose findings were reported in medical or bioscience journals of the highest impact. For more comprehensive information on antioxidant-based clinical trials, the reader may refer to the ClinicalTrials.gov (https://clinicaltrials.gov), the largest clinical trials database, run by the US National Library of Medicine, that holds registrations from over 368,000 trials from 219 countries. 2020 LIST IN REVERSE CHRONOLOGICAL ORDER Feofanova et al. A Genome-wide association study discovers 46 loci of the human metabolome in the Hispanic Community Health Study/Study of Latinos. Am J Hum Genet 2020 Nov 5; 107(5):849-863. doi: https://dx.doi.org/10.1016/j.ajhg.2020.09.003. Key finding: High levels of vitamin E metabolites were associated with lower odds of coronary heart disease. Note: Vitamin E and derivatives are antioxidants, but also possess other biological activities, such as inhibition of protein kinase C-mediated signaling. Horsfall et al. Genetically raised serum bilirubin levels and lung cancer: a cohort study and Mendelian randomisation using UK Biobank. Thorax 2020 Nov; 75(11):955-964. doi: https://dx.doi.org/10.1136/thoraxjnl-2020-214756. Key finding: High serum bilirubin was associated with decreased lung cancer incidence. Note: Bilirubin is a potent antioxidant. According to Dr Davey Smith, Mendelian randomization is a method of using measured variation in genes of known function to examine the causal effect of a modifiable exposure on disease in observational studies (from the US CDC website: https://cdc.gov). A positive finding in a Mendelian randomization study provides strong evidence for a causal relationship. Morris et al. Impact of arginine therapy on mitochondrial function in children with sickle cell disease during vaso-occlusive pain. Blood 2020 Sep 17;136(12):1402-1406. doi: https://dx.doi.org/10.1182/blood.2019003672. Key finding: Arginine therapy increased mitochondrial activity and reduced oxidative stress in children with sickle cell disease with vaso-occlusive pain episodes. Note: Arginine is the substrate for nitric oxide synthetase and possesses antioxidative activities. Nitric oxide acts also as an antioxidant in biological systems. Yubero-Serrano et al. Mediterranean diet and endothelial function in patients with coronary heart disease: an analysis of the CORDIOPREV randomized controlled trial. PLoS Med 2020 Sep 9; 17(9):e1003282. doi: https://dx.doi.org/10.1371/journal.pmed.1003282. Key finding: Mediterranean diet intake led to improved endothelial function and lower ROS production. Note: Mediterranean diet is rich in
{"title":"Clinical Research on Antioxidant-Based Modalities in 2020","authors":"E. Ros","doi":"10.20455/ros.2021.s.803","DOIUrl":"https://doi.org/10.20455/ros.2021.s.803","url":null,"abstract":"This Education & Resources web page lists major clinical studies on antioxidant-based modalities or related entities in disease intervention and health promotion, which were published in highly influential journals during 2020. It should be noted that this is not intended to be a complete list, but is rather to focus on rigorously designed and well conducted high-profile randomized controlled trials (RCTs) whose findings were reported in medical or bioscience journals of the highest impact. For more comprehensive information on antioxidant-based clinical trials, the reader may refer to the ClinicalTrials.gov (https://clinicaltrials.gov), the largest clinical trials database, run by the US National Library of Medicine, that holds registrations from over 368,000 trials from 219 countries.\u00002020 LIST IN REVERSE CHRONOLOGICAL ORDER\u0000Feofanova et al. A Genome-wide association study discovers 46 loci of the human metabolome in the Hispanic Community Health Study/Study of Latinos. Am J Hum Genet 2020 Nov 5; 107(5):849-863. doi: https://dx.doi.org/10.1016/j.ajhg.2020.09.003.\u0000Key finding: High levels of vitamin E metabolites were associated with lower odds of coronary heart disease.\u0000Note: Vitamin E and derivatives are antioxidants, but also possess other biological activities, such as inhibition of protein kinase C-mediated signaling.\u0000Horsfall et al. Genetically raised serum bilirubin levels and lung cancer: a cohort study and Mendelian randomisation using UK Biobank. Thorax 2020 Nov; 75(11):955-964. doi: https://dx.doi.org/10.1136/thoraxjnl-2020-214756.\u0000Key finding: High serum bilirubin was associated with decreased lung cancer incidence.\u0000Note: Bilirubin is a potent antioxidant. According to Dr Davey Smith, Mendelian randomization is a method of using measured variation in genes of known function to examine the causal effect of a modifiable exposure on disease in observational studies (from the US CDC website: https://cdc.gov). A positive finding in a Mendelian randomization study provides strong evidence for a causal relationship.\u0000Morris et al. Impact of arginine therapy on mitochondrial function in children with sickle cell disease during vaso-occlusive pain. Blood 2020 Sep 17;136(12):1402-1406. doi: https://dx.doi.org/10.1182/blood.2019003672.\u0000Key finding: Arginine therapy increased mitochondrial activity and reduced oxidative stress in children with sickle cell disease with vaso-occlusive pain episodes.\u0000Note: Arginine is the substrate for nitric oxide synthetase and possesses antioxidative activities. Nitric oxide acts also as an antioxidant in biological systems.\u0000Yubero-Serrano et al. Mediterranean diet and endothelial function in patients with coronary heart disease: an analysis of the CORDIOPREV randomized controlled trial. PLoS Med 2020 Sep 9; 17(9):e1003282. doi: https://dx.doi.org/10.1371/journal.pmed.1003282.\u0000Key finding: Mediterranean diet intake led to improved endothelial function and lower ROS production.\u0000Note: Mediterranean diet is rich in","PeriodicalId":91793,"journal":{"name":"Reactive oxygen species (Apex, N.C.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48296233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Being updated biweekly till the end of the year, this Education & Resources web page lists major clinical studies on antioxidant-based modalities or related entities in disease intervention and health promotion, which have been published in highly influential journals during 2021. It should be noted that this is not intended to be a complete list, but is rather to focus on rigorously designed and well conducted high-profile randomized controlled trials (RCTs) whose findings were reported in medical or bioscience journals of the highest impact. For more comprehensive information on antioxidant-based clinical trials, the reader may refer to the ClinicalTrials.gov (https://clinicaltrials.gov), the largest clinical trials database, run by the US National Library of Medicine, that holds registrations from over 368,000 trials from 219 countries. 2021 LIST IN REVERSE CHRONOLOGICAL ORDER Xu et al. Edaravone dexborneol versus edaravone alone for the treatment of acute ischemic stroke: a phase III, randomized, double-blind, comparative trial. Stroke 2021 Mar; 52(3):772-780. doi: https://dx.doi.org/10.1161/STROKEAHA.120.031197. Key finding: Edaravone dexborneol (a combination of edaravone and borneol) was superior to edaravone alone in improving the clinical outcomes of the acute ischemic stroke patients. Note: Edaravone, a synthetic free radical scavenger, was approved by the US FDA in 2017 for treating amyotrophic lateral sclerosis (ALS). Borneol is a phytochemical with diverse biological activities including antioxidative and anti-inflammatory effects. Kim et al. Reactive oxygen species scavenger in acute intracerebral hemorrhage patients: a multicenter, randomized controlled trial. Stroke 2021 Feb 25; doi: https://doi.org/10.1161/STROKEAHA.120.032266. Key finding: Giving N-acetylcysteine 2000 mg/day and selenium 1600 µg/day, intravenously, for 14 days significantly improved the clinical outcomes in the acute intracerebral hemorrhage patients. Note: N-Acetylcysteine is a precursor of glutathione (GSH). Selenium acts as an antioxidant element due, at least partly, to its essentialness for the function of various selenoproteins, including selenium-dependent glutathione peroxidases (GPx). Kalstad et al. Effects of n-3 fatty acid supplements in elderly patients after myocardial infarction: a randomized, controlled trial. Circulation 2021 Feb 9; 143(6):528-539. doi: https://dx.doi.org/10.1161/CIRCULATIONAHA.120.052209. Key finding: Null Note: n-3 Fatty acids, also known as omega-3 fatty acids, possess potent antioxidative and anti-inflammatory activities. Lynch et al. Safety and efficacy of omaveloxolone in Friedreich ataxia (MOXIe Study). Ann Neurol 2021 Feb; 89(2):212-225. doi: https://dx.doi.org/10.1002/ana.25934. Key finding: Omaveloxolone significantly improved neurological function compared to placebo and is well tolerated. Note: Omaveloxolone, a synthetic oleanane triterpenoid, is an activator of Nrf2, the chief regulator of cellular antioxidant and ot
{"title":"Clinical Research on Antioxidant-Based Modalities in 2021","authors":"E. Ros","doi":"10.20455/ros.2021.s.805","DOIUrl":"https://doi.org/10.20455/ros.2021.s.805","url":null,"abstract":"Being updated biweekly till the end of the year, this Education & Resources web page lists major clinical studies on antioxidant-based modalities or related entities in disease intervention and health promotion, which have been published in highly influential journals during 2021. It should be noted that this is not intended to be a complete list, but is rather to focus on rigorously designed and well conducted high-profile randomized controlled trials (RCTs) whose findings were reported in medical or bioscience journals of the highest impact. For more comprehensive information on antioxidant-based clinical trials, the reader may refer to the ClinicalTrials.gov (https://clinicaltrials.gov), the largest clinical trials database, run by the US National Library of Medicine, that holds registrations from over 368,000 trials from 219 countries.\u00002021 LIST IN REVERSE CHRONOLOGICAL ORDER\u0000Xu et al. Edaravone dexborneol versus edaravone alone for the treatment of acute ischemic stroke: a phase III, randomized, double-blind, comparative trial. Stroke 2021 Mar; 52(3):772-780. doi: https://dx.doi.org/10.1161/STROKEAHA.120.031197.\u0000Key finding: Edaravone dexborneol (a combination of edaravone and borneol) was superior to edaravone alone in improving the clinical outcomes of the acute ischemic stroke patients.\u0000Note: Edaravone, a synthetic free radical scavenger, was approved by the US FDA in 2017 for treating amyotrophic lateral sclerosis (ALS). Borneol is a phytochemical with diverse biological activities including antioxidative and anti-inflammatory effects.\u0000Kim et al. Reactive oxygen species scavenger in acute intracerebral hemorrhage patients: a multicenter, randomized controlled trial. Stroke 2021 Feb 25; doi: https://doi.org/10.1161/STROKEAHA.120.032266.\u0000Key finding: Giving N-acetylcysteine 2000 mg/day and selenium 1600 µg/day, intravenously, for 14 days significantly improved the clinical outcomes in the acute intracerebral hemorrhage patients.\u0000Note: N-Acetylcysteine is a precursor of glutathione (GSH). Selenium acts as an antioxidant element due, at least partly, to its essentialness for the function of various selenoproteins, including selenium-dependent glutathione peroxidases (GPx).\u0000Kalstad et al. Effects of n-3 fatty acid supplements in elderly patients after myocardial infarction: a randomized, controlled trial. Circulation 2021 Feb 9; 143(6):528-539. doi: https://dx.doi.org/10.1161/CIRCULATIONAHA.120.052209.\u0000Key finding: Null\u0000Note: n-3 Fatty acids, also known as omega-3 fatty acids, possess potent antioxidative and anti-inflammatory activities.\u0000Lynch et al. Safety and efficacy of omaveloxolone in Friedreich ataxia (MOXIe Study). Ann Neurol 2021 Feb; 89(2):212-225. doi: https://dx.doi.org/10.1002/ana.25934.\u0000Key finding: Omaveloxolone significantly improved neurological function compared to placebo and is well tolerated.\u0000Note: Omaveloxolone, a synthetic oleanane triterpenoid, is an activator of Nrf2, the chief regulator of cellular antioxidant and ot","PeriodicalId":91793,"journal":{"name":"Reactive oxygen species (Apex, N.C.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47036409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This Education & Resources web page provides a list, in alphabetical order, of highly influential journals (typically with an impact factor of 10 or above) where high profile research articles on ROS may be found. This, however, is not intended to be a complete list. LIST IN ALPHABETICAL ORDER American Journal of Gastroenterology American Journal of Human Genetics American Journal of Respiratory and Critical Care Medicine Annals of Internal Medicine Annals of Neurology Autophagy Blood Brain British Medical Journal Cancer Research Cell (and Molecular Cell, Cancer Cell, Cell Metabolism, Cell Stem Cell, Developmental Cell, Cell Host Microbe) Cell Research Chest Circulation Circulation Research Current Biology EMBO J (and EMBO Molecular Medicine) European Heart Journal European Journal of Heart Failure European Respiratory Journal Gastroenterology Genes and Development Genome Biology Genome Research Gut Hepatology Immunity JAMA (and JAMA Internal Medicine, JAMA Cardiology) Journal of Allergy and Clinical Immunology Journal of the American College of Cardiology (and JACC Cardiovascular Imaging, JACC Cardiovascular Interventions, JACC Heart Failure) Journal of Cell Biology Journal of Clinical Investigation Journal of Experimental Medicine Journal of the American Chemical Society Journal of the National Cancer Institute Lancet (and Lancet Oncology, Lancet Neurology, Lancet Diabetes & Endocrinology) Microbiome Molecular Biology and Evolution Molecular Cancer Molecular Plant Nature (and Nature Genetics, Nature Medicine, Nature Methods, Nature Biotechnology, Nature Materials, Nature Nanotechnology, Nature Communications, Nature Structural & Molecular Biology, Nature Neuroscience, Nature Immunology, Nature Cell Biology, Nature Chemical Biology, Nature Microbiology, Nature Plants, Nature Chemical Biology) Neuron New England Journal of Medicine Nucleic Acids Research Plant Cell PLOS Medicine Proceedings of the National Academy of Sciences of the United States of America Science (and Science Signaling, Science Translational Medicine, Science Immunology)
{"title":"A List of Highly Influential Journals","authors":"E. Ros","doi":"10.20455/ros.2021.s.801","DOIUrl":"https://doi.org/10.20455/ros.2021.s.801","url":null,"abstract":"This Education & Resources web page provides a list, in alphabetical order, of highly influential journals (typically with an impact factor of 10 or above) where high profile research articles on ROS may be found. This, however, is not intended to be a complete list.\u0000LIST IN ALPHABETICAL ORDER\u0000American Journal of Gastroenterology\u0000American Journal of Human Genetics\u0000American Journal of Respiratory and Critical Care Medicine\u0000Annals of Internal Medicine\u0000Annals of Neurology\u0000Autophagy\u0000Blood\u0000Brain\u0000British Medical Journal\u0000Cancer Research\u0000Cell (and Molecular Cell, Cancer Cell, Cell Metabolism, Cell Stem Cell, Developmental Cell, Cell Host Microbe)\u0000Cell Research\u0000Chest\u0000Circulation\u0000Circulation Research\u0000Current Biology\u0000EMBO J (and EMBO Molecular Medicine)\u0000European Heart Journal\u0000European Journal of Heart Failure\u0000European Respiratory Journal\u0000Gastroenterology\u0000Genes and Development\u0000Genome Biology\u0000Genome Research\u0000Gut\u0000Hepatology\u0000Immunity\u0000JAMA (and JAMA Internal Medicine, JAMA Cardiology)\u0000Journal of Allergy and Clinical Immunology\u0000Journal of the American College of Cardiology (and JACC Cardiovascular Imaging, JACC Cardiovascular Interventions, JACC Heart Failure) \u0000Journal of Cell Biology\u0000Journal of Clinical Investigation\u0000Journal of Experimental Medicine\u0000Journal of the American Chemical Society\u0000Journal of the National Cancer Institute\u0000Lancet (and Lancet Oncology, Lancet Neurology, Lancet Diabetes & Endocrinology)\u0000Microbiome\u0000Molecular Biology and Evolution\u0000Molecular Cancer\u0000Molecular Plant\u0000Nature (and Nature Genetics, Nature Medicine, Nature Methods, Nature Biotechnology, Nature Materials, Nature Nanotechnology, Nature Communications, Nature Structural & Molecular Biology, Nature Neuroscience, Nature Immunology, Nature Cell Biology, Nature Chemical Biology, Nature Microbiology, Nature Plants, Nature Chemical Biology)\u0000Neuron\u0000New England Journal of Medicine\u0000Nucleic Acids Research\u0000Plant Cell\u0000PLOS Medicine\u0000Proceedings of the National Academy of Sciences of the United States of America\u0000Science (and Science Signaling, Science Translational Medicine, Science Immunology)","PeriodicalId":91793,"journal":{"name":"Reactive oxygen species (Apex, N.C.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46338691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Water channels, also known as aquaporins, were discovered by Peter C. Agre, the recipient of the 2003 Nobel Prize in Chemistry. In addition to facilitating transport of water, these channels have been shown to also mediate the diffusion of hydrogen peroxide across cell membranes and consequently control the biological functions of this important reactive oxygen species. Findings from multiple recent studies published in highly influential journals have further advanced our understanding on how to control the biological effects of hydrogen peroxide via targeting specific water channels. REFERENCES Hopkins RZ. Hydrogen Peroxide in biology and medicine: an overview. React Oxyg Species (Apex) 2017; 3(7):26–37. doi: https://dx.doi.org/10.20455/ros.2017.809. Bienert GP, Moller AL, Kristiansen KA, Schulz A, Moller IM, Schjoerring JK, et al. Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes. J Biol Chem 2007; 282(2):1183‒92. doi: https://dx.doi.org/10.1074/jbc.M603761200. Miller EW, Dickinson BC, Chang CJ. Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling. Proc Natl Acad Sci USA 2010; 107(36):15681‒6. doi: https://dx.doi.org/10.1073/pnas.1005776107. Watanabe S, Moniaga CS, Nielsen S, Hara-Chikuma M. Aquaporin-9 facilitates membrane transport of hydrogen peroxide in mammalian cells. Biochem Biophys Res Commun 2016; 471(1):191‒7. doi: https://dx.doi.org/10.1016/j.bbrc.2016.01.153. Hara-Chikuma M, Chikuma S, Sugiyama Y, Kabashima K, Verkman AS, Inoue S, et al. Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake. J Exp Med 2012; 209(10):1743‒52. doi: https://dx.doi.org/10.1084/jem.20112398. Hara-Chikuma M, Satooka H, Watanabe S, Honda T, Miyachi Y, Watanabe T, et al. Aquaporin-3-mediated hydrogen peroxide transport is required for NF-kappaB signalling in keratinocytes and development of psoriasis. Nat Commun 2015; 6:7454. doi: https://dx.doi.org/10.1038/ncomms8454. Satooka H, Hara-Chikuma M. Aquaporin-3 controls breast cancer cell migration by regulating hydrogen peroxide transport and its downstream cell signaling. Mol Cell Biol 2016; 36(7):1206‒18. doi: https://dx.doi.org/10.1128/MCB.00971-15. Montiel V, Bella R, Michel LYM, Esfahani H, De Mulder D, Robinson EL, et al. Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide. Sci Transl Med 2020; 12(564). doi: https://dx.doi.org/10.1126/scitranslmed.aay2176. Steinhorn B, Sorrentino A, Badole S, Bogdanova Y, Belousov V, Michel T. Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction. Nat Commun 2018; 9(1):4044. doi: https://dx.doi.org/10.1038/s41467-018-06533-2. Hara-Chikuma M, Tanaka M, Verkman AS, Yasui M. Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury. Nat Commun 2020; 11(1):5666. doi: https://dx.doi.org/10.1038/s41467-020-19491-5. Han
{"title":"Hydrogen Peroxide, Water Channels, and Tissue Injury","authors":"E. Ros","doi":"10.20455/ros.2021.n.803","DOIUrl":"https://doi.org/10.20455/ros.2021.n.803","url":null,"abstract":"Water channels, also known as aquaporins, were discovered by Peter C. Agre, the recipient of the 2003 Nobel Prize in Chemistry. In addition to facilitating transport of water, these channels have been shown to also mediate the diffusion of hydrogen peroxide across cell membranes and consequently control the biological functions of this important reactive oxygen species. Findings from multiple recent studies published in highly influential journals have further advanced our understanding on how to control the biological effects of hydrogen peroxide via targeting specific water channels.\u0000REFERENCES\u0000\u0000Hopkins RZ. Hydrogen Peroxide in biology and medicine: an overview. React Oxyg Species (Apex) 2017; 3(7):26–37. doi: https://dx.doi.org/10.20455/ros.2017.809.\u0000Bienert GP, Moller AL, Kristiansen KA, Schulz A, Moller IM, Schjoerring JK, et al. Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes. J Biol Chem 2007; 282(2):1183‒92. doi: https://dx.doi.org/10.1074/jbc.M603761200.\u0000Miller EW, Dickinson BC, Chang CJ. Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling. Proc Natl Acad Sci USA 2010; 107(36):15681‒6. doi: https://dx.doi.org/10.1073/pnas.1005776107.\u0000Watanabe S, Moniaga CS, Nielsen S, Hara-Chikuma M. Aquaporin-9 facilitates membrane transport of hydrogen peroxide in mammalian cells. Biochem Biophys Res Commun 2016; 471(1):191‒7. doi: https://dx.doi.org/10.1016/j.bbrc.2016.01.153.\u0000Hara-Chikuma M, Chikuma S, Sugiyama Y, Kabashima K, Verkman AS, Inoue S, et al. Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake. J Exp Med 2012; 209(10):1743‒52. doi: https://dx.doi.org/10.1084/jem.20112398.\u0000Hara-Chikuma M, Satooka H, Watanabe S, Honda T, Miyachi Y, Watanabe T, et al. Aquaporin-3-mediated hydrogen peroxide transport is required for NF-kappaB signalling in keratinocytes and development of psoriasis. Nat Commun 2015; 6:7454. doi: https://dx.doi.org/10.1038/ncomms8454.\u0000Satooka H, Hara-Chikuma M. Aquaporin-3 controls breast cancer cell migration by regulating hydrogen peroxide transport and its downstream cell signaling. Mol Cell Biol 2016; 36(7):1206‒18. doi: https://dx.doi.org/10.1128/MCB.00971-15.\u0000Montiel V, Bella R, Michel LYM, Esfahani H, De Mulder D, Robinson EL, et al. Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide. Sci Transl Med 2020; 12(564). doi: https://dx.doi.org/10.1126/scitranslmed.aay2176.\u0000Steinhorn B, Sorrentino A, Badole S, Bogdanova Y, Belousov V, Michel T. Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction. Nat Commun 2018; 9(1):4044. doi: https://dx.doi.org/10.1038/s41467-018-06533-2.\u0000Hara-Chikuma M, Tanaka M, Verkman AS, Yasui M. Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury. Nat Commun 2020; 11(1):5666. doi: https://dx.doi.org/10.1038/s41467-020-19491-5.\u0000Han","PeriodicalId":91793,"journal":{"name":"Reactive oxygen species (Apex, N.C.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49666278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In addition to the diverse well-known physiological functions and pathophysiological effects of sodium ion (Na⁺), regulation of mitochondrial reactive oxygen species (ROS) by Na⁺ has recently been demonstrated by several studies published in highly influential journals. The findings from these studies, especially the proposed “cytosolic Na⁺‒Na⁺/Ca²⁺ exchanger‒mitochondrial ROS” axis, have greatly broadened our understanding of this most popular element in physiology and disease. REFERENCES Kohlhaas M, Liu T, Knopp A, Zeller T, Ong MF, Bohm M, et al. Elevated cytosolic Na+ increases mitochondrial formation of reactive oxygen species in failing cardiac myocytes. Circulation 2010; 121(14):1606-13. doi: https://dx.doi.org/10.1161/CIRCULATIONAHA.109.914911. Dey S, DeMazumder D, Sidor A, Foster DB, O'Rourke B. Mitochondrial ROS drive sudden cardiac death and chronic proteome remodeling in heart failure. Circ Res 2018; 123(3):356-71. doi: https://dx.doi.org/10.1161/CIRCRESAHA.118.312708. Murphy E, Eisner DA. Regulation of intracellular and mitochondrial sodium in health and disease. Circ Res 2009; 104(3):292-303. doi: https://dx.doi.org/10.1161/CIRCRESAHA.108.189050. Adrogue HJ, Madias NE. Sodium and potassium in the pathogenesis of hypertension. N Engl J Med 2007; 356(19):1966-78. doi: https://dx.doi.org/10.1056/NEJMra064486. Hernansanz-Agustin P, Choya-Foces C, Carregal-Romero S, Ramos E, Oliva T, Villa-Pina T, et al. Na+ controls hypoxic signalling by the mitochondrial respiratory chain. Nature 2020; 586(7828):287-91. doi: https://dx.doi.org/10.1038/s41586-020-2551-y. Wolf SG, Mutsafi Y, Dadosh T, Ilani T, Lansky Z, Horowitz B, et al. 3D visualization of mitochondrial solid-phase calcium stores in whole cells. Elife 2017; 6. doi: https://dx.doi.org/10.7554/eLife.29929. Shadel GS, Horvath TL. Mitochondrial ROS signaling in organismal homeostasis. Cell 2015; 163(3):560-9. doi: https://dx.doi.org/10.1016/j.cell.2015.10.001. Oberkampf M, Guillerey C, Mouries J, Rosenbaum P, Fayolle C, Bobard A, et al. Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells. Nat Commun 2018; 9(1):2241. doi: https://dx.doi.org/10.1038/s41467-018-04686-8. Sena LA, Li S, Jairaman A, Prakriya M, Ezponda T, Hildeman DA, et al. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity 2013; 38(2):225-36. doi: https://dx.doi.org/10.1016/j.immuni.2012.10.020.
{"title":"Sodium Ion Regulates Mitochondrial ROS","authors":"E. Ros","doi":"10.20455/ros.2021.n.805","DOIUrl":"https://doi.org/10.20455/ros.2021.n.805","url":null,"abstract":"In addition to the diverse well-known physiological functions and pathophysiological effects of sodium ion (Na⁺), regulation of mitochondrial reactive oxygen species (ROS) by Na⁺ has recently been demonstrated by several studies published in highly influential journals. The findings from these studies, especially the proposed “cytosolic Na⁺‒Na⁺/Ca²⁺ exchanger‒mitochondrial ROS” axis, have greatly broadened our understanding of this most popular element in physiology and disease.\u0000REFERENCES\u0000\u0000Kohlhaas M, Liu T, Knopp A, Zeller T, Ong MF, Bohm M, et al. Elevated cytosolic Na+ increases mitochondrial formation of reactive oxygen species in failing cardiac myocytes. Circulation 2010; 121(14):1606-13. doi: https://dx.doi.org/10.1161/CIRCULATIONAHA.109.914911.\u0000Dey S, DeMazumder D, Sidor A, Foster DB, O'Rourke B. Mitochondrial ROS drive sudden cardiac death and chronic proteome remodeling in heart failure. Circ Res 2018; 123(3):356-71. doi: https://dx.doi.org/10.1161/CIRCRESAHA.118.312708.\u0000Murphy E, Eisner DA. Regulation of intracellular and mitochondrial sodium in health and disease. Circ Res 2009; 104(3):292-303. doi: https://dx.doi.org/10.1161/CIRCRESAHA.108.189050.\u0000Adrogue HJ, Madias NE. Sodium and potassium in the pathogenesis of hypertension. N Engl J Med 2007; 356(19):1966-78. doi: https://dx.doi.org/10.1056/NEJMra064486.\u0000Hernansanz-Agustin P, Choya-Foces C, Carregal-Romero S, Ramos E, Oliva T, Villa-Pina T, et al. Na+ controls hypoxic signalling by the mitochondrial respiratory chain. Nature 2020; 586(7828):287-91. doi: https://dx.doi.org/10.1038/s41586-020-2551-y.\u0000Wolf SG, Mutsafi Y, Dadosh T, Ilani T, Lansky Z, Horowitz B, et al. 3D visualization of mitochondrial solid-phase calcium stores in whole cells. Elife 2017; 6. doi: https://dx.doi.org/10.7554/eLife.29929.\u0000Shadel GS, Horvath TL. Mitochondrial ROS signaling in organismal homeostasis. Cell 2015; 163(3):560-9. doi: https://dx.doi.org/10.1016/j.cell.2015.10.001.\u0000Oberkampf M, Guillerey C, Mouries J, Rosenbaum P, Fayolle C, Bobard A, et al. Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells. Nat Commun 2018; 9(1):2241. doi: https://dx.doi.org/10.1038/s41467-018-04686-8.\u0000Sena LA, Li S, Jairaman A, Prakriya M, Ezponda T, Hildeman DA, et al. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity 2013; 38(2):225-36. doi: https://dx.doi.org/10.1016/j.immuni.2012.10.020.\u0000","PeriodicalId":91793,"journal":{"name":"Reactive oxygen species (Apex, N.C.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47244265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dimethyl fumarate, a potent Nrf2 activator and antioxidant-inducing compound, has been approved by the US Food and Drug Administration (FDA) as a first-line drug for treating relapsing forms of multiple sclerosis (MS). Two latest studies published in Nat Commun demonstrated that the efficacy of the drug in treating MS may be associated with increased reactive oxygen species production instead. REFERENCES Rothstein JD. Edaravone: a new drug approved for ALS. Cell 2017; 171(4):725. doi: https://dx.doi.org/10.1016/j.cell.2017.10.011. Ashrafian H, Czibik G, Bellahcene M, Aksentijevic D, Smith AC, Mitchell SJ, et al. Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. Cell Metab 2012; 15(3):361–71. doi: https://dx.doi.org/10.1016/j.cmet.2012.01.017. Gold R, Kappos L, Arnold DL, Bar-Or A, Giovannoni G, Selmaj K, et al. Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med 2012; 367(12):1098–107. doi: https://dx.doi.org/10.1056/NEJMoa1114287. Schulze-Topphoff U, Varrin-Doyer M, Pekarek K, Spencer CM, Shetty A, Sagan SA, et al. Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2. Proc Natl Acad Sci USA 2016; 113(17):4777–82. doi: https://dx.doi.org/10.1073/pnas.1603907113. Kornberg MD, Bhargava P, Kim PM, Putluri V, Snowman AM, Putluri N, et al. Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity. Science 2018; 360(6387):449–53. doi: https://dx.doi.org/10.1126/science.aan4665. Carlstrom KE, Ewing E, Granqvist M, Gyllenberg A, Aeinehband S, Enoksson SL, et al. Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes. Nat Commun 2019; 10(1):3081. doi: https://dx.doi.org/10.1038/s41467-019-11139-3. Luckel C, Picard F, Raifer H, Campos Carrascosa L, Guralnik A, Zhang Y, et al. IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis. Nat Commun 2019; 10(1):5722. doi: https://dx.doi.org/10.1038/s41467-019-13731-z.
富马酸二甲酯是一种有效的Nrf2激活剂和抗氧化剂诱导化合物，已被美国食品和药物管理局(FDA)批准作为治疗复发型多发性硬化症(MS)的一线药物。发表在《Nat common》上的两项最新研究表明，该药治疗多发性硬化症的疗效可能与活性氧产生的增加有关。REFERENCESRothstein JD。依达拉奉:一种被批准治疗渐冻症的新药。细胞2017;171(4): 725。doi: https://dx.doi.org/10.1016/j.cell.2017.10.011.Ashrafian H, Czibik G, Bellahcene M, Aksentijevic D, Smith AC, Mitchell SJ，等。富马酸通过激活Nrf2抗氧化途径起到心脏保护作用。Cell Metab 2012;15(3): 361 - 71。doi: https://dx.doi.org/10.1016/j.cmet.2012.01.017.Gold R, Kappos L, Arnold DL, Bar-Or A, Giovannoni G, Selmaj K，等。口服BG-12治疗复发性多发性硬化的安慰剂对照3期研究。中华医学杂志2012;367(12): 1098 - 107。doi: https://dx.doi.org/10.1056/NEJMoa1114287.Schulze-Topphoff U, Varrin-Doyer M, Pekarek K, Spencer CM, Shetty A, Sagan SA，等。富马酸二甲酯处理诱导不依赖于Nrf2的适应性和先天免疫调节。2016;113(17): 4777 - 82。doi: https://dx.doi.org/10.1073/pnas.1603907113.Kornberg MD, Bhargava P, Kim PM, Putluri V, Snowman AM, Putluri N，等。富马酸二甲酯靶向GAPDH和有氧糖酵解来调节免疫。科学2018;360(6387): 449 - 53。[doi: https://dx.doi.org/10.1126/science.aan4665.Carlstrom] KE, Ewing E, Granqvist M, Gyllenberg A, aeinehhs, Enoksson SL，等。富马酸二甲酯治疗复发缓解型多发性硬化症的疗效与单核细胞中的ROS通路有关。Nat comm2019;10(1): 3081。[j]张勇，刘建军，张勇，等。富马酸二甲酯抑制IL-17+ CD8+ T细胞与多发性硬化症的临床反应相关Nat comm2019;10(1): 5722。doi: https://dx.doi.org/10.1038/s41467 - 019 - 13731 - z。
{"title":"The US FDA-Approved Drug Dimethyl Fumarate, an Nrf2 Activator, for Treating Multiple Sclerosis: The Mechanisms of Action Revisited","authors":"E. Ros","doi":"10.20455/ros.2021.n.807","DOIUrl":"https://doi.org/10.20455/ros.2021.n.807","url":null,"abstract":"Dimethyl fumarate, a potent Nrf2 activator and antioxidant-inducing compound, has been approved by the US Food and Drug Administration (FDA) as a first-line drug for treating relapsing forms of multiple sclerosis (MS). Two latest studies published in Nat Commun demonstrated that the efficacy of the drug in treating MS may be associated with increased reactive oxygen species production instead.\u0000REFERENCES\u0000\u0000Rothstein JD. Edaravone: a new drug approved for ALS. Cell 2017; 171(4):725. doi: https://dx.doi.org/10.1016/j.cell.2017.10.011.\u0000Ashrafian H, Czibik G, Bellahcene M, Aksentijevic D, Smith AC, Mitchell SJ, et al. Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. Cell Metab 2012; 15(3):361–71. doi: https://dx.doi.org/10.1016/j.cmet.2012.01.017.\u0000Gold R, Kappos L, Arnold DL, Bar-Or A, Giovannoni G, Selmaj K, et al. Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med 2012; 367(12):1098–107. doi: https://dx.doi.org/10.1056/NEJMoa1114287.\u0000Schulze-Topphoff U, Varrin-Doyer M, Pekarek K, Spencer CM, Shetty A, Sagan SA, et al. Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2. Proc Natl Acad Sci USA 2016; 113(17):4777–82. doi: https://dx.doi.org/10.1073/pnas.1603907113.\u0000Kornberg MD, Bhargava P, Kim PM, Putluri V, Snowman AM, Putluri N, et al. Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity. Science 2018; 360(6387):449–53. doi: https://dx.doi.org/10.1126/science.aan4665.\u0000Carlstrom KE, Ewing E, Granqvist M, Gyllenberg A, Aeinehband S, Enoksson SL, et al. Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes. Nat Commun 2019; 10(1):3081. doi: https://dx.doi.org/10.1038/s41467-019-11139-3.\u0000Luckel C, Picard F, Raifer H, Campos Carrascosa L, Guralnik A, Zhang Y, et al. IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis. Nat Commun 2019; 10(1):5722. doi: https://dx.doi.org/10.1038/s41467-019-13731-z.\u0000","PeriodicalId":91793,"journal":{"name":"Reactive oxygen species (Apex, N.C.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43636902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The latest cutting-edge research findings published in highly influential journals have greatly advanced our current understanding of hydrogen peroxide (H₂O₂), a notable reactive oxygen species, in chemistry, biology, and medicine. In this context, recent studies by J.K. Lee et al., published in Proc Natl Acad Sci USA, discovered a novel mechanism of spontaneous production of H₂O₂ from pure water in the absence of catalysts or external electric field. This discovery by J.K. Lee et al. has changed our view on the chemical connection between H₂O₂ and H₂O though the biological significance of the discovery remains unknown. REFERENCES Hopkins RZ, Li YR. Essentials of Free Radical Biology and Medicine. Cell Med Press, Raleigh, NC, USA. 2017. Hopkins RZ. Hydrogen peroxide in biology and medicine: an overview. React Oxyg Species (Apex) 2017; 3(7):26–37. doi: https://dx.doi.org/10.20455/ros.2017.809. Bergman P, Parise B, Liseau R, Larsson B, Olofsson H, Menten KM, et al. Detection of interstellar hydrogen peroxide. Astronomy Astrophysics 2011; 531:L8. doi: https://dx.doi.org/10.1051/0004-6361/201117170. Lee JK, Walker KL, Han HS, Kang J, Prinz FB, Waymouth RM, et al. Spontaneous generation of hydrogen peroxide from aqueous microdroplets. Proc Natl Acad Sci USA 2019; 116(39):19294‒8. doi: https://dx.doi.org/10.1073/pnas.1911883116. Lee JK, Han HS, Chaikasetsin S, Marron DP, Waymouth RM, Prinz FB, et al. Condensing water vapor to droplets generates hydrogen peroxide. Proc Natl Acad Sci USA 2020; 117(49):30934‒41. doi: https://dx.doi.org/10.1073/pnas.2020158117.
{"title":"Hydrogen Peroxide: A Novel Mechanism of Its Production from Pure Water","authors":"E. Ros","doi":"10.20455/ros.2021.n.801","DOIUrl":"https://doi.org/10.20455/ros.2021.n.801","url":null,"abstract":"The latest cutting-edge research findings published in highly influential journals have greatly advanced our current understanding of hydrogen peroxide (H₂O₂), a notable reactive oxygen species, in chemistry, biology, and medicine. In this context, recent studies by J.K. Lee et al., published in Proc Natl Acad Sci USA, discovered a novel mechanism of spontaneous production of H₂O₂ from pure water in the absence of catalysts or external electric field. This discovery by J.K. Lee et al. has changed our view on the chemical connection between H₂O₂ and H₂O though the biological significance of the discovery remains unknown.\u0000REFERENCES\u0000\u0000Hopkins RZ, Li YR. Essentials of Free Radical Biology and Medicine. Cell Med Press, Raleigh, NC, USA. 2017.\u0000Hopkins RZ. Hydrogen peroxide in biology and medicine: an overview. React Oxyg Species (Apex) 2017; 3(7):26–37. doi: https://dx.doi.org/10.20455/ros.2017.809.\u0000Bergman P, Parise B, Liseau R, Larsson B, Olofsson H, Menten KM, et al. Detection of interstellar hydrogen peroxide. Astronomy Astrophysics 2011; 531:L8. doi: https://dx.doi.org/10.1051/0004-6361/201117170.\u0000Lee JK, Walker KL, Han HS, Kang J, Prinz FB, Waymouth RM, et al. Spontaneous generation of hydrogen peroxide from aqueous microdroplets. Proc Natl Acad Sci USA 2019; 116(39):19294‒8. doi: https://dx.doi.org/10.1073/pnas.1911883116.\u0000Lee JK, Han HS, Chaikasetsin S, Marron DP, Waymouth RM, Prinz FB, et al. Condensing water vapor to droplets generates hydrogen peroxide. Proc Natl Acad Sci USA 2020; 117(49):30934‒41. doi: https://dx.doi.org/10.1073/pnas.2020158117.\u0000","PeriodicalId":91793,"journal":{"name":"Reactive oxygen species (Apex, N.C.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44622573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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