{"title":"Interactive test to categorize metamorphopsia","authors":"D. Claessens, Ronald V Krueger","doi":"10.15761/nfo.1000256","DOIUrl":"https://doi.org/10.15761/nfo.1000256","url":null,"abstract":"","PeriodicalId":91933,"journal":{"name":"New frontiers in ophthalmology (London)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67500558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Segewkal H Heruye, Ya Fatou Njie Mbye, Sunny E Ohia, Catherine A Opere
{"title":"Regulation of time-dependent lens opacification by hydrogen sulfide-releasing compounds","authors":"Segewkal H Heruye, Ya Fatou Njie Mbye, Sunny E Ohia, Catherine A Opere","doi":"10.15761/nfo.1000258","DOIUrl":"https://doi.org/10.15761/nfo.1000258","url":null,"abstract":"","PeriodicalId":91933,"journal":{"name":"New frontiers in ophthalmology (London)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67500599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ocular immunity and peculiarities around COVID-19: Can universal protective eye wear be a game changer?","authors":"Mohamed A. Hussein, E. Hussein","doi":"10.15761/nfo.1000255","DOIUrl":"https://doi.org/10.15761/nfo.1000255","url":null,"abstract":"","PeriodicalId":91933,"journal":{"name":"New frontiers in ophthalmology (London)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67501012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intra- and early postoperative complications after standard cataract surgery or femtosecond laser-assisted cataract surgery combined with pars plana vitrectomy in cases of retinal diseases","authors":"F. Hengerer, G. Auffarth, I. Conrad‐Hengerer","doi":"10.15761/nfo.1000257","DOIUrl":"https://doi.org/10.15761/nfo.1000257","url":null,"abstract":"","PeriodicalId":91933,"journal":{"name":"New frontiers in ophthalmology (London)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67500587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Wawrzynski, Ramiro Salom, A. Pouncey, M. Martin, M. Ozturk
Purpose: “Observe and Plan” (O&P) is a novel treatment regimen for neovascular AMD (nAMD). It aims to optimise the intravitreal anti-VEGF injection frequency whilst dramatically reducing the number of clinical reviews (compared to PRN/ treat and extend). However, there has been no head-to-head comparison of O&P versus the other regimens: We aim to establish whether O&P is non-inferior to PRN and whether there is an economic advantage. Methods: Prospective interventional cohort study: Patients undergoing treatment with PRN aflibercept for nAMD were enrolled. All were switched to O&P aflibercept for one year. Best corrected visual acuity (BCVA) and central macular thickness (CMT) were recorded in addition to the number of clinic visits and intravitreal injections. Their results were compared in a paired analysis to their own data whilst on PRN treatment the preceding year. Results: 25 patients were enrolled. 17 completed one year of treatment, one of whom was subsequently excluded (confounding pathology). Analysis of area under the curve for BCVA and CMT found O&P to be non-inferior to PRN p=0.03, p<0.01. The mean number of clinical reviews was significantly reduced under O&P (1.80 (SD 0.68) vs. 8.66 (SD 0.72) visits per year; P=<0.01) with an improvement in injection to visit ratio (1.01 vs. 1.67 vists/injection), equating to an estimated saving of £1,228 per patient per year. Conclusion: The O&P regimen for treatment of nAMD was clinically non-inferior to PRN. The O&P regimen was superior to PRN in terms of reducing the health economic burden and treatment burden of nAMD.
目的:“观察与计划”(O&P)是一种治疗血管性AMD (nAMD)的新方案。它旨在优化玻璃体内抗vegf注射频率，同时显著减少临床审查次数(与PRN/治疗和延长相比)。然而，目前还没有对O&P与其他方案进行正面比较:我们的目标是确定O&P是否优于PRN，以及是否具有经济优势。方法:前瞻性干预性队列研究:纳入接受PRN afliberept治疗nAMD的患者。所有人都换成了O&P，为期一年。记录最佳矫正视力(BCVA)、中央黄斑厚度(CMT)、就诊次数和玻璃体内注射次数。他们的结果在配对分析中与他们自己在前一年接受PRN治疗时的数据进行了比较。结果:25例患者入组。17例完成了一年的治疗，其中1例随后被排除(混淆病理)。BCVA和CMT的曲线下面积分析发现，O&P不逊于PRN p=0.03, p<0.01。O&P组的平均临床回顾次数显著减少(每年1.80次(SD 0.68) vs. 8.66次(SD 0.72);P=<0.01)，注射就诊比(1.01 vs 1.67次/注射)有所改善，相当于每位患者每年节省1228英镑。结论:O&P方案治疗nAMD的临床疗效不逊于PRN。在减轻nAMD的健康经济负担和治疗负担方面，O&P方案优于PRN方案。
{"title":"Head to head comparison of the clinical and cost effectiveness of Observe and Plan versus PRN for the treatment of wet macular degeneration","authors":"J. Wawrzynski, Ramiro Salom, A. Pouncey, M. Martin, M. Ozturk","doi":"10.15761/NFO.1000243","DOIUrl":"https://doi.org/10.15761/NFO.1000243","url":null,"abstract":"Purpose: “Observe and Plan” (O&P) is a novel treatment regimen for neovascular AMD (nAMD). It aims to optimise the intravitreal anti-VEGF injection frequency whilst dramatically reducing the number of clinical reviews (compared to PRN/ treat and extend). However, there has been no head-to-head comparison of O&P versus the other regimens: We aim to establish whether O&P is non-inferior to PRN and whether there is an economic advantage. Methods: Prospective interventional cohort study: Patients undergoing treatment with PRN aflibercept for nAMD were enrolled. All were switched to O&P aflibercept for one year. Best corrected visual acuity (BCVA) and central macular thickness (CMT) were recorded in addition to the number of clinic visits and intravitreal injections. Their results were compared in a paired analysis to their own data whilst on PRN treatment the preceding year. Results: 25 patients were enrolled. 17 completed one year of treatment, one of whom was subsequently excluded (confounding pathology). Analysis of area under the curve for BCVA and CMT found O&P to be non-inferior to PRN p=0.03, p<0.01. The mean number of clinical reviews was significantly reduced under O&P (1.80 (SD 0.68) vs. 8.66 (SD 0.72) visits per year; P=<0.01) with an improvement in injection to visit ratio (1.01 vs. 1.67 vists/injection), equating to an estimated saving of £1,228 per patient per year. Conclusion: The O&P regimen for treatment of nAMD was clinically non-inferior to PRN. The O&P regimen was superior to PRN in terms of reducing the health economic burden and treatment burden of nAMD.","PeriodicalId":91933,"journal":{"name":"New frontiers in ophthalmology (London)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67500433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The presence of cotton-wool spots warrants a full systemic workup. We present a case of an isolated cotton-wool spot in a pregnant woman with visual changes after a recent flu-like illness. Case Report: A 25 year-old Middle Eastern female at the 20 th gestational age with a past medical history of Lyme disease, presented with a 24-hour history of a sudden onset of a dark, horizontal line in the center of her right eye vision. She experienced a flu-like illness while on a recent trip to Puerto Rico. Dilated fundus exam revealed an isolated cotton-wool spot along the superior temporal arcade of the right eye, producing focal Retinal Nerve Fiber Layer thickness. Buried optic disc drusen were detected by ocular ultrasound bilaterally. Inflammatory/infectious blood workup, including antibody against Zika virus, was negative except for a mild increase of ANA titer (1:40) in the absence of rheumatologic disease. The patient was managed conservatively and no treatment was initiated. At 4-month follow-up, there was a nearly complete resolution of the cotton-wool spot in the absence of any visual symptoms. The patient had a full-term uncomplicated vaginal delivery. Discussion: The presence of cotton-wool spots, alone or in combination with other clinical findings, warrants further investigation. Although most cotton-wool spots resolve without long-term visual sequelae and could be managed with close observation only, they have been associated with life- or sight-threatening conditions. Therefore, any underlying causes should be identified and treated appropriately. Given the absence of a pre-specified workup for cotton-wool spots, the extent and type of workup should be dictated by the appropriate clinical context.
{"title":"Isolated cotton-wool spot during pregnancy: A case report","authors":"Praveena K. Gupta, G. Taibbi","doi":"10.15761/NFO.1000244","DOIUrl":"https://doi.org/10.15761/NFO.1000244","url":null,"abstract":"Introduction: The presence of cotton-wool spots warrants a full systemic workup. We present a case of an isolated cotton-wool spot in a pregnant woman with visual changes after a recent flu-like illness. Case Report: A 25 year-old Middle Eastern female at the 20 th gestational age with a past medical history of Lyme disease, presented with a 24-hour history of a sudden onset of a dark, horizontal line in the center of her right eye vision. She experienced a flu-like illness while on a recent trip to Puerto Rico. Dilated fundus exam revealed an isolated cotton-wool spot along the superior temporal arcade of the right eye, producing focal Retinal Nerve Fiber Layer thickness. Buried optic disc drusen were detected by ocular ultrasound bilaterally. Inflammatory/infectious blood workup, including antibody against Zika virus, was negative except for a mild increase of ANA titer (1:40) in the absence of rheumatologic disease. The patient was managed conservatively and no treatment was initiated. At 4-month follow-up, there was a nearly complete resolution of the cotton-wool spot in the absence of any visual symptoms. The patient had a full-term uncomplicated vaginal delivery. Discussion: The presence of cotton-wool spots, alone or in combination with other clinical findings, warrants further investigation. Although most cotton-wool spots resolve without long-term visual sequelae and could be managed with close observation only, they have been associated with life- or sight-threatening conditions. Therefore, any underlying causes should be identified and treated appropriately. Given the absence of a pre-specified workup for cotton-wool spots, the extent and type of workup should be dictated by the appropriate clinical context.","PeriodicalId":91933,"journal":{"name":"New frontiers in ophthalmology (London)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67500475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Attenuated HSV-2 (HSV TK-) has been inoculated in the deep nasal mucosa where the attenuated virus proliferated. Subsequently, it elicited educated CD4T+ cells jn the nasal mucosa but not in local dorsal lymph nodes. These CD4 T cells migrated to the vaginal mucosa and educated cervical and/or vaginal mucosal B cells to secrete secretary IgA. However, application of these protocols to the corneal herpes (HSK), there are many pit falls in these projects. Olfactory nerve
{"title":"Vaccination of corneal herpes (HSK)","authors":"Kozaburo Hayashi","doi":"10.15761/NFO.1000253","DOIUrl":"https://doi.org/10.15761/NFO.1000253","url":null,"abstract":"Attenuated HSV-2 (HSV TK-) has been inoculated in the deep nasal mucosa where the attenuated virus proliferated. Subsequently, it elicited educated CD4T+ cells jn the nasal mucosa but not in local dorsal lymph nodes. These CD4 T cells migrated to the vaginal mucosa and educated cervical and/or vaginal mucosal B cells to secrete secretary IgA. However, application of these protocols to the corneal herpes (HSK), there are many pit falls in these projects. Olfactory nerve","PeriodicalId":91933,"journal":{"name":"New frontiers in ophthalmology (London)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67500959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Greiner, Michael E. Lindsay, K. Kenyon, Paula J Oliver, H. El-Rayess
Purpose: To report a case of toxic epidermal necrolysis (TEN) with meibomian gland dysfunction demonstrating improvement in signs and symptoms after a single thermal pulsation system treatment (TPST). Methods: Baseline signs (meibomian gland assessment [MGA] scores and lipid layer thickness [LLT]) and symptoms (SPEED and OSDI scores) were evaluated in a 41 year old Caucasian female with a 16 years history of dry eye diseases secondary to a TEN episode. The patient was treated with a single 12-min TPST and re-evaluated at 3, 9, and 36 months post-treatment. Results: At 3 months post-TPST, both signs and symptoms scores improved relative to baseline and when re-measured at 9 months and 3 years. Conclusion: This report is the first to suggest the benefit of TPST on improving dry eye signs and symptoms in TEN. Interestingly, the improvement in symptoms as measured by SPEED and OSDI, was paralleled by the improvement in signs (MGA and LLT). Improvements in signs and symptoms were sustained over baseline including the relative decline at 3 years from the optimum improvements post-TPST.
{"title":"Toxic epidermal necrolysis associated with meibomian gland dysfunction: Report of a case managed by thermal pulsation treatment","authors":"J. Greiner, Michael E. Lindsay, K. Kenyon, Paula J Oliver, H. El-Rayess","doi":"10.15761/NFO.1000246","DOIUrl":"https://doi.org/10.15761/NFO.1000246","url":null,"abstract":"Purpose: To report a case of toxic epidermal necrolysis (TEN) with meibomian gland dysfunction demonstrating improvement in signs and symptoms after a single thermal pulsation system treatment (TPST). Methods: Baseline signs (meibomian gland assessment [MGA] scores and lipid layer thickness [LLT]) and symptoms (SPEED and OSDI scores) were evaluated in a 41 year old Caucasian female with a 16 years history of dry eye diseases secondary to a TEN episode. The patient was treated with a single 12-min TPST and re-evaluated at 3, 9, and 36 months post-treatment. Results: At 3 months post-TPST, both signs and symptoms scores improved relative to baseline and when re-measured at 9 months and 3 years. Conclusion: This report is the first to suggest the benefit of TPST on improving dry eye signs and symptoms in TEN. Interestingly, the improvement in symptoms as measured by SPEED and OSDI, was paralleled by the improvement in signs (MGA and LLT). Improvements in signs and symptoms were sustained over baseline including the relative decline at 3 years from the optimum improvements post-TPST.","PeriodicalId":91933,"journal":{"name":"New frontiers in ophthalmology (London)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67500825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Although the transcription factor, nuclear factor-kappa-B (NF- κ B) is known to regulate programed-cell death and survival, its precise role in cell death within the central nervous system (CNS) remains unknown. We previously reported that mice with a homozygous deficiency for Nf- κ b1p50 spontaneously developed optic neuropathy. We investigated the expression and activation of pro-apoptotic factor(s), which mediate optic nerve neuropathy in Nf- κ b1p50- deficient mice. Recombination activating gene 1 (RAG1) is known to control the recombination of immunoglobulin V(D)J. Experiments with genetically engineered mice revealed the involvement of RAG1 expression in the programmed-cell death of POU domain protein (POU4f2)/brain-specific homeobox 3A (BRN3a)-positive retinal ganglion cells (RGCs), and also showed the specific effects of a Nf- κ b1p50 - deficient on the activation of Rag1 gene transcription. Furthermore, a genetic analysis of murine neuronal stem-like cells clarified the biological significance of RAG1 in N-methyl-D-aspartate (NMDA)-induced neuronal cell death. The apoptotic inducing factors were detected in human cell line expressing the external molecule of RAG1, and human histopathological examinations with retina tissues revealed the expression of RAG1 in RGCs. Recent studies indicated that RAG1 played a key role in optic nerve neuropathy as a pro-apoptotic candidate in Nf- κ b1p50- deficient mice. These results may lead to new therapeutic targets in optic nerve neuropathy.
{"title":"Biological significance of recombination-activating gene 1, RAG1 in optic nerve neuropathy","authors":"Takao Hirano, Tomoko Nakamura-Yanagidaira, Takuma Hayashi","doi":"10.15761/NFO.1000245","DOIUrl":"https://doi.org/10.15761/NFO.1000245","url":null,"abstract":"Although the transcription factor, nuclear factor-kappa-B (NF- κ B) is known to regulate programed-cell death and survival, its precise role in cell death within the central nervous system (CNS) remains unknown. We previously reported that mice with a homozygous deficiency for Nf- κ b1p50 spontaneously developed optic neuropathy. We investigated the expression and activation of pro-apoptotic factor(s), which mediate optic nerve neuropathy in Nf- κ b1p50- deficient mice. Recombination activating gene 1 (RAG1) is known to control the recombination of immunoglobulin V(D)J. Experiments with genetically engineered mice revealed the involvement of RAG1 expression in the programmed-cell death of POU domain protein (POU4f2)/brain-specific homeobox 3A (BRN3a)-positive retinal ganglion cells (RGCs), and also showed the specific effects of a Nf- κ b1p50 - deficient on the activation of Rag1 gene transcription. Furthermore, a genetic analysis of murine neuronal stem-like cells clarified the biological significance of RAG1 in N-methyl-D-aspartate (NMDA)-induced neuronal cell death. The apoptotic inducing factors were detected in human cell line expressing the external molecule of RAG1, and human histopathological examinations with retina tissues revealed the expression of RAG1 in RGCs. Recent studies indicated that RAG1 played a key role in optic nerve neuropathy as a pro-apoptotic candidate in Nf- κ b1p50- deficient mice. These results may lead to new therapeutic targets in optic nerve neuropathy.","PeriodicalId":91933,"journal":{"name":"New frontiers in ophthalmology (London)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67500814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Kareliotis, E. Drakaki, C. Bacharis, M. Makropoulou, A. Serafetinides
Today, 60 years after the laser discovery, the long experience in refractive surgery, the evaluation of the accumulated clinical outcomes and the limitations of kerato- refractive surgery generated the demand to develop alternative methods for treating vision defects. In the frame of this new philosophy for vision correction, the use of polymeric intraocular lenses (IOLs) provides sufficient predictability and optical quality. The new Ophthalmology era takes their use one step further, through the IOLs’ customization, aiming at the long desired personalized treatment. Inspired by the need to correct some post-operative complications in cataract surgery and IOLs implantation, the laser use is proposed, for in situ refractive modification of the implanted polymeric material, without any alteration in IOL’s light transmittance behavior. In this work we present a brief literature overview of new perspectives in this field, enriched with some of our experimental studies. Through discussion of the laser-material interactions we intend to present the prospects, the limitations and the aspects that have to be considered in the route for in situ laser-based IOL- surgery and finally, vision correction.
{"title":"Laser-intraocular lenses interaction: Aspects to consider for in situ vision correction","authors":"G. Kareliotis, E. Drakaki, C. Bacharis, M. Makropoulou, A. Serafetinides","doi":"10.15761/NFO.1000250","DOIUrl":"https://doi.org/10.15761/NFO.1000250","url":null,"abstract":"Today, 60 years after the laser discovery, the long experience in refractive surgery, the evaluation of the accumulated clinical outcomes and the limitations of kerato- refractive surgery generated the demand to develop alternative methods for treating vision defects. In the frame of this new philosophy for vision correction, the use of polymeric intraocular lenses (IOLs) provides sufficient predictability and optical quality. The new Ophthalmology era takes their use one step further, through the IOLs’ customization, aiming at the long desired personalized treatment. Inspired by the need to correct some post-operative complications in cataract surgery and IOLs implantation, the laser use is proposed, for in situ refractive modification of the implanted polymeric material, without any alteration in IOL’s light transmittance behavior. In this work we present a brief literature overview of new perspectives in this field, enriched with some of our experimental studies. Through discussion of the laser-material interactions we intend to present the prospects, the limitations and the aspects that have to be considered in the route for in situ laser-based IOL- surgery and finally, vision correction.","PeriodicalId":91933,"journal":{"name":"New frontiers in ophthalmology (London)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67500857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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