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Analysis of repeated computed tomography scans and cumulative effective dose of patients in a hospital 某医院患者重复计算机断层扫描与累积有效剂量分析
Pub Date : 2023-04-27 DOI: 10.15392/2319-0612.2023.2241
Ana Luiza Milani, A. F. Alves, Matheus Alvarez, S. P. Souza, Túlio Guilherme Soares Marques, Marcos Aureliano Araújo Silva, J. T. Trindade Filho, Diana Rodrigues Pina
Computed tomography exams are considered diagnostic imaging exams that generate significant radiation dose to the patient. Justification, optimization, and dose limitation are radiological protection principles used to minimize patient and staff exposure, ensuring the quality of the service provided. The objective of this study was to analyze CT scan data, analyzing the number of exams, the patients' effective cumulated dose, and the repeatability of the exams. The study data covers the 2013 to 2022 period during which a progressive increase was observed in the number of exams performed over time, with exams doubling in this period. The most used Computed Tomography protocols were brain/skull (27.4%), pelvis (17.3%), and abdomen (13.7%) during the study period. Approximately 76.3% of patients have a cumulative dose of less than 25 mSv, while about 1% accumulated more than 100 mSv. The repeatability of CT scans for the same patient over a short period varies, reaching until 17 scans in 30 days for a single patient. The results indicated a necessity to develop strategies for individual dose management methods for the institution’s internal practices. An intervention could be implemented by creating periodically updated handouts and guidelines based on professionals' knowledge.
计算机断层扫描检查被认为是诊断性影像学检查,对患者产生显著的辐射剂量。合理化、优化和剂量限制是用于尽量减少患者和工作人员暴露、确保所提供服务质量的放射防护原则。本研究的目的是分析CT扫描数据,分析检查次数、患者有效累积剂量和检查的可重复性。研究数据涵盖了2013年至2022年期间,在此期间,随着时间的推移,考试数量逐渐增加,考试数量在此期间翻了一番。在研究期间,使用最多的计算机断层扫描是脑/颅骨(27.4%)、骨盆(17.3%)和腹部(13.7%)。约76.3%的患者累积剂量低于25毫西弗,而约1%的患者累积剂量超过100毫西弗。短期内对同一患者进行CT扫描的可重复性各不相同,对于单个患者,30天内可进行17次扫描。结果表明,有必要为该机构的内部实践制定个人剂量管理方法战略。可以根据专业人员的知识,通过定期更新讲义和指导方针来实施干预。
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引用次数: 0
[18F]FDG/PET: a non-invasive technique for the study of stroke in murine and rat models [18]FDG/PET:一种无创脑卒中研究方法
Pub Date : 2023-04-13 DOI: 10.15392/2319-0612.2023.2240
B. G. A. Schirmer, E. V. Santos, J. M. Pereira, N. V. S. Cardoso, R. D. B. Dias de Brito Oliveira, C. Malamut
The use of mouse and rat models in conjunction with anatomic functional imaging techniques has directly contributed to expanding knowledge about the complex pathophysiology of stroke. Therefore, this study aims to identify the most relevant mouse and rat models of stroke and how [18F]FDG/PET can contribute to this pathology study. A narrative review of the literature was performed to describe applications of positron emission tomography in conjunction with the radiopharmaceutical [18F]FDG in stroke models. PubMed, Scopus, and Web of Science were searched for relevant articles published between 2015 and 2022. In this study, we describe applications of positron emission tomography in combination with the radiopharmaceutical [18F]FDG in mouse and rat stroke models. The most commonly used model was middle cerebral artery occlusion (MCAO) in rats. This study demonstrates that using murine and rat models in conjunction with anatomic functional imaging techniques has directly contributed to expanding knowledge about the complex pathophysiology of stroke. In addition, they have been essential for studies aimed at discovering and developing therapeutic and prophylactic strategies for the disease.
使用小鼠和大鼠模型结合解剖功能成像技术,直接有助于扩大对中风复杂病理生理学的认识。因此,本研究旨在确定与脑卒中最相关的小鼠和大鼠模型,以及[18F]FDG/PET如何参与该病理研究。对文献进行了叙述性回顾,以描述正电子发射断层扫描与放射性药物[18F]FDG在中风模型中的应用。检索了PubMed、Scopus和Web of Science在2015年至2022年间发表的相关文章。在这项研究中,我们描述了正电子发射断层扫描结合放射性药物[18F]FDG在小鼠和大鼠中风模型中的应用。大鼠最常用的模型是大脑中动脉闭塞(MCAO)。这项研究表明,将小鼠和大鼠模型与解剖功能成像技术相结合,直接有助于扩大对中风复杂病理生理学的了解。此外,它们对于旨在发现和制定该疾病的治疗和预防战略的研究至关重要。
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引用次数: 1
Effectiveness of polymeric gloves in radioprotection against contamination in nuclear medicine 高分子手套在核医学中防辐射污染的有效性
Pub Date : 2023-04-11 DOI: 10.15392/2319-0612.2023.2187
When handling unsealed radioactive sources, radiological protection attention must be taken to avoid unnecessary exposure and radioactive contaminations, and an important and necessary practice to prevent such contaminations is the use of gloves when handling these sources. The present work aimed to determine the effectiveness of contamination protection provided by different types of disposable polymeric gloves used in Nuclear Medicine Service in Clinic Hospital of Porto Alegre, testing the main radiopharmaceuticals used at this site: [99mTc]sodium pertechnetate, [18F]FDG and [131I]sodium iodide. The analysis was performed using the wipe test inside gloves intentionally contaminated on the outside with these radiopharmaceuticals. The radiation detector used to measure the contamination was a NaI(Tl) scintillator well-type counter. The results indicate that three types of gloves analyzed protect the user from [99mTc]sodium pertechnetate and [18F]FDG contamination, for permanence times with the glove after contamination for up to 15 min (interval tested). For [131I]sodium iodide, gloves are completely effective in protection as long as they are used for a time interval after contamination of the external surface of up to: Latex – 5 min; Vinyl – 5 min; Nitrile – 10 min. Among them, the nitrile glove are the most effective, since contamination was not observed on the inner face for times equal to or less than 10 min; and, for an interval of 15 min, the percentage of permeation obtained was lower than the other two types: 3.3 times lower than vinyl glove permeation and 1.3 times lower of the latex glove permeation. It was also possible to estimate the skin dose rate due to contamination caused by iodine permeation for each glove case and time tested.
在处理未密封的放射源时,必须注意放射防护,避免不必要的照射和放射性污染,在处理这些放射源时使用手套是防止这种污染的重要和必要的做法。本工作旨在确定阿雷格里港临床医院核医学服务处使用的不同类型的一次性聚合物手套提供污染防护的有效性,测试了该地点使用的主要放射性药物:[99mTc]高技术酸钠,[18F]FDG和[131I]碘化钠。分析是通过手套内部的擦拭试验进行的,手套外部被这些放射性药物故意污染。用于测量污染的辐射探测器是NaI(Tl)闪烁阱式计数器。结果表明,所分析的三种类型的手套可以保护用户免受[99mTc]高技术酸钠和[18F]FDG的污染,在污染后手套的永久时间长达15分钟(间隔测试)。对于[131I]碘化钠,手套只要在污染后的一段时间间隔内使用,就可以完全有效地保护:乳胶- 5分钟;乙烯基- 5分钟;丁腈- 10分钟。其中,丁腈手套是最有效的,因为在等于或小于10分钟的时间内没有观察到内表面的污染;在间隔15 min时,获得的渗透率低于其他两种类型:比乙烯基手套渗透率低3.3倍,比乳胶手套渗透率低1.3倍。还可以估计每个手套箱因碘渗透造成的污染的皮肤剂量率和测试时间。
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引用次数: 0
Assessment of the environmental radiological impact in the emergency exposure phase through the simulation of a uranium mining tailings dam breach 模拟铀矿尾矿坝溃坝应急暴露阶段环境辐射影响评价
Pub Date : 2023-04-03 DOI: 10.15392/2319-0612.2023.2228
R. Lamour, M. Wasserman, E. Rochedo, J. Lugon Junior
This work is aiming at estimating the radiation doses to members of the public in case of an emergency exposure situation related to a hypothetical uranium mining tailings dam rupture at the UDC - Decommissioning Unit of Caldas, MG, Brazil. The calculations will help to managing the exposures of emergency workers and residents in the region downstream the dam. The computer code chosen to perform the simulations was FLO-2D@ software. Due to the uncertainties involved, mainly regarding the waste rheology and activity concentrations and in parameters values to be used in the dose assessment, considerations were made for the study to present results derived from conservative assumptions. Through the creation of flood maps, it was possible to estimate the extent of the areas affected by the released materials. The results showed that in a scenario of the tailings dam breach, deposition of mud shall extend over 20 km downstream affecting an area of nearly 3 km2. Total dose for a member of the public living in most affected areas would be around 43 mSv/y in the early phase after the accident. Although only shielding would be recommended under current radiation protection regulation, evacuation/relocation is suggested due to the presence of long-lived radionuclides. This protective measure would probably already be indicated by the accident itself, regardless of radiological reasons. More realistic assessment should be performed before returning people, considering long-term environmental transport and uses of the area. It must also be considered that long-term exposures have more restricted recommended acceptable levels than those for the emergency phase.
这项工作的目的是估计在巴西MG州卡尔达斯UDC -退役单位假定的铀矿尾矿坝破裂的紧急照射情况下对公众的辐射剂量。计算结果将有助于管理大坝下游地区应急工作人员和居民的暴露情况。选择执行模拟的计算机代码是FLO-2D@软件。由于所涉及的不确定性,主要涉及废物流变学和活性浓度以及剂量评估中使用的参数值,因此考虑到该研究提出的结果来自保守假设。通过绘制洪水地图,可以估计受释放物质影响的地区的范围。结果表明:尾矿坝溃坝情景下,泥沙淤积向下游延伸20 km以上,影响面积近3 km2;在事故发生后的早期阶段,生活在受影响最严重地区的公众的总剂量约为43毫西弗/年。虽然根据目前的辐射防护条例只建议采取屏蔽措施,但由于存在长寿命放射性核素,建议进行疏散/重新安置。这种保护措施可能已经在事故本身中得到了体现,而不考虑放射性原因。在人们返回之前应该进行更现实的评估,考虑到该地区的长期环境运输和使用。还必须考虑到,与紧急阶段相比,长期接触的建议可接受水平更为有限。
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引用次数: 0
Detection limit calculation according to ISO 11929 for in vitro 210Pb radiobioassay determinations by LSC 根据ISO 11929 LSC法测定210Pb的检出限计算
Pub Date : 2023-03-29 DOI: 10.15392/2319-0612.2023.2185
C. Sampaio, M. M. Martins, W. O. Sousa
According to the limit of detection (DL) presented in ISO 11929:2010, the International Organization for Standardization (ISO) abandoned the concept of minimum detectable amount (MDA) described in ISO 12790-1:2001. In this work we demonstrate and discuss how we calculate the detection limit for the determination of 210Pb by liquid scintillation counter (LSC) for the previously developed methodology and compare its results with the MDA value. The DL value found was 0.033 Bq/L instead of 0.032 Bq/L for MDA. The MDA and LD values ​​did not differ virtually, the results highlight that the main change between the two Standard is related to the definition approach.
根据ISO 11929:2010中提出的检测限(DL),国际标准化组织(ISO)放弃了ISO 12790-1:2001中描述的最小可检测量(MDA)的概念。在这项工作中,我们演示和讨论了如何计算液体闪烁计数器(LSC)测定210Pb的检出限,并将其结果与MDA值进行了比较。MDA的DL值为0.033 Bq/L,而不是0.032 Bq/L。MDA和LD值实际上没有差异,结果突出表明两个标准之间的主要变化与定义方法有关。
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引用次数: 0
Validation and study of different parameters in the simulation of diagnostic X-ray spectra using the MCNPX code 使用MCNPX代码对诊断x射线光谱模拟中不同参数的验证和研究
Pub Date : 2023-03-28 DOI: 10.15392/2319-0612.2023.2119
K.C.W. Consatti, W. S. Santos, J. V. Valença, M. Yoshizumi
In radiology, knowing the X-ray spectrum characteristics makes it possible to estimate the absorbed dose in the patient and to improve image quality. In this study, an X-ray generator was proposed using the MCNPX code and to validate it, the simulated spectrum was compared to the data provided from AAPM Task Group 195, which resulted in a percentage difference of 8.7%. Furthermore, several X-ray spectra were generated and compared to the spectra obtained from commercially available softwares as xpecgen and SpekCalc. The percentage differences were of the order of 13% in comparison with SpekCalc and 8% with xpecgen. The major differences obtained between those spectra were concentrated in the region of characteristic peaks, independently if variations in electron beam energy, target angle or filtration thickness were performed.
在放射学中,了解x射线光谱特征可以估计患者的吸收剂量,提高图像质量。在本研究中,使用MCNPX代码提出了一个x射线发生器,并将模拟的光谱与AAPM Task Group 195提供的数据进行了比较,结果显示其百分比差异为8.7%。此外,生成了几个x射线光谱,并与商用软件(如expecgen和SpekCalc)获得的光谱进行了比较。与SpekCalc相比,百分比差异约为13%,与expecgen相比为8%。这些光谱之间的主要差异集中在特征峰区域,如果进行电子束能量、目标角度或过滤厚度的变化,则它们之间的差异是独立的。
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引用次数: 0
An overview study on the TL and OSL dosimetry patent processes over time TL和OSL剂量学专利过程的综述研究
Pub Date : 2023-03-24 DOI: 10.15392/2319-0612.2023.2107
P. Gasparian, A. Malthez, L. Mariano, L. Campos, R. Politano
Since its discovery, ionizing radiation has been used in many different applications. Materials and methods have been developed to measure and quantify radiation doses.  Thermoluminescence (TL) and Optically Stimulated Luminescence (OSL) are two techniques used for radiation dosimetry. Both TL and OSL are primarily applied in several areas, such as dating of ancient materials, equipment quality control and individual monitoring. One of the parameters to measure the knowledge and development of a technology is the number of patents related to the field. In this work, we established a methodology for patent search on the World Intellectual Property Organization (WIPO) database aiming to review the development of TL and OSL dosimetry over time. We concluded that along with the OSL technique development, the TL technique should continue to be explored in radiation dosimetry.
自发现以来,电离辐射已被用于许多不同的应用。已经研制出测量和量化辐射剂量的材料和方法。热释光(TL)和光激发发光(OSL)是两种用于辐射剂量测定的技术。TL和OSL主要应用于古物测年、设备质量控制和个人监测等领域。衡量一项技术的知识和发展的参数之一是与该领域相关的专利数量。在这项工作中,我们在世界知识产权组织(WIPO)数据库中建立了一种专利检索方法,旨在回顾TL和OSL剂量学的发展。我们认为,随着OSL技术的发展,TL技术在辐射剂量学中应继续探索。
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引用次数: 0
Evaluation of the radiation shielding properties of ornamental rocks produced in Brazil: A Monte Carlo approach 巴西产观赏岩石的辐射屏蔽性能评价:蒙特卡罗方法
Pub Date : 2023-03-22 DOI: 10.15392/2319-0612.2023.2104
W. S. Santos, C. J. Santos, L. P. Neves, W. Belinato, M. R. Soares, J. V. Valença, A. Perini
In this work, the Monte Carlo MCNPX (2.7.0) code was used to evaluate the radioprotective properties of ten ornamental granitic samples produced in Brazil. For each sample of granite, the mass attenuation coefficient (µ/ρ) and half-value layer (HVL) were evaluated using the photon energy emitted by the following radioisotopes: 241Am (59,5 keV), 133Ba (356 keV), 137Cs (662 keV), 60Co (1250 keV), and 22Na (1274 keV). The MCNPX results showed agreement with the values obtained by using the XCOM database, as well as with theoretical and experimental results, available on the literature. The computational model built in this work can be used by the scientific community interested in parameters involving new materials for gamma radiation shielding, which has been used in different areas of the nuclear sciences.
本文采用蒙特卡罗MCNPX(2.7.0)程序对巴西产的10种观赏花岗岩样品进行了辐射防护性能评价。利用放射性同位素241Am (55,5 keV)、133Ba (356 keV)、137Cs (662 keV)、60Co (1250 keV)和22Na (1274 keV)发射的光子能量,对每个花岗岩样品的质量衰减系数(µ/ρ)和半值层(HVL)进行了评估。MCNPX的计算结果与XCOM数据库的计算结果以及文献中的理论和实验结果一致。在这项工作中建立的计算模型可以被科学界对涉及伽马辐射屏蔽新材料的参数感兴趣,这已经在核科学的不同领域得到了应用。
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引用次数: 0
A feasibility study for a new one-day protocol for [99mTc]TcDTPA2- and [99mTc]TcDMSA2- renal scintigraphy on dilated and non-dilated pediatric patients: underlying rationale [99mTc]TcDTPA2-和[99mTc]TcDMSA2-肾造影治疗扩张型和非扩张型儿科患者新方案的可行性研究:基本原理
Pub Date : 2023-03-14 DOI: 10.15392/2319-0612.2023.2158
Fabiana Trevisan, B. Nascimento, Gabriel Chibana, Luciana Maeda, M. Vila, V. Yoshida, N. Aranha, V. Balcão, J. O. Oliveira Júnior
Purpose. This work aimed at evaluating the possibility of performing renal exams of dynamic renal (DRS) and static renal (SRS) scintigraphy on the same day (one-day protocol, ODP), exams that are currently performed in two days. Approach. 25 infants (50 kidneys) of both genders, aged 8.4 ± 5.9 years, underwent an F+20 DRS protocol with [99mTc]TcDTPA2- followed by [99mTc]TcDMSA2- administration for the performance of SRS images at 3, 6 and 24 h. Dynamic images (DRS) were classified as dilated (D), undetermined (U), and non-dilated (P). Static images (SRS) were classified as: depressed in accented degree (DA); depressed in moderate degree (DM); depressed in mild degree (DL) and normal (NL). Results. Out of the 25 patients (50 kidneys), 7 (14 kidneys) were excluded by functional exclusion, hence 18 patients (36 kidneys) were clinically compared regarding their static images after 3, 6 and 24 h, resulting in 33.0% of dilated and 66.7% non-dilated. Only two patients of the dilated group were classified as obstructed. At the group with non-dilated and dilated but non-obstructed kidneys, 100% of them had the same clinical classification at 6 and 24 h images. Conclusions. Performance of both DRS and SRS exams in a single day for pediatric patients, when medical requests are carried out jointly, is feasible in a population with or without dilatation, when the difference between dynamic and static images is of at least 6 h. Due to the small number of obstructed kidneys in this study, further evaluation in this population is needed.
目的。这项工作旨在评估在同一天进行动态肾脏检查(DRS)和静态肾脏检查(SRS)的可能性(一天方案,ODP),目前检查在两天内进行。方法:25名男女婴儿(50个肾脏),年龄8.4±5.9岁,接受F+20 DRS方案,使用[99mTc]TcDTPA2-,然后使用[99mTc]TcDMSA2-治疗3、6和24小时的SRS图像表现。动态图像(DRS)分为扩张(D)、不确定(U)和非扩张(P)。静态图像(SRS)分为:加重程度下降(DA);中度抑郁(DM);轻度抑郁(DL)和正常抑郁(NL)。结果。25例患者(50个肾脏)中有7例(14个肾脏)被功能排除,因此18例患者(36个肾脏)在3、6、24 h后的静态图像进行临床比较,其中33.0%的肾脏扩张,66.7%的肾脏未扩张。扩张组中仅有2例患者被归为梗阻。肾脏未扩张组和肾脏扩张但未阻塞组在6 h和24 h图像上100%具有相同的临床分类。结论。在有或没有扩张的人群中,当动态图像和静态图像之间的差异至少为6小时时,儿科患者在一天内同时进行DRS和SRS检查是可行的。由于本研究中肾脏阻塞的数量较少,需要对该人群进行进一步评估。
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引用次数: 0
Development of anthropomorphic computational phantoms at the UFPE 在upe拟人化计算幻影的发展
Pub Date : 2023-03-09 DOI: 10.15392/2319-0612.2023.2243
J. W. Vieira, Pedro Henrique Avelino Andrade, A. C. H. Oliveira, V. Lima, Isabelle Viviane Batista de Lacerda, Arykerne Casado Silva, Ivan Eufrázio Santana, Whoody Alem Wanderley Farias, Larissa Cristina Silva dos Santos, Fernanda Gonçalves Oliveira, F. Lima
To evaluate the amount of energy deposited in radiosensitive organs and tissues of the human body, when an anthropomorphic phantom is irradiated, researchers in numerical dosimetry use the so-called exposure computational models (ECMs). One can imagine an ECM as a virtual scene composed of a phantom in a mathematically defined position in relation to a radioactive source. The source in these ECMs produces the initial state of the simulation:  the position, direction, and energy with which each particle enters the phantom are essential variables. For subsequent states of a particle history, robust Monte Carlo (MC) codes are used. For the subsequent states of a particle's history, robust Monte Carlo (MC) codes are used, which simulate the average free path that the particle performs without interacting, its interaction with the atoms in the medium and the amount of energy deposited per interaction. MC codes also evaluate normalization quantities, so the results are printed in text files in the form of conversion coefficients between the absorbed dose and the selected normalization quantity. From the 2000s, the authors have published ECMs where a voxel phantom is irradiated by photons in the environment of the MC code EGSnrc (EGS = Electron Gamma Shower; nrc = National Research Council Canada). The production of articles, dissertations and theses required the use of specific computational tools, such as the FANTOMAS, DIP (Digital Image Processing) and Monte Carlo applications, for the various steps of numerical dosimetry, which ranges from the preparation of input files to the execution from the ECM to the organization and graphical and numerical analysis of the results. This article reviews computational phantoms for dosimetry mainly those produced in DEN-UFPE dissertations and thesis.
为了评估在人体的辐射敏感器官和组织中沉积的能量,当一个拟人化的幻影被照射时,数值剂量学的研究人员使用了所谓的暴露计算模型(ecm)。我们可以把ECM想象成一个虚拟场景,由一个与放射源相关的数学定义位置的幻影组成。这些ecm中的源产生模拟的初始状态:每个粒子进入幻影的位置、方向和能量是基本变量。对于粒子历史的后续状态,采用鲁棒蒙特卡罗(MC)码。对于粒子历史的后续状态,使用鲁棒蒙特卡罗(MC)代码,模拟粒子在没有相互作用的情况下的平均自由路径,它与介质中原子的相互作用以及每次相互作用所沉积的能量。MC代码还评估归一化量,因此结果以吸收剂量与所选归一化量之间的转换系数的形式打印在文本文件中。从2000年代开始,作者发表了ecm,其中体素幻影在MC代码EGSnrc (EGS = Electron Gamma Shower;加拿大国家研究委员会。文章、论文和论文的制作需要使用特定的计算工具,如FANTOMAS、DIP(数字图像处理)和蒙特卡罗应用程序,用于数值剂量学的各个步骤,从准备输入文件到执行ECM,再到组织和结果的图形和数值分析。本文主要综述了DEN-UFPE学位论文和论文中有关剂量学的计算模型。
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引用次数: 0
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Brazilian Journal of Radiation Sciences
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