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Evaluation of systemic inflammation- and nutrition-based indices in the prediction of HPV persistence. 评估全身性炎症和营养指标在预测HPV持续性中的作用。
IF 2.7 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-17 DOI: 10.1186/s12905-025-04147-7
Fatma Ozmen, Burcu Ozata, Burcu Erol
<p><strong>Aim: </strong>Persistent high-risk human papillomavirus (HPV) infection is the primary etiological factor in cervical cancer, with HPV16 and HPV18 posing the greatest oncogenic risk. Although systemic inflammation and nutritional indices such as the Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score and Prognostic Nutritional Index (PNI) have prognostic value in various malignancies, their role in predicting HPV persistence remains unclear. This study aimed to evaluate the predictive value of HALP and PNI scores for one-year HPV persistence and additionally assessed other inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and C-reactive protein (CRP).</p><p><strong>Methods: </strong>This retrospective study included 470 HPV-positive women aged 31-67 years who were followed for at least one year between January 2021 and March 2025. Participants were categorized into Group N (HPV clearance, n = 271) and Group P (HPV persistence, n = 199) according to one-year HPV results. Baseline demographic, clinical, histopathological, and laboratory data were collected. HALP and PNI scores were calculated from hemoglobin, albumin, lymphocyte, and platelet counts, and inflammatory markers including NLR, PLR, and CRP were evaluated. Group comparisons were performed using appropriate statistical tests, and predictive performance was assessed using receiver operating characteristic (ROC) analysis. Continuous variables were standardized using Z-score transformation before multivariate logistic regression to minimize scale differences among predictors.</p><p><strong>Results: </strong>Within a year, 271 (57.7%) of the 470 women achieved viral clearance, whereas 199 (42.3%) had persistent infection. No substantial differences were observed in demographic or histological parameters. Vaccination after diagnosis did not affect clearance rates. The median HALP and PNI scores were similar between groups and provided no discriminatory ability [HALP AUC = 0.475 (95% CI: 0.422-0.528); PNI AUC = 0.487 (95% CI: 0.434-0.540)], as did PLR [AUC = 0.513 (95% CI: 0.460-0.566)] and CRP [AUC = 0.462 (95% CI: 0.409-0.515)]. In contrast, NLR was significantly higher in the persistence group (p < 0.001) and demonstrated modest discriminatory ability [AUC = 0.623 (95% CI: 0.573-0.673)]. HPV16 and HPV18 positivity was strongly associated with persistence.</p><p><strong>Conclusions: </strong>When the researchers evaluated the subjects' systemic inflammatory and nutritional status, they found that HALP, PNI, PLR, and CRP did not provide effective predictive value for one-year HPV persistence. Conversely, NLR exhibited a promising capacity to function as a straightforward systemic inflammatory marker. The presence of HPV16 and HPV18 was found to be significantly associated with the persistence of the infection, thereby corroborating the established immune evasion mechanisms associated with these types. These findings und
目的:持续的高危人乳头瘤病毒(HPV)感染是宫颈癌的主要病因,其中HPV16和HPV18的致癌风险最大。尽管全身炎症和营养指标,如血红蛋白、白蛋白、淋巴细胞和血小板(HALP)评分和预后营养指数(PNI)在各种恶性肿瘤中具有预后价值,但它们在预测HPV持续性方面的作用尚不清楚。本研究旨在评估HALP和PNI评分对HPV持续一年的预测价值,并额外评估其他炎症标志物,包括中性粒细胞与淋巴细胞比率(NLR),血小板与淋巴细胞比率(PLR)和c反应蛋白(CRP)。方法:这项回顾性研究包括470名年龄在31-67岁之间的hpv阳性女性,这些女性在2021年1月至2025年3月期间随访至少一年。根据一年的HPV结果,参与者被分为N组(HPV清除,N = 271)和P组(HPV持续,N = 199)。收集基线人口统计学、临床、组织病理学和实验室数据。根据血红蛋白、白蛋白、淋巴细胞和血小板计数计算HALP和PNI评分,并评估NLR、PLR和CRP等炎症标志物。采用适当的统计检验进行组间比较,并采用受试者工作特征(ROC)分析评估预测效果。在多元逻辑回归之前,对连续变量进行Z-score转换标准化,以尽量减少预测因子之间的量表差异。结果:在一年内,470名妇女中271人(57.7%)获得病毒清除,而199人(42.3%)持续感染。在人口统计学或组织学参数上没有观察到实质性差异。诊断后接种疫苗不影响清除率。HALP和PNI评分中位数在两组之间相似,没有区别性[HALP AUC = 0.475 (95% CI: 0.422-0.528);句AUC = 0.487(95%置信区间:0.434—-0.540)],PLR一样(AUC = 0.513(95%置信区间:0.460—-0.566)和c反应蛋白(AUC = 0.462(95%置信区间:0.409—-0.515)]。结论:当研究人员评估受试者的全身炎症和营养状况时,他们发现HALP、PNI、PLR和CRP不能为HPV持续一年提供有效的预测价值。相反,NLR作为一种直接的全身性炎症标志物表现出了良好的功能。发现HPV16和HPV18的存在与感染的持续存在显著相关,从而证实了与这些类型相关的既定免疫逃避机制。这些发现强调了结合局部粘膜免疫反应和全身炎症途径的预后标志物的必要性,以加强hpv相关疾病的风险分层和管理。
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引用次数: 0
Mesenchymal stem cell therapy for endometrial injury: a meta-analysis of preclinical studies. 间充质干细胞治疗子宫内膜损伤:临床前研究的荟萃分析。
IF 2.7 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-17 DOI: 10.1186/s12905-025-04211-2
YangYang Liu, Zahra Ghorbaninejad Koubanani, DaZhou Jia, Min Ma
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引用次数: 0
Determinants of access to maternal healthcare services among women in the Wolaita Zone, Southern Ethiopia: an unmatched case‒control study. 埃塞俄比亚南部Wolaita区妇女获得孕产妇保健服务的决定因素:一项无与伦比的病例对照研究。
IF 2.7 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-17 DOI: 10.1186/s12905-025-04105-3
Kassahun Tafesse Hidoto, Kassa Daka Gidebo, Mengistu Meskele Koyra, Maria Luisa Guillen Domínguez
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引用次数: 0
Knowledge, attitudes, and practices of refugee women in Lebanon towards contraception use and family planning: insights from vulnerable populations. 黎巴嫩难民妇女对避孕和计划生育的知识、态度和做法:来自弱势群体的见解。
IF 2.7 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-16 DOI: 10.1186/s12905-025-04140-0
Samar Karout, Hani M J Khojah, Tareq L Mukattash, Abdalla El-Lakany

Background: Syrian refugee women in Lebanon face significant barriers to accessing family planning (FP) due to cultural norms, financial constraints, and disrupted healthcare systems.

Objectives: This study aimed to assess the knowledge, attitudes, and practices related to FP and contraception among these women.

Methods: A survey of 790 married Syrian refugee women (aged 18-50) was conducted between November 2023 and March 2024 across four Lebanese governorates. Participants were selected through stratified cluster sampling with household-level convenience sampling. Data on knowledge, attitudes, and practices regarding FP and contraception were collected through structured face-to-face interviews.

Results: The mean age of participants was 31.86 ± 8.09 years, with most showing moderate knowledge of FP (mean score: 8.08 ± 2.11). Younger women, recent arrivals, and those with lower education had lower knowledge levels. Misconceptions about oral contraceptive pills (OCPs) were widespread. Overall, 67.1% of women reported using contraception, with withdrawal (33.2%), intrauterine devices (30.4%), and OCPs (19.8%) being the most common methods. Attitudes were influenced by patriarchal norms, with male approval playing a key role in decision-making. Positive attitudes were more common among women with higher education and employment status.

Conclusion: Syrian refugee women in Lebanon face multiple barriers to effective FP use, including cultural misconceptions and limited autonomy in reproductive decisions. Educational interventions, alongside efforts to involve men in FP discussions, are essential to improve reproductive health outcomes and contribute to sustainable development efforts in Lebanon.

背景:黎巴嫩的叙利亚难民妇女由于文化规范、财政限制和医疗保健系统中断,在获得计划生育(FP)方面面临重大障碍。目的:本研究旨在评估这些妇女对计划生育和避孕的知识、态度和做法。方法:在2023年11月至2024年3月期间,对黎巴嫩四个省的790名已婚叙利亚难民妇女(18-50岁)进行了调查。调查对象采用分层整群抽样和家庭便利抽样。通过结构化的面对面访谈收集有关计划生育和避孕的知识、态度和做法的数据。结果:被试平均年龄为31.86±8.09岁,大部分被试对FP的认知程度中等,平均得分为8.08±2.11分。年轻女性、新来者和受教育程度较低的女性的知识水平较低。关于口服避孕药(ocp)的误解普遍存在。总体而言,67.1%的妇女报告使用避孕措施,其中停药(33.2%)、宫内节育器(30.4%)和ocp(19.8%)是最常见的方法。态度受到父权规范的影响,男性的认可在决策中起着关键作用。积极态度在受过高等教育和就业状况良好的妇女中更为普遍。结论:黎巴嫩的叙利亚难民妇女在有效使用计划生育方面面临多重障碍,包括文化误解和生育决策自主权有限。教育干预措施以及让男子参与计划生育讨论的努力,对于改善生殖健康成果和促进黎巴嫩的可持续发展努力至关重要。
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引用次数: 0
Diagnostic discrepancies and clinical value of second medical opinions (SMO) for endometriosis: a nationwide study analysis. 子宫内膜异位症第二医学意见诊断差异及临床价值:一项全国性研究分析。
IF 2.7 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-15 DOI: 10.1186/s12905-025-04052-z
Constance Durant des Aulnois, Elie Zerbib, Hélène Barberousse, Pierre Panel, Isabelle Holway, Corinne Balleyguier, Alexandre Bellucci, Téodor Grand, Jonathan Zerbib, Corinne Bordonné, Thibault Carteret, Anne-Coline Monseau-Thiburce, Sophie Gehin, Erick Petit, Marie Ceccarelli, Anne-Marie Tardivel, Shahed Borojeni, Sarah Eskenazi, Jean-Philippe Estrade, François Guillibert, Ludovic Friederich, Elise Furet, Vincent Lavoue, Benjamin Merlot, Paul Pirtea, Sophie Warembourg, Hélène Creux, Yohann Dabi, Sofiane Bendifallah
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引用次数: 0
Self-efficacy and self-esteem are associated with health-promoting lifestyle in Iranian post-menopausal women: a cross-sectional study. 伊朗绝经后妇女的自我效能感和自尊与促进健康的生活方式有关:一项横断面研究
IF 2.7 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-15 DOI: 10.1186/s12905-025-04219-8
Majid Movahed Majd, Razieh Rayanpour, Farzaneh Mosahebfard

Introduction: The number of postmenopausal women is expected to grow dramatically in the coming decades in Iran. Adopting a health-promoting lifestyle (HPL) is essential for improving health and quality of life of this population. This study pursues two objectives: (1) to assess the HPL levels among Iranian postmenopausal women and (2) to investigate the socio-demographic and psychological variables including self-efficacy and self-esteem associated with HPL.

Methods: In this cross-sectional study with correlational design, 400 married postmenopausal women in Shiraz (southwestern Iran) were selected via stratified random sampling. The data collection tools were the Health-Promoting Lifestyle Profile-II (HPLP-II), General Self-Efficacy Scale (GSE), the Rosenberg Self-Esteem Scale, and a sociodemographic information questionnaire. Pearson's correlation coefficient test, independent samples t-tests, and stepwise multiple linear regression were used for analyzing the data in SPSS v. 22.

Results: The average age of natural menopause among participants was 49.33 ± 3.43 years, and they had relatively good HPLP (136.52 ± 21.46). The results highlighted that among all the HPLP subscales, the highest mean score was observed for health responsibility (33.62 ± 6.98), whereas the lowest scores were observed for stress management (12.26 ± 3.13) and physical activity (17.64 ± 6.52). Both self-efficacy (r = 0.445, p < 0.01) and self-esteem (r = 0.425, p < 0.01) demonstrated significant, moderate positive correlations with the total HPL score. Also, there was a significant association between the total HPLP score and two demographic variables: women's education (r = 0.17, p < 0.01) and husband's educational level (r = 0.113, p < 0.05). In addition, the HPLP total score had a significant negative relationship with the number of children (r=-0.114, p < 0.05). The stepwise multiple linear regression analysis revealed that the variables independently associated with the HPL of participants were self-efficacy (β = 0.32, p < 0.001), self-esteem (β = 0.27, p < 0.001), and occupation (β = 0.144, p < 0.001).

Conclusion: It is suggested that health care professionals implement comprehensive planning to enhance the HPL of postmenopausal women. Interventions aimed at improving HPL in this population should prioritize strategies to enhance self-efficacy and self-esteem. Particular attention should be paid to women with lower education, unemployment, and a higher number of children.

在伊朗,绝经后妇女的数量预计将在未来几十年急剧增长。采用促进健康的生活方式(HPL)对于改善这一人群的健康和生活质量至关重要。本研究有两个目的:(1)评估伊朗绝经后妇女的HPL水平;(2)调查与HPL相关的社会人口学和心理变量,包括自我效能感和自尊。方法:采用相关设计的横断面研究,采用分层随机抽样的方法在设拉子(伊朗西南部)选取400名已婚绝经妇女。数据收集工具为健康促进生活方式量表(HPLP-II)、一般自我效能量表(GSE)、Rosenberg自尊量表和社会人口学信息问卷。使用SPSS v. 22软件对数据进行Pearson相关系数检验、独立样本t检验和逐步多元线性回归分析。结果:参与者自然绝经的平均年龄为49.33±3.43岁,HPLP较好(136.52±21.46)。结果显示,健康责任得分最高(33.62±6.98),压力管理得分最低(12.26±3.13),体力活动得分最低(17.64±6.52)。结论:建议医护人员实施综合规划,提高绝经后妇女的自我效能感。旨在改善这一人群HPL的干预措施应优先考虑提高自我效能感和自尊的策略。应特别注意受教育程度较低、失业和子女较多的妇女。
{"title":"Self-efficacy and self-esteem are associated with health-promoting lifestyle in Iranian post-menopausal women: a cross-sectional study.","authors":"Majid Movahed Majd, Razieh Rayanpour, Farzaneh Mosahebfard","doi":"10.1186/s12905-025-04219-8","DOIUrl":"https://doi.org/10.1186/s12905-025-04219-8","url":null,"abstract":"<p><strong>Introduction: </strong>The number of postmenopausal women is expected to grow dramatically in the coming decades in Iran. Adopting a health-promoting lifestyle (HPL) is essential for improving health and quality of life of this population. This study pursues two objectives: (1) to assess the HPL levels among Iranian postmenopausal women and (2) to investigate the socio-demographic and psychological variables including self-efficacy and self-esteem associated with HPL.</p><p><strong>Methods: </strong>In this cross-sectional study with correlational design, 400 married postmenopausal women in Shiraz (southwestern Iran) were selected via stratified random sampling. The data collection tools were the Health-Promoting Lifestyle Profile-II (HPLP-II), General Self-Efficacy Scale (GSE), the Rosenberg Self-Esteem Scale, and a sociodemographic information questionnaire. Pearson's correlation coefficient test, independent samples t-tests, and stepwise multiple linear regression were used for analyzing the data in SPSS v. 22.</p><p><strong>Results: </strong>The average age of natural menopause among participants was 49.33 ± 3.43 years, and they had relatively good HPLP (136.52 ± 21.46). The results highlighted that among all the HPLP subscales, the highest mean score was observed for health responsibility (33.62 ± 6.98), whereas the lowest scores were observed for stress management (12.26 ± 3.13) and physical activity (17.64 ± 6.52). Both self-efficacy (r = 0.445, p < 0.01) and self-esteem (r = 0.425, p < 0.01) demonstrated significant, moderate positive correlations with the total HPL score. Also, there was a significant association between the total HPLP score and two demographic variables: women's education (r = 0.17, p < 0.01) and husband's educational level (r = 0.113, p < 0.05). In addition, the HPLP total score had a significant negative relationship with the number of children (r=-0.114, p < 0.05). The stepwise multiple linear regression analysis revealed that the variables independently associated with the HPL of participants were self-efficacy (β = 0.32, p < 0.001), self-esteem (β = 0.27, p < 0.001), and occupation (β = 0.144, p < 0.001).</p><p><strong>Conclusion: </strong>It is suggested that health care professionals implement comprehensive planning to enhance the HPL of postmenopausal women. Interventions aimed at improving HPL in this population should prioritize strategies to enhance self-efficacy and self-esteem. Particular attention should be paid to women with lower education, unemployment, and a higher number of children.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sexual assault and cancer pathways: a scoping review of biomedical and screening outcomes. 性侵犯和癌症途径:生物医学和筛查结果的范围审查。
IF 2.7 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-15 DOI: 10.1186/s12905-025-04223-y
R Chatterjee

Background: Sexual assault (SA) is a pervasive global health problem with long-term psychological and physical consequences. While the mental health effects of SA are well documented, growing evidence suggests that SA may increase cancer vulnerability through biological, behavioural, and healthcare-access mechanisms.

Objective: To examine the relationship between SA and cancer-related outcomes with a focus on behavioural and infection-related mechanisms reported in empirical studies.

Methods: A scoping review was conducted of studies published between 2000 and 2025 in PubMed. Eligible studies reported cancer outcomes among SA survivors. Data were extracted on study design, population characteristics, and effect measures. This scoping review followed PRISMA-ScR reporting guidance.

Results: Twelve studies met inclusion criteria. Survivors demonstrated lower participation in cervical and breast cancer screening (reductions of 20-40%), higher cancer-related infection rates (relative risk 1.13-1.9), and greater odds of cancer or precancerous disease (OR 1.27-4.5). Qualitative findings described distress and re-traumatisation during pelvic examinations as major screening barriers.

Conclusion: Sexual assault is associated with increased cancer vulnerability through converging biological, behavioural, and structural pathways. Incorporating trauma-informed approaches into cancer prevention, screening, and treatment is essential to addressing this overlooked aspect of survivor health.

背景:性侵犯(SA)是一个普遍的全球性健康问题,具有长期的心理和身体后果。虽然SA对心理健康的影响已被充分记录,但越来越多的证据表明SA可能通过生物、行为和医疗保健获取机制增加癌症易感性。目的:研究SA与癌症相关结果之间的关系,重点关注实证研究中报道的行为和感染相关机制。方法:对2000年至2025年间发表在PubMed上的研究进行范围综述。符合条件的研究报告了SA幸存者的癌症结局。从研究设计、人群特征和效果测量中提取数据。本次范围审查遵循PRISMA-ScR报告指南。结果:12项研究符合纳入标准。幸存者的宫颈癌和乳腺癌筛查参与率较低(减少20-40%),癌症相关感染率较高(相对危险度1.13-1.9),癌症或癌前病变的几率较高(危险度1.27-4.5)。定性研究结果描述了盆腔检查时的痛苦和再创伤是主要的筛查障碍。结论:性侵犯通过生物学、行为学和结构途径与癌症易感性增加相关。将创伤知情方法纳入癌症预防、筛查和治疗,对于解决幸存者健康中这一被忽视的方面至关重要。
{"title":"Sexual assault and cancer pathways: a scoping review of biomedical and screening outcomes.","authors":"R Chatterjee","doi":"10.1186/s12905-025-04223-y","DOIUrl":"10.1186/s12905-025-04223-y","url":null,"abstract":"<p><strong>Background: </strong>Sexual assault (SA) is a pervasive global health problem with long-term psychological and physical consequences. While the mental health effects of SA are well documented, growing evidence suggests that SA may increase cancer vulnerability through biological, behavioural, and healthcare-access mechanisms.</p><p><strong>Objective: </strong>To examine the relationship between SA and cancer-related outcomes with a focus on behavioural and infection-related mechanisms reported in empirical studies.</p><p><strong>Methods: </strong>A scoping review was conducted of studies published between 2000 and 2025 in PubMed. Eligible studies reported cancer outcomes among SA survivors. Data were extracted on study design, population characteristics, and effect measures. This scoping review followed PRISMA-ScR reporting guidance.</p><p><strong>Results: </strong>Twelve studies met inclusion criteria. Survivors demonstrated lower participation in cervical and breast cancer screening (reductions of 20-40%), higher cancer-related infection rates (relative risk 1.13-1.9), and greater odds of cancer or precancerous disease (OR 1.27-4.5). Qualitative findings described distress and re-traumatisation during pelvic examinations as major screening barriers.</p><p><strong>Conclusion: </strong>Sexual assault is associated with increased cancer vulnerability through converging biological, behavioural, and structural pathways. Incorporating trauma-informed approaches into cancer prevention, screening, and treatment is essential to addressing this overlooked aspect of survivor health.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":" ","pages":"16"},"PeriodicalIF":2.7,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12790115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A longitudinal study of early postoperative symptom cluster trajectories in patients with gynecologic malignancies. 妇科恶性肿瘤患者术后早期症状群轨迹的纵向研究。
IF 2.7 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-15 DOI: 10.1186/s12905-025-04221-0
Liu Jiarui, Li Xia, Wang Zhe, Zhang Yan, Chang Huixia, Yan Hong, Yan Shurong, Liu Mengzhen

Objective: To explore the dynamic evolution of symptom clusters in patients with gynecologic malignancies during the early postoperative period and identify key transition points and influencing factors, providing evidence for precision symptom management in clinical nursing.

Methods: A longitudinal study was conducted among 324 patients using the MDASI-PeriOp-GYN on postoperative days 1 (T1), 5 (T2), and 7 (T3). Exploratory factor analysis identified symptom clusters at each time point, and growth mixture modeling (GMM) was applied to examine trajectory patterns. Latent profile analysis (LPA) and network analysis were performed at T2 to identify patient subgroups, influencing factors, and core symptoms.

Results: Five symptom clusters were identified: disease behavior, gastrointestinal, endocrine, neurological, and emotional. The emotional cluster, independent at T1 and T3, merged with the disease behavior cluster at T2. GMM indicated that all clusters declined from T1 to T2, followed by divergence after T2. LPA identified high- and low-symptom subgroups. Patients with ovarian cancer and those with KPS_1 were more likely to belong to the high-symptom group. Network analysis revealed "poor appetite" as the most central symptom at T2.

Conclusion: Postoperative day 5 (T2) represents a critical transition point in symptom evolution. Ovarian and KPS_1 are at higher risk for severe symptoms, and "poor appetite" plays a key driving role. Targeted assessment and intervention at T2 may reduce symptom burden and improve recovery outcomes in patients with gynecologic malignancies.

目的:探讨妇科恶性肿瘤患者术后早期症状群的动态演变,找出关键转折点及影响因素,为临床护理中症状的精准管理提供依据。方法:对324例术后第1天(T1)、第5天(T2)和第7天(T3)使用mdasi - perio - gyn的患者进行纵向研究。探索性因素分析确定了每个时间点的症状群,并应用生长混合模型(GMM)检查轨迹模式。T2时进行潜伏剖面分析(LPA)和网络分析,确定患者亚组、影响因素和核心症状。结果:确定了5个症状群:疾病行为、胃肠、内分泌、神经和情绪。情绪类在T1和T3独立,在T2与疾病行为类合并。GMM显示,从T1到T2,所有聚类呈下降趋势,T2后呈发散趋势。LPA确定了高症状和低症状亚组。伴有KPS_1的卵巢癌患者多属于高症状组。网络分析显示,“食欲不振”是T2时最主要的症状。结论:术后第5天(T2)是症状演变的关键转折点。卵巢和KPS_1出现严重症状的风险更高,“食欲不振”起着关键的驱动作用。T2期有针对性的评估和干预可以减轻妇科恶性肿瘤患者的症状负担,改善康复效果。
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引用次数: 0
Prevalence and determinants of caesarean section delivery in Ethiopia: analysis of the 2019 EMDHS using Poisson regression with robust standard errors. 埃塞俄比亚剖宫产的患病率和决定因素:使用具有稳健标准误差的泊松回归分析2019年EMDHS
IF 2.7 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-13 DOI: 10.1186/s12905-025-04225-w
Temesgen Gebeyehu Wondmeneh
{"title":"Prevalence and determinants of caesarean section delivery in Ethiopia: analysis of the 2019 EMDHS using Poisson regression with robust standard errors.","authors":"Temesgen Gebeyehu Wondmeneh","doi":"10.1186/s12905-025-04225-w","DOIUrl":"https://doi.org/10.1186/s12905-025-04225-w","url":null,"abstract":"","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145741155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of anemia and iron status in Japanese patients with gynecological malignancy: retrospective cohort study : Author. 评价日本妇科恶性肿瘤患者的贫血和铁状态:回顾性队列研究:作者。
IF 2.7 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-13 DOI: 10.1186/s12905-025-04220-1
Tetsuya Kokabu, Saiko Yamauchi, Miho Iwai, Kota Aoki, Ayaka Okamura, Yosuke Tarumi, Hisashi Kataoka, Kaori Yoriki, Taisuke Mori

Background: Anemia and iron deficiency are common among patients with cancer and can have a significant impact on their prognosis. However, the current status of anemia and iron deficiency in Japanese patients with gynecological malignancies remains unclear. This study aimed to clarify the prevalence of anemia and iron deficiency at the time of diagnosis and to evaluate their influence on hemoglobin levels during cancer treatment in Japanese patients with gynecological malignancies.

Methods: Eligible patients were those diagnosed with gynecological cancers. Anemia and iron status were evaluated before and within 6 months of initiating cancer treatments at our institution between January 2022 and July 2024. Statistical comparison of risk factors was performed with the Mann-Whitney U test, Student t-test, and one-way analysis of variance. Iron status and transferrin saturation (TSAT) were classified using the National Comprehensive Cancer Network guidelines.

Results: A total of 103 patients were assessed for eligibility. The median (interquartile range) hemoglobin level was 12.5 (10.6-13.2) g/dL, and 29.1% of patients had hemoglobin ≤ 11.0 g/dL before cancer treatment. TSAT < 20% and < 50% accounted for 46.7% and 99.0% of patients, respectively; 9.9% and 11.1% were classified as having absolute and functional iron deficiency anemia, respectively. Sixty-two patients received chemotherapy or concurrent chemoradiotherapy for their cancers, and 90.3% developed anemia within 6 months of initiation of treatment. Lower hemoglobin and serum ferritin before treatment, as well as hemoglobin at its lowest point within 6 months of treatment, were found in patients with TSAT < 20%.

Conclusions: Anemia and iron deficiency were prevalent among Japanese patients with gynecological cancers. TSAT < 20% before treatment was associated with more severe anemia during treatment. TSAT may be a useful biomarker for predicting and managing treatment-related anemia. Early intervention based on TSAT levels could help maintain hemoglobin levels and prevent treatment interruption.

背景:贫血和缺铁在癌症患者中很常见,并对其预后有重大影响。然而,日本妇科恶性肿瘤患者贫血和缺铁的现状尚不清楚。本研究旨在阐明日本妇科恶性肿瘤患者诊断时贫血和缺铁的患病率,并评估其在癌症治疗期间对血红蛋白水平的影响。方法:入选的患者均为诊断为妇科癌症的患者。在2022年1月至2024年7月期间,在我们机构开始癌症治疗之前和6个月内评估贫血和铁状态。危险因素的统计比较采用Mann-Whitney U检验、Student t检验和单因素方差分析。铁状态和转铁蛋白饱和度(TSAT)根据国家综合癌症网络指南进行分类。结果:共有103例患者被评估为合格。血红蛋白水平中位数(四分位数范围)为12.5 (10.6-13.2)g/dL,癌症治疗前29.1%的患者血红蛋白≤11.0 g/dL。TSAT结论:贫血和缺铁在日本妇科癌症患者中普遍存在。TSAT
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引用次数: 0
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