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Evaluating the safety and efficacy of wormwood vaginal cream on sexual satisfaction and quality of sexual life of postmenopausal women: a randomized, triple-blinds, placebo-controlled clinical trial. 评估艾草阴道乳膏对绝经后妇女性满意度和性生活质量的安全性和有效性:一项随机、三盲、安慰剂对照的临床试验。
IF 2.4 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-12-23 DOI: 10.1186/s12905-024-03515-z
Hajatpoor Niloufar, Babazadeh Raheleh, Salari Roshanak, Jamali Jamshid, Izanlou Sharbanoo

Background: The physical and mental changes created during menopause cause sexual dysfunction, which affects the quality of life, self-esteem, and emotional relationships. Wormwood cream contains tannins, terpenoids, flavonoids, phytosterols, and alkaloids. The purpose of this study is to evaluate the safety and effectiveness of wormwood vaginal cream on the sexual satisfaction and quality of sexual life of postmenopausal women.

Method: This study was a randomized, triple-blind, placebo-controlled clinical trial conducted on 112 postmenopausal women (45-65 years old) in 2021. The studied women were randomly assigned to two wormwood cream or placebo groups. Wormwood cream or placebo was used for 4 weeks and 3 times a week. The main data collection tools included the Larson Sexual Satisfaction Questionnaire (LSSQ) and the Sexual Quality of Life Questionnaire (SQOL-F). SPSS software version 26 and independent t, Mann-Whitney, paired t and Wilcoxon tests were used for statistical analysis. P < 0.05 was considered significant.

Results: Before the intervention, the mean and standard deviation of sexual satisfaction was 73.57 ± 3.84 in the intervention group and 73.16 ± 4.52 in the placebo group. After the intervention, the mean and standard deviation of sexual satisfaction in the intervention group was 75.34 ± 3.85 and in the placebo group was 72.82 ± 4.32. The quality of women's sexual life before of the intervention in the intervention and placebo groups was 59.16 ± 14.10 and 57.18 ± 12.38, and after the intervention, it was 83.00 ± 11.51and 69.64 ± 12.97, respectively. At the end of 4 weeks, participants in the wormwood cream group showed a significant improvement in sexual satisfaction and the quality of women's sexual life (P < 0.001). It was meaningful.

Conclusion: Based on the findings of this trial, wormwood vaginal cream can be used as an uncomplicated topical supplement to improve sexual satisfaction and quality of sexual life in postmenopausal women with low sexual satisfaction and quality of sexual life.

背景:绝经期的生理和心理变化会导致性功能障碍,从而影响生活质量、自尊和情感关系。苦艾膏含有单宁、萜类、黄酮类、植物甾醇和生物碱。本研究的目的是评价艾草阴道乳膏对绝经后妇女的性满意度和性生活质量的安全性和有效性。方法:本研究是一项随机、三盲、安慰剂对照的临床试验,于2021年对112名绝经后妇女(45-65岁)进行研究。被研究的女性被随机分配到艾草膏和安慰剂两组。使用苦艾膏或安慰剂4周,每周3次。主要数据收集工具包括Larson性满意度问卷(LSSQ)和性生活质量问卷(SQOL-F)。采用SPSS软件26版,采用独立t检验、Mann-Whitney检验、配对t检验和Wilcoxon检验进行统计分析。结果:干预前,干预组的性满意度均值和标准差分别为73.57±3.84和73.16±4.52。干预后,干预组性满意度均值为75.34±3.85,安慰剂组性满意度均值为72.82±4.32。干预组和安慰剂组女性在干预前的性生活质量分别为59.16±14.10和57.18±12.38,干预后分别为83.00±11.51和69.64±12.97。在4周结束时,艾草乳膏组的参与者在性满意度和女性性生活质量方面表现出明显的改善(P结论:根据本试验的发现,艾草阴道乳膏可以作为一种简单的外用补充剂,用于改善性满意度和性生活质量较低的绝经后女性的性满意度和性生活质量。
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引用次数: 0
Associations between mental health conditions in pregnancy and maternal socioeconomic status: a population-based retrospective cohort study in Ontario, Canada. 孕期心理健康状况与产妇社会经济地位之间的关系:加拿大安大略省一项基于人群的回顾性队列研究
IF 2.4 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-12-23 DOI: 10.1186/s12905-024-03499-w
Qun Miao, Gwyneth Zai, Ian Joiner, Jessica Burnside, Mark Walker

Background: The World Health Organization has recognized maternal mental illness as an emerging issue. Previous studies have indicated that maternal mental illness is associated with socioeconomic status (SES). However, there is a lack of research concerning the mental health of pregnant people with low SES in Ontario, Canada. In this study, we examined associations between mental health conditions during pregnancy and two SES indicators: the pregnant person's residential neighbourhood income and education level.

Methods: A population-based retrospective cohort study was conducted, consisting of all singleton pregnancies resulting in stillbirths or live births in Ontario hospitals from April 1, 2012, to March 31, 2021. Data were linked from the BORN Information System database, Canadian Institute for Health Information Discharge Abstract Database, and Canadian Census. Poisson regression with robust error variance models was performed to estimate the relative risks of anxiety, depression, anxiety and/or depression, or any mental health condition during pregnancy, by SES indicator. We adjusted for maternal age, obesity status in pre-pregnancy, certain pre-existing maternal health conditions, substance use during pregnancy, race, and rural or urban residence.

Results: Within the cohort (n = 1,202,292), 10.5% (126,076) and 8.1% (97,135) of pregnant individuals experienced anxiety and depression, respectively, and 15.8% (189,616) had at least one mental health condition during pregnancy. The trend test (p < 0.0001) showed a significant downward trend in the total rates of mental health conditions by increasing SES quintiles. Pregnant individuals in the lowest neighbourhood income quintile tended to have a higher risk of anxiety (aRR: 1.24, 95%CI: 1.22-1.27), depression (aRR: 1.56, 95%CI: 1.52-1.59), anxiety and/or depression (aRR: 1.13, 95%CI: 1.11-1.15), or any mental health condition (aRR: 1.18, 95%CI: 1.16-1.19). Similarly, pregnant people living in the lowest education level neighbourhoods had higher likelihoods of anxiety (aRR: 1.66, 95%CI: 1.62-1.69), depression (aRR: 2.09, 95%CI: 2.04-2.14), anxiety and/or depression (aRR: 1.42, 95%CI: 1.39-1.44), and any mental health condition (aRR: 1.41, 95%CI: 1.38-1.43).

Conclusions: Despite a universal healthcare system, the variations in mental health prevalence and risk during pregnancy based on SES suggest health inequity in Ontario, Canada. Future studies are needed to examine the mechanisms of this health inequity to guide policy makers in reducing disparities in Ontario.

背景:世界卫生组织已认识到产妇精神疾病是一个新出现的问题。以往的研究表明,产妇精神疾病与社会经济地位(SES)有关。然而,在加拿大安大略省,缺乏关于低社会经济地位孕妇心理健康的研究。在这项研究中,我们研究了怀孕期间的心理健康状况与两个社会经济地位指标:孕妇的居住社区收入和教育水平之间的关系。方法:进行了一项基于人群的回顾性队列研究,包括2012年4月1日至2021年3月31日在安大略省医院中导致死产或活产的所有单胎妊娠。数据链接自BORN信息系统数据库、加拿大卫生信息研究所出院摘要数据库和加拿大人口普查。用稳健误差方差模型进行泊松回归,以SES指标估计妊娠期焦虑、抑郁、焦虑和/或抑郁或任何心理健康状况的相对风险。我们调整了产妇年龄、孕前肥胖状况、某些先前存在的产妇健康状况、怀孕期间药物使用、种族和农村或城市居住。结果:在队列中(n = 1,202,292), 10.5%(126,076)和8.1%(97,135)的孕妇分别经历焦虑和抑郁,15.8%(189,616)的孕妇在怀孕期间至少有一种心理健康状况。结论:尽管有一个普遍的医疗保健系统,但基于SES的怀孕期间心理健康患病率和风险的差异表明加拿大安大略省的健康不平等。未来的研究需要检查这种健康不平等的机制,以指导决策者减少安大略省的差距。
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引用次数: 0
The pandemic within a pandemic: mental health and wellbeing of racially Minoritised women experiencing domestic abuse during the COVID-19 pandemic in the UK. 大流行中的大流行:英国2019冠状病毒病大流行期间遭受家庭虐待的少数族裔妇女的心理健康和福祉。
IF 2.4 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-12-23 DOI: 10.1186/s12905-024-03502-4
Ankita Mishra, Jilly Gibson-Miller, Chantelle Wood

Background: The prevalence of domestic abuse is greater in times of humanitarian crisis, and the COVID-19 pandemic has been no different. Considerable evidence indicates that domestic abuse disproportionately impacts the mental health and wellbeing of racially Minoritised women. The present study aimed to explore racially Minoritised women's experiences of domestic abuse and mental health in the COVID-19 pandemic in the UK.

Method: An online cross-sectional survey was used with racially Minoritised women (n = 1202) in the UK during the third national lockdown.

Results: Results demonstrate complex interplay of psychosocial factors, such as the roles of autonomy, resilience, self-silencing, family functioning, and social support as predictors of mental health and wellbeing during the 'shadow pandemic'.

Conclusion: Implications such as incorporating culturally competent mental health support, exploring the complex and multiple underpinnings of mental health in racially Minoritised victim-survivors of domestic abuse for future pandemic preparedness and support provision are discussed.

背景:在人道主义危机时期,家庭暴力的发生率更高,2019冠状病毒病大流行也不例外。相当多的证据表明,家庭虐待对少数族裔妇女的心理健康和福祉造成了不成比例的影响。本研究旨在探讨英国2019冠状病毒病大流行期间少数族裔妇女遭受家庭虐待和心理健康的经历。方法:在第三次全国封锁期间,对英国少数民族妇女(n = 1202)进行了在线横断面调查。结果:结果表明,社会心理因素之间存在复杂的相互作用,例如自主性、复原力、自我沉默、家庭功能和社会支持在“影子大流行”期间作为心理健康和福祉预测因素的作用。结论:讨论了诸如纳入具有文化能力的心理健康支持、探索少数族裔家庭虐待受害者-幸存者心理健康的复杂和多重基础等影响,以便为未来的流行病准备和提供支持。
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引用次数: 0
Validation of the premenstrual symptoms questionnaire among Mongolian nursing school students. 蒙古护理学校学生经前症状问卷的验证。
IF 2.4 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-12-23 DOI: 10.1186/s12905-024-03492-3
Dorjderem Choijiljav, Tuya Sukhbat, Shota Ogawa, Enkhjargal Yanjmaa, Oyungoo Badamdorj, Asuka Saito, Yoko Arai, Hiromitsu Shinozaki

Background: Premenstrual disorders (PMDs) significantly affect the daily lives of women. This study evaluated the reliability and validity of the Mongolian-translated Premenstrual Symptoms Questionnaire (PSQ) among female nursing students at the Mongolian National University of Medical Sciences.

Methods: This cross-sectional study was conducted from February 2023 to January 2024. The PSQ was translated into Mongolian, and its reliability and validity were assessed. A total of 431 participants completed the translated PSQ along with the Premenstrual Dysphoric Disorder (PMDD) Scale, Somatic Symptom Scale (SSS-8), Patient Health Questionnaire (PHQ-9), and Beck Anxiety Inventory (BAI). Reliability was evaluated via Cronbach's alpha for internal consistency. Validity was assessed via factor analysis and correlations with external measures.

Results: The internal consistency of the Mongolian PSQ was 0. 945. Factor analysis supported the tool's construct validity, which revealed a one-factor structure consistent with that of the original Japanese PSQ. The PSQ had strong positive correlations with the PMDD Scale (r = 0.760), SSS-8 (r = 0.640), PHQ-9 (r = 0.580), and BAI (r = 0.620), which indicated good convergent validity.

Conclusion: The Mongolian-translated PSQ is a reliable and valid tool for assessing premenstrual symptoms in female nursing students. These findings suggest that the PSQ is a useful tool for screening PMDs in this population.

背景:经前紊乱(PMDs)显著影响女性的日常生活。本研究旨在评估蒙古国立医科大学护生经前症状问卷(PSQ)的信度与效度。方法:横断面研究于2023年2月至2024年1月进行。将PSQ翻译成蒙古语,并对其信度和效度进行评估。共有431名参与者完成了翻译后的PSQ、经前烦躁不安(PMDD)量表、躯体症状量表(SSS-8)、患者健康问卷(PHQ-9)和贝克焦虑量表(BAI)。信度通过Cronbach's alpha来评估内部一致性。通过因子分析和与外部测量的相关性来评估效度。结果:蒙药PSQ内部一致性为0。945. 因子分析支持该工具的构效度,结果显示该工具的构效度与原日语PSQ的构效度一致。PSQ与PMDD量表(r = 0.760)、SSS-8量表(r = 0.640)、PHQ-9量表(r = 0.580)、BAI量表(r = 0.620)呈显著正相关,具有较好的收敛效度。结论:蒙译PSQ量表是评价女护生经前症状的一种可靠、有效的工具。这些发现表明PSQ是筛查该人群pmd的有用工具。
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引用次数: 0
Implication of the enteric glia in the IBS-like colonic inflammation associated with endometriosis. 肠胶质细胞在ibs样结肠炎症与子宫内膜异位症相关中的意义。
IF 2.4 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-12-21 DOI: 10.1186/s12905-024-03480-7
Luis A Rivera-Arce, Myrella L Cruz, Ulises Rodriguez-Cintron, James P Torres-Pirela, Caroline B Appleyard

Background: Endometriosis is a complex gynecological disorder characterized by the ectopic growth of endometrial tissue. Symptoms of endometriosis are known to impair the quality of life of patients, and among these are found dysmenorrhea, chronic pelvic pain, and gastrointestinal (GI) issues. GI issues such as painful bowel movements, bloating and constipation or diarrhea, are one of the common reasons for misdiagnosis with irritable bowel syndrome (IBS). Enteric glial cells (EGC) are known to play a role in pain associated with IBS, and reactive gliosis has been reported in patients with IBS, but the role of EGC in endometriosis has yet to be elucidated. We hypothesized that endometriosis will induce reactive gliosis, with increased expression of the glial fibrillary acidic protein (GFAP) and S100B, in the myenteric plexus of colonic sections in an animal model of endometriosis.

Methods: In the present study animal experiments were employed to explore the impact of endometriosis on the gastrointestinal tract. Using a surgically induced endometriosis rat model, we collected ileal and colonic segments for analysis. We used H&E to assess microscopic damage in colon and ileum, immunofluorescence to measure GFAP and S100B expression in the colon, and toluidine blue staining to measure mast cell infiltration in colon and ileum. Immunofluorescence images were captured using confocal microscope and analyzed using ImageJ software.

Results: All endometriosis animals developed vesicles. These animals had a significant increase in the colonic macroscopic damage compared to Sham and Naïve controls. Colonic and ileal sections didn't show statistical differences in microscopic damage between groups, yet endometriosis ileum had significantly increased mast cell infiltration compared to Naïve. GFAP immunostaining showed significantly increased integrated density in endometriosis when compared to Sham or Naïve, while no statistical difference was found in S100B integrated density between groups.

Conclusions: We conclude that endometriosis can alter GI homeostasis by inducing colon inflammation, reactive gliosis, and ileal mast cell infiltration. Taken together this suggests endometriosis can mimic IBS histopathology beyond the symptomatology, reinforcing this disease's complexity and the need to treat it beyond the gynecological setting.

背景:子宫内膜异位症是一种复杂的妇科疾病,其特征是子宫内膜组织异位生长。众所周知,子宫内膜异位症的症状会损害患者的生活质量,其中包括痛经、慢性盆腔疼痛和胃肠道(GI)问题。胃肠道问题,如排便疼痛、腹胀、便秘或腹泻,是肠易激综合征(IBS)误诊的常见原因之一。肠胶质细胞(Enteric glial cells, EGC)在IBS相关的疼痛中发挥作用,反应性胶质增生在IBS患者中也有报道,但EGC在子宫内膜异位症中的作用尚未阐明。在子宫内膜异位症动物模型中,我们假设子宫内膜异位症会诱导反应性胶质细胞增生,胶质纤维酸性蛋白(GFAP)和S100B在结肠肠系膜丛中的表达增加。方法:采用动物实验方法探讨子宫内膜异位症对胃肠道的影响。使用手术诱导的子宫内膜异位症大鼠模型,我们收集回肠和结肠段进行分析。我们使用H&E评估结肠和回肠的显微损伤,免疫荧光检测结肠中GFAP和S100B的表达,甲苯胺蓝染色检测结肠和回肠肥大细胞的浸润。共聚焦显微镜采集免疫荧光图像,ImageJ软件分析。结果:所有子宫内膜异位症动物均出现囊泡。与Sham和Naïve对照组相比,这些动物的结肠宏观损伤显著增加。结肠和回肠切片显微损伤组间无统计学差异,但回肠子宫内膜异位症肥大细胞浸润较Naïve明显增加。GFAP免疫染色显示,与Sham或Naïve相比,子宫内膜异位症的综合密度显著增加,而组间S100B综合密度无统计学差异。结论:我们认为子宫内膜异位症可以通过诱导结肠炎症、反应性胶质瘤和回肠肥大细胞浸润来改变胃肠道稳态。综上所述,这表明子宫内膜异位症可以在症状学之外模仿肠易激综合征的组织病理学,从而加强了这种疾病的复杂性,并需要在妇科之外进行治疗。
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引用次数: 0
Association of dietary preferences with primary ovarian insufficiency (POI): a mendelian randomization-based analysis. 饮食偏好与原发性卵巢功能不全(POI)的关联:一项基于孟德尔随机化的分析
IF 2.4 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-12-21 DOI: 10.1186/s12905-024-03488-z
Zhengqi Qiu, Emma Yun Zhi Huang, Yufei Li, Jun Du, Juntao Kan

Background: Primary ovarian insufficiency (POI) is a critical cause of infertility and is increasingly recognized as a complex metabolic disorder. Dietary factors may influence the risk of POI, but causal relationships remain unclear.

Methods: We conducted an MR study using genetic instrumental variables for 83 dietary preferences from the UK Biobank, with the Inverse Variance Weighted method as the primary analysis.

Results: Consumption of butter and full-fat dairy products was strongly associated with an increased risk of primary ovarian insufficiency (POI). Women who consumed butter had nearly ten times the risk of developing POI (OR = 9.54, p = 0.048), while full-cream milk was associated with an even greater risk (OR = 29.22, p = 0.018). Interestingly, semi-skimmed milk, despite its lower fat content, also showed a significant positive association with POI (OR > 100, p = 0.008). In contrast, dietary patterns including oily fish and pork were protective against POI. Oily fish, rich in omega-3 fatty acids, was linked to a 82% reduced risk of POI (OR = 0.18, p = 0.008), and pork consumption also showed a protective effect (OR = 0.13, p = 0.041). Additionally, women who did not consume eggs had a significantly lower risk of POI (OR < 0.001, p = 0.044).

Conclusion: This study demonstrates that high-fat dairy products may increase the risk of POI, while oily fish and pork consumption could offer protective effects. These findings providing a foundation for future clinical and public health strategies targeting reproductive health.

背景:原发性卵巢功能不全(POI)是导致不孕症的重要原因,越来越被认为是一种复杂的代谢紊乱。饮食因素可能影响POI的风险,但因果关系尚不清楚。方法:我们使用来自英国生物银行的83种饮食偏好的遗传工具变量进行了一项MR研究,并以反方差加权法作为主要分析方法。结果:食用黄油和全脂乳制品与原发性卵巢功能不全(POI)的风险增加密切相关。食用黄油的女性患POI的风险几乎是食用黄油的女性的10倍(OR = 9.54, p = 0.048),而食用全脂牛奶的女性患POI的风险更高(OR = 29.22, p = 0.018)。有趣的是,半脱脂牛奶尽管脂肪含量较低,但也与POI呈显著正相关(OR bbb100, p = 0.008)。相比之下,含油性鱼类和猪肉的饮食模式对POI有保护作用。富含omega-3脂肪酸的油性鱼类与POI风险降低82%有关(OR = 0.18, p = 0.008),猪肉消费也显示出保护作用(OR = 0.13, p = 0.041)。此外,不吃鸡蛋的女性患POI的风险显著降低。结论:本研究表明,高脂肪乳制品可能会增加患POI的风险,而食用含油的鱼和猪肉可能有保护作用。这些发现为今后针对生殖健康的临床和公共卫生战略提供了基础。
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引用次数: 0
Marital rights: Lived experiences of Iranian women with retired spouses in a qualitative study. 婚姻权利:有退休配偶的伊朗妇女的生活经历的定性研究。
IF 2.4 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-12-21 DOI: 10.1186/s12905-024-03485-2
Maryam Nosrati Beigzade, Behzad Shalchi, Hossein Ghamari Kivi, Nasrin Haghighat, Atefeh Heyrat

Background: The aim of the present study was to analyze the lived experiences of Iranian women living with their retired spouses in relation to their marital rights.

Methods: The research method was qualitative and descriptive phenomenology. The statistical population included women living with their retired spouses in the city of Isfahan, and the sample consisted of 15 women. Data were collected through semistructured interviews, with three general questions on emotional rights, economic rights, and sexual rights, and were approved by five experts. Data were analyzed using the seven-step Colaizzi method.

Results: After transcribing the interviews and coding the data, the following axial codes were identified. Emotional rights included the two categories of camaraderie and dissatisfaction. Economic rights included the four categories of economic management, economic well-being, respect for women's economic property, and economic problems. Finally, sexual rights consisted of the two categories of satisfaction and dissatisfaction with sexual relationships. The results showed that some participants were satisfied with the implementation of their rights during their spouse's retirement, while others were dissatisfied. Most current marital problems related to emotional, economic, and sexual rights result from past and unresolved marital life conflicts that lead to the escalation of family tensions.

Conclusions: According to the dissatisfied participants, the best strategy for resolving these problems was to "sweep them under the rug,", i.e., to rehire the men and protest the lack of support for the retirees by the state organization. In contrast, satisfied participants played an important role in solving the problems and actively dealt with their spouse's retirement rather than taking a passive and protesting role to realize their marital rights.

背景:本研究的目的是分析与退休配偶生活在一起的伊朗妇女在婚姻权利方面的生活经历。方法:采用定性和描述现象学相结合的研究方法。统计人口包括与退休配偶一起生活在伊斯法罕市的妇女,样本由15名妇女组成。数据通过半结构化访谈的方式收集,包括情感权利、经济权利和性权利三个一般性问题,并由五位专家批准。数据分析采用Colaizzi七步法。结果:对访谈资料进行转录和编码后,识别出以下轴向编码。情感权利包括同志情谊和不满两类。经济权利包括经济管理、经济福利、尊重妇女经济财产和经济问题四大类。最后,性权利包括对性关系的满意和不满意两类。调查结果显示,部分受访者对配偶退休期间权利的落实情况感到满意,而另一些人则不满意。目前大多数与情感、经济和性权利有关的婚姻问题都是由过去和未解决的婚姻生活冲突造成的,这些冲突导致家庭关系紧张升级。结论:根据不满的参与者,解决这些问题的最佳策略是“把他们扫到地毯下”,即重新雇用这些人,并抗议国家组织对退休人员缺乏支持。相比之下,满意的参与者在解决问题方面发挥了重要作用,积极应对配偶的退休,而不是采取被动和抗议的角色来实现他们的婚姻权利。
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引用次数: 0
Comparative effectiveness of vitrification and slow freezing after heterotopic transplantation of human ovarian tissues. 人卵巢组织异位移植后玻璃化与慢速冷冻的比较效果。
IF 2.4 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-12-21 DOI: 10.1186/s12905-024-03505-1
Yucui Zeng, Yushan Li, Hui Du, Changzhong Li, Wenkui Dai, Ruifang Wu

Background: The aim of this study was to compare the effectiveness of two different vitrification methods and slow freezing in terms of the recovery of endocrine function, follicular morphology and proliferation, apoptosis of stromal cells, and angiogenesis after heterotopic transplantation of human ovarian tissue.

Methods: Ovarian tissue from young women aged 29 to 40 was subjected to two vitrification methods and one slow freezing method. The thawed ovarian tissue was then transplanted into nude mice and divided into three groups (VF1 group, VF2 group, SF group) according to the different freezing methods. Ovarian tissue samples were collected at 4 and 6 weeks post-transplantation. The recovery of ovarian function was evaluated by observing the estrous cycle and measuring estradiol levels using Elisa. Histological evaluation was performed to assess the integrity of ovarian follicles. TUNEL assay was used to detect stromal cell apoptosis, and immunohistochemistry was conducted to evaluate follicular proliferation and tissue angiogenesis.

Results: After heterotopic transplantation, mice in the experimental groups exhibited restoration of the estrous cycle. Hormone levels showed an increasing trend in the vitrification groups. At 6 weeks post-transplantation, the VF2 group had significantly higher hormone levels compared to the VF1 group and the slow freezing (SF) group (P < 0.05). At 4 weeks post-transplantation, the proportion of normal follicles was higher in the VF2 group compared to the other two groups (P > 0.05), and at 6 weeks post-transplantation, the VF2 group was significantly higher than the SF group (P < 0.05) and slightly higher than the VF1 group. Immunohistochemistry analysis indicated a higher proportion of proliferating follicles in the vitrification groups compared to the slow freezing group (P > 0.05). CD31 expression was established in all groups at 4 and 6 weeks post-transplantation, with better results in the slow freezing group compared to the vitrification group. TUNEL analysis showed that stromal cell apoptosis was higher in the SF group compared to the vitrification group at 4 weeks post-transplantation (P < 0.05), while there was no significant statistical difference among the groups at 6 weeks post-transplantation.

Conclusions: Vitrification showed better results than slow freezing, with the VF2 group performing slightly better than the VF1 group. Considering the lower economic and time costs associated with vitrification, it may be more suitable for ovarian tissue cryopreservation in major research centers in the future.

背景:本研究的目的是比较两种不同的玻璃化冷冻和慢速冷冻对人卵巢组织异位移植后内分泌功能恢复、卵泡形态和增殖、基质细胞凋亡和血管生成的影响。方法:对29 ~ 40岁年轻女性卵巢组织进行玻璃化冷冻和慢速冷冻。将解冻后的卵巢组织移植到裸鼠体内,根据冷冻方式的不同分为三组(VF1组、VF2组、SF组)。在移植后4周和6周采集卵巢组织样本。采用Elisa法观察发情周期和测定雌二醇水平,评价卵巢功能恢复情况。进行组织学评价以评估卵巢卵泡的完整性。TUNEL法检测基质细胞凋亡,免疫组化法检测滤泡增殖和组织血管生成。结果:异位移植后,实验组小鼠的发情周期明显恢复。玻璃化组的激素水平呈上升趋势。移植后6周,VF2组激素水平显著高于VF1组和慢速冷冻(SF)组(P 0.05),移植后6周,VF2组激素水平显著高于慢速冷冻(SF)组(P 0.05)。在移植后4周和6周,所有组均有CD31表达,慢速冷冻组的结果优于玻璃化组。TUNEL分析显示,移植后4周,SF组间质细胞凋亡高于玻璃化组(P)。结论:玻璃化比慢速冷冻效果好,VF2组稍好于VF1组。考虑到与玻璃化相关的较低的经济和时间成本,它可能更适合未来主要研究中心的卵巢组织冷冻保存。
{"title":"Comparative effectiveness of vitrification and slow freezing after heterotopic transplantation of human ovarian tissues.","authors":"Yucui Zeng, Yushan Li, Hui Du, Changzhong Li, Wenkui Dai, Ruifang Wu","doi":"10.1186/s12905-024-03505-1","DOIUrl":"10.1186/s12905-024-03505-1","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to compare the effectiveness of two different vitrification methods and slow freezing in terms of the recovery of endocrine function, follicular morphology and proliferation, apoptosis of stromal cells, and angiogenesis after heterotopic transplantation of human ovarian tissue.</p><p><strong>Methods: </strong>Ovarian tissue from young women aged 29 to 40 was subjected to two vitrification methods and one slow freezing method. The thawed ovarian tissue was then transplanted into nude mice and divided into three groups (VF1 group, VF2 group, SF group) according to the different freezing methods. Ovarian tissue samples were collected at 4 and 6 weeks post-transplantation. The recovery of ovarian function was evaluated by observing the estrous cycle and measuring estradiol levels using Elisa. Histological evaluation was performed to assess the integrity of ovarian follicles. TUNEL assay was used to detect stromal cell apoptosis, and immunohistochemistry was conducted to evaluate follicular proliferation and tissue angiogenesis.</p><p><strong>Results: </strong>After heterotopic transplantation, mice in the experimental groups exhibited restoration of the estrous cycle. Hormone levels showed an increasing trend in the vitrification groups. At 6 weeks post-transplantation, the VF2 group had significantly higher hormone levels compared to the VF1 group and the slow freezing (SF) group (P < 0.05). At 4 weeks post-transplantation, the proportion of normal follicles was higher in the VF2 group compared to the other two groups (P > 0.05), and at 6 weeks post-transplantation, the VF2 group was significantly higher than the SF group (P < 0.05) and slightly higher than the VF1 group. Immunohistochemistry analysis indicated a higher proportion of proliferating follicles in the vitrification groups compared to the slow freezing group (P > 0.05). CD31 expression was established in all groups at 4 and 6 weeks post-transplantation, with better results in the slow freezing group compared to the vitrification group. TUNEL analysis showed that stromal cell apoptosis was higher in the SF group compared to the vitrification group at 4 weeks post-transplantation (P < 0.05), while there was no significant statistical difference among the groups at 6 weeks post-transplantation.</p><p><strong>Conclusions: </strong>Vitrification showed better results than slow freezing, with the VF2 group performing slightly better than the VF1 group. Considering the lower economic and time costs associated with vitrification, it may be more suitable for ovarian tissue cryopreservation in major research centers in the future.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"24 1","pages":"654"},"PeriodicalIF":2.4,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using an electronic patient reported outcome measure (ePAQ-MPH) to assess potential harm for long-waiting patients in gynaecology. 使用电子患者报告结果测量(ePAQ-MPH)来评估长时间等待的妇科患者的潜在危害。
IF 2.4 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-12-21 DOI: 10.1186/s12905-024-03506-0
Thomas Gray, Sandra Johnson, Edward Prosser-Snelling, Paul Simpson

Background: During the COVID-19 pandemic, outpatient waits for gynaecology appointments increased by 60% in the UK National Health Service (NHS). The aim of this study was to use the electronic Personal Assessment Questionnaire-Menstrual, Pain and Hormonal (ePAQ-MPH) electronic patient reported outcome measure (ePROM) to assess symptoms, impact and potential harm for patients waiting > 60 weeks for general gynaecology appointments at a teaching hospital.

Methods: 1070 patients waiting > 60 weeks for a new appointment (range 60-72 weeks) were invited to complete ePAQ-MPH online to measure gynaecological symptoms and health-related quality-of-life (HRQoL). Patients could also call to cancel appointments no longer needed. Non-responders were telephoned weekly for three further weeks and asked to complete ePAQ-MPH. Patients scoring > 80/100 for ePAQ-MPH domains relating to HRQoL had their appointment escalated to be seen within six-eight weeks. Thematic content analysis was undertaken of free-text concerns recorded using ePAQ-MPH.

Results: 526 patients completed ePAQ-MPH (49.2%), 169 of these scored greater than 80/100 for one or more HRQoL domains and were seen within 6-8 weeks. 103 patients (9.6%) requested to cancel their appointment. Reasons included problem resolving spontaneously (33%), problem treated by general practitioner (10%) and being seen by a private provider (28%). Commonly recorded free-text concerns related to wanting a diagnosis (n = 142), management of condition (n = 98) and pain management (n = 77).

Conclusions: ePAQ-MPH may be used effectively to prioritise patients waiting for an outpatient appointment in gynaecology. Wider use of ePROMs to support waiting list validation within the NHS and elsewhere should be considered.

背景:在2019冠状病毒病大流行期间,英国国家卫生服务(NHS)门诊等待妇科预约的人数增加了60%。本研究的目的是使用电子个人评估问卷-月经、疼痛和激素(ePAQ-MPH)电子患者报告结果测量(ePROM)来评估在教学医院等待60周普通妇科预约的患者的症状、影响和潜在危害。方法:邀请1070例等待60周(60-72周)新就诊的患者在线完成ePAQ-MPH,以测量妇科症状和健康相关生活质量(HRQoL)。病人也可以打电话取消不再需要的预约。无应答者在接下来的三周内每周打电话,并要求完成ePAQ-MPH。与HRQoL相关的ePAQ-MPH域评分为bbb80 /100的患者在6 - 8周内就诊。对使用ePAQ-MPH记录的自由文本问题进行主题内容分析。结果:526例患者完成了ePAQ-MPH(49.2%),其中169例患者在6-8周内完成了一个或多个HRQoL域的评分高于80/100。103名患者(9.6%)要求取消预约。原因包括问题自行解决(33%),由全科医生治疗(10%)和由私人提供者治疗(28%)。通常记录的自由文本关注与想要诊断(n = 142)、病情管理(n = 98)和疼痛管理(n = 77)有关。结论:ePAQ-MPH可有效地用于妇科门诊患者的优先等待预约。应该考虑更广泛地使用eprom来支持NHS和其他地方的等待名单验证。
{"title":"Using an electronic patient reported outcome measure (ePAQ-MPH) to assess potential harm for long-waiting patients in gynaecology.","authors":"Thomas Gray, Sandra Johnson, Edward Prosser-Snelling, Paul Simpson","doi":"10.1186/s12905-024-03506-0","DOIUrl":"10.1186/s12905-024-03506-0","url":null,"abstract":"<p><strong>Background: </strong>During the COVID-19 pandemic, outpatient waits for gynaecology appointments increased by 60% in the UK National Health Service (NHS). The aim of this study was to use the electronic Personal Assessment Questionnaire-Menstrual, Pain and Hormonal (ePAQ-MPH) electronic patient reported outcome measure (ePROM) to assess symptoms, impact and potential harm for patients waiting > 60 weeks for general gynaecology appointments at a teaching hospital.</p><p><strong>Methods: </strong>1070 patients waiting > 60 weeks for a new appointment (range 60-72 weeks) were invited to complete ePAQ-MPH online to measure gynaecological symptoms and health-related quality-of-life (HRQoL). Patients could also call to cancel appointments no longer needed. Non-responders were telephoned weekly for three further weeks and asked to complete ePAQ-MPH. Patients scoring > 80/100 for ePAQ-MPH domains relating to HRQoL had their appointment escalated to be seen within six-eight weeks. Thematic content analysis was undertaken of free-text concerns recorded using ePAQ-MPH.</p><p><strong>Results: </strong>526 patients completed ePAQ-MPH (49.2%), 169 of these scored greater than 80/100 for one or more HRQoL domains and were seen within 6-8 weeks. 103 patients (9.6%) requested to cancel their appointment. Reasons included problem resolving spontaneously (33%), problem treated by general practitioner (10%) and being seen by a private provider (28%). Commonly recorded free-text concerns related to wanting a diagnosis (n = 142), management of condition (n = 98) and pain management (n = 77).</p><p><strong>Conclusions: </strong>ePAQ-MPH may be used effectively to prioritise patients waiting for an outpatient appointment in gynaecology. Wider use of ePROMs to support waiting list validation within the NHS and elsewhere should be considered.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"24 1","pages":"646"},"PeriodicalIF":2.4,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mediating role of anxiety between body image distress and quality of life among women with polycystic ovary syndrome: a multicentre cross-sectional study. 多囊卵巢综合征女性身体形象困扰与生活质量之间焦虑的中介作用:一项多中心横断面研究
IF 2.4 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-12-21 DOI: 10.1186/s12905-024-03490-5
Mengyuan Sun, Qifeng Yi

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Body image distress (BID) refers to psychological distress caused by deviations in the individual's self-aesthetic ability. The objectives of this study are to investigate the prevalence of psychological distress; and to assess the role of anxiety in the relationship between body image distress and quality of life (QoL) among women with polycystic ovary syndrome using a path analysis approach.

Method: A multi-center cross-sectional study design was conducted among 294 women with PCOS in 29 provinces in mainland China from July 2021 to December 2021, and the data were analyzed using path analysis. The Multidimensional Body-Self Relations Questionnaire-Appearance Scales, Modified Polycystic Ovary Syndrome Questionnaire, and Hospital Anxiety and Depression Scale were administered to women who gave informed consent to participate.

Result: The results of path analysis are indicated that anxiety significantly mediated BID and QoL in women with PCOS (p < 0.05) and the structural equation model analysis further confirmed the statistical significance of this mediating effect. The fit indices CFI = 1.00, TLI = 1.00, and RMSEA = 0.00, indicating that the model represents the data well. A good fit of the proposed model to the observed data was obtained, which revealed that BID not only directly influenced QoL, but also had a significant indirect effect on QoL via anxiety.

Conclusion: Psychological counseling clinics is as well needed to provide patients with individualized psychological counseling and avoid mental health problems caused by body image troubles. Anxiety mediated the relationship between BID and QoL, adding to the paucity of research for women with polycystic ovary syndrome.

背景:多囊卵巢综合征(PCOS)是育龄妇女最常见的内分泌疾病。Body image distress (Body image distress, BID)是指个体因自我审美能力偏差而产生的心理困扰。本研究的目的是调查心理困扰的患病率;并采用通径分析方法评估焦虑在多囊卵巢综合征女性身体形象困扰与生活质量(QoL)关系中的作用。方法:采用多中心横断面研究设计,于2021年7月至2021年12月对中国大陆29个省份的294名PCOS患者进行研究,并采用通径分析法对数据进行分析。对知情同意参与的妇女使用多维身体-自我关系问卷-外貌量表、改良多囊卵巢综合征问卷和医院焦虑和抑郁量表。结果:通径分析结果显示,焦虑显著调节PCOS女性的BID和QoL (p)。结论:心理咨询诊所需要为患者提供个性化的心理咨询,避免身体形象困扰引起的心理健康问题。焦虑介导BID与生活质量之间的关系,增加了对多囊卵巢综合征女性研究的匮乏。
{"title":"Mediating role of anxiety between body image distress and quality of life among women with polycystic ovary syndrome: a multicentre cross-sectional study.","authors":"Mengyuan Sun, Qifeng Yi","doi":"10.1186/s12905-024-03490-5","DOIUrl":"10.1186/s12905-024-03490-5","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Body image distress (BID) refers to psychological distress caused by deviations in the individual's self-aesthetic ability. The objectives of this study are to investigate the prevalence of psychological distress; and to assess the role of anxiety in the relationship between body image distress and quality of life (QoL) among women with polycystic ovary syndrome using a path analysis approach.</p><p><strong>Method: </strong>A multi-center cross-sectional study design was conducted among 294 women with PCOS in 29 provinces in mainland China from July 2021 to December 2021, and the data were analyzed using path analysis. The Multidimensional Body-Self Relations Questionnaire-Appearance Scales, Modified Polycystic Ovary Syndrome Questionnaire, and Hospital Anxiety and Depression Scale were administered to women who gave informed consent to participate.</p><p><strong>Result: </strong>The results of path analysis are indicated that anxiety significantly mediated BID and QoL in women with PCOS (p < 0.05) and the structural equation model analysis further confirmed the statistical significance of this mediating effect. The fit indices CFI = 1.00, TLI = 1.00, and RMSEA = 0.00, indicating that the model represents the data well. A good fit of the proposed model to the observed data was obtained, which revealed that BID not only directly influenced QoL, but also had a significant indirect effect on QoL via anxiety.</p><p><strong>Conclusion: </strong>Psychological counseling clinics is as well needed to provide patients with individualized psychological counseling and avoid mental health problems caused by body image troubles. Anxiety mediated the relationship between BID and QoL, adding to the paucity of research for women with polycystic ovary syndrome.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"24 1","pages":"658"},"PeriodicalIF":2.4,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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